自血穴位注射联合外用药序贯疗法治疗寻常型银屑病疗效观察

<正>银屑病是一种常见的红斑鳞屑性皮肤病,难以治愈,复发率较高,寻常型银屑病占85%~90%[1]。该病的发病机制尚未完全阐明,但通过合理用药可有效控制病情,提高生活质量。本院采取自血穴位注射联合卡泊三醇、哈西萘德外用药序贯疗法治疗寻常型银屑病患者,取得满意疗效,报道如下。1临床资料2013年1月—2015年6月本院皮肤科门诊寻常型银屑病患者92例,均为初诊患者,男54例,女38例,年龄18~72岁,平均(36.3±9.0)岁,病程0.3~     

中药联合吡硫翁锌气雾剂治疗进行期寻常型银屑病疗效观察

笔者于2009年6月至2010年1月用中西药结合方法治疗进行期寻常型银屑病取得了一定的疗效,现报告如下. 1 资料与方法 1.1 临床资料 选择临床符合进行期的寻常型银屑病诊断标准患者56例,分为2组,治疗组30例,男18例,女12例,年龄14～76岁,平均41.1岁;病程26个月～43年,平均29.8年;对照组26例,男16例,女10例,年龄17～74岁,平均39.7岁;病程29个月～41年,平均30.4年;两组患者在性别、年龄、病程、症状、体征、发病部位、病情严重程度上差异无统计学意义,所有患者在1个月内均无与银屑病相关的治疗史.     

阿维A联合窄谱紫外线治疗寻常型银屑病疗效分析

寻常型银屑病是皮肤科常见的慢性疾病,病程迁延,易于复发,临床治疗方法较多,但均未能取得满意的效果。2005年1月-2007年12月采用阿维A胶囊联合窄谱紫外线照射治疗寻常型银屑病患者116例,疗效满意。现报告如下。     

银屑病的护理

银屑病即牛皮癣，是一种易复发的慢性、炎症性皮肤病，发病于不同年龄。我科于２００１年２月至９月，共收治３２例重症银屑病患者，现将护理体会报告如下：１临床资料３２例患者中，男１８例，女１４例，年龄在１９至７２岁之间，病程３个月～４５年，入院天数平均１９d。２７例为寻常型银屑病，其中点滴状４例，蛎克状１例，泛发性２２例。脓疱型４例，均为掌跖脓疱型银屑病。红皮症型１例。２护理２．１心理护理：患者在得知自己所患银屑病时，均存在不同程度的心理障碍。对于发疹于皮表，妨碍观瞻的部位，患者既关心能否一次性根治不再…     

氨甲蝶呤治疗斑块样寻常型银屑病13例报告

银屑病是一种慢性、顽固难治 ,易于复发的皮肤病 ,我院自 1998年 5月～ 2 0 0 1年 12月用氨甲蝶呤治疗斑块样寻常型银屑病 13例 ,现将结果报告如下。1　资料与方法1 1　一般资料 :病例来自 1998年 5月～ 2 0 0 1年 12月住院患者 13例 ,全部患者符合《皮肤性病学》寻常型银屑病患者诊断标准[1 ] :其中两例行皮肤组织病理检查 ,除具备寻常型银基本病理改变外 ,还伴角化过度 ,未见Munro微脓肿及Kogoj细绵状脓疱。其中男性 9例 ,女性 4例 ,年龄 4 2～5 3岁 ,病程 5～ 2 0余年不等 ,所有患者均经门诊给予一般药物治疗 ,到 3个月以后 (包括 ;外用…     

滋补肾阴预防女性寻常性痤疮复发的疗效观察

寻常性痤疮又名青年痤疮 ,是一种临床常见的毛囊皮脂腺的慢性炎症性疾病。寻常性痤疮多为青春期常见 ,且病理与性激素分泌失衡有关 ,而中医又认为肾主生长发育 ,观察补肾阴对 46例女性寻常性痤疮复发的预防作用 ,取得较为理想的疗效 ,现总结报告如下。1　临床资料46例患者均系门诊病人 ,按随机原则分为复发预防组和对照组。其中复发预防组 2 4例 ,1例为初发 ,2 3例为复发 ;丘疹型 19例、脓疱型 4例、囊肿型 1例 ;病程 2 3ｄ～ 10年不等 ,平均 3 2年 ;年龄 15～ 33岁 ,平均 2 4 3岁。对照组 2 2例 ,2例为初发 ,2 0例为复发 ;丘疹型 19例 ,脓…     

临床图片对照法对银屑病患者临床疗效的影响

银屑病是一种常见并易复发的炎症性皮肤病,我科于2009年8月以来,为就诊于我科的寻常型银屑病患者实施临床图片对照法,取得满意疗效,现报告如下: 1 资料与方法 1.1 一般资料:本组病例为2009年8月至2011年8月以来就诊于承德市中心医院皮肤科的寻常型银屑病患者,共42例,均为初发,年龄为18-55岁之间,42例患者均符合银屑病的诊断标准[1].     

迪银片治疗寻常型银屑病36例临床观察

我们自1997年采用重庆华语制药有限公司生产的迪银片治疗寻常型银屑病36例，获得满意疗效，现将结果报告如下。1资料与方法11临床资料从门诊，住院患者中随机选择寻常型银屑病患者36例均具有典型临床症状，部分病例经皮肤组织病理而确诊。其中男19例，女17例病程2个月～12年，门诊、住院患者中随机选择寻常型银屑病患者36例，均具有典型平均64年。年龄16～61岁，平均387岁。轻局限型4例，重全身泛发32例，进行期14例，静止期22例。所有病例在治疗前1个月未服过免疫抑制药、皮质类固醇激素及其他治疗银屑病的药物。无明显肝、肾及血液系统疾…     

氨甲喋呤治疗银屑病44例疗效观察

银屑病是一种常见的易复发皮肤病,病因不明,且无有效的预防措施,目前治疗方法很多,但只能达到近期临床控制。现将本院近１０年来４４例用氯甲喋呤治疗各型银屑病的疗效观察结果分析如下。１临床资料和方法一般情况１９８６年１０月～１９９６年９月本院住院银屑病患者共４４例,其中男性２８例,女性１６例;年龄最小１２岁,最大７２岁,平均４６．３岁;病程最长３０年,最短２０天,平均８．７年。病损分型红皮病型１８例,脓疮型７例,寻常型１１例,关节型３例,红皮症伴肤癌１例,脓疮型伴关节症４例。治疗方法治疗初期均采用静脉…     

蒽林软膏治银屑病疗效观察

蒽林是治疗银屑病的主要外用药,对28例银屑病我们分别使用了蒽林和水杨酸软膏进行疗效对比。报告如下: 一、本组28例寻常型银屑病,其中男16,女12。年龄9～18岁。病期1个月至20年。初发的11例,复发的慢性银屑病17例。为准确观察两种药物的疗效,我们所选定的28例患者均有双下肢基本对称的皮疹,其中皮损为进展期及静     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.