原发性小肠肿瘤诊断治疗的临床分析(附58例报告)

目的探讨原发性小肠肿瘤临床特型、病理分型及诊治经验。方法回顾性分析1993年10月。2003年10月收治的有完整资料的58例原发性小肠肿瘤病例。结果本组包括13例(22．4％)良性肿瘤，45例(77．6％)。小肠良性肿瘤均行局部肠段切除，除2例死于其它疾患外，余11例健在；小肠恶性肿瘤患者中，院内死亡6例，仅11例能行根治性肠切除，37例行化疗(总有效率83．4％)，随访33例(随访率89．5％)，存活5年以上者14例(5年生存率42．4％)，多为T细胞性非何杰金淋巴瘤。结论原发性小肠肿瘤恶性所占比例较高，缺乏特征性的临床表现及有效的诊断手段，易致长期延误诊治，预后甚差；对原因不明的腹痛、消化道出血及定位不明的腹部包块患者及早行剖腹探查是避免小肠肿瘤长期误诊、改善患者预后的可靠手段。     

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原发性小肠肿瘤较少见。我院 1981～ 2 0 0 1年共收治了 15例经手术和病理证实的原发性小肠肿瘤 ,现就该病的临床特点及诊断方法进行初步探讨如下。1　临床资料15例均为经手术及病理证实的原发性小肠肿瘤 ,其中男性 6例 ,女性 9例。年龄 14～ 59岁 ,平均 43 1岁。临床表现 :原发性小肠肿瘤以腹痛、肠梗阻、腹部包块和消化道出血为主要症状。本组 12例出现腹痛 ,8例肠梗阻 ,7例腹部包块 ,3例消化道出血 ,1例合并肠套叠而出现腹痛、肠梗阻、腹部包块和便血 ,1例急性穿孔表现为转移性右下腹痛 ,麦氏点压痛及反跳痛等急性阑尾炎的临床表现 ,1例…     

原发性小肠肿瘤的诊断和治疗

目的 探讨原发性小肠肿瘤的诊断及治疗。方法 回顾性分析近17年来收治并经过手术及病理确诊的65例原发性小肠肿瘤的临床资料、诊断及治疗情况。结果 肿瘤位于十二指肠25例(38．5％)，空肠16例(24．6％)，回肠24例(36.9％)，其中恶性肿瘤47例(72．3％)，良性18例(27．7％)。本组常见症状为腹痛(70．7％)，消化道出血(46．2％)和腹部肿块(13．8％)。术前误诊率为36．9％，其中空回肠肿瘤误诊率为59．5％。65例均手术治疗，手术后死亡2例。随访恶性肿瘤患者1，3，5年生存率分别为65．8％，42．1％，20．3％。结论 小肠肿瘤缺乏特异性症状和体征，术前误诊率高。对有出血、腹痛、梗阻、包块等临床表现者应怀疑本病可能；对诊断不明者，应综合采用各项检查，必要时剖腹探查。治疗应以手术切除为主，恶性肿瘤应加以化疗。     

小肠肿瘤12l例临床分析

目的　探讨小肠肿瘤的临床表现及诊断方法。方法　对 1980年以来我院 12 1例小肠肿瘤的临床资料进行回顾性探讨。结果　 12 1例中 ,恶性肿瘤 81例 ,良性肿瘤 4 0例。最常见的临床表现为腹痛、腹块、消化道出血、急性肠梗阻、大便性状改变、黄疸等。 12 1例均经手术证实。肿瘤位于十二指肠 11例 ,空肠 6 3例 ,回肠 4 7例 ,术前诊断符合率 6 2 % (75 / 12 1)。恶性肿瘤 81例 ,根治切除率为 4 4 .4 % (36 / 81) ,其中 71例获随访 ,已死亡 38例 ,平均存活 (36± 18)个月。结论　B型超声、CT、全消化道钡餐诊断符合率低 ,病人膝胸位腹部查体发现可移动性腹块是发现小肠肿瘤的一种重要手段。小肠肿瘤临床表现极不典型 ,早期诊断极其困难 ,医生加强对本病的重视和认识是改善病人预后的关键     

原发性小肠肿瘤手术治疗分析

目的 :探讨原发性小肠肿瘤的诊断与治疗方法。方法 :回顾性分析 2 0例原发性小肠肿瘤的临床资料。结果 :2 0例均经手术和病理检查证实诊断。肿瘤位于十二指肠 4例 ,空肠 8例 ,回肠 8例 ,其中恶性肿瘤 7例 ,良性肿瘤 13例。常见的症状为腹痛、消化道出血、肠梗阻和腹部肿块等。术前确诊 8例 (4 0 % ) ,误诊 12例 (60 % )。 2 0例均行手术治疗 ,13例良性肿瘤行肿瘤及局部肠管切除 ,恶性肿瘤行根治性切除术 6例 ,姑息性切除术 1例。无手术死亡病例。结论 :小肠肿瘤早期诊断困难 ,综合各项检查可提高术前诊断 ,手术治疗是首选     

成人原发性小肠肿瘤46例外科治疗体会

目的总结成人原发性小肠肿瘤的临床特点、诊断及外科治疗经验。方法对收治的46例成人原发性小肠肿瘤患者临床资料进行回顾性分析。结果46例均行手术治疗,经术后病理学检查确诊,其中恶性肿瘤32例,良性肿瘤14例,恶性肿瘤以腺癌居多,良性肿瘤以平滑肌瘤为主,临床表现不典型,术前不易确诊,以剖腹探查急诊手术发现较多。结论成人原发性小肠肿瘤早期诊断困难,误诊率高,手术是治疗该病的主要手段。     

空回肠间质瘤13例诊治分析

目的　探讨空回肠间质瘤的诊断和治疗经验。方法　对我院 1993年 10月～ 2 0 0 4年 1月收治的有完整资料的 13例空回肠间质瘤病例进行回顾性分析 ,本组患者均经术后病理和免疫组化证实。结果　本组患者主要临床表现为消化道出血、腹痛。发病至确诊时间 2个月至 7年。剖腹探查确诊 7例 ,腹腔镜腹腔探查确诊 4例 ,术前确诊的仅 2例。随访 2个月至 9年 ,除 1例死于其它疾患外 ,余 12例均健在 ,无空回肠间质瘤复发病例发现。结论　小肠间质瘤预后甚好 ,但本病缺乏特征性的临床表现及有效的诊断手段 ,易致长期延误诊治 ;对长期不明原因的消化道出血患者 ,及早行剖腹探查或腹腔镜腹腔探查是避免小肠间质瘤长期延误诊治 ,改善患者预后的关键     

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目的　探讨原发性小肠肿瘤的临床特点及其诊断。方法　对 1991年以来诊治的 4 3例原发性小肠肿瘤的临床资料及随访结果进行回顾性分析。结果　 4 3例中 ,良性肿瘤 11例 ,恶性肿瘤 32例 ;肿瘤位于十二指肠者 18例 ,空肠 14例 ,回肠 11例。最常见的临床表现为腹痛、腹块、消化道出血、肠梗阻、黄疸等。 4 3例均经手术治疗 ,术前诊断率为 5 5 80 % (2 4 /43) ,32例恶性肿瘤根治性切除率为 37 5 % (12 /32 ) ,其中 2 3例获随访 ,死亡 14例 ,平均存活期 (34± 18)个月 ,存活 9例。B超、CT诊断符合率较低 ,DSA检查有助于确定病变的部位及性质。结论　原发性小肠肿瘤临床表现不典型、恶性肿瘤早期诊断极为困难 ,改善病人预后的关键是加强对本病的重视和认识。     

原发性小肠恶性肿瘤的早期诊断

目的探讨原发性小肠恶性肿瘤疾病的早期诊断方法。方法回顾性总结和分析临床16例原发性小肠恶性肿瘤患者的临床资料。结果肿瘤位于十二指肠9例，位于空肠3例，位于回肠4例。术前得以确诊10例，确诊率为62．5％，内镜诊断十二指肠肿瘤阳性率高。对位于空回肠肿瘤以小肠钡剂灌肠的价值最高，阳性率达80％以上。消化道梗阻和（或）腹部包块在半数以上病例中出现。结论原发性小肠恶性肿瘤无特异性临床早期表现，提高对该疾病的早期认识，恰当的术前检查方法，对疾病的早期诊断有较大帮助，对高度疑似病例可放宽剖腹探查指征。     

原发性小肠肿瘤38例临床分析

目的总结原发性小肠肿瘤的临床特点。方法回顾性分析1981-2003年38例原发性小肠肿瘤的临床资料。结果本组良性肿瘤6例,恶性肿瘤32例;良、恶性比例1.0∶5.3。肿瘤位于十二指肠者18例,空肠8例,回肠12例。主要临床表现为腹痛、腹部肿块、消化道出血、肠梗阻和黄疸。诊断符合率:内镜检查68.2%(15/22),小肠钡餐造影或吞碘剂造影64.0%(16/25)。38例均行手术治疗。32例恶性肿瘤患者平均生存时间(31±17)个月,6例良性肿瘤患者2例失访,4例存活至今。结论原发性小肠肿瘤临床表现无特异性,内镜和X线钡餐造影检查诊断率高,主要为手术治疗。     

空肠回肠间质瘤的诊断和治疗

目的 探讨空肠回肠间质瘤诊断和治疗经验。方法 对我院1993～2003年收治的有完整资料经术后病理和免疫组化证实的15例空肠回肠间质瘤病例进行回顾性分析。结果 本组病人主要临床表现为黑便、腹痛、头晕、乏力。术前选择性血管造影发现小肠出血2例、核素扫描发现小肠出血1例。剖腹探查确诊7例,腹腔镜腹腔探查确诊4例,术前明确诊断的仅1例。发病至确诊时间2月～7年。14例病人行间质瘤切除、小肠吻合术,1例肿瘤无法切除的病人行口服Gleevec保守治疗。随访2月～9年,除1例病人死于其它疾患,1例在继续服用格列卫治疗外,余13例病人均健在,空肠回肠问质瘤无复发。结论 空肠回肠间质瘤缺乏特征性临床表现及有效诊断手段,易致长期延误诊治。对长期不明原因的消化道出血病人及早行剖腹探查或腹腔镜腹腔探查是避免空肠回肠间质瘤长期延误诊治、改善病人预后的关键。     

Jejunal GIST masquerading as an ovarian mass: A case report

Introduction and importanceGastrointestinal stromal tumors (GIST) are rare mesenchymal tumors originating in the wall of the gastrointestinal tract. Jejunal GIST is the rarest subtype. Large GIST can present with an abdominopelvic mass which can be preoperatively misdiagnosed as a gynecological tumor.Case historyA 44-year regularly menstruating woman presented with lower abdominal pain which was diagnosed as a malignant ovarian tumor preoperatively with an MRI. However, intraoperatively, a lobulated mass was present in the abdominal cavity arising from a jejunal portion of the small intestine. With an intraoperative diagnosis of jejunal GIST, the mass was excised and jejunum anastomosed. Histopathology examination report showed GIST which was further confirmed by immunohistochemistry.DiscussionGIST presenting as a large abdominopelvic mass can mimic a gynecological tumor. Contrast-enhanced CT scan is the preferred imaging modality for the evaluation of patients with suspected GIST to determine the extent of the tumor, the presence or absence of metastatic disease alongside evaluation of the possibility of complete resection. Adjuvant imatinib therapy following complete excision can decrease the disease recurrence.ConclusionGynecologists should keep in mind that primary gastrointestinal tumors can present as a pelvic mass. A proper histopathological examination helps to confirm the diagnosis. Complete surgical removal of the tumor should be obtained as it determines the prognosis of the disease.     

Malignant Fibrous Histiocytoma of the Abdominal Cavity: Report of a Case

Malignant fibrous histiocytoma (MFH) is a soft-tissue sarcoma originating from fibroblast cells, characterized by a high rate of metastasis or recurrence. This tumor rarely develops in the gastrointestinal tract, with no more than 30 cases described in the literature. We report a case of MFH of the abdominal cavity in a 45-year-old woman who presented with epigastric pain, anorexia, and weight loss. A computed tomography (CT) scan of the abdomen revealed multiple solid tumors in the peritoneal cavity. We performed exploratory laparotomy and found at least 15 solid whitish tumors attached to the wall of the small intestine, as well as to the parietal peritoneum. There were three metastases in the liver. All of the tumors were excised, most of which were about 10cm in diameter. Histopathological findings indicated a stromal tumor consisting of spindle cells, and immunohistochemical examination of the resected specimens established the definite diagnosis of a pleomorphic MFH. The patient had an uneventful postoperative course and was given adjuvant chemotherapy. She is currently well 2 years after her operation. We review the clinical picture of this tumor in the abdominal cavity, and discuss its diagnosis, pathogenesis, and treatment.     

腹腔镜技术在普通外科急腹症及腹部外伤诊治中的应用体会

目的:探讨腹腔镜技术在普通外科急腹症及腹部外伤诊治中的临床效果及应用价值。方法:回顾分析2008年10月至2013年10月应用腹腔镜技术诊治248例普通外科急腹症及腹部外伤患者的临床资料。结果:248例均在腹腔镜探查下明确诊断,211例成功完成腹腔镜手术,37例(14.92%)中转开腹;发现术前误诊11例、腹腔无明显病变及脏器损伤5例,共16例(占6.45%)。死亡2例。结论:腹腔镜技术诊治急腹症及腹部外伤具有独特优点,在快速明确诊断减少误诊的同时可一并于镜下进行治疗;镜下不能处理的患者也可为开腹手术提供合理方案及路径,是积极、微创、安全的诊治方法,患者创伤小、痛苦轻、康复快,值得推广应用尤其基层医院。     

Sarcoma of the Abdominal Aorta Involving Marginal Arteries of the Small Intestine: A Case Report

Primary sarcoma of the aorta is extremely rare. In the past, the disease was commonly diagnosed on autopsy. However, now it is possible to make a diagnosis preoperatively using various imaging studies such as computed tomographic scanning and magnetic resonance imaging. The authors have experienced one case of abdominal aortic sarcoma in a patient who complained of the symptoms of typical intestinal angina. We diagnosed an aortic sarcoma preoperatively but failed to resect the tumor on thoracolaparotomy because of the tumor extension to marginal arteries of the whole small intestine. We recommend preoperative laparoscopy for evaluation of tumor extension to marginal arteries of the small intestine in a patient having aortic sarcoma and intestinal angina if the patient is considered to be a surgical candidate.     

小肠间质瘤18例分析

目的:探讨小肠间质瘤的诊断和治疗方法。方法:回顾性分析18例小肠间质瘤患者的临床资料。结果:18例患者平均发病年龄46.6岁,病程5h~2年。主要临床表现为黑便、腹痛、腹部肿块、腹胀不适、贫血、体重下降等。发生部位:空肠12例,回肠5例,空回肠多原发性1例。B超检查13例提示腹腔肿块,其中10例提示来源于肠道,3例不能提示来源。CT增强及血管三维成像均发现肿瘤或转移病灶,其中15例定位于肠道肿瘤(83.3%)。手术后获得0.5~6年的随访,复发3例,2例广泛转移死亡。结论:空回肠间质瘤缺乏特征性临床表现,B超和CT对诊断有帮助,手术及分子靶向治疗是有效方式。     

Gastrointestinal stromal tumors. A case of small intestine stromal tumor (SIST) with an uncertain biological aspect

Tumors of the small intestine are relatively rare. The diagnosis is difficult to establish because the symptoms are vague and non-specific. Although the small intestine constitutes 75% of the length and over 90% of the mucosal surface area of the gastrointestinal tract, only 1 to 2% of gastrointestinal malignancies occur in this segment. Metastases are usually present at the time of diagnosis. The outcome of these patients can be improved if the possibility of a malignant small bowel tumor is considered in all cases of unexplained abdominal pain or gastrointestinal bleeding, especially in younger age. Malignant tumors occur with increasing frequency in distal small bowel with a preponderance of malignant lesions in the ileum compared with the jejunum and the duodenum. Adenocarcinoma is the most common tumor of the primary malignant small bowel tumors, followed by carcinoid, lymphoma and leiomyosarcoma. Mesenchymal tumors of the gastrointestinal tract, traditionally regarded as smooth muscle tumors, have demonstrated different cellular differentiations based on immunohistochemical and ultrastructural features. Therefore the terms leiomyoma and leiomyosarcoma have been replaced by a more encompassing term, gastrointestinal stromal tumor (GIST). The majority of GISTs occurs in the stomach; stromal tumors involving the small intestine (SISTs) are far less common but seem to have greater malignant potential. The clinical a case of a small intestinal stromal tumor (SIST), localised in the jejunum and characterised by an uncertain histological aspect, is presented and a review of the literature is made.     

Primary Malignant Melanoma of the Small Intestine: Report of a Case

The small intestine is the most common site of gastrointestinal (GI) metastases from cutaneous malignant melanoma; however, primary malignant melanoma originating in the small intestine is extremely rare. We report the case of a 72-year-old man found to have a primary malignant melanoma in the ileum. The patient presented with anorexia, weight loss, diffuse colicky abdominal pain, and episodic rectal bleeding. A preoperative diagnosis of a small intestinal tumor was based on the findings of enteroclysis and computed tomography scanning. This diagnosis was confirmed at laparotomy and an enterectomy was performed. Histopathological examination of the resected specimen clarified the exact nature of the lesion, confirming the diagnosis of melanoma. A thorough postoperative investigation did not reveal a primary lesion in the skin, anus, oculus, or any other location. Thus, we diagnosed this tumor as a primary lesion. One year after his operation, the patient remains well without any evidence of recurrence. Primary malignant melanoma of the small intestine is an extremely rare lesion, which must be differentiated from other intestinal tumors. Received: August 6, 2001 / Accepted: March 5, 2002     

Primary Malignant Melanoma of the Small Intestine: a Case Report

The small intestine is the most common site of gastro-intestinal metastasis from cutaneous malignant melanoma. A primary origin at this site has been reported in rare cases. We report a case of a 71-year-old man with a primary malignant melanoma in the jejunum. The patient presented with weakness, weight loss, non-specific abdominal pain and episodes of fainting. After clinical examination, laboratory evaluation and radiological work-up, which included CT of the abdomen, the patient was diagnosed with a tumour mass in the jejunum. This diagnosis was confirmed at laparotomy. The patient underwent enterectomy with wide excision of the tumour. A primary malignant melanoma of the small intestine is an extremely rare neoplasm.

A definite diagnosis can only be made after a thorough investigation has been made to exclude the co-existence of a primary lesion elsewhere. Curative resection of the tumour remains the treatment of choice.