Binswanger病脑血流及红细胞变形性的研究

本文测定了Ｂｉｎｓｗａｎｇｅｒ病患者和相应对照组的局部大脑血流量及红细胞滤过指数的变化。结果发现，疾病组双侧大脑皮质及白质血流值间均无明显差异，大脑白质血流明显低于健康对照组和各病例对照组，疾病组红细胞滤过指数明显高于各对照组、提示Ｂｉｎｓｗａｎｇｅｒ病患者存在红细胞变形能力低下，检测脑血流对于鉴别不同类型的大脑白质疏松症具有一定的参考价值。     

急性脑梗死患者血液流变学及血细胞成分临床观察

目的：探讨急性脑梗死患者血液流变学及血细胞成分的变化。方法：对６２例急性脑梗死患者进行血液流变学及血细胞成分检测并与对照组相比较。结果：患者组血液流变学指标及红细胞（ＲＢＣ）计数显著高于对照组（Ｐ〈０．０５～０．０１），血红蛋白（ＨＧＢ）、平均红细胞体积（ＭＣＶ）、平均血红蛋白含量（ＭＣＨ）和平均红细胞血红蛋白浓度（ＭＣＨＣ）显著低于对照组（Ｐ〈０．０１～０．００１）；与对照组比较男性患者白细胞（     

Binswanger＇s病若干临床问题探讨

回顾１９８９～１９９３年住院的２６例Ｂｉｎｓｗａｎｇｅｒ＇ｓ病，复习文献，对其临床表现。诊断及鉴别诊断进行探讨．对ＣＴ和ＭＲＩ在Ｂｉｎｓｗａｎｇｅｒ＇ｓ病的诊断价值进行讨论。     

Binswanger病血液流变学及血液成份的研究

本文测定了35例老年Binswanger病患者的部分血液流变学及血液成分的变化，结果发现，与健康对照组和脑动脉硬化组比较，疾病组高切变率全血粘度显著升高，红细胞变形能力明显降低，血液成份HG1、MCV、MCH、MCHC、RDW显著增加，提示红细胞的老化性改变参与了Binswanger病的发生，设法提高患红细胞变形的能力和降低血粘度将有益于阻止该病的进展。     

Binswanger氏病临床与CT,MR分析

Ｂｉｎｓｗａｎｇｅｒ氏病临床与ＣＴ、ＭＲ分析吴跃，杨秀卿Ｂｉｎｓｗａｎｇｅｒ氏病（ＢＤ）又称皮质下动脉硬化性脑病。现将我院１９８９～１９９２年６月共收治的１２例病人临床表现和ＣＴ、ＭＲ资料报告如下：临床资料一、一般资料本组１２例中，男８例，女４例。４...     

Binswanger病患者免疫状态的研究

目的：探讨Ｂｉｎｓｗａｎｇｅｒ病患者免疫功能的变化，方法：疾病组和对照组各２３例，分别检测外周血和脑脊液体液，细胞免疫系列指标。结果：与对照组比较，疾病组外周血抗心磷脂抗体阳性率明显升高，脑脊液ＩｇＧ指数明显升高，疾病组与对照组间脑脊液淋巴细胞亚群存在显著差异。两组间其它免疫指标无显著差异，结论：Ｂｉｎｓｗａｎｇｅｒ病患者中枢神经系统可能存在免疫应答异常。     

Binswanger病的临床与MRI

近年来，随着ＣＴ和ＭＲＩ检查手段的问世，尤其是ＭＲＩ在临床上的广泛应用，Ｂｉｎｓｗａｎｇｅｒ病的诊断率明显提高。我院１９９５年～１９９７年４月收治６８例Ｂｉｎｓｗａｎｇｅｒ病患者，现报告如下。１临床资料１．１一般资料本组男６２例，女６例，年龄６０～９...     

血脂康治疗高血脂及血液流变异常的观察

目的 探讨血脂康胶囊在调节血脂和血液流变学方面的作用。方法 取病人６０例随机分作两组，血脂康组和藻酸双脂钠组，疗程８周，服药前及疗程结束后各测血脂及血液流变变学一次。结果 血脂康在调节血脂在液流变学方面明显优于藻酸双脂钠（Ｐ〈０．０１）。结论 血脂康含有羟甲基戊二酰辅酶Ａ（ＨＭＧ－ＣＯＡ）还原酶抑制剂，具有调节血脂和降低血粘度及红细胞压积、纤维蛋白原含量，提高红细胞变形能力的作用。     

普遍脑萎缩与血液流变学关系的探讨

采用Ｈｕｃｋｍａｎｎ氏方法对１４２例颅脑ＣＴ平片进行脑室、脑沟测量，并逐一测定有关血液流变学指标：ＲＢＣ变形性、全血粘度、ＲＢＣ压积、血小板聚集率、纤维蛋白原含量，结果表明：（１）有随年龄增长逐渐出现普遍性脑萎缩的趋向，但大都在进入老年期后才日益明显；（２）普遍脑萎缩病人存在某些显著的血液流变学异常，如ＲＢＣ变形能力下降、全血粘度升高等；（３）显著皮层萎缩组与显著脑白质萎缩组血液流变学指标变化不尽相同，前者ＲＢＣ压积、全血粘度、纤维蛋白原含量，ＲＢＣ变形性明显高于后者，而后者的血小板聚集率高于前者。     

动脉硬化性皮层下白质脑病（附22例临床及CT分析）

动脉硬化性皮层下白质脑病（附２２例临床及ＣＴ分析）唐明耀，曾祥发，张永全动脉硬化性皮层下白质脑病又称为血管性进行性皮层下脑病（Ｂｉｎｓｗａｎｇｅｒ病，简称ＢＤ），是一种主要累及脑室周围白质及顶枕白质的综合征。于１８９４年由Ｂｉｎｓｗａｎｇｅｒ首先报告...     

Binswanger病脑血流及红细胞变形性的研究

本文测定了Binswanger病患者和相应对照组的局部大脑血流量及红细胞滤过指数的变化。结果发现,疾病组双侧大脑皮质及白质血流均无明显差异,大脑白质血流明显低于健康对照组和各病例对照组,疾病组红细胞滤过指数明显高于各对照组。提示Binswanger病患者存在红细胞变形能力低下,检测脑血流对于鉴别不同类型的大脑白质疏松症有一定的参考价值。     

术前匀速补液对烟雾病患者血液流变学的影响

目的 探讨术前禁饮后开始静脉匀速补液对烟雾病患者血液流变学的影响。方法 选取27例拟行间接颅内外血管重建术的烟雾病患者,于入院第二天取空腹血液行血液流变学检查为对照组,并在拟行手术前一天晚上开始禁饮、禁食后予以静脉匀速补液至入手术室前并再次采血行血液流变学检查为实验组;对比两组之间的全血低切粘度、全血中切粘度、全血高切粘度、血浆粘度、红细胞压积、红细胞聚集指数、红细胞刚性指数、红细胞变形指数。结果 对照组的血液粘度指标中的全血低切粘度、红细胞压积及红细胞变形指标中的红细胞聚集指数均高于实验组,而对照组红细胞变形指标中的红细胞刚性指数、红细胞变形指数低于实验组,均有统计学差异（P<0.05）。结论 术前禁饮后开始静脉匀速补液能够降低烟雾病患者血液粘度并提高红细胞的变形性。     

术前匀速补液对烟雾病患者血液流变学的影响

目的探讨术前禁饮后开始静脉匀速补液对烟雾病患者血液流变学的影响。方法选取27例拟行间接颅内外血管重建术的烟雾病患者,于入院第二天取空腹血液行血液流变学检查为对照组,并在拟行手术前一天晚上开始禁饮、禁食后予以静脉匀速补液至入手术室前并再次采血行血液流变学检查为实验组;对比两组之间的全血低切粘度、全血中切粘度、全血高切粘度、血浆粘度、红细胞压积、红细胞聚集指数、红细胞刚性指数、红细胞变形指数。结果对照组的血液粘度指标中的全血低切粘度、红细胞压积及红细胞变形指标中的红细胞聚集指数均高于实验组,而对照组红细胞变形指标中的红细胞刚性指数、红细胞变形指数低于实验组,均有统计学差异(P 0.05)。结论术前禁饮后开始静脉匀速补液能够降低烟雾病患者血液粘度并提高红细胞的变形性。     

Rheological and fibrinolytic findings in multiple sclerosis

Blood viscosity indices, fibrinolytic activity and other serum proteins related to haemocoagulation have been studied in 36 patients with multiple sclerosis. The whole blood viscosity was found to be increased in multiple sclerosis. The increase was caused by a decrease in erythrocyte deformability since plasma viscosity and haematocrit were normal. Plasminogen, fibrinogen and alpha 2 antitrypsin levels were found to be lower than normal. Such alterations were not observed in a group of patients with other non-immunological neurological diseases. In the latter group some coagulation indices were even higher than normal. The higher mean age of the pathological controls could explain the observed levels. The abnormalities observed in multiple sclerosis patients are considered to be a consequence of a non-specific activation of the coagulative system in a chronic immunological disease.     

缺血性脑卒中患者红细胞膜磷脂组分的改变及其与红细胞流变学的关系

目的探讨缺血性脑卒中患者红细胞膜磷脂各组分的改变及其对红细胞流变功能的影响。方法采用高效液相色谱法对５８例缺血性脑卒中、２３例有脑动脉硬化症状的患者和２６名健康人的红细胞膜磷脂各组分含量进行测定，并同时检测红细胞膜胆固醇含量、膜微粘度及红细胞变形能力。结果缺血性脑卒中患者红细胞膜总磷脂（ＴＰＬ）、磷脂酰胆碱（ＰＣ）、磷脂酰乙醇胺（ＰＥ）含量低于对照组；胆固醇（ＣＨＯ）、胆固醇与总磷脂比值（ＣＨＯ／ＴＰＬ比值）高于对照组；红细胞膜流动性、红细胞变形能力降低。直线相关分析，ＰＣ与红细胞膜微粘度、红细胞滤过指数呈负相关；ＰＥ与红细胞膜微粘度呈负相关；神经鞘磷脂（ＳＭ）与红细胞膜微粘度呈正相关。有脑动脉硬化症状的患者红细胞变形能力降低，膜胆固醇、胆固醇与总磷脂比值升高，但膜总磷脂及磷脂各组分无明显改变。结论缺血性脑卒中患者红细胞膜存在以ＰＣ、ＰＥ变化为主的磷脂代谢障碍，并对红细胞流变特性产生影响。     

Hemorheological effect of ticlopidine in the rat

Hemorheological effect of ticlopidine was studied with rats in various tests including whole blood viscosity, blood filtrability through a micropore membrane, mechanical hemolysis and shear stress-induced red cell deformability which was studied by a new technique developed by us.Ticlopidine treatment (30–300 mg/kg, p.o.) resulted in decrease in viscosity of heparinized whole blood, increase in blood filtrability and red cell stability against mechanical hemolysis. Ticlopidine was also found to increase reversible deformability of the red cells in response to shear stress which was evoked by passing whole blood through a thin tube (0.15 mm Ø) in a high speed (0.1 ml/0.2 sec). However, ticlopidine did not affect hematocrit values, plasma fibrinogen levels and plasma viscosity. Red cell morphology was not affected under the conditions without shear stress.These findings indicate that ticlopidine decreases whole blood viscosity by increasing red cell deformability, and that the effect may be favorable for improvement of microcirculation disorders.     

Erythrocyte deformability, plasma viscosity and oxidative status in patients with severe obstructive sleep apnea syndrome

BACKGROUND AND PURPOSE: In patients with severe obstructive sleep apnea syndrome (OSAS), diurnal changes of plasma viscosity and erythrocyte deformability were measured to elucidate the possible mechanism of cardiovascular diseases in OSAS patients. PATIENTS AND METHODS: Plasma viscosity and erythrocyte deformability was determined in 11 OSAS patients and 11 healthy subjects matched by sex and age. Plasma viscosity was measured by a cone-plate viscometer, and erythrocyte deformability was determined by filtration technique. Whole blood counts were performed and oxidative status of the patients' plasma and erythrocytes were evaluated. RESULTS: OSAS patients had higher plasma viscosity than controls, both in the morning (1.74+/-0.3 vs. 1.36+/-0.2 mPas, P<0.002) and evening (1.55+/-0.2 vs. 1.27+/-0.1 mPas, P<0.002), and morning plasma viscosity was significantly higher than the evening level (P<0.05). Morning plasma viscosity of patients was inversely correlated with their mean nocturnal SaO(2). Morning plasma malonyldialdehyde level was significantly higher in the patients than in the controls (69.7+/-30.5 vs. 45.5+/-11.0 nmol/l, P<0.005). Erythrocyte deformability of the patients was slightly lower. CONCLUSIONS: We have observed that plasma viscosity is high both in the morning and in the evening in severe OSAS patients. This elevation may predispose OSAS patients to myocardial infarction and stroke by increasing blood viscosity. Low nocturnal mean SaO(2) may be responsible for the high plasma viscosity in these patients.     

Hemorheological alterations in mild essential hypertension.

Blood rheological properties were studied in 21 patients suffering from essential hypertension (EHT), degree I-II according to WHO criteria. These patients were diagnosed "de novo". The whole blood filterability (WBF), blood viscosity (BV) at 230 s-1 and 23 s-1, red cell deformability (FI), erythrocyte aggregation in autologous (MEA) and normal plasma (MEAc), fibrinogen (Fbg) and hematocrit (Ht) have been evaluated. In the hypertensive patients we have found decreased WBF, greater BV and FI in comparison with the control group (p less than 0.001). Likewise, MEA and Fbg were increased, though the differences were less significant (p less than 0.01). The evaluation of Ht did not show any differences between the two groups. The results suggest that in the newly diagnosed EHT, clear hemorheological alterations occur, both in plasma and in the erythrocytes, which could play a role in the pathogenesis of the aforementioned disease.     

Hemorheological factors in cerebral ischemia.

We investigated 100 consecutive cerebral ischemia patients for hemorheological alterations. We measured whole and adjusted blood viscosity at 75 and 1,500 sec-1, plasma viscosity, red blood cell aggregation by the zeta sedimentation ratio, and red blood cell deformability using the centrifugal deformability technique. Patients were studied within 72 hours of the acute ischemic event, and 66 were available for follow-up evaluation approximately 2 months later. Two age- and sex-matched control groups were evaluated: 20 nonvascular neurological inpatients (patient controls) and 45 normal volunteers (normal controls). Compared with normal controls, we found significant acute increases in whole blood viscosity (1,500 sec-1), plasma viscosity, fibrinogen concentration, and zeta sedimentation ratio; the latter two variables were also increased at follow-up. Fibrinogen concentration was significantly associated with zeta sedimentation ratio and plasma viscosity and was increased for patient controls. There was a trend toward normalization of acute abnormalities over the 2-month follow-up period, and patients with more severe strokes tended to have more extensive hemorheological abnormalities. Among patients with severe stroke, fibrinogen concentration was significantly associated with the platelet activation peptide beta-thromboglobulin acutely (r = 0.63, p less than 0.005). We conclude that hemorheological abnormalities in cerebral ischemia are largely nonspecific findings, with the likely exception of patients with severe stroke.     

Haemorheological alterations in Behçet's disease are not related to a tendency for venous thrombosis

INTRODUCTION:Beh?et's disease is associated with an increased risk of thrombosis, although the prothrombotic mechanisms are unclear. Alterations in blood rheology, particularly increased erythrocyte aggregation, might play a role in the development of such thrombotic events. MATERIALS AND METHODS: We measured plasma lipids, fibrinogen, haematocrit, erythrocite aggregation, erythrocyte deformability, blood viscosity, plasma viscosity and erythrocyte indexes in patients with a nonactive disease at sampling, and in a well-matched control group. The patient group comprised 42 patients with BD (21 male, 21 female aged 43+/-12 years) and the control group comprised 46 healthy volunteers (23 male, 23 female aged 45+/-13 years). Twelve of the 42 patients with BD had a previous documented history of deep vein thrombosis at least 6 months before entering the study, and the other 30 did not. RESULTS: Compared with controls, patients showed statistically higher fibrinogen concentrations (P=0.001), plasma viscosity (P=0.002), blood viscosity (P=0.006) and erythrocyte aggregation, both at stasis (P=0.001) and at a low shear rate (P=0.002): the other rheological parameters were not statistically significant. No differences were observed in the rheological parameters when patients with and without previous thrombotic episodes were compared. CONCLUSIONS: Although patients with BD show a moderate hyperviscosity syndrome, possibly related to chronic inflammation, this does not seem to play a role in the development of thrombotic events.