共查询到19条相似文献,搜索用时 93 毫秒
1.
2.
3.
4.
仙茅苷对自由基的清除作用 总被引:5,自引:0,他引:5
目的研究仙茅(Curculigo orchioidesGaertn.)主要成分仙茅苷(curcu ligoside)对羟自由基和超氧阴离子自由基的清除作用。方法分别采用比色法及电子顺磁共振技术(ESR)测定仙茅苷对羟自由基和超氧阴离子自由基的清除效果。结果仙茅苷对羟自由基和超氧阴离子自由基均有良好的清除作用,其清除率略低于茶多酚。结论仙茅苷对自由基具有明显的清除作用,是一种有效的天然抗氧化剂。 相似文献
5.
石榴皮鞣质对羟自由基和超氧阴离子自由基的清除作用 总被引:8,自引:0,他引:8
目的:研究石榴皮鞣质清除自由基的作用。方法:通过罗丹明B—Cu^2+-H2O2体系产生·OH,邻苯三酚自氧化体系产生O2^-。同时比较石榴皮鞣质提取物,鞣花酸一没食子酸混合溶液,以及维生素C的作用效果,根据作用常数的大小讨论3种溶液及其各自的浓度对自由基的清除作用,并初步推断作用机制。结果:石榴皮鞣质对羟自由基和超氧阴离子自由基均具有较好的清除作用,较低浓度时即可发挥清除作用。结论:石榴皮鞣质对自由基侵害有保护作用。 相似文献
6.
7.
川芎嗪及其衍生物对羟自由基的清除作用 总被引:29,自引:0,他引:29
目的:探讨川芎嗪及其衍生物对羟自由基的清除作用。方法:应用Fenton反应检测并计算50%羟自由基被清除时的药物浓度(EC_(50))。结果:结果显示对羟自由基均有明显清除作用,且呈剂量依赖关系。川芎嗪及其衍生物与苯甲酸和甘露醇的清除作用差异有极显著性(P<0.01),而相互间作用无明显差异(P>0.05)。结论:川芎嗪及其衍生物对羟自由基有明显的清除作用。 相似文献
8.
9.
10.
丁香酚对氧自由基的清除作用 总被引:11,自引:0,他引:11
研究了丁香酚、丁香油、丹皮酚、黄芩甙和芸香甙对氧自由基的清除作用。结果表明这几种药物对Fenton反应生成的·OH有明显的清除作用,其清除活性均高于OH特异性清除剂甘露醇(其EC50为2.1mmol/L),以丁香酚清除效果最好(其k-50为0。17mmol/L)。丁香酚对核黄素-甲硫氨酸光照还原生成的O2亦有明显的清除作用。 相似文献
11.
目的研究溪黄草提取物抗脂质过氧化作用。方法采用组织匀浆MDA比色法测定不同质量浓度溪黄草水提取物及乙醇提取物对SD大鼠离体肾脏、肝脏、心脏、脾脏和肺脏组织脂质过氧化的影响。结果2种提取物均具有明显的抗脂质过氧化活性,其中水提取物活性大于乙醇提取物,在1.00g.L-1质量浓度时,水提取物对SD大鼠离体组织MDA的抑制率大小为:肾脏>肝脏>心脏>脾脏>肺脏。结论溪黄草水提取物及乙醇提取物具有抗脂质过氧化作用。 相似文献
12.
13.
14.
Network pharmacology-based strategy to investigate harmacological mechanisms of Isodon serra (Maxim.) Hara for treatment of inflammatory 下载免费PDF全文
Weiwei Xie Xuqing Wen Dedong Zhang Yuqian Zhang Zhiqing Zhang Yiran Jin Yingfeng Du 《中国药学》2022,31(4):250-263
Widely distributed in plants, ent-kaurane diterpenoids could reduce the incidence of inflammatory. The most important active ingredient of Isodon serra (Maxim.) Hara is ent-kaurane diterpenoids, which contribute to the anti-inflammatory pharmacological effects of Isodon serra. However, the ingredients, the active compounds, drug targets, inflammatory targets and exact molecular mechanism of Isodon serra in treating inflammatory are still unclear. The purpose of this study was to use the method of network pharmacological analysis to find the active compounds in Isodon serra. These active compounds match the library of ent-kaurane diterpenoids compounds we established, and we find all the eligible ent-kaurane diterpenoids compounds. Isodon serra related and anti-inflammatory targets were found and then combined to get intersection, which represented potential anti-inflammatory targets of active compounds in Isodon serra. Moreover, anti-inflammatory targets and active compounds targets protein-protein interaction network were merged to get the protein-protein interaction network intersection and core genes in anti-inflammatory target protein-protein interaction network. For the anti-inflammatory targets of Isodon serra, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were executed to confirm gene functions of Isodon serra in antagonizing inflammation. Finally, TCMSP analysis identified 10 active compounds out of 48 ent-kaurane. The pathway analysis showed enrichment for different pathways like AGE-RAGE signaling pathway in diabetic complications, small cell lung cancer and human cytomegalovirus infection, which were all connected to inflammatory. On the whole, the proposed method clearly identified the ent-kaurane diterpenoids of Isodon serra and the results gave the active compounds of Isodon serra for the first time. The combining use of the qualitative analysis of traditional Chinese medicine (TCM) and network pharmacological methods could discover potential drug targets and reveal the biological process of TCM, which would open up a new approach in the study of TCM in future. 相似文献
15.
目的 建立高效液相色谱法测定毛叶香茶菜中迷迭香酸和冬凌草甲素含量的方法。方法 采用Kromasil C18色谱柱(250 mm×4.6 mm,5 μm),以甲醇-0.1%磷酸为流动相,梯度洗脱,流速:1 mL·min-1,检测波长:239 nm,柱温30 ℃。结果 迷迭香酸和冬凌草甲素的线性范围分别为9.53~4 765 ng和13.66~6 830 ng,平均加样回收率分别为103.3%和95.8%,RSD%分别为1.4%和1.9%。结论 该法简便、稳定、可靠、耐用性良好,可用于毛叶香茶菜的质量控制。 相似文献
16.
溪黄草有机酸提取分离及抑制亚硝化反应研究 总被引:2,自引:0,他引:2
目的提取分离溪黄草中有机酸并研究其对亚硝化反应的抑制作用。方法采用直接电位滴定法测定溪黄草中总有机酸含量,试验其最佳提取工艺条件,依此条件提取总有机酸并进行分离纯化,鉴定有机酸结构类型并研究其对亚硝化反应的抑制作用。结果溪黄草总有机酸提取率可达3.97%,主要为乌苏烷型三萜类有机酸,在一定浓度范围能阻断亚硝胺的合成及清除亚硝酸盐。结论溪黄草有机酸对亚硝化反应具有抑制作用。 相似文献
17.
枸杞多糖的提取及其对活性氧自由基的清除作用 总被引:51,自引:0,他引:51
李贵荣 《中国现代应用药学》2002,19(2):94-96
目的 :研究枸杞多糖 (LBP)的提取及其对活性氧自由基的清除作用。方法 :L BP提取采用水煮醇沉法粗提 ,Polyerde滤柱膜吸附洗脱精制 :采用分光光度法测定枸杞多糖对 O2-· 和 OH·的抑制作用。结果 :粗品 LBP对 O2-· 和 OH·清除率分别可达5 8.6%和 49.7% ,精品 L BP对二者的清除率分别可达 40 .7%和 3 1.4%。结论 :LBP对 O2-· 和 OH· 均有良好的清除能力 相似文献
18.
An ethanol-soluble pigment extract was separated from fermented Zijuan Pu-erh tea. The compositions of the ethanol soluble pigment extract were analyzed by high-performance liquid chromatography–tandem mass spectroscopy (HPLC–MS/MS). The extract was prepared into a series of ethanol solutions and analyzed for free radical-scavenging activities (against two free radicals: 1,1-diphenyl-2-picrylhydrazyl (DPPH) and (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO)) and in vitro anti-oxidative properties. Electron spin resonance spectroscopy showed that the peaks of DPPH and TEMPO decreased with increasing extract concentration, suggesting that the extract had excellent free radical-scavenging activities. In vitro cell culture suggested that, at 50–200 mg/L, the extract had no measurable effect on the viability of vascular endothelial cells (ECV340) but produced significant protective effects for cells that underwent oxidative injuries due to hydrogen peroxide (H2O2) treatment. Compared with the H2O2 treatment alone cells group, 200 mg/L of the extract increased the activity of superoxide dismutase (SOD) in cells by 397.3%, and decreased the concentration of malondialdehyde (MDA) and the activity of lactate acid dehydrogenase (LDH) by 47.8% and 69.6%, respectively. These results suggest that the extract has excellent free radical scavenging and anti-oxidative properties. 相似文献
19.