冠状动脉旁路移植术

目的介绍我院冠状动脉旁路移植术的临床经验。方法采用常规体外循环和非体外循环下共完成90例冠状动脉旁路移植术。男65例，女25例，单支冠状动脉病变3例，2支病变10例，3支及以上病变77例。46例患者术前有心肌梗死，8例合并室壁瘤，2例合并二尖瓣关闭不全。30例患者在体外循环下手术，同时行室壁瘤切除术8例，行二尖瓣替换2例，60例在非体外循环下手术。应用左乳内动脉89例次，桡动脉45例次，大隐静脉170例次。结果围手术期死亡3例，病死率约3．3％，1例为围手术期心肌梗死低心排血量综合征，2例为鱼精蛋白过敏心脏骤停除颤后顽固性心律失常。本组患者随访3个月～5年（平均3年），临床症状均明显改善，心功能均有恢复。结论冠状动脉多支病变行冠状动脉旁路移植术具有良好的临床效果，其中非体外循环手术费用低，创伤小，术后恢复快。     

非体外循环下冠状动脉内膜剥脱后搭桥治疗弥漫性冠状动脉病变

目的探讨非体外循环心脏跳动下冠状动脉内膜剥脱后搭桥治疗弥漫性冠状动脉病变的早期临床结果和经验。方法2003年5月—2005年5月,对53例弥漫性冠状动脉病变患者行非体外循环下冠状动脉内膜剥脱后搭桥手术治疗。53例中,男性41例、女性12例,年龄55～79(64±7)岁。加拿大心脏病协会心绞痛分级：Ⅰ～Ⅱ级15例,Ⅲ级6例,Ⅳ级32例。有心肌梗死史26例(49%)。冠状动脉造影：双支病变3例,3支病变50例,其中合并左主于病变9例。左心室射血分数0．26～0．65(0．52±0．17)。53例共行70支冠状动脉内膜剥脱：左前降支系统38支,其中5例内膜剥脱后先用大隐静脉片行前降支成形,再在补片上用乳内动脉搭桥;回旋支的钝缘支8支;右冠状动脉系统24支。应用左乳内动脉53支,桡动脉2支,余均为大隐静脉桥,人均搭桥(3．8±1．1)支,再血管化指数1．03±0．07。结果术中桥血流测定显示63支桥血流满意,7支欠满意。术后2例发生围手术期心肌梗死,但对血流动力学无明显影响。53例皆痊愈出院。44例随访6～29个月,无心绞痛发作;9例失访。6例在手术后3～27个月复查冠状动脉造影,显示桥血管均通畅。结论非体外循环下冠状动脉内膜剥脱后搭桥,安全可行,再血管化程度高,是治疗弥漫性冠状动脉病变的有效方法。     

不停跳下冠状动脉旁路移植加左心室室壁瘤闭式成形术46例

目的总结46例不停跳下冠状动脉旁路移植（冠脉搭桥）加左心室室壁瘤闭式成形术的手术经验。方法在非体外循环及不停跳下以1．0～1．5mg／kg体重肝素抗凝。明确室壁瘤基底位置及其长度以2-0Surgipro843缝线平行左心室长轴加毡片行间断褥式缝合，使瘤腔与左心室功能心腔隔离。45例同期行冠脉搭桥术。结果27例搭桥3根，12例搭桥2根，6例搭桥1根。39例应用左乳内动脉吻合于前降支，3例于转机不停跳下完成手术，2例行前降支内膜剥脱术，2例应用IABP。全组死亡1例。余者无术后心梗发生，10—14d治愈出院。结论不停跳下冠脉搭桥加左心室室壁瘤闭式成形术可有效消除左心室矛盾运动及无效心腔，加固薄弱心室壁，防止心脏破裂；减少恶性心律失常发生；避免体外循环并发症。     

胸部小切口冠状动脉搭桥术

目的 评价胸部小切口冠状动脉搭桥术的临床疗效。方法 采用左胸部小切口取左乳内动脉,左心脏跳动下行冠状动脉搭桥术141例。其中前降支单支病变83例,多支病变58例。合并高危因素者58例,经行皮冠状动脉腔内成型术（PTCA）术后45例,冠状动脉搭桥术后10例。结果 全组均完成手术,其中左乳内动脉搭至前降支139例,第一对角支2例。无围手术期死亡。术后行2次冠状动脉搭桥术1例,PTCA21例。冠状动脉造影显示血管桥通畅率98．5％。结论 胸部小切口冠状动脉搭桥术主要适用于前降支的再血管化。该手术安全可靠,疗效优良,在合并高危因素或常规搭桥手术效果不满意者中应用更佳。     

1110例冠状动脉搭桥术的早期结果

目的　回顾性总结１９９６ 年１ 月以来１１１０ 例冠状动脉搭桥术（ＣＡＢＧ） 的近期疗效,介绍冠心病搭桥术的体会和经验。　方法　体外循环下行ＣＡＢＧ１０４８ 例,非体外循环ＣＡＢＧ６０ 例。心肌保护均采用冷血含钾停跳液,体外循环时间１１５ ±３５ 分钟,主动脉阻断时间７２ ±２４ 分钟,单支搭桥１１０ 例,２ 支搭桥１４５ 例,３ 支搭桥４１５ 例（３７－３ ％） ,４ 支搭桥或４ 支以上４３９ 例（３９－５％） 。搭桥材料：左乳内动脉７５１ 例,大隐静脉８７７ 例,桡动脉１０１ 例,全动脉化７２ 例。合并手术：室壁瘤切除１１２ 例,室壁瘤折叠１４ 例,左室成形５ 例,瓣膜手术４８ 例,室间隔穿孔修补术５ 例。　结果　住院死亡９ 例,死亡率０－８１％ 。其余患者痊愈出院,心绞痛基本缓解。术后并发症：低心排１１ 例,主动脉球囊反搏７例,围术期心肌梗塞２ 例,脑部并发症３ 例,二次开胸止血４ 例。　结论　选择好靶血管和充分血管化是冠状动脉搭桥术的关键。另外要重视围术期处理。     

微创冠状动脉搭桥术(附23例报告)

目的　探索冠状动脉搭桥术的微创治疗方法。　方法 1999年 1月至 2 0 0 0年 8月 ,用Octo pus方法给 2 3位冠状动脉狭窄的患者行冠状动脉搭桥术。搭桥数 1根 1例 ,2根 3例 ,3根以 19例。移植部位 :前降支 2 3例 ,对角支 8例 ,回旋 15例 ,右冠 14例 ,后降支 8例。移植血管 :左乳内动脉 2 0根 ,大隐静脉 4 8根。　结果　无手术死亡 ,无中转体外循环 ,术后心绞痛消失 ,MRI提示桥血管通畅。　结论　非体外循环下冠状动脉搭桥术适用于多支血管病变 ,包括回旋支和后降支。桥血管通畅率与常规冠状动脉搭桥术相同。并发症少 ,费用低 ,是一种安全、经济的微创手术方法。     

冠状动脉搭桥42例报告

<正> 1998年10月19日至今我们为42例冠状动脉硬化性心脏病施行了冠状动脉(CA)搭桥术,手术获得圆满成功,病人至今生存质量良好。心绞痛症状完全消失,现报告如下。 1 临床资料 1.1 一般资料:42例中,男34例,女8例,年龄38～79岁,平均54.3岁。同时伴有高血压12例,糖尿病8例,不稳定心绞痛25例,20例有心肌梗死,其中合并心梗后室间隔穿孔,纵膈肿瘤各1例,6例形成室壁瘤,2例合并主动脉瓣关闭不全,EF32～65％,手术前均行CA造影证实有多支CA病变。其中全动脉化搭桥4例,其余的为动脉、静脉桥,平均搭桥2.7     

非体外循环冠状动脉旁路移植术中升主动脉粥样硬化的处理(附35例报告)

目的总结非体外循环冠状动脉旁路移植术中升主动脉粥样硬化(ascending aortic athero-sclerosis,AAA)的临床处理经验。方法合并AAA行非体外循环冠脉搭桥术患者35例,5例联合应用左前外侧小切口不停跳冠脉搭桥和经皮腔内冠状动脉成形术(杂交技术);30例采用胸骨正中切口,其中9例行双侧乳内动脉原位移植,1例将大隐静脉桥近端吻合到无名动脉,12例以左乳内动脉为唯一的供血来源,其静脉桥或桡动脉桥吻合到左乳内动脉,8例应用"易扣"近端吻合辅助装置完成静脉桥的近端吻合。所有患者均未应用主动脉侧壁钳。结果35例手术均顺利完成,无死亡。术后主要并发症:二次开胸止血1例,肺部感染2例,切口感染1例,无围术期心肌梗死,无严重神经系统并发症。结论对于AAA患者,采用非体外循环冠脉搭桥结合杂交技术、主动脉不接触技术或近端吻合装置可以有效减少术后神经系统并发症,临床效果满意。     

465例非体外循环下冠脉搭桥术的麻醉体会

由于手术辅助器械的应用和手术技术、方式及麻醉方法的改进 ,近年来我国也开创了非体外循环下冠脉搭桥术[1] ,即不用体外循环 ,在跳动的心脏上用特制的血管固定器将心脏表面冠状动脉的吻合部位相对固定 ,利用血管腔内分流管来保留其原有血流 ,保证手术野清晰可见 ,从而完成满意的冠状动脉血管吻合。我院自 1998年 8月～ 2 0 0 2年 4月共进行冠状动脉搭桥术 5 5 3例 ,除 88例伴有室壁瘤或心脏瓣膜病 ,需同时切除室壁瘤或置换瓣膜 ,必须在体外循环下行搭桥外 ,共实施非体外循环下搭桥 46 5例 ,包括主动脉内球囊反搏 (IABP)下非体外循环搭桥…     

高危患者主动脉内球囊反搏辅助下不停跳冠脉搭桥体会

目的探讨严重冠状动脉三支血管病变（狭窄〉75％）的高危患者在主动脉内球囊反搏（IABP）辅助下行非体外循环下冠脉搭桥术的安全性。方法回顾2002年1月至2007年12月间27例高危冠心病患者，在IABP支持下行非体外循环下冠脉搭桥术临床资料。结果本组患者冠状动脉造影均提示严重三支血管病变，15例合并左主干病变（狭窄〉75％），均属高危（EuroSeore〉6分），无术中死亡、术后死亡1例，搭桥2～7支、平均（3．2&#177;1．1）支。结论对于冠脉严重三支血管病变高危病例，在预先置入IABP的辅助下可以安全地施行非体外循环下的冠脉搭桥术。     

225例左主干狭窄冠状动脉旁路移植术

目的 总结冠状动脉左主干狭窄(LMS)的外科治疗效果和临床经验。方法1999年1月至2003年6月，225例LMS病人接受了冠状动脉旁路移植术(CABG)。平均年龄63．4岁。左室射血分数(LVEF)≤0．3011例。6例急诊手术，其中3例术前放置主动脉球囊反搏(IABP)。76例在常规体外循环下手术；149例应用非体外循环不停跳技术，术中改为体外循环5例。其中13例全动脉化、3例全静脉化旁路移植术。结果平均术前住院2．3d。平均每例远端吻合口2．95个。死亡13例(5．78％)。结论尽管LMS是预示CABG术后死亡率的独立危险因素，但CABG现在仍是其治疗的第一选择，且是安全、有效的方法。     

冠状动脉内膜剥脱联合旁路移植治疗弥漫性冠状动脉狭窄病变的近中期效果

目的探讨冠状动脉内膜剥脱术(CE)联合冠状动脉旁路移植术(CABG)治疗弥漫性冠状动脉狭窄病变的近中期效果。方法回顾性分析2010年1月至2019年1月在南京市第一医院心胸血管外科接受CE+CABG的248例弥漫性冠状动脉狭窄病变患者的临床资料。男性201例,女性47例;年龄(65.6±8.5)岁(范围:43~79岁)。体外循环手术156例,非体外循环手术92例。共对269根病变血管完成CE,包括前降支108根,右冠状动脉140根,钝缘支21根。共完成旁路移植872支,包括左胸廓内动脉248支,桡动脉48支,大隐静脉576支,每例患者移植(3.5±0.8)支(范围:2~6支)。CE后平均血流量为(26±8)ml/min(范围:13~59 ml/min),血流指数为3.1±0.8(范围:2.0~6.7)。采用t检验或χ²检验比较体外循环和非体外循环患者的手术结果及术后通畅率。结果全组围手术期病死率为1.2%(3/248),2例死于肾功能衰竭,1例死于术后顽固性低心排血量。9例发生围手术期心肌梗死。随访(41.8±21.4)个月(范围:1~68个月)。旁路血管术后1年通畅率为78.4%(182/232),3年通畅率为69.8%(162/232)。左冠状动脉系统通畅率明显高于右冠状动脉系统(1年:87.4%比73.1%,χ²=6.533,P=0.011;3年:78.2%比64.8%,χ²=4.588,P=0.032)。体外循环组和非体外循环组旁路血管通畅率无差异(1年:80.0%比76.9%,χ²=0.277,P=0.599;3年:71.5%比67.9%,χ²=0.300,P=0.584)。结论CE+CABG治疗弥漫性冠状动脉狭窄病变可以获得较满意的完全再血管化,有较好的早、中期效果和旁路血管通畅率。体外循环和非体外循环手术具有相似的早中期结果。     

1198例非体外循环冠状动脉旁路移植术的早期临床分析

目的　总结分析非体外循环冠状动脉旁路移植术 (OPCAB)的早期临床结果和经验体会。方法　 1996年 10月至 2 0 0 2年 5月在国内 15个冠心病微创外科中心完成非体外循环冠状动脉旁路移植术 1198例 ,占同期冠心病手术的 79 5 % ,OPCAB实施率 (即OPCAB占单纯冠状动脉旁路移植术的百分比 )为 85 2 %。年龄平均 (6 1 6± 9 0 )岁 ,男性占 77 3%。 18 7%为左主干病变 ,76 9%为 3支病变。左心室射血分数平均 0 5 6± 0 17。其中二次手术者占 1 5 % ,急诊手术占 9 9%。结果　 2 2例为小切口单支病变旁路移植手术 ,其余均为正中切口、多支病变的OPCAB手术。远端吻合口为 (3 1± 0 9)个 ,乳内动脉桥占 6 5 6 % ,桡动脉桥占 18 0 % ;5 2 %病人使用主动脉内球囊反搏。住院死亡 14例 ,病死率 1 2 %。其中术后心跳骤停或室颤 7例 ,大出血 2例 ,昏迷伴肾功能衰竭 2例 ,大面积脑梗塞 2例 ,呼吸衰竭 1例。并发症中 ,围术期心肌梗死占 0 4% ,急性左心功能衰竭占 0 3% ,严重心律失常占 1 2 % ,呼吸系统并发症占 2 0 % ,器质性神经系统并发症占 1 2 % ,新发或加重的肾功能不全占 0 7% ,出血二次开胸占1 0 % ,胸骨愈合不良占 0 6 %。结论　OPCAB手术安全可行 ,早期效果满意 ,远期效果有待进一步观察。OPCAB具备一     

Association of plasma osteopontin levels with coronary calcification evaluated by tomographic coronary calcium scoring

Evidence indicates that proteins controlling bone mineralization are also involved in the regulation of coronary calcification. The aim of the present study is to evaluate the association between plasma osteopontin (OPN) levels and coronary calcification quantified by using tomographic coronary calcium scoring. Plasma OPN levels were measured from samples of 80 intermediate-risk asymptomatic patients (56 ± 10 years) who underwent tomographic coronary calcium scoring via multislice computed tomography for incremental risk stratification. There was no significant difference regarding OPN levels between patients with and without coronary calcification in the whole study population. Of 49 patients not receiving renin–angiotensin system inhibitors and/or statins, plasma OPN levels of patients with coronary calcification (38.7%) were significantly higher than those without coronary calcification (61.3%) (8.88 ± 2.85 vs. 6.79 ± 2.41, P = 0.008, respectively). On a binary logistic regression model, only age and plasma OPN level were found to be significant independent associated variables for the presence of coronary calcification in patients not receiving these medications (odds ratio for age, 1.15, P = 0.017; for plasma OPN levels, 1.63, P = 0.014). Our results indicate that plasma OPN levels may be predictive of coronary calcification, suggesting an important role of OPN in the atherosclerotic calcification pathogenesis.     

Morphologic expression of the left coronary artery in pigs. An approach in relation to human heart

Introduction

In spite of its importance as an experimental model, the information on the left coronary artery in pigs is sparse.

Objective

To determine the morphologic features of the left coronary artery in pigs.

Methods

We evaluated 158 pig hearts. The left coronary artery was perfused with synthetic resin after their ostia had been catheterized. Diameters and courses of the vascular beds were measured with an electronic caliper (Mitutoyo^®).

Results

The diameter of left coronary artery was 6.98 ± 1.56 mm and its length was 3.51±0.99 mm. It was found to end up by bifurcating itself into the anterior interventricular artery and the circumflex artery in 79% of the cases, and by trifurcating in 21% of the cases, with the presence of the diagonal artery. The anterior interventricular artery ended up at the apex in 79.7% of the cases, and the circumflex artery at the posterior aspect of the left ventricle in 64% of the case, this artery never reached the posterior interventricular sulcus. An anastomosis between the terminal branches of the anterior interventricular artery and the posterior interventricular artery was found in 7.6% of the specimens. The antero-superior branch of the anterior interventricular artery occurred in 89.9% of the hearts. A left marginal branch was observed in 87.9% of the cases with a diameter of 2.25±0.55 mm.

Conclusion

Compared with humans, pigs have shorter left coronary artery trunks and branches; even the circumflex artery never reaches the posterior interventricular sulcus. Our findings are useful for the design of experimental hemodynamic and procedural models.     

Normal coronary artery dimensions in Indians

Background There is no available data on normal coronary artery size in the Indian population. We attempted to establish a database for normal dimensions of the coronary artery segments during life by using quantitative coronary angiography and compared these with Western estimates of coronary artery size. Material and Methods Between december 2003 and June 2004, 94 patients who underwent quantitative coronary angiography for evaluation of symptoms of ischemic heart disease and were found to have no coronary artery disease form the sample size. Results The dimensions of branches in the left coronary system in our patients were less and those of the distal circumflex, and the proximal and distal left anterior descending coronary arteries were significantly greater than those of Indian Asians living in the United Kingdom and the native Caucasians but the dimensions of the right coronary artery were significantly greater in our patients. Conclusions Coronary artery dimensions for at least some branches of the left coronary system are similar to that reported in the West and the dimensions of the right coronary are greater. These findings contradict the general perception that Indians have smaller coronary arteries.     

Intensive Use of Intravascular Ultrasound during Coronary Angioplasty. A Six-month Campaign

Background - Compared to coronary angiography, intravascular ultrasound (IVUS) gives additional information important for the percutaneous transluminal coronary angioplasty (PTCA) procedure, but is time-consuming and may cause complications. Aim - To evaluate, during a period of intensive use of IVUS, the impact of IVUS on the final decision on balloon/stent diameter, consumption of devices, time-consumption and IVUS-related complications. Method - During a 6-month period, IVUS was contemplated in all PTCA procedures and the reason for not using IVUS was specified. We used CVIS during the first, and Endosonics during the last 3 months, and both periods started with 1 week of hands-on practice. All procedures were to be planned according to an initial quantitative coronary angiography (QCA), and the finally achieved result, material used and complications were registered. Results - The proportion of IVUS/PTCA was 37% during, 8% 6 months before and 12% 6 months after the study period. Three hundred and twenty-three patients were included in the study (57% of all patients), 199 of them were subjected to IVUS. The indications for PTCA during the study period were stable angina (58%), unstable angina (32%) and acute myocardial infarction (10%). The main reasons for not doing IVUS were use of 6F guiding catheter (13%), urgent procedure (12%) and occluded vessel (11%). Initial QCA detected 253 stenoses in 199 patients and 64 additional stenoses were treated, most of them probably detected by IVUS. QCA systematically underestimated vessel size, particularly in small vessels. There was a non-significant trend to more accurate estimations towards the end of the study in small vessels. Dissection, probably due to IVUS, occurred in two cases (1%). There were no significant differences in the number of devices used in IVUS compared to non-IVUS patients. The procedural time was 24 min longer in IVUS than in non-IVUS cases and more stenoses were treated per procedure in the IVUS group. Conclusion - Coronary angiography often underestimated balloon/stent size but in an unpredictable way, with a substantial proportion of significant stenoses being undetected. IVUS had few serious complications, did not increase device consumption but prolonged procedural time.     

再次冠状动脉旁路移植术42例临床分析

目的 总结再次冠状动脉旁路移植术(CABG)的临床特点及手术效果.方法 对2002年1月至2010年12月连续收治的42例CABG术后患者行再次CABG.其中男性29例,女性13例;年龄46～78岁,平均(61.2±2.1)岁.非体外循环CABG患者31例,心肺转流下CABG患者11例,同期分别行主动脉瓣置换术及主动脉根部替换+右半主动脉弓置换术各1例.结果 全组死亡3例,1例因术中右心室破裂死亡,1例因术后心力衰竭死亡,1例发生肾功能衰竭导致多器官功能衰竭死亡,围手术期病死率为4.8%.其余40例术后呼吸机辅助呼吸时间9～27 h,平均(17±7)h.术后心绞痛均消失,围手术期无心肌梗死发生,顺利恢复出院.术中接受主动脉内球囊反搏6例.术后随访38例,随访时间6～54个月,均无心绞痛发作;12例复查冠状动脉CTA,显示移植血管均通畅.结论 随着手术技巧和围手术期管理的改进,合理采用各种技术,再次冠状动脉旁路移植术可以取得满意疗效.

Abstract：

Objective To determine the clinical characteristics and outcomes of redo CABG.Methods The outcomes of 42 consecutive patients who underwent redo CABG from January 2002 to December 2010 was analyzed.There were 29 males and 13 females,aging from 46 to 78 years old with a mean of(61.2 ± 2.1)years.Off-pump CABG was applied for 31 patients and on-pump CABG for 11 patients.There were 1 patient underwent concomitant aortic valve replacement and 1 patient underwent aortic root and right aortic arch replacement respectively.Results Three patients died of right ventricle rupture,heart failure and multiple system organ failure respectively and the perioperative mortality rate was 4.8%.The post-operatively mechanical ventilation time varied from 9 to 27 h with a mean of(17 ±7)h.There was no residual angina and perioperative myocardial infarction in the remaining patients who were all discharged uneventfully.Intraoperative 6 patients had accepted intraaortic balloon counterpulsation.During the followup from 6 months to 4.5 years for 38 patients,which showed no evidence of recurrent angina and postoperative coronary CT angiography in 12 patients showed the patency of grafts is good.Conclusion Satisfactory outcome of redo coronary artery bypass grafting can be achieved if proper indication were choosed and reasonable management were performed.     

血清新碟呤与冠状动脉病变程度关系的临床研究

目的探讨冠心病患者血清新碟呤与冠状动脉病变程度的关系。方法对经冠状动脉造影确诊的86例冠心病患者,分为急性心肌梗死组21例,不稳定型心绞痛组35例,稳定型心绞痛组30例;30例冠状动脉造影正常者为对照组。采用酶联免疫吸附法测定其新碟呤水平,比较不同冠脉病变程度者血清值,分析与冠状动脉病变狭窄程度、病变支数的关系。结果新喋呤浓度在急性心肌梗死组和不稳定型心绞痛组中均高于稳定型心绞痛（P〈0.01）;但急性心肌梗死组与不稳定型心绞痛组、稳定型心绞痛和对照组之间差异无统计学意义（P〉0.05）。新喋呤浓度在单支、双支、三支病变组之间差异无统计学意义（P〉0.05）。结论新喋呤参与动脉粥样硬化斑块的发生、发展过程,可作为预测斑块稳定性的标志物。