口腔基底样鳞状细胞癌1例报告及文献复习

基底样鳞状细胞癌(basaloid squamous cell carcinoma,BSCC)是鳞状细胞癌中一种罕见的、具有侵袭性的变异类型,好发于上消化-呼吸道。BSCC在病理学上与传统鳞状细胞癌及鳞状细胞异常增生相似,但更具侵袭性,预后也较差。本文报告1例少见的发生于右上牙龈的基底样鳞状细胞癌,并结合文献,对其临床表现、组织病理学特点、治疗及预后等进行讨论。     

面部基底细胞癌

本文报告了面部基底细胞癌37例,男性15例,女性22例,女:男为1.46:1。患病年龄从32～76岁,其中40～49,50～59和60～69岁三个年龄组最多见,占全组的72.97％。平均病程约为6年。眶周(占27.03％)和上唇(24.32％)罹患最多,其次为鼻部(18.92％),颊部(16.21％),下唇(8.11％)等等。组织病理学上,4例(10.81％)为实体型,33例(89.19％)为混合型(实体型和角化型或实体型和腺样型混合)。     

痣样基底细胞癌综合征1例报告

痣样基底细胞癌综合征（Naevoid basal cell carcinoma syn-drome,NBCCS）又称Gorlin-Goltz综合征。由White于1894首次描述,是由皮肤基底细胞癌、多发性颌骨角化囊肿及骨骼系统异常和各种其他病变组成的综合征,常伴有多器官发育障碍。我科最近收治1例,报告如下。     

面部黑痣激光治疗后发生基底细胞癌（附3例报告）

病例报告例 1,庞某 ,女 ,6 3岁 ,1998年 12月就诊。述左鼻翼外下方有绿豆大黑痣多年 ,无痛痒等不适症状。因恐恶变于 1年前在某医院行激光治疗 ,约半月余伤口愈合 ,该处平整颜色完全正常。近 3月来手术部位病变“复发” ,逐渐呈现黑色、常糜烂流黄水且结痂。检查 :左侧鼻唇沟旁见 1.2ｃｍ× 0 .8ｃｍ的黑褐色病变 ,表面不平 ,中央 0 .5ｃｍ× 0 .4ｃｍ部分略凹陷 ,边缘触诊较硬。初诊 :面部基底细胞癌。局麻下在病变外 0 .5ｃｍ处彻底切除 ,用岛状瓣修复缺损 ,术后愈合良好。随访 2年无复发。病理检查 :在真皮浅层见瘤细胞巢、由嗜硷性染色…     

痣样基底细胞癌综合征1例报告

痣样基底细胞癌综合征是一种罕见的常染色体显性遗传疾病，以颌骨多发性角化囊肿、皮肤痣样基底细胞癌及多种骨骼异常为主要临床表现。作者报告1例典型病例．并对其临床、病理和治疗进行了讨论．     

痣样基底细胞癌综合征伴先天性左眼缺失1例

痣样基底细胞癌综合征（NBCCS）又称基底细胞痣综合征或Goltz-Gorlin综合征,是一种复杂且罕见的常染色体显性遗传疾病,大量研究文献证实PTCH1基因与NBCCS有关。本文报道1例NBCCS伴先天性左眼缺失的病例,并结合相关文献探讨以进一步了解该综合征。     

痣样基底细胞癌综合征家系1例

痣样基底细胞癌综合征是一种罕见的常染色体显性遗传病,以发育异常和肿瘤发生为主要临床特征。本文报告1例痣样基底细胞癌综合征家系,并结合相关文献对该病的发病率、发病机制、临床表现、治疗方法等进行讨论。     

口腔颌面部基底细胞癌手术治疗35例分析

目的　探讨口腔颌面部基底细胞癌手术治疗的特点及方法。方法　回顾了近年来手术治疗的口腔颌面部基底细胞癌 35例 ,分析不同部位治疗特点及病变部位、术前诊断与切缘阳性间的关系。结果　切缘阳性与部位及术前诊断具有相关性。结论　提高术前临床诊断符合率 ,注意部位特点 ,可望获得更满意疗效     

痣样基底细胞癌综合征1例

痣样基底细胞癌综合征（Naevoid basal cell carcinoma sydrome,NBCCS）又称Gorlin-Goltz综合征,在人群中的发病率为1/56000,男女比为3∶1,临床上罕见[1]。该综合征为常染色体显性遗传疾病     

Large cell neuroendocrine carcinoma of the floor of mouth and retromolar trigone in association with basaloid squamous cell carcinoma

Large cell neuroendocrine carcinoma and basaloid squamous cell carcinoma are each rare but aggressive diseases of the head and neck. A case of large cell neuroendocrine carcinoma occurring simultaneously with a basaloid squamous cell carcinoma originating from the oral cavity is described in this report. The diagnosis of these pathologies can be challenging but is important, as staging and treatment recommendations differ from those for oral cavity squamous cell carcinoma.     

Multiple self-healing squamous cell carcinomas of the face

We report the case of a 73-year-old woman who developed multiple self-healing squamous cell carcinomas over a 6-year period. Some were excised and others resolved spontaneously.     

原发性下颌骨鳞状细胞癌1例报告及文献复习

原发性下颌骨鳞状细胞癌由于早期缺少特征性的临床表现,诊断较为困难。本文报告1例原发性下颌骨鳞状细胞癌,并复习相关文献,就其组织来源、临床表现、诊断、治疗及预后进行讨论。     

原发性颌骨内鳞状细胞癌1例报告及文献复习

原发性颌骨内癌是一种罕见的来源于牙源性上皮剩余的恶性肿瘤。本文报告1例发生于右侧下颌骨内的鳞状细胞癌病例。该患者表现为右侧下颌骨拔牙创口迁延不愈且伴肉芽组织形成,局部疼痛,但不影响进食及言语功能。采用手术切除、左侧血管化游离腓骨肌皮瓣修复,术后病理检查证实为鳞状细胞癌。     

Squamous cell carcinoma arising in a residual cyst: A case report

A case of squamous cell carcinoma (SCC) arising in a mandibular residual cyst in a 62-year-old man is presented. The treatment included enucleation followed by primary closure. Histologic examination revealed a poorly differentiated SCC in the cyst lining without invasion through the connective tissue wall. Eight and a half years later, the patient was still free from recurrence.     

Multiple distant organ metastases from squamous cell carcinoma of the lower gingiva that followed a rapid course: An autopsy case report

We experienced a rare case, which was distant organ metastatic squamous cell carcinoma (SCC) and had deteriorated rapidly. An 80-year-old man was transported to hospital because of a sudden loss of consciousness. A tumor was found in his right mandibular gingiva, which was histopathologically diagnosed as SCC. A large tumor was detected in the pelvic soft tissue on a thoracoabdominal computed tomography scan. The patient died on the 22nd day after he was admitted to hospital. We performed an autopsy. The autopsy revealed multiple distant organ metastases, and all of the lesions were histopathologically diagnosed as SCC.     

Oral squamous cell carcinoma associated with symphyseal dental implants: an unusual case report

BACKGROUND: The development of squamous cell carcinoma (SCCa) around dental implants is an uncommon pathological manifestation. This case report describes a patient with history of oral lichen planus (OLP) and previous SCCa of the gingiva who developed SCCa adjacent to symphyseal implants. CASE DESCRIPTION: An 81-year-old edentulous woman with history of OLP developed an in situ SCCa on the left mandibular edentulous ridge. One of the authors, an oral and maxillofacial surgeon, performed a marginal mandibular resection of the lesion. Functional oral rehabilitation was achieved by means of two endosseous symphyseal implants. Three years after the patient underwent implant-supported reconstruction, the oral and maxillofacial surgeon detected an exophytic mass adjacent to the right implant and diagnosed it as recurrent SCCa. Two of the authors performed a marginal mandibular resection. One year later, the patient developed a recurrence over the resected area, requiring segmental mandibulectomy. CLINICAL IMPLICATIONS: This case report demonstrates that recurrent primary malignancy can masquerade as benign peri-implant complications. A high degree of vigilance is required in the follow-up of patients with previous cancer or premalignant lesions.     

Spindle cell carcinoma of the gingiva: report of an autopsy case

An autopsied case of an 80-year-old man with spindle cell carcinoma of the gingiva is reported. The tumor was polypoid and mostly composed of a sarcomatous proliferation of spindle cells with a small focus of squamous cell carcinoma at the stalk portion. The carcinoma metastasized to a cervical lymph node, lungs and pleura with extension to the diaphragm. In the metastatic lymph node, the squamous cell component was more prominent than the spindle cell one, while only anaplastic pleomorphic carcinoma cells were found in the lungs. The spindle or anaplastic cells were immunohistochemically positive for vimentin and carci-noembryonic antigen (CEA) but not for other epithelial antigens. We have concluded that the sarcomatoid component arose from the oral squamous cell carcinoma by a metaplastic process. This is the first case report of an oral spindle cell carcinoma examined by autopsy.     

维吾尔族口腔鳞状细胞癌患者中血清鳞状细胞癌抗原的表达研究

目的 探讨维吾尔族口腔鳞状细胞癌(OSCC)患者血清中鳞状细胞癌抗原(SCC-Ag)的表达.方法 采用化学发光法检测90例维吾尔族OSCC患者(OSCC组)和90例维吾尔族其他口腔恶性肿瘤患者(口腔非OSCC恶性肿瘤组)、101例维吾尔族口腔良性肿瘤患者(良性肿瘤组)和120例维吾尔族正常对照者(正常组)的血清SCC-Ag水平,并对其中60例OSCC和60例口腔非OSCC恶性肿瘤患者治疗前后SCC-Ag水平进行检测,分析SCC-Ag在OSCC诊断、治疗疗效中的意义.结果 OSCC组的SCC-Ag水平明显高于口腔非OSCC恶性肿瘤组(P=0.002),良性肿瘤组(P=0.001)和正常组(P=0.001).OSCC患者血清SCC-Ag阳性率为43.3％(39/90),明显高于其他3组(P=0.000 1).OSCC患者TNM晚期的术前SCC-Ag水平的表达高于早期水平(P<0.05).复发组和未复发组的术前、术后、放化疗后SCC-Ag水平相比较,差异均有统计学意义(P＜0.05).手术及放化疗前后鳞状细胞癌患者血清SCC-Ag水平变化差异有统计学意义(P＜0.0 1),然而,在口腔非OSCC恶性肿瘤组治疗疗效差异无统计学意义(P>0.05).结论 血清SCC-Ag对维吾尔族OSCC患者的早期诊断敏感性不高,但在评价治疗疗效,预测肿瘤复发方面有重要的临床意义.