东莞地区孕妇缺铁性贫血的调查分析

目的了解东莞地区孕妇缺铁性贫血患病率及影响因素。方法选取2017年5月至2018年6月在东莞市谢岗医院妇产科产检的孕妇共1 280例,选择非妊娠期健康女性120例为非妊娠组,检测所有研究对象的血红蛋白、血清铁蛋白、叶酸和维生素B_(12)水平,并对结果进行分析。结果孕妇缺铁性贫血检出率为17.7%,血清铁蛋白缺乏率为41.7%,叶酸缺乏率为6.1%,维生素B_(12)缺乏率为10.4%。随着孕周增加,孕妇的缺铁性贫血发生率,血清铁蛋白、叶酸、维生素B_(12)缺乏率逐渐升高。结论孕妇缺铁性贫血的发病率在该地区依然较高。有必要在孕早、中、晚期检测血红蛋白、血清铁蛋白、叶酸和维生素B_(12)水平,并积极纠正妊娠期缺铁。     

血清铁蛋白、叶酸、维生素B_(12)检测对不同妊娠期孕妇的临床意义

目的探讨血清铁蛋白、叶酸、维生素B_(12)检测不同妊娠期孕妇的临床意义。方法收集120例孕妇为研究对象,根据孕期分为早孕组、中孕组和晚孕组,每组40例,选择同期40例非妊娠健康妇女为非孕组。比较各组妇女体内的血清铁蛋白、叶酸、维生素B_(12)水平,分析各组妇女血清铁蛋白、叶酸、维生素B_(12)缺乏情况。结果早孕组妇女叶酸值与非孕组比较,差异未见统计学意义(P0.05);早孕组妇女血清铁蛋白、维生素B_(12)低于非孕组,差异有统计学意义(P0.05);中孕组和晚孕组血清铁蛋白、叶酸、维生素B_(12)水平低于非孕组,中孕组和晚孕组的血清铁蛋白、维生素B_(12)缺乏率高于非孕组,差异有统计学意义(P0.05)。晚孕组妇女叶酸缺乏高于非孕组,差异有统计学意义(P0.05)。结论对不同妊娠期孕妇进行血清铁蛋白、叶酸、维生素B_(12)检测,可以快速准确分析孕妇贫血原因及状态,有效预防和治疗贫血症状,促进胎儿正常发育。     

叶酸、维生素B12、铁蛋白检测的临床应用价值

目的探讨妊娠妇女血清叶酸、维生素B12、铁蛋白水平与妊娠期并发症的关系,以指导临床干预。方法选取来本院产检的孕妇552例,分成两组,在医生指导下干预性治疗270例为干预组,未经干预282例为未干预组。两组均在早、中、晚期监测叶酸、维生素B12、铁蛋白和血常规。结果两组妊娠早期贫血3项结果的差异无统计学意义,妊娠中、晚期的差异均有统计学意义,两组贫血发生率和妊娠高血压发生率的差异均有统计学意义,干预组孕早期与孕中期的叶酸、维生素B12、铁蛋白检测结果的差异无统计学意义,未干预组孕早期和孕中期贫血3项结果的差异有统计学意义。结论孕妇在妊娠期间应监测叶酸、维生素B12、铁蛋白,并在医生指导下进行干预性治疗,对孕妇保健及优生有重要意义。     

孕妇血清HCY、FA、VitB12水平变化及其临床意义研究

目的研究孕妇血清同型半胱氨酸(HCY)、叶酸(FA)及维生素B12(VitB12)的变化情况及其与妊娠期高血压疾病及胎儿生长受限的关系,为母婴孕产期保健提供临床指导。方法 137例妊娠高血压疾病孕妇设为妊娠期高血压疾病组,119例胎儿生长受限孕妇设为胎儿生长受限组,并以同期144例健康孕妇为对照组,比较各组血清HCY、FA及VitB12血清水平。结果胎儿生长受限组、妊娠期高血压疾病组、对照组中血清HCY、FA及VitB12水平在任意两组之间比较,差异均有统计学意义(P0.05),胎儿生长受限组、妊娠期高血压疾病组、对照组血清HCY水平依次降低,FA及VitB12水平依次升高;胎儿生长受限组孕妇血清HCY水平与新生儿出生体质量、出生身长均呈负相关,相关系数分别为-0.424、-0.315,差异均有统计学意义(P0.05);妊娠期高血压疾病组孕妇血清HCY水平与孕期舒张压、收缩压均呈正相关,相关系数分别为0.398、0.421,差异均有统计学意义(P0.05)。结论妊娠晚期对孕妇血清HCY、FA、VitB12水平监测有利于防范妊娠高血压及胎儿生长受限的发生,对于妊娠期妇女的孕期保健及人口素质的提高具有重要的临床意义。     

血清叶酸、维生素B12、铁蛋白联合检测对妊娠期贫血的早期诊断价值

目的 分析叶酸、维生素B12、铁蛋白联合检测对妊娠期贫血的早期诊断价值。方法 选取2018年1月至2020年1月在湛江市第四人民医院治疗的86例妊娠期贫血患者,将其分为孕早期(n=30)、孕中期(n=32)、孕晚期(n=24)三组,同时,选取同期非妊娠期女性30例作为健康体检组。对所有研究对象进行叶酸、维生素B12、铁蛋白检测,并分析检测结果、检出率。同时分析干预组(n=43)与未干预组(n=43)的妊娠并发症情况。结果 不同孕期的受检者叶酸、铁蛋白、维生素B12水平均明显低于健康体检者(P 0. 05);且孕中期、孕晚期患者的三项指标均明显低于孕早期(P 0. 05),孕中期患者的三项指标明显低于孕晚期(P 0. 05)。铁蛋白单独检出率为67. 44%(58/86),维生素B12单独检出率为69. 77%(60/86),叶酸单独检出率为70. 93%(61/86),三项指标联合检测的检出率为98. 84%(85/86)。三项指标联合检测的检出率明显高于各项单独检测(P 0. 05)。结论 三项指标联合检测可提高妊娠期贫血检出率,及时采取恰当的干预措施可减少妊娠期并发症发生。     

血清铁蛋白、叶酸、维生素B_(12)检测对妊娠期妇女不同孕期的临床意义

目的通过检测妊娠期妇女不同孕期的血清铁蛋白、叶酸、维生素B_(12)的水平,为临床治疗妊娠贫血提供有效依据。方法选取2014年1-12月待产的妊娠妇女129例进行研究,将所有孕妇分成早、中、晚孕期组,每组43例;另外选择同期43例非妊娠期健康妇女为对照组。测定各组血清铁蛋白、叶酸、维生素B_(12)的水平,统计各组妇女的血清铁蛋白、叶酸、维生素B_(12)的缺乏情况以及新生儿出生体质量与叶酸、维生素B_(12)水平的相关性。结果随着孕期的增加,血清铁蛋白、叶酸、维生素B_(12)的水平呈减低趋势,早孕期妇女叶酸水平与对照组比较差异无统计学意义(P0.05);维生素B_(12)、铁蛋白水平较对照组低,差异有统计学意义(P0.05);中、晚孕期妇女铁蛋白、叶酸、维生素B_(12)的水平均低于对照组,差异有统计学意义(P0.05)。维生素B_(12)和铁蛋白在中、晚孕期的缺乏率高于对照组,差异有统计学意义(P0.05)。叶酸在晚期缺乏率高于对照组,差异有统计学意义(P0.05)。新生儿出生时体质量与母血中叶酸以及维生素B_(12)水平相关,差异有统计学意义(P0.05)。结论对妊娠期不同孕期的妇女进行血清铁蛋白、叶酸、维生素B_(12)的检测,可对妊娠期妇女的贫血原因、贫血状况进行及时、准确的分析,以期达到对孕期妇女的贫血症状有效预防、干预治疗的目的,对胎儿的正常发育也有重要的临床意义。     

妊娠妇女不同孕期血清叶酸、维生素B12和铁蛋白检测及其临床意义

目的：通过在不同孕期对妊娠妇女的血清叶酸、维生素B12和血清铁蛋白进行联合检测,为临床上治疗妊娠贫血提供有效依据。方法：对2013年4月~2013年11月期间,在我院待产的1067例妊娠妇女定为观察组,选取107例非妊娠妇女为对照组进行对比试验,分别进行血清叶酸、维生素B12和血清铁蛋白的含量分析,采用化学发光法检测对比两者间含量的差别。结果：随着孕期的增加,血清叶酸、维生素B。和血清铁蛋白的含量呈降低趋势,早孕期妇女的维生素B12与对照组相比无明显差异（P〉0．05）,血清叶酸和血清铁蛋白较对照组低,且差异有统计学意义（P〈0．05）;中、晚孕期妇女血清叶酸、维生素B12和血清铁蛋白的含量均低于对照组,差异有统计学意义（P〈0．05）。结论：对不同妊娠期的妇女进行血清叶酸、维生素B12和血清铁蛋白的含量检测,可对妊娠妇女的贫血原因进行准确分析,达到对妊娠妇女的贫血症状进行有效预防和治疗的目的,对胎儿的正常发育也有一定的临床意义。     

多指标监测妊娠期高血压疾病血液粘稠性

目的 对妊娠期高血压疾病孕妇、正常孕晚期孕妇及非孕育龄妇女血小板参数及红细胞参数的测定来探讨妊娠期高血压疾病患者血液粘稠性的变化，以寻求其对妊娠期高血压疾病病情监测及防治的指导意义。方法 检测、分析86例妊娠期高血压疾病孕妇与44例孕晚期孕妇及26例非孕育龄妇女（对照组）MAP、HCT、RBC、Hb、MCV、PLT、MPV、PCT、PDW的变化。结果 妊娠期高血压疾病孕妇与孕晚组相比随着MAP增高，PLT、PCT减少（P〈0．01）；MPV、PDW增加（P〈0．01）；RBC、Hb、MCV无显著性变化（P〉0．05）HCT（排除贫血患者）增高（P〈0．01）；随HCT值增高，血小板有相应增高趋势，但无统计学差异。结论 HCT是反应妊娠期高血压疾病血液粘度和血容量的一项重要指标：血小板各参数既可作为血液粘度的重要参数，又可作为血小板聚集状态的重要指标。     

孕妇血清叶酸、维生素B12及铁蛋白水平的分析

目的：探讨早、中期妊娠妇女血清叶酸、维生素B12及铁蛋白的含量水平。方法将新疆察布查尔县800例进行产前检查的孕妇按孕期的不同分为2组：早孕组（220例）和中孕组（580例）。选择同期体检的非妊娠健康妇女800例为对照组。对各组研究对象空腹血清中的叶酸、维生素B12和铁蛋白的含量进行测定,并对各数据进行统计分析。结果早孕组叶酸、维生素B12和铁蛋白含量与对照组比较差异均无统计学意义（均P＞0.05）;中孕组叶酸、维生素B12和铁蛋白含量均明显低于对照组[（7.9±30.2） ng·mL-1、（432.1±48.3） pg·mL-1和（58.5±39.6）ng·mL-1比（9.2±35.1）ng· mL-1、（598.5±60.9） pg·mL-1和（101.7±49.7）ng·mL-1,均P＜0.05]。孕妇分娩前红细胞内叶酸、维生素B12和铁蛋白与新生儿体质量无显著的相关性（r=0.021、0.016、0.037,均P＞0.05）。结论中期妊娠孕妇血清中的叶酸、维生素B12和铁蛋白的含量明显降低,及早采取补充或干预性治疗,对减少或杜绝缺陷新生儿的出生率、提高优生优育有极其重要的意义。     

孕妇血清中转铁蛋白、铁蛋白、叶酸和维生素B12测定与优生的相关性研究

目的通过检测孕妇血清转铁蛋白、铁蛋白、叶酸和维生素B12的含量,探讨转铁蛋白、铁蛋白、叶酸和维生素B12与优生的相关性。方法收集150例妊娠期的妇女及30例健康非妊娠妇女的血清标本,在全自动生化分析仪上用免疫比浊法测定血清中转铁蛋白,用化学发光免疫分析方法检测血清铁蛋白、叶酸和维生素B12的含量。结果血清叶酸和维生素B12含量随孕期增长逐渐降低。早孕期孕妇血清中叶酸和维生素B12含量与对照组妇女相比较,无显著性差异。中孕期及晚孕期妇女血清叶酸和维生素B12含量与对照组妇女相比较,显著低于对照组。新生儿体质量与母体叶酸和B12含量呈正相关;在早、中、晚期妊娠中,转铁蛋白铁蛋白含量显著低于对照组;而转铁蛋白含量在早、中、晚期妊娠均显著高于对照组。结论优生与孕妇转铁蛋白、铁蛋白、血清叶酸和维生素B12有相关性。测定孕妇血清中转铁蛋白、铁蛋白、叶酸和维生素B12含量,可判断孕妇是否存在营养缺乏,并可了解胎儿营养、生长状况,为尽早干预治疗提供依据。     

The influence of iron,vitamin B(12), and folate levels on soluble transferrin receptor concentration in pregnant women

BACKGROUND: Soluble transferrin receptor (sTfR) concentration is high in iron deficiency and in conditions of increased erythropoiesis. In developing countries like Brazil, pregnant women usually have concurrent iron, vitamin B(12), and folate deficiencies. This study investigated the relationship between serum sTfR concentration and iron, vitamin B(12), and folate status in pregnant women. METHODS: The concentration of the sTfR, hematocrit (Hct), hemoglobin (Hb), red blood cell (RBC) and white blood cell (WBC) counts, serum iron (SI), total iron-binding capacity (TIBC), transferrin saturation, serum ferritin, zinc protoporphyrin (ZPP), vitamin B(12), and serum and RBC folate were determined in 40 healthy pregnant women who delivered term babies. RESULTS: sTfR concentration was significantly higher when the women had iron deficiency (serum ferritin <10 microg/l, p<0.01), but there was no significant difference in sTfR concentration according to vitamin B(12), serum, and RBC folate concentrations. Women who had serum ferritin <10 microg/l also had lower vitamin B(12) values (p<0.01). There was no significant correlation between vitamin B(12) and serum folate with sTfR concentration. According to a regression analysis, sTfR concentration was associated with serum iron, serum ferritin, RBC count, and hemoglobin concentration. CONCLUSION: Iron was the only micronutrient that influenced the sTfR concentration. Vitamin B(12) and folate concentrations were probably not sufficiently low to have an impact on the sTfR concentration.     

18周内孕妇血清同型半胱氨酸、叶酸及维生素B12水平对妊娠结局的影响

目的观察18周内孕妇血清同型半胱氨酸、叶酸及维生素B12水平对产后胎盘重量、胎儿体重、早产结局的影响。方法我院2006年6至2011年12月孕龄小于18周的孕妇806例,抽血检测血清标志物同型半胱氨酸、叶酸及维生素B12的含量,生产后记录妊娠结局,并使用线性回归和Logistic回归分析孕早期血清标志物与不良妊娠结局的关系。结果高血清同型半胱氨酸水平(>8.3μmol/L)孕妇的胎盘重量比低同型半胱氨酸水平(<8.3μmol/L)孕妇平均轻30 g(P<0.001),新生儿体重轻110 g(P<0.001);而低叶酸水平(<9.2 nmol/L)孕妇的胎盘重量比高叶酸水平(>9.2 nmol/L)孕妇平均轻26 g(P<0.001),新生儿体重轻125 g(P<0.001),早产风险升高(OR 2.2,P=0.002),子痫前期风险上升(OR 2.1,P=0.04)。维生素B12的血清含量对妊娠结局无显著影响。结论血清同型半胱氨酸的含量升高,血清叶酸的含量降低,胎盘重量和新生儿体重会降低,早产和前期子痫的发生风险增高。     

The effect of serum vitamin B12, folate,ferritin levels and transferrin saturation on stem cell mobilization in allogeneic donors

IntroductionPeripheric blood derived stem cells are used in 75 % of allogeneic stem cell transplantations. Iron, vitamin B12 and folate involve in hematopoiesis. Therefore serum levels of iron, vitamin B12 and folat may effect stem cell mobilization. We aimed to analyze the effects of iron status, vitamin B12 and folate levels on peripheric blood stem cell mobilization in healthy donors.MethodThe mobilization results of 218 allogeneic donors were analyzed retrospectively.ResultsIn 64 donors, serum ferritin level was <15 μg / L and transferrin saturation was <20 %. When we compared the donors with iron deficiency to the donors without iron deficiency, the number of collected CD34 + cell was significantly higher in donors without iron deficiency. We did not find any impact of serum vitamin B12 and folate level on CD34+ cells collected.ConclusionOur study shows that serum ferritin and transferrin saturation have a greater effect on the amount of CD34+ cells collected from donors than serum vitamin B12 and folate levels. Consequently, when compliance tests of allogeneic donors are performed, the evaluation of vitamin B12 and folate levels is not necessary; whereas iron deficiency must be assessed and –if possible– corrected before apheresis is performed.     

Concentrations of B vitamins and homocysteine in children with sickle cell anemia

BACKGROUND: Elevated concentration of serum homocysteine contributes to thrombosis, a frequent event in patients with sickle cell anemia. We aimed to test whether children with sickle cell anemia have elevated concentrations of serum homocysteine with diminished levels of folate or B vitamins from accelerated blood cell turnover. METHODS: We conducted a case-control study of children with homozygous sickle cell anemia (n = 17) and unaffected children (n = 11). We measured serum and red blood cell folate, vitamin B6, vitamin B12, and homocysteine concentrations, and assessed micronutrient intake. RESULTS: Children with sickle cell anemia had concentrations of homocysteine slightly higher than those of unaffected children. They had lower vitamin B6 concentrations and comparable concentrations of folate and vitamin B12. Homocysteine concentration was inversely related to vitamin B12 concentration and was not independently associated with levels of vitamin B6 or folate. CONCLUSION: Despite comparable intake, children with sickle cell anemia had lower concentrations of vitamin B6 than unaffected children. Larger studies are needed to determine if chronically low serum vitamin B6 concentration contributes to hyperhomocysteinemia in this population.     

Maternal vitamin B12 and the risk of fetal neural tube defects in Egyptian patients

OBJECTIVE: Folic acid insufficiency is a known risk factor for neural tube defects (NTDs), while the role of vitamin B12 is questionable. Thus, our purpose was to investigate whether low maternal serum vitamin B12 is associated with an increased risk of NTDs. SETTING: Prenatal Diagnosis and Clinical Genetics Clinics, National Research Centre, in collaboration with the Radioisotope Department, Nuclear Research Centre, Cairo. MATERIALS AND METHODS: The study groups included 36 women who were, or had been, pregnant with a NTD-affected fetus. The control groups comprised 35 healthy women with normal prior or current pregnancy and uncomplicated obstetric histories. Fasting plasma homocysteine, serum folate and cobalamin (vitamin B12) were determined. Odds ratio (OR) and 95% confidence intervals were calculated. RESULTS: The fasting homocysteine was significantly higher in the study groups as compared to the controls. The median serum folate concentrations were similar in cases and controls, while the median vitamin B12 concentrations were significantly lower in the study groups compared to the controls. Low vitamin B12 concentration was associated with an approximately 2- to 3-fold increased risk for NTDs. CONCLUSION: Low maternal serum values of vitamin B12 can be considered an important etiologic factor for the development of neural tube defects in our population. This may help in both genetic counseling for families with a history of NTD malformation, and as a pre-conceptional prophylactic measure by maternal supplementation of vitamin B12 and folic acid.     

Folate and vitamin B12-deficiency anemias in Vietnamese immigrants living in Southern California

BACKGROUND: Although the occurrence of iron deficiency anemia and hemoglobinopathies in Vietnamese immigrants has been reported, folate and vitamin B12 deficiencies have not. Proper diagnosis and effective treatment is necessary to achieve a complete correction of anemia. METHODS: We retrospectively analyzed the records of Vietnamese immigrants seen in our medical clinic from 1991 to 1993. Fifty-nine anemic patients (48 females and 11 males) had low levels of red blood cell (RBC) folate and/or serum vitamin B12. RESULTS: The patients' mean age was 37.7+/-17 years. Mean hemoglobin and hematocrit values were 11.4+/-0.7 g/dL and 34.4%+/-2.2%, respectively. Mean corpuscular volume (MCV) was normal in 40 patients (68%) (mean, 89.1+/-5 fL) and low in 19 patients (32%) (mean, 69.7+/-6 fL). Forty-four patients had low RBC folate levels (mean, 157.7+/-41.7 ng/mL). Twenty patients had low serum vitamin B12 levels (mean, 165.6+/-47 pg/mL). Fourteen patients had ferritin levels of <20%. CONCLUSIONS: Concomitant folate, vitamin B12, and iron deficiencies or hemoglobinopathies might have been responsible for either normal or low MCV in some of our anemic patients. In this ethnic group, RBC folate and serum vitamin B12 levels should be determined in all anemic patients.     

Long-term diuretic therapy in hypertensive patients: effects on serum homocysteine, vitamin B6, vitamin B12, and red blood cell folate concentrations.

BACKGROUND: The effects of chronic diuretic use on serum homocysteine and its metabolic cofactors vitamin B6, vitamin B12, and red blood cell (RBC) folate have not been well studied. METHODS: Blood samples from 17 hypertensive patients receiving long-term diuretic therapy and 17 hypertensive patients not taking diuretics were analyzed for serum homocysteine, vitamin B6, vitamin B12, and RBC folate. RESULTS: The mean serum homocysteine concentration for patients taking diuretics (17.87 +/- 1.72 micromol/L) was significantly higher than the mean serum homocysteine concentration for patients not taking diuretics (10.31 +/- 0.99 micromol/L). The mean RBC folate concentration for patients taking diuretics (281.01 +/- 17.56 ng/mL) was significantly lower than the mean RBC folate concentration for patients not taking diuretics (430.85 +/- 28.58 ng/mL). Serum vitamin B6 and vitamin B12 concentrations were not significantly different between the two groups. CONCLUSIONS: Chronic diuretic use is associated with a significant increase in serum homocysteine concentration, a significant decrease in RBC folate concentration, and no significant change in concentrations of vitamins B6 and B12.