《中国临床神经科学》2012年征订启示

本刊主要刊登与临床神经病学有关的临床与基础研究,如生化、解剖、病理、心理、电生理、免疫、神经影像、流行病、药理、动物实验、分子生物学,WHO及国外医学信息等内容。设有论著、论著报道、进展、讲座、实验方法、疾病的新认识和新治疗、教育.思考.分析等栏目,内容新颖、编     

2012中国脑卒中大会隆重召开

“2012中国脑卒中大会”于5月4日至6日在国家会议中心隆重召开。全国人大副委员长桑国卫、卫生部副部长马晓伟、全国人大常委、卫生部原副部长、中国工程院院士王陇德、解放军总后卫生部原副部长傅征将军及卫生部办公厅、规财司、疾控局、农卫司、妇社司、医政司、医管司、科教司、总后卫生部医疗局等司局长、北京市领导及中华医学会、中华预防医学会、中国医院协会、中国医师协会等学会、协会领导、中国工程院、中国科学院院士及国内外著名专家学者、全国各级医疗机构3000余名医务工作者参会。大会开幕式由卫生部医政司司长王羽主持。     

泛北京地区多发性硬化协作小组第一次会议纪要

2007年12月22日,由许贤豪教授发起的泛北京地区多发性硬化(MS)协作小组讨论会在北京市昌平区白鹭园举行。参加会议的代表有许贤豪、崔丽英、吴卫平、于普林、牛俊英、李泽宇、安中平、张晓君、张星虎、时秋宽、刘广志、高枫、王向波、董会卿、徐雁、王蕊、金莎、谢琰臣、黄德晖     

中华医学会系列杂志版权声明

中华医学会系列杂志上刊载的所有内容,包括但不限于版面设计、数字资源、文字报道、图片、声音、录像、图表、标志、标识、广告、商标、商号、域名、软件、程序、版面设计、专栏目录与名称、内容分类标准以及为注册用户提供的任何或所有信息,均受《中华人民共和国著作权法》《中华人民共和国商标法》《中华人民共和国专利法》及适用之国际公约中有关著作权、商标权、专利权及(或)其他财产所有权法律的保护,为中华医学会及(或)相关权利人专属所有或持有。     

泛北京地区MS协作小组第三次会议通讯

2008-08-02,泛北京地区多发性硬化(MS)协作小组第三次会议在北京市雁栖湖法官进修学院召开.参加会议的代表有许贤豪、李存江、谢汝萍、牛俊英、安中平、李泽宇、张晓君、张星虎、高枫、靳二虎、李润今、刘广志、徐雁、矫毓娟、王佳伟、叶静、金莎、刘彩燕、陈宇丹、杨丽、殷宇慧、邹晨双、孙庆利、张麟伟、王丽共25人.     

《中国临床神经科学》2010年征订启示

本刊主要刊登与临床神经病学有关的神经基础研究,如生化、解剖、病理、心理、电生理、免疫、神经影像、流行病、药理、动物实验、分子生物学等方面的论著及经验交流、论著报道、综述、讲座、     

2005年悉尼第18届世界神经病学年会信息

癫癎和神经系统疾病Baialer等报道过去10年,有10种新型抗癫药物(AEDs)研究进展,包括:非氨酯(FBM)、加巴喷丁(GBP)、拉莫三嗪、levetiracetam(LEV)、奥卡西平(OXC)、pregabalin、tiagabine、托吡酯、氨己烯酸、zonisamide。这些药物(除FBM)均具有良好的药动学、耐受性好、药物相     

《中国临床神经科学》2009年征订启示

刊号:(ISSN1008/0678)/(CN31-1752/R)邮发代号:4-602本刊主要刊登与临床神经病学有关的神经基础研究,如生化、解剖、病理、心理、电生理、免疫、神经影像、流行病、药理、动物实验、分子生物学等方面的论著和研究结果、经验交流、报道、综述、讲座、实验方法、临床病理讨论、疾病的新认识和新治疗、WFIO及国外医学信息等。内容新颖、     

常用统计符号及使用基本要求

统计名词和符号请按国家标准《统计学名词和符号》的规定书写:样本数n、算术平均数x、标准差s、标准误Sx、t检验、F检验、相关系数r、概率P用英文斜体,卡方检验χ2、自由度υ用希文斜体;P值前应给出检验值,如t值、F值、χ2值等。     

《中国临床神经科学》2011年征订启示

本刊主要刊登与临床神经病学有关的临床与基础研究,如生化、解剖、病理、心理、电生理、免疫、神经影像、流行病、药理、动物实验、分子生物学,WHO及国外医学信息等内容。设有论著、论著报道、进展、讲座、实验方法、疾病的新认识和新治疗、教育·思考·分析等栏目,内容新颖、编     

Three strategies for changing attributions about severe mental illness

The effects of three strategies for changing stigmatizing attitudes--education (which replaces myths about mental illness with accurate conceptions), contact (which challenges public attitudes about mental illness through direct interactions with persons who have these disorders), and protest (which seeks to suppress stigmatizing attitudes about mental illness)--were examined on attributions about schizophrenia and other severe mental illnesses. One hundred and fifty-two students at a community college were randomly assigned to one of the three strategies or a control condition. They completed a questionnaire about attributions toward six groups--depression, psychosis, cocaine addiction, mental retardation, cancer, and AIDS--prior to and after completing the assigned condition. As expected, results showed that education had no effect on attributions about physical disabilities but led to improved attributions in all four psychiatric groups. Contact produced positive changes that exceeded education effects in attributions about targeted psychiatric disabilities: depression and psychosis. Protest yielded no significant changes in attributions about any group. This study also examined the effects of these strategies on processing information about mental illness.     

Attitudes about impairment and depression in elders suffering from chronic heart failure

OBJECTIVES: This study examines the relationship between functional impairment and depression in patients with heart failure using a new measure of Attitudes about Impairment. METHODS: Sixty-nine patients with chronic heart failure completed diagnostic interviews and questionnaires about mood, comorbid illness, functional impairment, and social support. Study design was case-control with cases selected because they met criteria for DSM-IV major or minor depression (n = 23). Controls reported no or very few depressive symptoms (n = 46). A preliminary study of the psychometric properties of a new 15-item measure of Attitudes about Impairment was conducted. RESULTS: The Attitudes about Impairment measure had a Cronbach's alpha = 0.81. A factor analysis revealed content domains of negative attitudes about dependency, lack of recreational activities, and concerns about being a burden both currently and in the future. This measure correlated highly with the Geriatric Depression Scale (r = 0.61) and remained high even after controlling for medical burden and social support. Patients were diagnosed with either major, minor or no depression using a DSM-IV based structured interview. Depressed patients had significantly more negative attitudes about impairment and the association between depression and physical impairment was no longer significant after controlling for scores on the Attitudes about Impairment measure. DISCUSSION: Negative attitudes about loss of autonomy, concerns about being a burden and having few recreational activities are strongly associated with depression in patients with heart failure. These attitudes account, in part, for the association between impairment and depression in these patients. The Attitudes about Impairment measure has adequate internal consistency and both convergent and discriminant validity with related measures of social support, functional disability and depression.     

Psychiatrists' knowledge about maternal filicidal thoughts

OBJECTIVE: Child murder by mentally ill mothers is an important public health and psychiatric concern. However, the authors' clinical and forensic experience has been that psychiatrists often do not inquire about maternal thoughts of harming their children. This study sought to elucidate the perceptions of psychiatrists and psychiatric residents regarding the frequency of such thoughts, and to clarify whether they inquire specifically about maternal filicidal thoughts. Psychiatrists were expected to underestimate the prevalence maternal thoughts of harming their children. It was hypothesized that psychiatrists often do not ask their patients about these thoughts. METHODS: This study surveyed psychiatrists and psychiatric residents at 2 academic institutions. Respondents were asked whether they routinely query women about motherhood, to estimate the frequency of thoughts of child harm, and whether they inquire about filicidal thoughts in psychotic or suicidal mothers. RESULTS: Two hundred twenty surveys (67%) were returned. Most psychiatrists underestimated the frequency of depressed mothers who experienced thoughts of harming their young children. Almost one half indicated that they do not ask specifically about filicidal ideation but rather ask about general homicidal thoughts only. CONCLUSIONS: Psychiatrists should have further education about the prevalence of filicidal thoughts and more frequently inquire about them.     

Knowing the risk of SUDEP: Two family's perspectives and The Danny Did Foundation

There is much debate in the epilepsy community about whether neurologists should discuss the risk of sudden unexpected death in epilepsy (SUDEP) with their patients and family members. Those in favor purport that patients have a right to know about SUDEP. Opponents say the risk is so low that discussions only worry patients and families, especially if there is nothing that can be done to prevent SUDEP. North American surveys show that the epilepsy community knows little about SUDEP and neurologists are unlikely to talk about it. However, surveys of those bereaved by SUDEP show that an overwhelming majority of the parents, spouses, and family members want to be told about SUDEP immediately after the diagnosis of epilepsy. This article is written by two families bereaved by SUDEP and their strong belief that neurologists should have the discussion about the risk of SUDEP soon after the diagnosis of epilepsy.     

A survey of psychiatric outpatients on quality of care

Despite increased emphasis on the quality of health care and on the dissemination of information about quality to the public, expectations are equivocal about consumers' interest in such information. A total of 110 psychiatric outpatients were asked about how they selected their mental health provider and were surveyed about their views on the quality of mental health care. Most study participants believed that quality can vary by provider, viewed themselves as active consumers of health care, desired more information about quality, and stated that if they had information about quality they would use such information when selecting a provider. Nevertheless, few sought such information in finding their clinician. Lower educational level of the participant was associated with a lower rating of interest in clinician quality.     

Microdialysis and electromyography of experimental muscle fatigue in healthy volunteers and patients with mitochondrial myopathy

Using a microstimulation technique for obtaining motor unit number estimates (MUNEs) of the hypothenar and extensor digitorum brevis (EDB) muscles, we performed a longitudinal study on the natural course of change in the clinical rating scale (Appel score) and of loss of functional spinal alpha motor neurons in amyotrophic lateral sclerosis. The Appel score increased to about 150% of normal at 12 months after onset, about 225% at 18 months after onset, and about 370% at 24 months after onset. By contrast, MUNEs decreased to about 27% of normal at 12 months after onset, about 12% at 18 months after onset, and about 5% at 24 months after onset. The relative merits of these different approaches in detecting changes in the disease process in its early phase are discussed.     

Psychosocial factors associated with knowledge about affective disorders in patients with depression

BACKGROUND: Increasing importance is attributed to the knowledge that patients have concerning their illness. For psychiatric disorders, imparting information about the illness has become a standard part of treatment. Despite the great clinical relevance of knowledge about depression, only few empirical studies on this subject have been carried out. This study aimed to identify psychosocial factors associated with greater or lesser knowledge about affective disorders. METHODS: Sixty-one in-patients with depression were recruited and tested with the Knowledge about Depression and Mania Inventory. RESULTS: Almost all patients sought specific information about their disorder prior to admission to hospital. There were large differences in patients' knowledge about the disorder and their choice of information source. Older and less educated patients had less knowledge about affective disorders. Patients with less illness knowledge also have a less favourable illness concept, poorer interpersonal relationships and more passive coping strategies. CONCLUSIONS: The results show that knowledge about affective disorders is a central illness characteristic that has numerous implications for the ability to cope with the disorder, as well as for psychotherapeutic management. The results contribute to a clarification of the relationship between psychoeducation and psychotherapy.     

Knowledge of the diagnosis and drug treatment of psychiatric patients

Among 117 patients of the psychiatric department of a university hospital, semistandardized interviews were conducted to examine their ideas about their diagnosis and psychopharmacological treatment. At the times of the interviews, 55.5% of the patients were fairly correct about their diagnosis, 49% could name more than half the drugs prescribed, 46.5% knew at least some of the side effects, and 32% had largely appropriate ideas about the desired drug effects. The level of knowledge about the diagnosis and psychopharmacological treatment was not related to the diagnosis or to the duration of disease. Patients who had had the benefit of further or higher education and patients whose physicians regard comprehensive patient information about diagnosis as favourable were better informed. Out-patients knew more about psychopharmacological treatment than in-patients. Information about diagnosis and therapy enables patients to understand their symptoms and to integrate them into their own disease concept, provided their existing medical knowledge and disease concepts are taken into consideration.     

Mothers' explanations of communicating past health and future risks to survivors of childhood cancer

Mothers of survivors of Retinoblastoma (Rb) experience unique challenges communicating with their child about the condition. Children are mostly diagnosed within their first year but the consequences continue into young adult life. Here 39 mothers of Rb survivors (23 males, mean age = 10.26 years) were interviewed about their experiences. Mothers were asked about communication with their children about Rb, and future health risks. Interviews were analysed using thematic analysis. Mothers reported that they had informed children about past diagnosis and treatment but had spoken less about genetic risk or risk of secondary cancer. The child's age and information-seeking behaviour were associated with mothers' disclosure, along with mothers' perceptions that information would facilitate child coping. Findings suggest that mothers may need more guidance during follow-up care in communicating about the disease and its consequences for future health. Medical staff should also take extra care to ensure that mothers are aware of genetic counselling services and how to access them before the child is discharged from specialist care.     

Expression of glutamate transporters and ionotropic glutamate receptors in GLAST knockout mice

In order to investigate the molecular mechanism underlying high seizure susceptibility of GLAST knockout mice, we carried out Western blotting for the expression of GLT-1, EAAC-1, and several kinds of glutamate receptors in the hippocampus and the cortex. Although no significant difference was observed between GLAST (+/+) and (-/-) mice in terms of expression of GLT-1 and EAAC-1 in the hippocampus, these proteins were over-expressed in the frontal cortex in GLAST (-/-) mice (GLT-1, about 210% increase; EAAC-1, about 180% increase). Expression of hippocampal Glu-R1 and Glu-R2 in GLAST (-/-) mice was remarkably increased (Glu-R1, about 140% increase; Glu-R2, about 160% increase), while Glu-R3 and NMDA receptors levels (NMDA-R1, 2A and 2B) were equal to those in control. Cortical levels of Glu-R1, -R2 and -R3 receptors in GLAST (-/-) mice were remarkably decreased (Glu-R1, about 60% decrease; Glu-R2, about 60% decrease; Glu-R3, about 70% decrease), while NMDA receptors were remarkably increased in comparison to those in GLAST (+/+) mice (N-R1, about 150% increase; N-R2A, about 150% increase; N-R2B, about 140% increase). These data suggest that the increased susceptibility to seizures in GLAST (-/-) mice might be derived from increased expression of Glu-R1 in the hippocampus coupled with decreased cortical expression of Glu-R2 and increased NMDA-R1 and -2A, -2B expression.