Treatment of trichomoniasis in females with and without gonorrhoea.

46 women with trichomoniasis and gonorrhea were treated with nimorazole (300 mg twice daily for 7 days) and a trichomonal cure rate of 90-2 per cent. was noted. In addition, 53 of 112 patients with trichomoniasis but without gonorrhoea, were treated with metronidazole (200 mg three times a day for 7 days) and 59 with nimorazole (300 mg twice daily for 7 days) in a randomized trial. The cure rates were 96 and 90-5 per cent. respectively. There was no significant difference in the results noted in the two groups. Neither the trichomonal infection itself nor the result of antitrichomonal therapy was affected by antigonococcal therapy (one-day treatment with ampicillin or single-dose therapy with doxycycline). No increase was noted in the frequency of candidiasis after antitrichomonal therapy (in patients without gonorrhoea) or after antigonococcal therapy, but there was substantial variation between consecutive specimens in the prevalence of C. albicans.     

Sectinomycin in the treatment of gonorrhoea in females and males.

126 female patients with proven gonococcal infection were treated with 4 g. spectinomycin bihydrochloride given intramuscularly in a single does. In 120 cases followed up there were four possible treatment failures, giving a cure rate of 97-6 per cent. 99 male patients with acute gonococcal urethritis were treated with a single dose of 2, g. sectinomycin bihydrochloride. Of 88 cases followed up, there were three possible treatment failures, giving a cure rate of 96-6 per cent. Spectinomycin is an important addition to gonorrhoea therapy but should be reserved for penicillin sensitive patients and penicillin insensitive infections.     

Sectinomycin in the treatment of gonorrhoea in females and males.

126 female patients with proven gonococcal infection were treated with 4 g. spectinomycin bihydrochloride given intramuscularly in a single does. In 120 cases followed up there were four possible treatment failures, giving a cure rate of 97-6 per cent. 99 male patients with acute gonococcal urethritis were treated with a single dose of 2, g. sectinomycin bihydrochloride. Of 88 cases followed up, there were three possible treatment failures, giving a cure rate of 96-6 per cent. Spectinomycin is an important addition to gonorrhoea therapy but should be reserved for penicillin sensitive patients and penicillin insensitive infections.     

Treatment of urogenital/rectal gonorrhoea in males and females with epicillin in combination with probenecid.

This paper describes the results of treatment of 124 patients (78 male and 46 female) with urogenital/rectal gonorrhoea with epicillin (3.5 g orally) in combination with 1 g of probenecid (instant therapy). High cure rates were found for both the male (98.6%) and female patients (100%). Serious drawbacks of this treatment are a high frequency of postgonococcal urethritis (45.6%) and a short-lived increase in the frequency and looseness of faecal discharge in a considerable amount of patients (6.8% in the male and 22.7% in the female patients).     

Spectinomycin in gonorrhoea.

Of 104 male and nine female patients with uncomplicated acute gonorrhoea who were treated with spectinomycin (males 2 g., females 4 g.), two patients (one male and one female) were considered to be treatment failures. No conclusions can be drawn from the small numbers of female patients investigated. Of the 104 male patients, 93 were followed for 2 weeks or more, giving a failure rate of 1-1 per cent. The drug was well tolerated. Sensitivity tests were carried out on 44 strains of N. gonorrhoeae; 42 strains were sensitive to 2-5 mug./ml. spectinomycin and all strains were sensitive to 5 mug./ml.     

Spectinomycin in gonorrhoea.

Of 104 male and nine female patients with uncomplicated acute gonorrhoea who were treated with spectinomycin (males 2 g., females 4 g.), two patients (one male and one female) were considered to be treatment failures. No conclusions can be drawn from the small numbers of female patients investigated. Of the 104 male patients, 93 were followed for 2 weeks or more, giving a failure rate of 1-1 per cent. The drug was well tolerated. Sensitivity tests were carried out on 44 strains of N. gonorrhoeae; 42 strains were sensitive to 2-5 mug./ml. spectinomycin and all strains were sensitive to 5 mug./ml.