微小RNA-18a联合子宫动脉血流参数对早发型子痫前期的预测价值

目的 探讨微小RNA-18a（miR-18a）联合阻力指数（RI）、搏动指数（PI）、子宫动脉收缩期与舒张期血流速 度比值（S/D）等子宫动脉血流参数对早发型子痫前期（E-PE）的预测价值。方法 纳入孕检的孕妇628例根据其是 否发生E-PE分为E-PE组（34例）和对照组（594例）。采用彩色多普勒超声诊断仪检测RI、PI、S/D等参数，采用实时 定量PCR法检测血清miR-18a的相对表达水平。采用受试者工作特征曲线分析血清miR-18a、RI、PI、S/D对E-PE的 预测价值。结果 E-PE组的血清miR-18a相对表达水平低于对照组，RI、PI、S/D高于对照组（P＜0.05）；E-PE患者 血清miR-18a相对表达水平与RI、PI、S/D均呈负相关（P＜0.05）；血清miR-18a、RI、PI均可用于预测E-PE的发生风 险，曲线下面积分别为0.780（95%CI：0.727～0.832）、0.729（95%CI：0.644～0.814）、0.782（95%CI：0.695～0.870），而S/D 对E-PE的预测价值较低，曲线下面积为0.602（95%CI：0.496～0.708）。miR-18a联合PI对E-PE的预测价值较高，敏 感度为82.35%、特异度为83.84%，约登指数为0.662。结论 miR-18a在E-PE患者血清中异常低表达，且其表达水 平与RI、PI、S/D等子宫动脉血流参数均呈负相关，miR-18a联合PI对E-PE的预测价值较高。     

Characterization of humanized liver from chimeric mice using coumarin as a human CYP2A6 and mouse CYP2A5 probe

Coumarin 7-hydroxylation (COH), which is catalyzed almost solely by human CYP2A6 and mouse CYP2A5, shows large differences in activity (humans>mice) and inhibitor specificity between mice and humans. To differentiate human and mouse liver functions of chimeric mice (CM1, CM2 and CM3) prepared with hepatocytes from 3 donors, the microsomal COH activities were measured with and without benzaldehyde and undecanoic gamma-lactone as a specific inhibitor of human CYP2A6 and mice CYP2A5, respectively. The replacement % to human hepatocytes designated as replacement index (RI) was calculated from human specific cytokeratin 8/18 expression in the liver section. The COH activities correlated well with RIs in CM2 (R(2)=0.98) and CM3 (R(2)=0.94), except CM1 whose genotype of donor is CYP2A6*4/*4. However, the COH activities expressed as % of donor activities were not always coincident with RIs, and the inhibition pattern of CM2 and CM3 was human-type after RI exceeded approximately 50%. Subsequently, our attempts to use % of COH activities or inhibition patterns as an accurate functional replacement index were unsuccessful. Since the detection of human CYP2A6 protein in the liver and the steep increase of human albumin (hAlb) levels in the blood were begun from almost RI=50% similarly to the changes of inhibition pattern, RI=50% is the turning point for chimeric mice to have humanized liver function.     

肝肾阴虚及气阴两虚型糖尿病肾病肾脏叶间动脉血流状态超声分析

目的 借助彩色多普勒频谱图,对糖尿病肾病患者肾脏叶间动脉血流参数进行分析,探索该病中医分型的客观指标。方法 选择糖尿病肾病３７例,将其分为气阴两虚及肝肾阴虚两组,对其双肾叶间动脉测量;收缩期峰血流速度（ＶＳ）、舒张期末血流速度（ＶＤ）、平均血流速度（ＶＭ）、搏动指数（ＰＩ）、阻力指数（ＲＩ）。结果 肝肾阴虚、气阴两虚及正常组进行ＶＤ、ＰＩ及ＲＩ均值比较,三线间有显著差异（Ｐ〈０．０５）。ＶＤ：气阴     

改良超滤对犬体外循环肺功能的影响

目的 通过观察改良超滤对犬体外循环肺功能的影响,探讨应用超滤对肺的保护作用.方法 选择18只健康成年犬随机分成对照组、CPB组和改良超滤组三组.三组动物均腹腔内注射戊巴比妥,麻醉生效后,仰卧位固定,气管插管,监测心电图、舌粘膜氧饱和度(SpO2)等,行右侧股动、静脉置管分别测平均动脉压(MAP)及中心静脉压(CVP).开胸时接麻醉工作站行机械通气,三组分别在开胸未行机械通气前、停机时、停机60 min采集动脉血行血气分析,计算犬RI和OI;取肺组织行HE染色观察病理学变化.结果 (1)肺组织病理学变化:对照组犬肺组织未见明显的病理变化,CPB后肺组织见大量的炎性细胞浸润,肺泡间隔增宽,甚至肺泡腔内有水肿波;改良超滤组肺组织改变明显轻于CPB组.(2)RI和OI的变化:开胸未行机械通气前三组犬RI和OI比较差异无统计学意义(P＞0.05).组内比较:A组各时间点RI、OI差异无统计学意义;B组、C组T2、T3时点的RI明显高于T1,而OI相反,差异有统计学意义(P＜0.05).组间比较:与对照组比较,CPB组、超滤组RI均增大、OI均减小;改良超滤组与CPB组比较在T3时点RI值减小、OI值增大,差异均有统计学意义(P＜0.05),T2时点差异无统计学意义.结论 体外循环中应用改良超滤可提高氧合指数,降低呼吸指数,减轻肺组织炎症反应,从而改善术后肺功能.     

Increase in renal vascular resistance after intake of cyclosporin A and tacrolimus and reversal by nitroglycerin spray: a study in patients with stable renal allograft function

PURPOSE: Acute effects of drug administration on renal arterial resistance index (RI) are still discussed controversially. In our study we investigated the immediate effects of cyclosporin A (CyA) and tacrolimus (FK-506) on renal arterial resistance indices in patients with stable graft function after renal transplantation. Additionally we studied the effects of nitroglycerin spray on resistance indices. METHODS: RI was measured by color Doppler sonography at baseline, at 1 and 2 hours after intake of medication and 30 minutes after administration of nitroglycerin spray which followed the 2-hour measurement. 34 renal transplant recipients were examined. 16 patients received CyA, 18 patients received FK-506. Whole blood levels of calcineurin inhibitors were taken at each time point. Arterial blood pressure and heart rate were measured to assess possible systemic hemodynamic effects. RESULTS: Mean RI values increased significantly in both groups 1 hour after calcineurin inhibitor intake and remained still significantly elevated after 2 hours. There was no significant increase of mean arterial blood pressure nor was there any correlation between whole blood levels of calcineurin inhibitors and mean RI. 30 minutes after administration of nitroglycerin spray, mean RI values decreased significantly to a level even below baseline. Mean arterial blood pressure also decreased after administration of nitroglycerin. CONCLUSION: Renal RI values are markedly influenced by a recent intake of calcineurin inhibitors and vasoactive substances such as nitrates. This demonstrates the necessity of keeping standardized conditions when using RI as a tool in followup investigations after renal transplantation.     

经阴道或直肠彩色多普勒超声在多囊卵巢综合征中的临床应用

目的:观察经阴道或直肠彩色多普勒超声在多囊卵巢综合征中的诊断价值。方法:经阴道或经直肠行彩色多普勒超声检查,显示双侧卵巢内部结构,记录最多切面卵泡数,测量最大切面卵巢径线,计算卵巢体积,选用面积测量软件包测量卵巢面积(TA)、髓质面积(SA),然后计算SA/TA,并记录。启动彩色多普勒和频谱多普勒测量卵巢间质动脉搏动指数(PI)、阻力指数(RI)值。所有数据均测量3次并取平均值。结果:多囊卵巢综合征组患者卵巢体积增大(>10mL),双侧卵巢呈多囊样改变,多见10个以上小囊,小囊直径约4～6mm。卵巢间质回声增强,面积增大,间质面积比例较对照组显著增大,P<0.05,卵巢间质血流较丰富,卵巢间质动脉血流RI、PI与对照组比较,差异有统计学意义。结论:经阴道或经直肠彩色多普勒超声,可更直观准确显示卵巢特征。最多切面卵巢小卵泡数目、间质面积比、卵巢间质动脉阻力指数相结合对诊断多囊卵巢综合征(PCOS)有很重要的临床价值。     

前列腺被膜支血管阻力指数测定在前列腺癌的诊断价值

目的探讨前列腺被膜支血管阻力指数(RI)与前列腺癌(PCa)的关系。方法利用彩色多普勒超声检测87例前列腺穿刺活检患者的前列腺被膜支血管RI,并行前列腺穿刺组织活检。分析前列腺被膜支血管RI在PCa中的诊断价值,并与血清总前列腺特异性抗原(tPSA)、游离/总前列腺特异性抗原(f/tPSA)及前列腺特异性抗原密度(PSAD)的诊断价值比较。运用受试者工作特性(ROC)曲线,确定前列腺被膜支血管RI最佳临界点。结果 87例前列腺穿刺活检患者中,良性前列腺增生(BPH)56例(64.4%),PCa 31例(35.6%)。与BPH相比,PCa的前列腺被膜支血管RI明显升高(0.72±0.10vs.0.78±0.10)P<0.05)。tPSA、f/tPSA、PSAD在PCa和BPH患者之间均有统计学差异(P<0.05)。但在灰区(tPSA为4-10ng/ml)患者中,仅前列腺被膜支血管RI和PSAD存在统计学差异(P<0.05)。ROC曲线确定前列腺被膜支血管RI诊断PCa最佳临界点为0.72,当RI≥0.72系列联合PSAD>0.15ng.ml-1.cm-3时,诊断PCa的敏感度77.4%、特异度78.6%。结论测定前列腺被膜支血管RI对鉴别PCa与BPH有着重要临床应用价值,尤其当tPSA处于灰区时。前列腺被膜支血管RI联合PSAD在诊断PCa时有较好的敏感度和特异度。     

肾动脉阻力指数和搏动指数对移植肾功能的预测作用

目的运用彩色多普勒超声早期测量肾动脉和叶间动脉的阻力指数和搏动指数,观察两者能否预测无明显并发症同种异体肾移植患者术后1年的肾功能。方法对100例无并发症肾移植患者,应用彩色多普勒超声,于肾移植术后1周内,测量移植肾肾动脉和叶间动脉的阻力指数和搏动指数,并与术后1年的移植肾肾小球滤过率(GFR)进行相关分析。结果术后1周测得的肾动脉的阻力指数和搏动指数与术后1年的GFR无明显的相关关系;叶间动脉的阻力指数和搏动指数与术后1年的GFR呈明显的负相关,叶间动脉阻力指数和(或)搏动指数升高,移植后1年肾功能下降,如果叶间动脉阻力指数≥0.7或者搏动指数≥1.2,移植后1年肾功能有明显的下降。结论早期多普勒彩超测量叶间动脉的阻力指数和搏动指数能够预测无明显并发症的移植肾的术后1年肾功能。     

彩色多普勒检测脑梗死患者颈动脉血流动力学变化与动脉硬化程度的关系研究

目的:探讨脑梗死患者颈动脉血流动力学变化指标与血管内-中膜厚度(IMT)的关系。方法:58例经头颅CT、MRI检查确诊为脑梗死患者及26例健康体检成人,采用双功能彩色多普勒超声检测颈动脉血流动力学指标及IMT。结果:脑梗死组的颈总动脉的收缩期峰值流速(PSV)、舒张末血流速度(EDV)、EDV/PSV及血流加速度(AC-CEL)减低,搏动指数(PI)及阻力指数(RI)增高;脑梗死组血流PI与颈总动脉-IMT(CCA-IMT)及颈内动脉-IMT(BIF-IMT)呈正相关性(r=0.263,P=0.023;r=0.261,P=0.024);RI与BIF-IMT呈正相关性(r=0.265,P=0.022);EDV与BIF-IMT呈负相关性(r=-0.407,P=0.01),差异有显著性。结论:颈动脉血流动力学指标可以作为评价脑梗死患者颈动脉粥样硬化程度的可靠指标之一。     

右美托咪啶预处理对下肢缺血再灌注性肺损伤及一氧化氮/内皮素-1失衡的影响

摘要： 目的 观察右美托咪啶预处理对止血带引起的肢体缺血/再灌注 （LIR） 致肺损伤的保护作用和对一氧化氮（NO） /内皮素 （ET） -1 失衡的影响。方法 选取 60 例 ASA 评分Ⅰ～Ⅱ级拟行单侧下肢手术的患者。随机分为对照组 （R 组, n=30） 和右美托咪啶预处理组 （PD 组, n=30）。所有患者均在神经刺激仪引导下行腰丛-坐骨神经阻滞麻醉后手术。PD 组于使用止血带前 10 min 静脉泵注右美托咪啶 0.125 mL/kg （4 mg/L）; R 组在相应时间点给予等量生理盐水 0.125 mL/kg。分别于使用止血带前 10 min（T0）和松止血带后 15 min（T1）、 2 h（T2）、 6 h（T3）及 24 h（T4）行动脉血气分析, 计算呼吸指数（RI）和氧和指数（OI）, 测定 NO、 ET-1、 白细胞介素（IL） -8、 丙二醛（MDA）水平。结果 与 T0 比较, R 组 T3时 RI 升高, T2~T4时 OI 降低 （P＜0.01）, PD 组各时点 RI、 OI 值比较差异无统计学意义; R 组和 PD 组在松止血带后 ET-1、 IL-8、 MDA 浓度升高, NO 浓度、 NO/ET-1 比值显著降低 （P＜0.05）。与 R 组比较, PD 组在 T3时 RI 降低、 OI 升高 （P＜0.01）; PD 组在松止血带后 ET-1、 IL-8、 MDA、 NO 浓度和 NO/ET-1 比值与 R 组比较差异有统计学意义（P＜0.05）。R 组患者血浆 ET-1、 IL-8 水平与 RI 值呈正相关, 与 OI 值呈负相关（P < 0.01）; 血浆 NO 水平、 NO/ ET-1 比值与 RI 值呈负相关, 与 OI 值呈正相关 （P < 0.01）。结论 右美托咪啶预处理通过保护内皮细胞和减轻脂质过氧化损伤, 改善患者使用止血带造成的 LIR 致肺换气功能的障碍。     

Microvascular resistance in response to iodinated contrast media in normal and functionally impaired kidneys

Contrast‐induced nephropathy (CIN) is considered to result from intrarenal vasoconstriction, and occurs more frequently in impaired than in normal kidneys. It was hypothesized that iodinated contrast media would markedly change renal blood flow and vascular resistance in functionally impaired kidneys. Thirty‐six patients were enrolled (32 men; mean age, 75.3 ± 7.6 years) undergoing diagnostic coronary angiography and were divided into two groups based on the presence of chronic kidney disease (CKD), defined as an estimated glomerular filtration rate (eGFR) of < 60 mL/min per 1.73 m² (CKD and non‐CKD groups, n = 18 in both). Average peak velocity (APV) and renal artery resistance index (RI) were measured by Doppler flow wire before and after administration of the iodinated contrast media. The APV and the RI were positively and inversely correlated with the eGFR at baseline, respectively (APV, R = 0.545, P = 0.001; RI, R = ?0.627, P < 0.001). Mean RI was significantly higher (P = 0.015) and APV was significantly lower (P = 0.026) in the CKD than in the non‐CKD group. Both APV (P < 0.001) and RI (P = 0.002) were significantly changed following contrast media administration in the non‐CKD group, but not in the CKD group (APV, P = 0.258; RI, P = 0.707). Although renal arterial resistance was higher in patients with CKD, it was not affected by contrast media administration, suggesting that patients with CKD could have an attenuated response to contrast media.     

三维能量多普勒及彩色多普勒超声评估慢性肾脏病肾损害的价值

目的探讨三维能量多普勒（3D-CPA）超声参数血管指数（VI）及肾叶间动脉阻力指数（RI）评估慢性肾脏病（CKD）肾损害的价值。方法选择50例慢性肾脏病患者进行3D-CPA及彩色多普勒检查,计算血管指数（VI）及阻力指数（RI）,与正常对照组30例比较。结果不同分期的慢性肾脏病有不同的VI及RI值。VI与CKD分期呈正相关,RI与CKD分期呈负相关。结论 VI和RI均能无创的反映CKD的血流变化,为疾病的诊断、治疗、监测提供依据。     

Metyrapone and mifepristone reverse recognition memory loss induced by spontaneous morphine withdrawal in mice

Morphine withdrawal leads to an increase in corticosterone concentration in plasma, and cognitive deficits are found after withdrawal. Evidence indicates that glucocorticoid hormones affect memory. The aim of the current study was to evaluate the effects of metyrapone and mifepristone on memory deficit following spontaneous morphine withdrawal. Memory was tested by using the object recognition task. The novel object recognition task was carried out in a square wooden open-field apparatus using objects. The test was comprised of three sections: habituation for 15 min., first trial for 12 min. and test trial for 5 min. In this learning paradigm, the difference in exploration between a previously seen object and a novel object is taken as an index of memory performance (recognition index - RI). Male mice were made dependent by increasing doses of morphine (30-90 mg/kg) subcutaneously twice daily for 3 days. RI was assessed 4 hr after the last dose of morphine on the third day. Mifepristone (50 and 100 mg/kg) and metyrapone (12.5 and 25 mg/kg) were used subcutaneously before the first trial and effects were compared to control values. Metyrapone (25 mg/kg) and mifepristone (50 mg/kg) improved RI to 34.8 +/- 10.8% and 25.4 +/- 11.7%, respectively, which are significantly different from control values (RI = -14.8 +/- 10.7%, P < 0.05). These results show that increased glucocorticoid concentration may be involved in memory deficit caused by morphine withdrawal. Metyrapone by inhibiting glucocorticoid formation, and mifepristone by inhibiting glucocorticoid receptors may be useful for preventing memory deficit following morphine withdrawal.     

Oxidation of flavonoids which promote DNA degradation induced by bleomycin-Fe complex

Sixteen flavonoids including quercetin and kaempferol and their relatives were examined for their ability to promote DNA degradation induced by the bleomycin (BLM)-Fe complex. Three hydroxyl groups in the flavonoidal nucleus were proposed as a crucial structural requirement for effectively promoting DNA degradation: 1). the C7-hydroxyl substitution in the A-ring; 2). the C4'-hydroxyl substitution in the B-ring; and 3). the C3-hydroxyl substitution in the C-ring. Flavonoids, which lack even one of these hydroxyl substitutions, showed remarkably diminished activity. There was a good correlation (r=0.920, p<0.001) between activity to promote DNA degradation and oxidizability, which was measured following the Fe(III)-induced oxidation of flavonoids themselves, among the 16 flavonoids. The oxidizability of flavonoids which have the crucial hydroxyl substitutions, was remarkably enhanced in the presence compared with the absence of BLM. On the other hand, the extent of oxidation of flavonoids lacking these substitutions was enhanced little or not at all by BLM. No correlation between the Fe(III)-reducing activity and DNA degradation-promoting activity was found among flavonoids satisfying the crucial structural requirements. Furthermore, the correlation between the extent of oxidation of flavonoids and the Fe(III)-reducing activity was not confirmed among these flavonoids. Therefore, it was suggested that Fe(III)-reducing activity was not the only factor determining DNA degradation-promoting activity in flavonoids having the three hydroxyl groups necessary for effectively promoting DNA degradation induced by BLM-Fe complex.     

The pharmacokinetics of peginterferon lambda-1a following single dose administration to subjects with impaired renal function

Aims

This open label study was conducted to assess the effect of renal impairment (RI) on the pharmacokinetics (PK) of peginterferon lambda-1a (Lambda).

Methods

Subjects (age 18–75 years, BMI 18–35 kg m^–2) were enrolled into one of five renal function groups: normal (n = 12), mild RI (n = 8), moderate RI (n = 8), severe RI (n = 7), end-stage renal disease (ESRD, n = 8) based on estimated glomerular filtration rate (eGFR) calculated using the Modification of Diet in Renal Disease (MDRD) equation. Subjects received a single dose of Lambda (180 µg) subcutaneously on day 1 followed by PK serum sample collections through day 29. Safety, tolerability and immunogenicity data were collected through day 43. PK parameters were estimated and summarized by group. Geometric mean ratios (GMR) and 90% confidence intervals (CIs) were calculated between normal and RI groups.

Results

With decreasing eGFR, Lambda exposure (C_max, AUC) increased while apparent clearance (CL/F) and apparent volume of distribution (V/F) decreased. Relative to subjects with normal renal function (geometric mean AUC = 99.5 ng ml^–1 h), Lambda exposure estimates (AUC) were slightly increased in the mild RI group (geometric mean [90% CI]: 1.20 [0.82, 1.77]) and greater in the moderate (1.95 [1.35, 2.83]), severe RI (1.95 [1.30, 2.93]) and ESRD (1.88 [1.30, 2.73]) groups. Lambda was generally well tolerated.

Conclusions

The results demonstrated that RI reduces the clearance of Lambda and suggests that dose modifications may not be required in patients with mild RI but may be required in patients with moderate to severe RI or ESRD.     

Differential Response in Left Ventricular Mass and Arterial Resistive Index following Fosinopril Therapy

The aim of this study was to assess the differential response in left ventricular mass and resistive index (RI) of renal and carotid arteries in mild to moderate essential hypertensive patients after 1 year of ACE inhibitor therapy. Twenty-six patients (mean age 42.9 +/- 10.9 years) underwent 24-hour ambulatory blood pressure monitoring, echocardiography and renal and carotid echo-Doppler (by measuring RI, as an expression of arterial impedance) after a placebo period and 12 months of fosinopril treatment (20 mg/day). Our study showed a significant decrease in 24-hour BP (p < 0.05), left cardiac mass (p < 0.05) and RI of common carotid and hilum renal arteries (p < 0.05). In contrast, there were no significant reductions in the interlobar renal RI (as an expression of unchanged intrarenal resistance) and in the internal carotid artery RI. While the 24-hour BP decrease was strongly correlated with the left cardiac mass modifications (r = 0.73, p < 0.005), no significant relationship was observed with the renal and carotid artery parameters. In conclusion, the present study demonstrated that long-term treatment with fosinopril produced a differential response in left ventricular mass and arterial RI in patients with mild to moderate essential hypertension. In addition, the arterial impedance modifications of common carotid and hilum renal artery were largely unrelated to the 24-hour BP reduction.     

多普勒超声在急性单侧上尿路梗阻中的应用

目的 评估多普勒超声在急性单侧上尿路梗阻性疾病中的应用价值.方法 利用多普勒超声测定肾内阻力指数,并在此基础上分别计算其它相关指标.IVP作为诊断急性上尿路梗阻的标准.分别评估阻力指数、阻力指数率、利尿后阻力指数率与IVP诊断急性单侧上尿路梗阻结果之间的差异.另外,尚对比了治疗前、后双肾阻力指数的差异.结果 阻力指数与ⅣP诊断结果之间的差异有统计学意义;阻力指数率、利尿后阻力指数率与IVP诊断结果之间的差异无统计学意义.治疗前,梗阻肾与对侧肾阻力指数之间的差异有统计学意义;治疗后2者之间的差异无统计意义.结论 多普勒超声可以作为急性单侧上尿路梗阻性疾病的一种诊断和随访工具.     

透析治疗慢性肾功不全彩色多普勒血流动力学分析

目的：应用彩色多普勒血流显像（CDFI）及脉冲多普勒（PO）检测多囊肾所致慢性肾功不全（CRF）的肾血流动力学改变．方法：运用CDFI和PD检测多囊肾所致的CRF30例的肾动脉内径，血流量和阻力指数（RI），并以30例老年健康查体做对照．结果：多囊肾所致CRF肾动脉内径变细，血流量明显减低，阻力指数增高，与正常对照组比较有显著性的差异（P＜0．01）．结论：CDFI及PD快速实时动态的优点,为临床评价肾动脉的功能状态及疾病的转归,疗效的判定提供了又一新的方法     

复合酶法提取龙眼核总黄酮的工艺研究

目的:优化复合酶法提取龙眼核总黄酮的工艺条件。方法:在单因素试验的基础上,根据响应面法的Box-Behnke试验设计原理,以总黄酮含量为评价指标,分别考察酶解时间、pH和酶用量对龙眼核总黄酮提取效果的影响,并建立了总黄酮含量与各因素的多元二次回归数学模型。结果:各因素对总黄酮得率的影响次序为酶用量>酶解时间>pH值。最佳提取工艺条件为60%乙醇为提取溶剂,料液比为1∶30,复合酶(纤维素酶∶果胶酶=1∶2)用量1.12%,pH=6.0,酶解时间2.18 h。实际测得龙眼核总黄酮含量为30.40 mg/g,与预测值相符度为95%。结论:酶法提取条件温和、污染小、效率高,优选的工艺稳定可行,可为工业生产提供有益的参考。     

超声诊断子宫内膜病变的临床价值分析

目的 探讨经阴道超声诊断子宫内膜病变的临床价值.方法 选择本院妇产科经病理诊断确诊的80例子宫内膜病变患者作为研究对象,并将经阴道超声检查结果与病理诊断结果进行对比分析.结果 术后病理诊断为子宫内膜息肉、子宫内膜增生、子宫内膜癌及子宫黏膜下肌瘤的患者数分别为20、12、22、26例,超声诊断分别为18、8、18、23例,超声诊断的总符合率为83.75％ （67/80）;经阴道超声诊断的49例子宫内膜良性病变（包括子宫内膜息肉、子宫内膜增生、子宫黏膜下肌瘤）血流显示例数为14例,显示率为28.57％（14/49）,动脉阻力指数（RI） =0.67±0.13;子宫内膜癌血流显示例数为18例,显示率为100.00％（18/18）,RI=0.38±0.08,两种血流显示率及RI比较,差异均有统计学意义（P＜0.05）.结论 经阴道超声诊断子宫内膜病变准确率高,且能敏感地显示病变周围及内部的彩色血流信号及其血流动力学变化情况,有利于子宫良恶性病变的鉴别.