共查询到20条相似文献,搜索用时 31 毫秒
1.
Carinci F Piattelli A Martinelli M Palmieri A Rubini C Fioroni M Scapoli L Laino G Caputi S Becchetti A Pezzetti F 《The Journal of craniofacial surgery》2005,16(3):399-407
Central giant cell granuloma (CGCG) of the jaws is a central osteolytic lesion characterized histologically by multinucleated giant cells in a background of ovoid to spindle-shaped mesenchymal cells. Whether CGCG is a reactive lesion or a truly benign neoplasm remains undetermined, and the mechanism determining the onset of the disease remains unknown. To have more information regarding the genetic events involved in CGCG, the authors decided to perform an expression profile. Samples were derived from two surgically resected CGCG of the mandible. RNA extracted from a pool of three normal bone tissues was used as control. By using DNA microarrays containing 19,200 genes, the authors identified several genes whose expression was significantly up- or down-regulated. The differentially expressed genes cover a broad range of functional activities: cell cycle regulation; signal transduction; and vesicular transport. It was also possible to detect some genes whose function is unknown. The authors believe the data reported to be the first genetic portrait of CGCG of the jaws. Several markers have been identified that can potentially help in identifying some biological behavior (ie, quiescent versus aggressive lesions), as well as genes whose products could be potentially disease-specific targets for therapy. However, the authors think that more cases are needed, especially those comparing quiescent and aggressive lesions, before the exact profile of CGCG is known. 相似文献
2.
Andrade ES Filho JR Rocha NS Neto IC Camargo IB 《Acta odontológica latinoamericana : AOL》2010,23(2):99-104
Granular cell tumor (GCT) is a relatively uncommon lesion occurring in almost any part of the body, including the orofacial region. The tongue and the buccal mucosa are common intra oral sites. Although aggressive and malignant variants of this neoplasm have been described, most GCTs are benign. The histogenesis of the lesion still remains unknown. However, histochemical and ultra-structural studies propose the origin of the lesion from Schwann cells, striated muscle, mesenchymal cells, histiocytes and epithelial cells. The tumor generally occurs in middle-aged or older adults. The lesion is typically seen as an uninflamed asymptomatic mass measuring about two cm in diameter with reddish surface coloring. As most granular cell tumors are benign, surgical excision of the lesion is the treatment of choice. In this study, 2 oral GCT cases are presented, corresponding to 2 male patients, with a mean age of 27 years and a mean time of evolution of the lesions of 8 months. Both lesions were located on the tongue. Differential diagnoses include fibrous hyperplasia, minor salivary gland tumor condyloma acuminatum and neurilemmoma. In all the cases a resection with safety margins of the lesions was carried out under local anesthesia. The samples were fixed and processed for histopathological study. The main clinical pathology and diagnostic features of this neoplasm are reviewed and discussed. 相似文献
3.
Sargenti-Neto S Brazão-Silva MT do Nascimento Souza KC de Faria PR Durighetto-Júnior AF Loyola AM Cardoso SV 《The British journal of oral & maxillofacial surgery》2009,47(1):62-64
Granular cell tumor (GCT) is an uncommon benign neoplasm of soft tissue that characteristically affects the oral cavity, with increased frequency in the tongue. In this paper, we report a multicentric GCT affecting a 41-year-old black woman, with nodules in perineum, groin, vulva, tongue and lip. Some of these lesions were surgically resected, but in a six-year follow-up, new primary lesions and recurrences were observed. In addition, the patient opted to do not remove some of these lesions, but there were not significant intercurrences. In view of the present findings, aspects related to clinical presentation, multiplicity, malignant potential, and treatment of GCT are discussed. 相似文献
4.
Eguia A Uribarri A Gay Escoda C Crovetto MA Martínez-Conde R Aguirre JM 《Medicina oral, patología oral y cirugía bucal》2006,11(5):E425-E428
Granular cell tumor (GCT) is an uncommon neoplasm of controversial origin that can appear in any corporal localization, including the orofacial region. Although aggressive and malignant variants of this neoplasm have been described, most of GCTs are benign. In spite of the amount of research, the etiology of this neoplasm remains unclear and its histogenesis and its possible muscular, connective or neural origin has been broadly debated. In this paper 8 oral cases are presented, corresponding to 5 women and 3 men, with a mean age of 36.1 years old and a mean time of evolution of the lesions of 8.3 months. The most common localization was the tongue (75%). In all the cases a resection with safety margins of the lesions was carried out under local anesthesia. The samples were fixed and processed for histopathological study. The main clinicopathologic and diagnostic features of this neoplasm are reviewed and discussed. 相似文献
5.
F Carinci A Marzola A Hassanipour 《International journal of oral and maxillofacial surgery》1999,28(5):383-384
Granular cell tumor (GCT), or granular cell myoblastoma, is a relatively uncommon lesion of the soft tissues. The tumor is thought to derive from a Schwann cell or from a perineural undifferentiated mesenchymal cell. GCT can occur in any organ, but the parotid gland is very unusual. A case of GCT of the parotid gland in a 30-year-old woman is described. 相似文献
6.
Benign lesions occurring on the dorsum of the tongue have at times been diagnosed as carcinoma. A retrospective investigation into the problem is described and the clinical and histological difficulties that arise in the diagnosis of these lesions are discussed. It is concluded that the occurrence of primary carcinoma on the dorsum of the tongue is a rare entity. It may be erroneously diagnosed in cases of median rhomboid glossitis, granular cell myoblastoma and any other lesion associated with pseudoepitheliomatous hyperplasia. These conditions should always be considered when examining lesions in this location. Histological diagnosis, although difficult, is greatly facilitated by good biopsy technique but, above all, good liaison between surgeon, radiotherapist and pathologist is essential if these mistakes in diagnosis are to be avoided. 相似文献
7.
Carinci F Pezzetti F Volinia S Francioso F Arcelli D Marchesini J Caramelli E Piattelli A 《Clinical oral implants research》2004,15(2):180-186
Surface implant modifications have been shown to have a relevant importance in modifying cell response. Expression profiling by DNA microarray is a new molecular technology that allows the analysis of gene expression in a cell system. By using DNA microarrays containing 19,200 genes, we identified in osteoblast-like cells line (MG-63) on new implant surface (nanoPORE, Out-Link, Sweden and Martina, Due Carrare, Padova, Italy), several genes whose expressions were significantly down-regulated. The differentially expressed genes cover a broad range of functional activities: (a) immunity, (b) vesicular transport (c) apoptosis and cell cycle regulation. It was also possible to detect some genes whose function is unknown. The data reported are, to our knowledge, the first genetic portrait of an implant surface. They can be relevant to better understand the molecular mechanism of implant osseointegration and as a model for comparing other materials. 相似文献
8.
Sander van de Loo Erik Thunnissen Pieter Postmus Isa?c van der Waal 《Medicina oral, patología oral y cirugía bucal》2015,20(1):e30-e33
The granular cell tumor (GCT) is a rare, benign tumor that most commonly occurs in the oral cavity, particularly in the anterior part of the tongue.
In this study the experience with 16 patients with a GCT observed in a single Institution will be discussed. Although no radicality has been obtained in most cases, recurrences are rare. In one patient, a recurrence was noted four years after excision of the primary. In the same patient a pulmonary lesion occurred five years after excision of the recurrence in the oral cavity, most likely representing an example of metachronous occurrence and not a distant metastasis.
Since recurrences and metachronous lesions are rare, as are distant metastases, routine follow-up does not seem warranted in patients treated for a granular cell tumor of the oral cavity.
Key words:Granular cell tumor, mouth, tongue, metachronous occurrence, metastasis. 相似文献
9.
J C de Vicente Rodriguez J M Santos Oller L M Junquera Gutierrez J S López Arranz 《The British journal of oral & maxillofacial surgery》1991,29(5):350-352
Primary malignant lymphomas of the tongue have rarely been described, and reported cases are usually related to the posterior part of the tongue which is rich in lymphoid tissue, forming part of Waldeyer's ring. Making a distinction between pseudolymphoma and malignant lymphoma is important. Pseudolymphoma is a benign lesion not requiring aggressive therapy. Several lesions in the oral cavity, including atypical histiocytic granuloma, angiolymphoid hyperplasia with eosinophilia, and traumatic ulcerative granuloma with stromal eosinophilia have been described as having certain microscopic features similar to those of pseudolymphoma. Atypical histiocytic granuloma is not associated with systemic disease or dissemination and heals spontaneously despite its microscopic appearance. 相似文献
10.
Carinci F Pezzetti F Volinia S Laino G Arcelli D Caramelli E Degidi M Piattelli A 《Journal of periodontology》2004,75(1):66-83
BACKGROUND: P-15 is an analog of the cell-binding domain of collagen. P-15 has been shown to facilitate physiological processes in a way similar to collagen; to serve as an anchorage for cells; and to promote the binding, migration, and differentiation of cells. METHODS: Expression profiling by DNA microarray is a molecular technology that allows the analysis of gene expression in a cell system. By using DNA microarrays containing 19,200 genes, we identified in osteoblast-like cell line (MG-63) cultured with P-15 several genes whose expression was significantly up- or downregulated. RESULTS: The differentially expressed genes cover a broad range of functional activities: 1) signaling transduction, 2) differentiation, 3) apoptosis, and 4) cell-cycle regulation. It was also possible to detect some genes whose function is unknown. CONCLUSIONS: The data reported are, to our knowledge, the first genetic portrait of P-15 effects. They can help us to better understand the molecular mechanism of osteogenesis and can serve as a model for comparing different cell cultures and/or other materials with similar effect. 相似文献
11.
12.
Marilena Vered William M. Carpenter Amos Buchner 《Journal of oral pathology & medicine》2009,38(1):150-159
Background: Granular cell tumor (GCT) is a benign lesion that occurs at different body sites with preponderance to the oral cavity. It is generally believed to be of schwann cell/neural cell origin. We used a large panel of both traditional and recently developed antibodies in an attempt to trace the origin of GCTs on the basis of their immunoprofile.
Methods: The patients' demographic data and the cytological and architectural features of the lesions were analyzed in a large series of oral GCTs ( n = 68). Forty-two lesions were also submitted to a panel of immunohistochemical stains with antibodies against S-100, CD-68 (KP-1 and PG-M1), vimentin, calretinin, NKI/C3, PGP9.5, p75/NGFR and inhibin-α.
Results: The tongue was the most common location of oral GCTs (81%). The granular cells demonstrated a wide array of cytological features in terms of cell shape and position of the nucleus. In addition, the lesions showed different architectural patterns, including 'infiltration' with satellite nodules. Interestingly, no recurrences were reported, even in lesions that were not completely excised. Granular cells were usually found to be strongly and diffusely positive for p75, vimentin, calretinin and NKI/C3, inhibin-α, PGP9.5, and S-100.
Conclusions: Immunoreactivity of the granular cells to a broad panel of antibodies that characterize different tissues does not confirm any particular cell type for the histogenetic origin of GCTs. Furthermore, GCTs could be regarded as lesions that reflect a local metabolic or reactive change rather than a true neoplasm. 相似文献
Methods: The patients' demographic data and the cytological and architectural features of the lesions were analyzed in a large series of oral GCTs ( n = 68). Forty-two lesions were also submitted to a panel of immunohistochemical stains with antibodies against S-100, CD-68 (KP-1 and PG-M1), vimentin, calretinin, NKI/C3, PGP9.5, p75/NGFR and inhibin-α.
Results: The tongue was the most common location of oral GCTs (81%). The granular cells demonstrated a wide array of cytological features in terms of cell shape and position of the nucleus. In addition, the lesions showed different architectural patterns, including 'infiltration' with satellite nodules. Interestingly, no recurrences were reported, even in lesions that were not completely excised. Granular cells were usually found to be strongly and diffusely positive for p75, vimentin, calretinin and NKI/C3, inhibin-α, PGP9.5, and S-100.
Conclusions: Immunoreactivity of the granular cells to a broad panel of antibodies that characterize different tissues does not confirm any particular cell type for the histogenetic origin of GCTs. Furthermore, GCTs could be regarded as lesions that reflect a local metabolic or reactive change rather than a true neoplasm. 相似文献
13.
Gayani Pitiyage W. M. Tilakaratne Mahvash Tavassoli Saman Warnakulasuriya 《Journal of oral pathology & medicine》2009,38(10):737-752
The clinical and histologic features alone cannot accurately predict whether potentially malignant disorders of the oral mucosa remain stable, regress or progress to malignancy. Some of them, with or without epithelial dysplasia, may transform to invasive oral squamous cell carcinomas (OSCC). Identification of molecular markers which can predict disease progression is necessary to improve the management of these disorders. Many genes and signaling pathways have been shown to be involved in the development of OSCC. This review summarizes some molecular markers researched in the detection of pre-cancer. We highlight selected markers that are reported to be significantly associated with progression of potentially malignant disorders to OSCC. These include alterations in genes/pathways which control cellular signaling, cell cycle, apoptosis, genomic stability, cytoskeleton, angiogenesis, etc. However, these genetic tumor markers have so far not gained any use in routine diagnosis and their utility in the prediction of risk of malignant transformation remains unknown. It is, however, clear from the large number of studies, some described in this review, that multiple genes/pathways are involved in the progression from normal to metaplastic/dysplastic, and subsequently to cancer. It is therefore necessary to study those significant alterations in multiple genes simultaneously in biopsy samples from large cohorts of subjects. 相似文献
14.
A cyst of the tongue lined by gastric mucosa is described, and eight previously reported cases are reviewed. All the patients with heterotopic gastric mucosa of the tongue have been males whose ages range from 2 months to 31 years, the sole exception being our case in a newborn infant. Six lesions were cystic and three were solid. Five were located on the anterior one-third of the tongue, three at the base, and one at the tip. Conservative excision is the procedure of choice, and of the patients reviewed, only our patient required a second excision. No additional abnormalities have been reported in these patients, except for one patient who had a double upper lip. 相似文献
15.
Effects of demineralized freeze-dried bone allograft on gene expression of osteoblastlike MG63 cells
Carinci F Piattelli A Degidi M Palmieri A Perrotti V Scapoli L Martinelli M Zuccarino L Pezzetti F 《The International journal of periodontics & restorative dentistry》2007,27(6):596-601
Demineralized freeze-dried bone allograft (DFDBA) is widely used in periodontal regeneration procedures as a scaffold for new bone formation in periodontal defects. How this biomaterial alters osteoblast activity to promote bone formation is poorly understood. We therefore attempted to address this question by using microarray techniques to identify genes that are differently regulated in osteoblasts exposed to DFDBA. By using DNA microarrays containing 20,000 genes, the authors identified in an osteoblastlike cell line (MG-63) cultured with DFDBA (Allogro, Dentsply/Friadent-Ceramed) several genes whose expression was significantly up-regulated or down-regulated. The differently expressed genes cover a broad range of functional activities: (1) cell cycle regulation, (2) immunity, (3) vesicular transport, (4) production of cytoskeletal elements, and (5) bone remodeling. The data reported are, to the authors' knowledge, the first genetic portrait of DFDBA effects. They can be relevant to a better understanding of the molecular mechanism of bone regeneration and as a model for comparing other materials with similar clinical effects. 相似文献
16.
B C Shiro J R Jacoway S A Mirmiran W F McGuirt G P Siegal 《Oral surgery, oral medicine, and oral pathology》1989,67(6):725-730
We have identified 14 cases that over the last 40 years have been reported under a series of names, most commonly granular cell ameloblastic fibroma. An additional case in the mandibular premolar region of a 45-year-old woman is described. The tumor was conservatively removed and 4 years later shows no evidence of recurrence. On the basis of our examination of the clinical and histologic features of this lesion and a comparison with the previous cases, we agree with the recent suggestion that the tumor should be designated as a central odontogenic fibroma, granular cell variant. By means of S-100 protein immunostaining techniques, the granular cells in this lesion were compared with the granular cell population in a granular cell tumor (myoblastoma) and the mesenchymal component of an ameloblastic fibroma. The results reveal a lack of S-100 protein reactivity in the granular cells of the central odontogenic fibroma and suggest an origin of those cells different from the origin of cells in a granular cell tumor. 相似文献
17.
G Beemster W A van der Kwast J Schoen I van der Waal 《International journal of oral surgery》1979,8(2):128-132
The granular cell tumor has been and still is a debatable lesion in several aspects. The etiology and pathogenesis are still unknown. Granular cell tumors may occur everywhere in the body, but the oral cavity is a favorite location. The majority of the oral lesions are found in the dorsum and the borders of the anterior two-thirds of the tongue. Seven patients with a granular cell tumor of the tongue are described. The clinical and microscopic findings have been discussed. In all cases an excisional biopsy had been aimed at. In spite of incomplete excision in six out of the seven cases, local recurrences were noticed in only one patient. In one patient "metastatic" occurrence of granular cell tumors was noticed. 相似文献
18.
C T Dixter M S Konstat J L Giunta E Schreier G E White 《Oral surgery, oral medicine, and oral pathology》1975,40(2):270-277
Granular-cell tumors in the oral cavity occur primarily on the tongue (myoblastoma) in adults and on the gum pads (congenital epulis) in infants. Because of the usual location and age, these histologically and histochemically similar tumors have been separate clinical entities. These case reports, however, report the concurrence of both clinical entities in the same patient. A 7-day-old female infant had a 1 cm. epulis on the right anterior maxilla and two 1.5 mm. masses on the anterior ventrum of the tongue. A 12-day-old girl had a 1 cm. epulis on the anterior mandible and two 1.5 mm. masses on the anterior tongue near the tip. In both cases, all lesions were histologically and histochemically similar and were granular-cell tumors. This suggests a relationship in the origin of these entities and tends to rule out an odontogenic origin for the epulis. 相似文献
19.
John Spencer M. Daniels 《Saudi Dental Journal》2009,21(2):75-78
Granular cell tumour, also known as Abrikossoff tumour, is a relatively uncommon benign neoplasm, which is more commonly found in females in the 4th to 6th decades of life even though it can occur in all ages.It occurs in all areas of the body but about 45–65% of all lesions are reported in the head and neck region. Intraoral lesions represent about 70% of the granular cell tumours of the head and neck, and account for 1/3 of all cases affecting the whole body.Most of the intraoral lesions occur on the tongue, usually on the lateral aspect, followed by the buccal mucosa and hard palate. Although majority of granular cell tumours are benign, some are clinically aggressive and a few frankly malignant forms have been reported. Some benign lesions exhibit surface ulcerations and this clinical appearance, combined with the overlying pseudoepitheliomatous hyperplasia, seen histologically, may lead to misdiagnosis of malignancy if adequate biopsy material was not taken.A case of granular cell tumour which occurred on the midline area of the dorsum of the posterior 1/3 of the tongue is reported in a 20-year-old female patient. It is interesting because the patient was younger than the average age of occurrence and the tumour occurred in a similar site to that of a lingual thyroid. 相似文献
20.
目的应用抑制消减杂交(SSH)技术筛选舌鳞癌干细胞相关差异表达基因。方法以舌鳞癌Tca8113细胞株中的醛脱氢酶(ALDH)高表达(ALDHbr)细胞与低表达(ALDHlow)细胞互为实验组和对照组,进行正反向消减杂交后建立差异表达基因文库,随机挑选差异基因克隆进行测序及生物信息学分析。结果经Blast比对分析,得到62条差异表达基因;功能聚类发现多数与细胞周期调节、细胞分化等生物行为相关;信号通路分析显示有11条基因参与的12条信号通路发生显著改变。结论应用SSH技术成功筛选出了与舌鳞癌干细胞相关的一些基因,进一步研究这些基因对探索舌鳞癌干细胞特异性表面标志物具有重要意义。 相似文献