特比萘芬与克霉唑栓联合治疗念珠菌性阴道炎疗效观察

目的观察特比萘芬与克霉唑栓联合治疗念珠菌性阴道炎的疗效.方法门诊念珠菌性阴道炎患者108例,其中治疗组62例口服特比萘芬并联合外用克霉唑栓;对照组46例外用克霉唑栓.结果治疗后1周治疗组与对照组治疗效果近似,4周时治疗组总有效率为98.39%,高于对照组的84.78%,两组比较差异有显著性(χ2=9.2,P＜0.05).结论特比萘芬与克霉唑栓联合治疗念珠菌性阴道炎效果良好.     

盐酸特比萘芬治疗念珠菌性阴道炎疗效观察

为观察盐酸特比萘芬治疗念珠菌性阴道炎疗效，选择念珠菌性阴道炎60例，口服特比萘芬25mg．每日1次，连服2周，2周后及停药后4周复诊，观察疗效。结果口服特比萘芬治疗念珠菌性阴道炎治愈率为86．7％。有效率为91．7％，口服特比萘芬治疗念珠菌性阴道炎疗效良好。     

特比萘芬治疗念珠菌性包皮龟头炎疗效观察

目的 观察特比萘芬口服加外用治疗念珠菌性包皮龟头炎的临床疗效。方法 86例念珠菌性包皮龟头炎患者分两组,1组51例患者口服特比萘芬片并外用特比萘芬乳剂,而2组35例患者仅外用特比萘芬乳剂。结果 1组患者治疗后总有效率为90．2％,而2组患者治疗后总有效率48．6％,两组总有效率统计学比较有显著性差异（P〈0．01）。结论 特比萘芬口服加外用治疗念珠菌性包皮龟头炎取得满意效果。     

特比萘芬与氟康唑序贯疗法治疗难治性念珠菌性阴道炎的疗效观察

目的 探讨特比萘芬与氟康唑序贯疗法治疗难治性念珠菌性阴道炎的临床疗效.方法 治疗组先予特比萘芬片250 mg,每日1次,共7天,第8天予氟康唑分散片150 mg,单次口服.特比萘芬组予特比萘芬片250 mg,每日1次,共14天.氟康唑组予氟康唑分散片150 mg,每周1次,共3周.治疗结束后2周及12周分别进行临床观察及真菌检查,判定疗效.结果 三组患者的近期有效率差异无统计学意义(P>0.05),但远期有效率存在显著性差异,治疗组明显优于两个对照组(P<0.05).不良反应发生率三组无统计学意义.结论 特比萘芬与氟康唑序贯治疗难治性念珠菌性阴道炎的长期疗效较好.     

酮康唑联合克霉唑栓治疗老年念珠菌性阴道炎效果分析

目的:分析酮康唑联合克霉唑栓治疗老年念珠菌性阴道炎的临床效果。方法:随机选取获嘉县人民医院2010年9月至2013年9月收治的100例老年念珠菌性阴道炎患者,按门诊单号分为观察组与对照组。对照组患者给予酮康唑治疗,观察组患者给予酮康唑联合克霉唑栓治疗,比较两组患者临床治疗效果。结果:对照组患者治疗总有效率为60.0%,观察组患者治疗总有效率为94.0%。两组对比后者治疗效果更佳,差异具有统计学意义(P<0.05)。对照组患者不良反应发生率为10%,观察组不良反应发生率为8%,组间差异无统计学意义(P>0.05)。结论:酮康唑联合克霉唑栓治疗老年念珠菌性阴道炎临床效果显著,复发及不良反应率低,值得推广与应用。     

特比萘芬与萘替芬酮康唑联合治疗外耳道真菌病的疗效分析

目的观察口服特比萘芬联合外用萘替芬酮康唑治疗外耳道真菌病的疗效、安全性。方法将66例外耳道真菌病患者随机分为两组：治疗组34例,口服特比萘芬联合外用萘替芬酮康唑,疗程1月;对照组32例,局部外用萘替芬酮康唑,疗程1月。结果治疗组1月后有效率为94.1%,高于对照组的53.1%,有显著性差异。结论联合疗法和单一外用药物治疗外耳道真菌病均有效,但联合疗法起效快、疗程短、效果好。     

特比萘芬片联用达克宁栓治疗复发性念珠菌性阴道炎86例疗效观察

念珠菌性阴道炎是常见的妇科炎性疾病，均有易复发的特点，特比萘芬是一种具有广谱抗真菌的丙烯胺类药物，我们用特比萘芬片联用达克宁栓治疗复发性念珠菌性阴道炎86例，疗效满意，现报道如下。     

特比萘芬、氟康唑联合治疗复发性念珠菌性外阴、阴道炎疗效观察

目的　观察特比萘芬、氟康唑联合治疗复发性念珠菌性外阴、阴道炎的疗效。方法　治疗组采用特比萘芬加氟康唑治疗 ,对照组单用氟康唑治疗。结果　治疗组临床痊愈率 83 33% ,有效率 91 6 6 % ,真菌清除率 94 4 4 % ,明显高于对照组 (P<0 0 5 )。结论　联合用药优于单一用药 ,值得推广。     

克霉唑联合氟康唑治疗复发性念珠菌性阴道炎的临床效果观察

目的 探讨克霉唑联合氟康唑治疗复发性念珠菌性阴道炎的临床效果.方法 将104例复发性念珠菌性阴道炎患者分为观察组(52例,给予克霉唑+氟康唑)和对照组(52例,克霉唑),观察2组疗效以及复发率.结果 观察组总有效率98.1%,治愈患者复发率4.0%,与对照组比较差异均有统计学意义(P<0.05).结论 克霉唑联合氟康唑治疗复发性念珠菌性阴道炎临床效果较好,复发率低,值得推广使用.     

氟康唑联合克霉唑栓治疗念珠菌性阴道炎临床疗效分析

目的：回顾性分析氟康唑联合克霉唑栓治疗念珠菌性阴道炎的临床疗效。方法将115例念珠菌性阴道炎患者随机分成观察组和对照组,观察组采用氟康唑联合克霉唑栓治疗,对照组采用单纯氟康唑治疗,比较两组临床治疗2周后疗效。结果观察组治愈率89．83％,对照组治愈率的67．85％,两组比较差异有统计学意义（P＜0．05）;观察组总有效率94．92％,对照组总有效率87．50％,两组比较差异有统计学意义（P＜0．05）。结论克霉唑栓与氟康唑联合治疗念珠菌性阴道炎疗效显著,值得临床推广应用。治愈后注意个人卫生,防止不良习俗引发炎症复发。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.