Going back to normal,but how? Re-opening policies and the standards for a new normal

Governments implemented to nonpharmacological methods and various limitation policies such as closing nonessential businesses, schools and limiting group gatherings, promoting social distancing, use of personal protective equipment, advising staying at home. These policies have caused various problems in social and economic life and gradual increase in psychosocial well-being problems. All societies yearningly are waiting for the COVID-19 pandemic to be brought under control and the measures to be lifted in order to return to their previous lives. Indicators are needed to assess the burden of disease in the country while lifting measures to control the COVID-19 pandemic. When using these indicators, it is necessary to consider the own characteristics of the countries. Personal precautions need to be continued for a while until vaccination becomes widespread and effective all over the world.     

‘They won't do any harm and might do some good’: time to think again on the use of antidepressants?

Despite NICE guidance that should have limited it, antidepressant prescribing continues to increase. Research evidence suggests that much if not all of the observed efficacy should be attributed to complex non-specific effects rather than ‘restoration of disturbed brain chemistry’. According to this view the uncertain benefits of antidepressants are unlikely to outweigh the risks, suggesting the need to explore other approaches to treatment.     

What does it mean to be a donor offspring? The identity experiences of adults conceived by donor insemination and the implications for counselling and therapy

In the absence of research with adult donor offspring, this study begins to bridge that gap by asking individuals about their experiences as donor offspring and considering the implications for psychotherapeutic and counselling practice. Sixteen participants (13 male, three female, age range 26-55 years) recruited through donor insemination support networks in the UK, USA, Canada and Australia, were sent semi-structured questionnaires by E-mail and post. Using identity process theory as a framework for understanding participants' accounts, the data were qualitatively analysed using interpretative phenomenological analysis. Participants consistently reported mistrust within the family, negative distinctiveness, lack of genetic continuity, frustration in being thwarted in the search for their biological fathers and a need to talk to a significant other (i.e. someone who would understand). These experiences could be postulated as being indicative of a struggle to assimilate, accommodate and evaluate information about their new identities as donor offspring. Psychotherapists and counsellors need to be aware of these identity issues if they are to meet the needs of donor offspring within therapeutic practice.     

Does the relationship of ambulatory blood pressure to position and location vary by age,sex, race/ethnicity,or body mass index?

The effects of position and location on ambulatory blood pressure, and the variability in these effects across individuals was examined. The extent to which the variability among individuals could be predicted by age, sex, race/ethnicity, and body mass was also assessed. The data include 24-hour ambulatory blood pressure recordings of 246 subjects from an ongoing worksite study. A random coefficients model yielded estimates of within-person and between-person effects. The position and location of individuals significantly affect their ambulatory blood pressure. As position changes from reclining to sitting to standing, blood pressure increases, after controlling for location. Likewise, blood pressure is typically higher at work than at home, controlling for position. The effects on blood pressure of both position and location vary considerably across persons. Interpersonal variability, measured by the standard deviation, is typically 30–75% as large as the variability in mean levels of blood pressure. There is also an interaction effect of position and location: the difference in blood pressure between standing and sitting down at work is not the same as the corresponding difference at home. Age, sex, race/ethnicity, and body mass index (BMI) predict 17% of the interpersonal variability in average systolic blood pressure while sitting at home, and 6% in diastolic blood pressure. The analysis of whether the effects of position or location vary by age, sex, race/ethnicity or BMI shows that the difference between work and home blood pressures is not significantly related to any of these four factors. However, the difference between awake and sleep diastolic blood pressures can be predicted, in part, by age and perhaps race/ethnicity. As age increases, the drop in diastolic blood pressure during sleep is attenuated. Hispanics also appear to experience a smaller drop in blood pressure during sleep. The drop in blood pressure associated with lying down (while awake) is similarly related to age and race/ethnicity. The increase in blood pressure associated with standing (vs. sitting) while at work is also attenuated in older individuals. Although significant interaction effects were demonstrated, these four major risk factors for hypertension predicted only small percentages of the interpersonal variability in the effects of position and location on blood pressure. Am. J. Hum. Biol. 10:459–470, 1998. © 1998 Wiley-Liss, Inc.     

Time to retire the theory of planned behaviour?: one of us will have to go! A commentary on Sniehotta,Presseau and Araújo-Soares

Abstract

Although research has consistently established that depression and elevated depressive symptoms are associated with an increased risk of coronary heart disease (CHD) recurrence and mortality, clinical trials have failed to show that conventional depression interventions offset this risk. As depression is a complex and heterogeneous syndrome, we believe that examining simpler, or intermediary, phenotypes rather than one complex phenotype may allow better identification of those at particular risk of CHD recurrence and mortality. This approach may further contribute to the development of specific depression treatments that would improve medical outcomes. Although there are many possible intermediary phenotypes (IPs), specifiers and dimensions of depression, we will focus on only two when considering the relation between depression and risk of CHD recurrence and mortality: Incident Depression and Anhedonic Depression. Future research on IPs of depression is needed to clarify which are associated with the greatest risk for CHD recurrence and mortality and which, if any, are benign. Theoretical advances in depression phenotyping may also help elucidate the behavioural and biological mechanisms underlying the increased risk of CHD among patients with specific depression phenotypes. Finally, tests of depression interventions may be guided by this new theoretical approach.     

Test–retest stability,convergent validity,and sensitivity to change for the Goal-Based Outcome tool for adolescents: Analysis of data from a randomized controlled trial

Objective(s)

To examine the psychometric properties of the idiographic Goal-Based Outcome (GBO) tool for young people: test–retest stability, convergent validity, and sensitivity to an intervention.

Methods

This measure validation study used data from a randomized controlled trial of school-based humanistic counseling. We used multilevel analyses to assess test–retest stability, convergent validity of the GBO tool against nomothetic measures of mental wellbeing, and sensitivity to an intervention.

Results

The GBO tool showed acceptable stability over a 6–24 week period; moderate convergent validity with nomothetic measures of mental well-being, self-esteem, and depression; and greater sensitivity to an intervention than a measure of psychological distress.

Conclusions

The GBO tool shows evidence of having acceptable psychometric properties and is suitable for monitoring change on individual goals. It may also have the capacity to function as a population-level indicator of outcomes in conjunction with the use of other measures of mental health and wellbeing.     

Cytokines and chemokines involved in the defense reaction against HIV-1 and hepatitis B virus: isn’t it time to use a standardized nomenclature of the involved mediators?

Discovery of new mediators of immune cell activation and interaction facilitated elucidation of the various ways of defense against infectious agents and happened some 40 years ago. Each involved group of researchers named the mediators according to their scope of investigation; often the same molecules were published at the same time with different names. To avoid confusion resulting from using different names for the same mediators and to prevent a Babylonian confusion, standardization was implemented—as in the field of metrics, music, or science including virology. For cytokines and chemokines a standard nomenclature was proposed some 10 years ago and in conclusion it should be used. In this paper the most relevant biomarkers in HIV-1 and HBV infection and their contribution during viral pathogenesis are listed.

     

A novel method to estimate changes in stress-induced salivary α-amylase using heart rate variability and respiratory rate,as measured in a non-contact manner using a single radar attached to the back of a chair

The authors have developed a non-contact system which estimates changes in salivary α-amylase (sAA ratio) induced by stress. Before and after stressful sound exposure, a single 24?GHz compact radar which is attached to the back of a chair measures the low frequency (LF) component of heart rate variability and respiratory rate, α-amylase in the subjects’ buccal secretions was measured by using an α-amylase assay kit. Using multiple regression analysis, sAA ratio was estimated using stress-induced LF change (LF ratio) and stress-induced respiratory rate change (respiratory rate ratio). Twelve healthy subjects were tested (12 males, 22?±?2 years), who were exposed to audio stimuli with a composite tone of 2120?Hz and 2130?Hz sine waves at a sound pressure level of 95?dB after a silent period through a headphone. The result showed that sAA ratio estimated using multiple regression analysis significantly correlated with measured sAA ratio (R?=?0.76, p?相似文献   

Can Paper Replace Laser Film to Communicate the Results of Wrist Radiographs in Trauma Cases? A Reproducibility Study of the Reading of Wrist Trauma Case Radiographs on a PACS Workstation, Laser Film, and Paper

The main goal of this study was to determine the reproducibility of the reading of wrist trauma case radiographs using three different media: laser film, a picture archiving and communication systems (PACS) workstation, and paper with an optimized layout. The study was conducted retrospectively in 200 consecutive patients consulting at the emergency department for wrist trauma and who underwent wrist X-ray investigation using a computed radiography system. There were 82 men and 118 women. The mean age was 48.3 years (16–95 years). Our institutional review board does not require patient approval or informed consent for retrospective review of case records. The readings were made by two independent readers who analyzed the 200 patient radiographs consecutively in one session for each type of media: paper, laser film, and on a PACS dual-screen workstation. The inter-reader agreements were substantial or almost perfect, with kappa values of 0.83 (0.76–0.90) for the PACS, 0.83 (0.76–0.90) for film, and 0.80 (0.72–0.87) for paper. The inter-technique agreement was almost perfect in all cases. There is a high interobserver agreement between PACS, laser film, and paper readings for wrist trauma cases. With a layout of one radiograph on each sheet, paper could replace laser films to communicate the results of wrist radiographs in trauma cases for outpatients.