胃镜在胃原发性恶性淋巴瘤诊断中的价值

为近一步探讨胃原发性恶性淋巴瘤的发病机制．提高对胃原发性恶性淋巴瘤胃镜及病理表现的认识，对１０年间经胃镜活检诊断为胃恶性淋巴瘤的１９例，可疑胃恶性淋巴瘤、低分化癌、未分化癌、溃疡及淋巴组织明显增生的１２１例病理标本、临床资料进行回顾复习，最后确认有３８例符合胃恶性淋巴瘤的诊断标准。，胃镜下多形性、多灶性、弥漫性、范围广是其特征表现，而组织学上粘膜相关淋巴组织的特点对确诊本病有重要意义。     

胃原发性恶性淋巴瘤22例临床分析

目的探讨胃原发性恶性淋巴瘤临床及内镜表现。方法分析总结22例患者临床、胃镜及病理。结果22例患者临床表现无特异性，上腹痛最常见(22／22)，其次为上消化道出血(16／22)、反酸嗳气(6／22)等。胃镜表现：病变发生2个以上部位多见(10／22)，其次为胃体(6／22)、胃窦(3／22)等；病变直径多大于2cm(占17／22)；病变形态以溃疡型多见(11／22)，其次为弥漫浸润型(7／22)；胃镜活检加免疫组化确诊率为63．63％(14／22)；Hp阳性检出率86．36％(19／22)。结论胃原发性恶性淋巴瘤临床表现无特异性；其镜下形态多种多样，其中累及2个以上部位者多见，病变范围较大。胃镜活检加免疫组化病理检查是诊断本病的重要手段，Hp感染与胃原发性恶性淋巴瘤的发生具有相关性。     

胃原发性恶性淋巴瘤9例报告

胃原发性恶性淋巴瘤临床非常少见,约占所有胃部恶性肿瘤的3—5％。术前诊断尤为困难,其治疗选择亦不尽一致。而手术切除预后良好。我院近10年来发现 9例,现报告如下。     

原发性甲状腺恶性淋巴瘤的诊断与治疗(附6例报告)

原发性甲状腺恶性淋巴瘤 ( Primary malignantlymphoma of thyroid,PMLT)是一种非常少见的恶性肿瘤 ,因其临床表现缺乏特异性 ,术前常易和慢性淋巴性甲状腺炎、结节性甲状腺肿、甲状腺癌等疾病混淆而误诊。 1 985～ 2 0 0 0年 ,我院共收治 6例患者。现报告如下。1　资料与方法1     

胃原发性恶性淋巴瘤的内镜诊断探讨

本文分析了我院１９９１的３月至１９９５年８月经手术病理证实的１６例胃恶性淋巴瘤的内镜下特点。点镜所见以溃疡型多见，共８例。病灶多为不规则巨大溃疡，呈放射状或地图状，形态各异。息肉样型５例，表现为息肉或结节样隆起。浸润型３例，呈广泛性浅表溃疡。     

原发性胃恶性淋巴瘤内镜诊断探讨

原发性胃恶性淋巴瘤(primary gastric malignant lymphoma，PGML)的诊断标准为：①全身无浅表淋巴结肿大。③胸片提示无纵膈淋巴结肿大。③血白细胞总数及分类正常。④手术证实病变局限于胃及引流区域淋巴结。⑤肝脾正常。本病是一种少见的胃恶性肿瘤，约占胃全部恶性肿瘤的2％～5％。近年来发病率有升高趋势，由于本病发病年龄较胃癌年轻约5～10年，治疗方法及预后与胃癌亦不尽相同。本病往往容易漏诊或误诊，尤其容易误诊为未分化胃癌，所以提高内窥镜医生对本病的认识是非常必要的。     

胃原发性恶性淋巴瘤13例临床分析

恶性淋巴瘤是一种起源于淋巴造血组织的实体瘤 ,胃肠道是结外淋巴瘤最常见的部位。胃原发性恶性淋巴瘤是起源于胃的淋巴网状系统的恶性肿瘤 ,约占胃肠道恶性肿瘤的1%～ 7% [1] 。现结合我院 1992年～ 2 0 0 1年间经病理证实的 13例胃原发性恶性淋巴瘤的临床资料 ,就其诊治情况进行分析、探讨。一、资料与方法1.一般资料 :男 5例 ,女 8例 ,年龄 16～ 6 3岁 ,平均 4 1.7岁。病程 1个月～ 2年 ,均经病理证实。2 .诊断标准 :符合Ｄａｗｓｏｎ诊断标准 ,即 :①全身无病理性淋巴结肿大 ;②白细胞分类无异常 ;③胸片无纵隔淋巴结肿大 ;④病变部位为…     

胃原发性恶性淋巴瘤13例临床分析

恶性淋巴瘤是一种起源于淋巴造血组织的实体瘤,通常首发于淋巴结,胃肠道是结外淋巴瘤最常见的部位。胃原发性恶性淋巴瘤是起源于胃的淋巴系统的恶性肿瘤,约占胃肠道恶性肿瘤的1％～7％。由于其临床表现缺乏特异性,目前胃原发性恶性淋巴瘤的误诊率高。现结合我院1992年～2001年间经病理证实的13例胃原发性恶性淋巴瘤的临床资料,就其诊治情况进行分析、探讨。     

原发性甲状腺恶性淋巴瘤1例报告

患者女,65岁,因发现颈部肿块1年,于2004年2月12日入院。B超检查示颈部实性肿物,6cm×5cm×4cm大小,随吞咽活动,无压痛,颈部无肿大淋巴结。12月15日行手术治疗,切除一侧甲状腺,切面见结节性肿物(约5cm×5cm×4cm),肿物切面呈灰白、灰黄色,质地细腻,侵犯甲状腺包膜。病理诊断:甲状腺非何杰金氏恶性淋巴瘤。讨论:原发性甲状腺恶性淋巴瘤好发于女性,多发于淋巴性甲状腺炎患者。恶性淋巴瘤细胞单一,具有异形性,同时破坏甲状腺滤泡。该瘤的预后与组织学类型、肿瘤大小、患者年龄有关;局限于甲状腺内者较累及甲状腺外者预后好,高分化小细胞型较低…     

内镜检查对原发性胃恶性淋巴瘤诊断意义

目的:分析原发性胃恶性淋巴瘤内镜下表现特征及其病理学特点.方法:我院2004-01/2008-03住院PGML患者34例,所有患者经病理组织学证实,患者均行电子胃镜检查,并行黏膜活检病理检查,同时行免疫组织化学染色检测CD3、CD20、CD45和CK等标志物,并行病理组织HE染色,阳性即判为有H pylori 感染.结果:内镜检查34例患者,病变主要在胃体(44.1%)和胃窦(29.4%),其中累及2个及其以上病变部位占61.8%,单一部位相对较少;形态表现多为溃疡型(61.8%),主要是多发性溃疡(66.7%),弥散浸润型(26.5%),隆起糜烂型(11.8%).病理结果均为B细胞非霍奇金淋巴瘤,4例(11.8%)为大B细胞性淋巴瘤,为高度恶性胃淋巴瘤,30例(88.2%)为低度恶性淋巴瘤;幽门螺杆菌(Hpylon)感染率为占82.4%.结论:内镜检查的广泛应用及活检的充分和准确,对于PGML具有重要的确诊意义.     

原发性胃恶性淋巴瘤与幽门螺杆菌感染的相关性初探

为了探讨原发性胃恶性淋巴瘤(RGML)与幽门螺杆菌(Hp)感染的相关性,本文收集39例 PGML了以及22例淋巴性胃炎、32例 Hp 无关疾病的胃粘膜行对照研究。结果:PGML 组 Hp 检出率87.18%,显著高于对照的63.64、53.13%(P<0.005)。粘膜相关淋巴样组织(MALT)来源的淋巴瘤占92.31%。Hp 检出率达86.11%,瘤周慢性活动性胃炎及淋巴滤泡检出率分别为84.62、56.41%,且炎症活动程度与 Hp 分布密度相关。组织学研究提示胃 B 细胞 MALT 淋巴瘤与 Hp 感染相关。     

Endoscopic Retrospective Study on Gastric Malignant Lymphoma—with Special Reference to the Appearance of the Initial Lesion—

An endoscopic retrospective study was performed on five lesions in four patients with gastric malignant lymphoma, in order to elucidate the characteristics of the initial lesion and the growth process of these lymphomas. In case 1 (protruding type of malignant lymphoma), an area of small macular redness and a shallow ulcer, which had neither a surrounding elevation due to edema nor the circumscribed redness caused by regenerative epithelium, were observed 23 and 11 months before, respectively, when a cobblestone appearance, indicative of early lymphoma of the stomach, was found. A shallow ulcer was also recognized in the initial stage of the disease in case 2 (giant rugal type). Discolored and lustrous granules were observed as a first endoscopic finding in cases 3 and 4 (ulcerative type). These endoscopic findings were thought to be key findings indicative of gastric malignant lymphoma in the initial stage. For the early diagnosis of gastric malignant lymphoma, a careful follow-up with a skillfully performed biopsy, i. e. an exactly aimed biopsy using large, sharp-edged forceps, should be carried out if the findings described above are once observed.     

Primary Gastrointestinal Follicular Lymphomas: A Prospective Study of 31 Patients with Long-term Follow-up Registered in the French Gastrointestinal Lymphoma Study Group (GELD) of the French Federation of Digestive Oncology (FFCD)

Background/AimsPrimary gastrointestinal follicular lymphomas (PGFL) are very rare. Our aim was to analyze the clinical features, management, and long-term outcomes in a prospective series of patients diagnosed with PGFL.MethodsAll adult patients with PGFL, consecutively enrolled into the multicenter French study between 1990 and 2017, were evaluated and followed up prospectively after undergoing a complete work-up. Clinical, pathological and endoscopic features, as well as treatment outcomes, were analyzed.ResultsThirty-one patients (16 men, median age 62 years, range 33 to 79 years) with PGFL were included. The median follow-up was 92 months (range, 6 to 218 months). In the majority of patients (n=14), lymphoma was incidentally diagnosed during endoscopy. Otherwise, the most frequent circumstances of diagnosis were abdominal pain (n=7) and dyspepsia (n=5). The duodenum was the most common site of involvement (n=19) and multifocal localizations were seen in seven patients (22%). The most frequent first line strategy was surveillance applied in 22 patients (71%), of whom nine reached spontaneous, complete remission and 11 had stable disease. Seven patients (23%) received chemotherapy as first line treatment, and two underwent resection. Of seven patients who received chemotherapy, four achieved complete remission. In three patients, transformation into a high-grade lymphoma occurred.ConclusionsThe diagnosis of PGFL is frequently fortuitous. The most common localization is in the duodenum. The disease has an indolent course and a good prognosis, however, rare cases of transformation into aggressive high-grade lymphoma may occur. An appropriate characterization and follow-up of these lymphomas is mandatory for their optimal management.     

The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11)

We report a patient with T-lymphoblastic leukemia/lymphoma and a t(7;8)(q22;p11). CUX1 was identified as the fusion partner of FGFR1 by fluorescence in situ hybridization and 5' RACE-PCR. We further investigated this novel FGFR1 fusion using the interleukin-3 (IL-3) dependent Ba/F3 cell line and demonstrated IL-3 independent cell growth of CUX1-FGFR1 expressing cells. TKI258 and PKC412 potently inhibited proliferation of CUX1-FGFR1 transformed Ba/F3 cells. This growth inhibition was shown to be mediated by inhibition of CUX1-FGFR1 kinase activity for TKI258 but not PKC412. In summary, we identified a novel CUX1-FGFR1 fusion oncogene in a patient with the 8p11 myeloproliferative syndrome and demonstrated its transforming potential in the Ba/F3 cell line. Our in vitro data support the further investigation of TKI258 for the treatment of constitutively active FGFR1 fusion proteins.     

Diagnostic yield and technical performance of the novel motorized spiral enteroscopy compared with single-balloon enteroscopy in suspected Crohn's disease: a prospective study (with video)

1. Download : Download high-res image (405KB)
2. Download : Download full-size image