酒精分离联合自体带蒂角膜缘结膜瓣转位移植治疗翼状胬肉

目的探讨酒精分离联合自体带蒂角膜缘结膜瓣转位移植治疗翼状胬肉的手术技巧和临床疗效。方法对初发和复发性翼状胬肉120例（140眼）采用加％酒精浸泡胬肉头部后,剥离、切除胬肉,再联合自体带蒂角膜缘结膜瓣转位移植手术。术后随访3-12月,平均10月。比较术前术后视力、BUT情况,观察角膜上皮修复及自体带蒂角膜缘结膜瓣转位移植后存活情况,胬肉复发情况。结果酒精分离法使胬肉纤维血管组织与其下角膜基质分离更加容易。术后角膜上皮修复快,带蒂角膜缘结膜瓣转位移植后100％存活,视力、BUT值较术前不同程度的提高,胬肉治愈138眼（98．57％）,胬肉复发2眼（复发倾向1眼,真性复发1眼）。结论酒精分离联合自体带蒂角膜缘结膜瓣转位移植治疗翼状胬肉术式简单、易操作,安全、可靠,手术损伤小、术后反应轻、恢复快、复发率低,无严重并发症,是值得临床推广的有效方法。     

自体角膜缘上皮移植联合球结膜移植治疗翼状胬肉

目的探讨自体角膜缘上皮移植联合球结膜移植治疗翼状胬肉的手术方法及临床疗效。方法显微镜下取自体角膜缘处角膜上皮及球结膜移植于原病灶切除处，角膜缘上皮含干细胞，限于上、下方角巩膜１ｍｍ宽范围内，手术强调在显微镜下操作。结果１０例（１２眼）行此术式者术后观察结膜植片生长良好，角膜上皮愈合早、好，且可保持角膜上皮表现型。随访一年，无一例复发。结论常规翼状胬肉手术复发率高，采用该术式复发率明显低于常规翼状胬肉手术。     

带结膜瓣的自体角膜缘移植治疗翼状胬肉临床观察

目的 :观察用带结膜瓣的自体角膜缘 (干细胞 )移植术治疗翼状胬肉的疗效 ,探索其显微手术技术的改进及其安全性。方法 :选择进行期翼状胬肉 2 5例 2 6眼、复发性翼状胬肉 5例 5眼 ,采取显微手术取同侧眼下方角膜缘带结膜瓣的角膜缘游离移植片进行移植。缝合时强调移植片移植床上角膜缘各自准确对位吻合。术后对角膜上皮化及植片生长情况严密追踪观察。结果 :经过平均 1年 9个月观察无 1例胬肉复发 ,角膜上皮稳定、泪膜正常、供区角膜创面正常愈合。结论 :同侧眼带结膜瓣自体角膜缘 (干细胞 )移植治疗翼状胬肉为较佳的方法。术后供区角膜创面能正常愈合 ,角膜上皮状态稳定 ,泪膜正常 ,未发现术眼出现干细胞代偿功能不全的有关表现及无 1例胬肉复发。此术式是一种高效安全的治疗胬肉的方法。     

自体角膜缘上皮移植治疗翼状胬肉疗效观察

目的观察自体角膜缘上皮干细胞移植治疗翼状胬肉的效果。方法选择单纯性翼状胬肉52例(52眼)，在显微镜下行常规切除术，取同侧眼上方或下方角膜缘上皮连同相应面积的球结膜作为移植片修补缺损区。结果术后平均随访16月，无1例复发，角膜上皮稳定，植片愈合良好，供区结膜创面自行愈合，除1例术后不规则散光外；无其它并发症出现。结论本术式能修复角膜缘缺损，恢复角膜缘干细胞的功能，有效预防胬肉的复发，是一种安全有效的治疗翼状胬肉的方法。     

自体角膜缘干细胞移植术治疗翼状胬肉

目的探讨用自体角膜缘干细胞移植方法，作术眼角膜缘重建术治疗翼状胬肉的疗效。方法进行期翼状胬肉17例(18眼)，复发性翼状胬肉4例(4眼)，共21例(22眼)，在手术显微镜下切除胬肉的基础上，联合自体带结膜瓣的角膜缘游离植片进行角膜缘移植术。术后对角膜上皮的重建和生长情况严密跟踪观察。结果经过平均13月的随访观察胬肉术后无复发，角膜上皮稳定。供区角膜创面与结膜创面愈合正常。结论在常规切除翼状胬肉的同时联合同侧带结膜瓣自体角膜上皮(干细胞)移植行角膜缘重建术，对防止胬肉复发的效果是肯定的。     

自体角膜缘上皮移植联合贝复舒治疗翼状胬肉的疗效观察

目的 观察自体角膜缘上皮移植联合贝复舒对角膜缘上皮修复的作用。方法 随机选择翼状胬肉患者98例(98只眼)，治疗组为自体角膜缘上皮移植联合贝复舒，对照组为翼状胬肉切除联合贝复舒。术后每日观察角膜上皮缺损区的修复情况，并随诊观察复发情况。结果 治疗组角膜缘上皮平均修复时间为3．1天，对照组4．2天，有显著差异性。随诊6个月发现对照组有一例复发，均未发现感染。结论 自体角膜缘上皮移植联合贝复舒可使角膜缘上皮修复时间快于翼状胬肉切除联合贝复舒。复发率均较低，表明自体角膜缘上皮移植联合贝复舒治疗翼状胬肉可以加快角膜缘上皮修复，减少复发及感染的机会。     

自体角膜缘上皮移植治疗翼状胬肉

目的评价自体角膜缘上皮移植治疗翼状胬肉的效果。方法采用自体角膜缘上皮移植治疗原发性和复发性翼状胬肉60例(82眼)。结果随访观察6月～2年，仅3眼术后复发(3．6％)。结论自体角膜缘上皮移植治疗翼状胬肉，可有效防止翼状肉的复发，是治疗翼状胬肉的理想手术方法。     

双向角膜缘干细胞移植治疗翼状胬肉

目的 评价双向角膜缘干细胞移植治疗翼状胬肉的疗效。方法 对48例(54眼)翼状胬肉行双向角膜缘干细胞移植，术后进行随访。结果 随访时间最短12月，最长38月，最少随访5次，无一例复发，视力无一例因手术而下降，未发现远期并发症。结论 双向角膜缘干细胞移植治疗翼状胬肉是一种经济、安全、有效、易掌握的方法。     

带角膜缘的自体结膜瓣移植术治疗翼状胬肉的疗效

目的:观察用带角膜缘的自体结膜瓣移植术治疗翼状胬肉的临床效果。方法:翼状胬肉50例56眼,采取显微手术取同侧眼上方带角膜缘的游离结膜瓣进行移植。行翼状胬肉切除联合带角膜缘的自体结膜瓣进行移植,缝合时注意移植片移植床上角膜缘各自准确对位吻合,术后对角膜上皮化及植片生长情况随访观察。结果:术后随访6～12mo,角膜上皮平整光滑,泪膜正常,供区角结膜创面正常愈合,术后角膜透明或仅遗留少许云翳,无新生血管长入,无1例复发。结论:用带角膜缘的自体结膜瓣移植术治疗翼状胬肉,有利于重建角膜缘功能,是一种治疗翼状胬肉安全有效的手术方法。     

单纯胬肉切除、角膜缘干细胞移植与带蒂结膜瓣移植治疗翼状胬肉疗效比较

目的比较单纯胬肉切除、角膜缘干细胞移植及带蒂结膜瓣移植术治疗翼状胬肉的疗效，探讨降低术后复发率的方法。方法667例（718眼）翼状胬肉，采用上述三种术式治疗，术后随访5～20个月观察胬肉复发情况。结果单纯胬肉切除术组62例（62眼），6眼胬肉复发，复发率为9．68％。联合角膜缘干细胞移植术组430例（462眼），3眼复发，复发率0．65％。联合带蒂结膜瓣移植术组175例（194眼），2眼复发，复发率1．03％。单纯切除组与其他两组复发率之间差异具有统计学意义（P〈0．01）。联合角膜缘干细胞移植组与联合带蒂结膜瓣移植组之间差异不具有统计学意义（P〉0．05）。结论胬肉切除联合角膜缘干细胞移植术治疗翼状胬肉其复发率与联合带蒂结膜瓣移植术相比无明显优势。两者术后复发率均明显低于单纯胬肉切除术。     

Strabisme Alternant - Etude clinique - traitement

The author defines motor and sensory alternation: the term alternation should not be used in isolation, it should always be accompanied by the name of the parameter concerned. Sensory alternation is always found together with motor alternation but the reverse is not true.The examining criteria for a diagnosis of sensory alternation are given, sensory alternation must not be confused with alternating inhibition. Working from clinical observations of cases of motor alternating strabismus, the author selects 2 types of binocular sensory relations which allow one to differentiate between:- cases of primary alternating strabismus- cases of secondary alternating strabismusThese forms will develop in different ways; in both cases a cure is possible providing that the right treatment is prescribed and once prescribed carefully followed, etc. It is always a case of serious forms of strabismus whose developmental period is spread over several years.According to the authors, the frequency of cases of true primary strabismus is from 1–3%, the frequency of cases of secondary alternating strabismus varies according to the type of therapy practised on cases of monocular strabismus with amblyopia. These latter will become cases of alternating strabismus under the influence of certain types of therapy carried out over several years (penalization, rocking, alternated occlusion, etc...).Experimental data on kittens confirm clinical data; kittens placed in abnormal environments during the sensitive period will show modification in the distribution of cortical cells and the absence of binocular cells (either because the excitation of the two eyes was not simultaneous, or not identical: artificial strabismus, occlusion, opaque glasses). This disturbances become irreversible after a certain period of exposure (a function of age, length of exposure, etc...).It is thus necessary to bear in mind: 1) the iatrogenic risks of certain orthoptic treatments, 2) the necessity for a binocular form of treatment as soon as possible, as once a certain stage is passed, cortical plasticity diminishes and the elaboration of normal binocular relations becomes impossible.

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Effects of Adenosine Agonists on Intraocular Pressure and Aqueous Humor Dynamics in Cynomolgus Monkeys

The effects of single or multiple topical doses of the relatively selective A₁adenosine receptor agonists (R)-phenylisopropyladenosine (R-PIA) and N⁶-cyclohexyladenosine (CHA) on intraocular pressure (IOP), aqueous humor flow (AHF) and outflow facility were investigated in ocular normotensive cynomolgus monkeys. IOP and AHF were determined, under ketamine anesthesia, by Goldmann applanation tonometry and fluorophotometry, respectively. Total outflow facility was determined by anterior chamber perfusion under pentobarbital anesthesia. A single unilateral topical application of R-PIA (20–250 μg) or CHA (20–500 μg) produced ocular hypertension (maximum rise=4.9 or 3.5 mmHg) within 30 min, followed by ocular hypotension (maximum fall=2.1 or 3.6 mmHg) from 2–6 hr. The relatively selective adenosine A₂antagonist 3,7-dimethyl-1-propargylxanthine (DMPX, 320 μg) inhibited the early hypertension, without influencing the hypotension. Neither 100 μg R-PIA nor 500 μg CHA clearly altered AHF. Total outflow facility was increased by 71% 3 hr after 100 μg R-PIA. In conclusion, the early ocular hypertension produced by topical adenosine agonists in cynomolgus monkeys is associated with the activation of adenosine A₂receptors, while the subsequent hypotension appears to be mediated by adenosine A₁receptors and results primarily from increased outflow facility.