石辛牙痛口含片治疗胃火牙痛智齿冠周炎Ⅲ期临床试验

目的:研究石辛牙痛口含片治疗胃火牙痛智齿冠周炎的疗效及安全性。方法:随机双盲双模拟平行对照多中心临床试验。纳入符合胃火牙痛智齿冠周炎患者432例。就诊当天行常规冠周袋冲洗。石辛组患者含化石辛牙痛口含片,口服牛黄解毒片赋形剂;牛黄组患者口服牛黄解毒片,含化石辛牙痛口含片赋形剂,疗程5 d。主症中疼痛按VAS法记分,其余主症、次症及舌象、舌苔、脉象均按等级计分。症状体征总积分减轻率≥90%判断为痊愈,70%～89%显效,30%～69%有效,≤29%无效。用药前后进行血、尿、粪常规及肝功、肾功、心电图检查,记录不良事件。用SAS 6.12软件统计分析。结果:符合方案数据集(PPS)石辛组309例、牛黄组101例。人口学特征、病情基线组间差别均无统计学意义(P>0.05)。治疗3 d和5d时2组症状体征总积分、主症积分、次症积分均下降(P=0.000),石辛组积分的下降值高于牛黄组(P<0.000 1)。第5天治愈率和显效率石辛组为45.6%和42.4%;牛黄组为8.9%和33.7%(P<0.000 1)。实验室检查未发现具有临床意义的异常结果。与研究药物有关的不良事件石辛组9例15次,牛黄组7例7次(P=0.084 8);各组均未发生导致病例脱落的不良事件和严重不良事件。结论:石辛牙痛口含片治疗胃火牙痛智齿冠周炎是安全、有效的。     

石辛牙痛口含片治疗胃火牙痛(智齿冠周炎)Ⅱ期临床试验

目的:研究石辛牙痛口含片治疗胃火牙痛(智齿冠周炎)的疗效及安全性.方法:随机双盲双模拟平行对照多中心法.纳入符合胃火牙痛(智齿冠周炎)试验组(石辛)、对照组(牛黄)各120 例.就诊当天行常规冠周袋冲洗.石辛组患者含化石辛牙痛口含片0.6 g×2, 4/d,口服牛黄解毒片的赋形剂0.3 g×3, 3/d;牛黄组患者口服牛黄解毒片0.3 g×3, 3/d,含化石辛牙痛口含片的赋形剂,0.6 g×2, 4/d.主症按0、2、4、6 分级计分;次症按0、1、2、3 分级计分.疗程5 d,用SAS 6.12软件统计分析.用药前后进行血、尿、粪常规及肝功、肾功、心电图检查,记录不良事件.结果:石辛组脱落(失访)3 例,牛黄组脱落2 例.受试者脱落率、人口学特征、病情基线组间差别均无统计学意义(P>0.05).第3 天和第5 天时主症、次症积分以及病情总积分均明显下降(P=0.000),其减少值石辛组大于牛黄组(P<0.001);石辛组显效率大于牛黄组(P=0.000).第5 天时主症各项指标石辛组积分下降值大于牛黄组 (P<0.05).生命体征治疗前后均在正常范围,组间差异无统计学意义(P>0.05),实验室检查全部患者治疗前未出现明显异常变化.3 例发生与研究药物有关不良事件,石辛组1 例,为"中度",停药后好转,退出试验.牛黄组2 例,为轻度,未影响试验.结论:石辛牙痛口含片治疗胃火牙痛(智齿冠周炎)疗效优于牛黄解毒片,安全性与牛黄解毒片相似.     

石辛牙痛口含片对智齿冠周炎的止痛效果评价

目的:评价石辛牙痛口含片对智齿冠周炎的止痛效果。方法:用随机、双盲、双模拟、阳性药(牛黄解毒片)平行对照的实验方法,记录冠周炎不同治疗方法、不同时间点疼痛积分的变化,根据积分的变化,判断石辛牙痛口含片和牛黄解毒片对冠周炎的止痛效果。结果:第3天时,石辛牙痛口含片疼痛缓解率为78.57%,牛黄解毒片为30.63%;第5天时,石辛牙痛口含片疼痛缓解率为98.21%,牛黄解毒片为70.27%,组间疼痛缓解率差别有统计学意义(P=0.0000)。结论:石辛牙痛口含片能早期明显缓解智齿冠周炎引起的疼痛症状,改善患者的生活质量,值得在临床推广使用。     

石辛牙痛含片治疗智齿冠周炎的临床疗效观察

我们采用石辛牙痛含片治疗智齿冠周炎80例,对其疗效进行了观察,现将结果报告如下。1资料与方法选择智齿冠周炎急性发作,近3 d未服用药物治疗的患者80例,随机分成治疗组和对照组,其中治疗组男15例,女25例;对照组男16例,女24例。试验采用随机双盲双模拟平等对照。两组均采用3%双氧水5 ml加生理盐水10 ml分别行冠周袋冲洗。试验组给予石辛牙痛口含片(由湖北恒安药业有限公司提供;批号040901),1次2片,4次/d,分别在三餐后及晚睡前含化。给予牛黄解毒片赋形剂,1次3片,3次/d,分别在三餐后口服。对照组:给予牛黄解毒片(武汉中联药业集团股分有限公司…     

石辛牙痛片治疗胃火牙痛临床疗效分析

目的：对石辛牙痛片治疗胃火牙痛的疗效及安全性进行临床观察。方法：采用随机、双盲、阳性药平行对照法。64例胃火牙痛病例随机分为治疗组和对照组。治疗组用石辛牙痛片,对照组用牛黄解毒片,疗程5d。所有患者用药前后均检查肝肾功能、心电图、血常规、尿常规和大便常规。结果：治疗组治疗总有效率与对照组无显著性差异（P〉0．05）。所有检查结果没有异常改变。结论：石辛牙痛片可以清胃泻火,缓解牙齿疼痛。对治疗胃火牙痛有效、且无副作用。     

半导体激光联合石辛含片治疗智齿冠周炎的临床疗效分析

目的 观察GaAIAS半导体激光联合石辛含片治疗智齿冠周炎的临床疗效。方法 选取2021年7月-2022年7月治疗的147例智齿冠周炎患者,随机分为3组,A组49例选用局部冲洗+碘甘油治疗;B组49例选用局部冲洗+石辛含片治疗;C组49例选用局部冲洗+半导体激光联合石辛含片治疗。3组患者持续治疗、观察7天。比较3组的总显效率、疼痛评分、局部症状缓解时间。结果 C组总显效率（97.96%）和B组总显效率（91.84%）显著高于A组（81.63%）(P<0.05)。VAS评分比较,C组相似文献   

抗生素-碘仿海绵盲袋内应用治疗急性智齿冠周炎

采用自制抗生素－碘仿海绵盲袋内应用,治疗急性智齿冠周炎。１　资料和方法１．１　资料治疗１６０例急性智齿冠周炎,男１０７例,女５３例。年龄１８～３３岁。其中牙位１８为２例,２８为１例,３８为７６例,４８为８１例。发病时间为０．５～３ｄ不等。临床症状为：患侧磨牙后区自发性钝痛或跳痛,咀嚼、吞咽疼痛,影响睡眠。口腔检查：覆盖牙冠及其周围软组织充血水肿,龈瓣边缘糜烂,触痛明显,有时可见脓性分泌物自盲袋溢出。病例选择按患者就诊顺序,以交互指派分组设计为两组,每组８０例,Ａ组用抗生素－碘仿海绵,Ｂ组用２０ｇ…     

Microbiology of the pericoronal pouch in mandibular third molar pericoronitis

The microorganisms associated with mandibular third molar pericoronitis were investigated using direct microscopy and anaerobic culture method. The pericoronal pouch was sampled with paper points in A) 8 patients without mandibular third molar pericoronitis and B) 6 patients with mandibular third molar pericoronilis. Under the microscope, the microflora was found to be a complex mixture comprising gram-positive and gram-negative cocci, rods and filaments (including fusiform and curved rods), motile rods and spirochetes. Significantly higher proportions of motile, gram-negative rods were found in group B than in group A. The predominant cultivable microflora of 9 samples: A (4) and B (5) comprised several species of facultative and obligate anaerobic bacteria, namely Peptostreptococcus. Streptococcus, Actinomyces, Eubacterium, Propionibacterium, Veillonella, Porphyromonas, Prevotella, Bacteroides, Fusobacterium, Campylobacter, Staphylococcus, Stomatococcus, Lactobacillus, Neisseria, Capnocytophaga, Haemophilia, Selenomonas and Centipeda species. The microflora in pericoronitis appeared similar to that of diseased periodontal pockets.     

艾亚林治疗智齿冠周炎的疗效观察

目的评价艾亚林治疗智齿冠周炎的临床疗效。方法选择门诊智齿冠周炎患者196例,按临床症状不同分为不口服抗生素组(A组)和口服抗生素组(B组),2组分别采用随机单盲对照法,实验组(A1、B1)用艾亚林放于盲袋中1次,对照组(A2、B2)用碘甘油放于盲袋中,每日1次,疗程3~7d,观察艾亚林治疗智齿冠周炎的临床效果。结果A组和B组中艾亚林组与碘甘油组(A1和A2、B1和B2)疗效的优良率无显著性差异(P>0.05),在总有效率中艾亚林组与碘甘油组有差异(P<0.05),艾亚林组疗效优于碘甘油组。结论临床应用艾亚林治疗智齿冠周炎,可以有效地改善临床症状,提高治疗效果。     

西吡氯铵口含片治疗复发性阿弗他溃疡临床疗效评价

目的 评价西吡氯铵口含片局部治疗复发性阿弗他溃疡(轻型)的疗效。方法 本研究采用随机、阳性药物对照、单中心临床研究的方法,将74例复发性阿弗他溃疡患者分成试验组即西吡氯铵口含片组(37例),对照组即华素片组(37例),含化,疗程为7 d。分别于初诊时(第1天)、首次用药后第7天,记录溃疡疼痛指数、平均溃疡期、溃疡面积、受试者使用印象。数据采用EpiData 3.0软件输入,SAS 8.2软件分析。结果 2组患者治疗后溃疡面积和疼痛强度均较治疗前有显著改善,2组患者治疗后溃疡面积和疼痛强度之间无显著差异,但试验组溃疡愈合天数较对照组短(P<0.05)。结论 西吡氯铵口含片治疗复发性阿弗他溃疡(轻型),能有效减轻溃疡造成的疼痛,促进溃疡快速愈合,无明显不良反应,且与对照组即华素片组比较,能明显缩短溃疡的愈合期。     

Effectiveness of green tea mouthwash in comparison to chlorhexidine mouthwash in patients with acute pericoronitis: a randomized clinical trial

The objective of this study was to evaluate the effectiveness of green tea mouthwash in controlling the pain and trismus associated with acute pericoronitis in comparison to chlorhexidine (CHX) mouthwash. Ninety-seven patients with acute pericoronitis underwent debridement and received 5% green tea mouthwash (study group) or 0.12% CHX mouth rinse (control group). Pain (visual analogue scale; VAS), number of analgesics, maximum mouth opening (MMO), and number of patients with trismus were determined. There were no significant differences in demographic variables (P > 0.05), or baseline VAS (P > 0.006), MMO (P > 0.017) or number of patients with trismus (P > 0.017) between the two groups. The mean VAS score of the study group was statistically lower than that of the control group between post-treatment days 3 and 5 (P < 0.006). A significantly lower number of analgesics were taken by the study group (P < 0.05). Although the MMO of the study group was significantly lower on day 3 (P < 0.017), no significant difference was observed on day 7 (P > 0.017). Fewer of the patients rinsing with green tea had trismus on days 3 and 7, but the difference was non-significant (P > 0.017). Hence, green tea mouth rinse could be an appropriate and effective choice for the control of pain and trismus in acute pericoronitis.     

金因肽与华素片联合治疗复发性阿弗他溃疡的疗效研究

目的观察金因肽(重组人表皮生长因子rhEGF)与华素片合用治疗口腔复发性阿弗他溃疡的局部疗效。方法90例轻型阿弗他溃疡患者随机分成3组,试验1组30例局部外用金因肽;试验2组30例含服华素片;试验3组30例局部外用金因肽,并含服华素片;疗程均为3天。观察3组药物治疗口腔溃疡的短期疗效,并且进行组间比较。结果发现试验1组显效率为66.67%,总有效率为93.33%;试验2组显效率为33.33%,总有效率为63.33%,试验3组显效率为86.67%,总有效率为100%。经统计学处理,3组间疗效差异有显著性(P<0.01),3组两两之间疗效差异有显著性(P<0.05)。结论金因肽对口腔阿弗他溃疡有较好的疗效,尤其与华素片联合使用时效果更佳。     

Comparison of the quality of life of patients with mandibular third molars and mild pericoronitis treated by extraction or by a periodontal approach

We have evaluated and compared the outcomes after conservatively treated and surgically managed third molars in patients with mild pericoronitis at the first, third, and sixth postoperative months, and we rated patients’ quality of life (QoL) using the Oral Health Impact Profile-14 (OHIP-14) index. Of the 128 patients who were originally assessed as eligible we studied 100 patients who fulfilled the protocol, being diagnosed with mild pericoronitis that affected the third molar teeth and who were followed up for six months. Fifty were treated by the periodontal approach and 50 by extraction of third molars. Their oral health-related QoL was assessed using the OHIP-14 index on a personal assessment question form and then repeated at the first, third, and sixth months. The data were analysed using the Mann Whitney, Friedman’s, and Wilcoxon’s test, as appropriate. There was a significant difference between the total OHIP-14 scores at different time points (p < 0.0001). In both groups the three postoperative total OHIP-14 scores were significantly lower than the baseline score, and we noted a further decrease in OHIP-14 scores in the surgical treatment group. Periodontal treatment of mandibular third molar teeth may effectively reduce (but does not eliminate) symptoms, whereas tooth extraction seems to be more effective at the long term.     

氯林可霉素药膜治疗急性局限型智齿冠周炎的随机对照研究

目的：对局部应用氯林可霉素药膜治疗急性局限型智齿冠周炎的结果进行临床观察和细菌学检测，以评价其在智齿冠周炎治疗中的意义。方法：用氯林可霉素为主要原料，明胶为基质研制成冠周炎药膜，并同常规的冲洗后导入碘甘油的传统疗法进行随机对照临床试验，分别于治疗后４ｄ进行细菌学检查。结果：药膜组和对照组检查结果经χ２统计处理（Ｐ＜０．０１），氯林可霉素药膜组疗效明显优于对照组。结论：表明氯林可霉素药膜治疗混合感染的智齿冠周炎有其独特作用。