Do calorie restriction or alternate-day fasting regimens modulate adipose tissue physiology in a way that reduces chronic disease risk?

Adipose tissue physiology plays an important role in the development of several obesity-related disorders. Dietary restriction regimens, i.e., daily calorie restriction (CR) or alternate-day fasting (ADF), have been shown to decrease the risk of these disorders. Whether changes in adipose mass or physiology are required for the beneficial effects of CR or ADF is an important question. Accordingly, this review summarizes the effects of CR and ADF regimens on parameters of adipose physiology, i.e., adipose tissue morphology, triglyceride metabolism, and adipokine release, and attempts to link these changes to indicators of chronic disease risk.     

Can alginate-based preloads increase weight loss beyond calorie restriction? A pilot study in obese individuals

This randomized, controlled, 2-week intervention study in 24 obese subjects tested the effect on body weight loss and gastrointestinal tolerance of consuming low viscous alginate fibre-based preloads of 3% concentration (500 ml volume) three times a day as an adjuvant to a calorie-restricted diet. The pilot study showed that intake of the alginate preloads was moderately acceptable to the majority of subjects but did not produce additional body weight loss beyond calorie restriction (−1.42 ± 0.38 kg) (n = 12) compared to control group (−1.56 ± 0.21 kg) (n = 8). These results do not support that alginate supplementation enhance the weight loss effects of a hypo-caloric diet, but a sufficiently powered long-term study is needed to explore whether alginate could be an aid for improving weight loss during caloric-restriction.     

Leadership and achieving a vision--how does a profession lead a nation?

The author examines the role of leadership in achieving a new vision for health promotion. Leadership challenges and threats, and contemporary views on leadership are reviewed to frame the opportunity available to the health promotion profession to change national health policy. He concludes by describing the actions every professional can take to play a leadership role in helping to achieve the new vision articulated in this special issue.     

Estimating a constant WTP for a QALY—a mission impossible?

Economic evaluations are an important input to decision-making and priority-setting in the health care sector. Measuring preferences for health improvements, as the demand-side value (willingness to pay) of gaining a quality-adjusted life year (QALY), is one relevant component in the interpretation of the results from health economic evaluations. Our article addresses whether willingness to pay for a QALY (WTP-Q) is sensitive to the size of the health differences and the probability for improvement. We use data from a contingent valuation survey based on 1400 respondents conducted in the spring of 2014. The results show that the expectation of sensitivity to scope, or higher WTP to the larger expected quality of life improvement, is not supported. We find WTP-Q values that conform reasonably well to previous studies in Sweden.