丁酸氢化可的松乳膏联合除湿止痒软膏治疗新生儿湿疹疗效及安全性分析

目的:探讨丁酸氢化可的松乳膏联合除湿止痒软膏治疗新生儿湿疹疗效及安全性。方法:将2011年6月~2013年6月该院皮肤科门诊就诊新生儿湿疹患儿80例按照随机数字表法分为治疗组和对照组,每组40例,治疗组给予丁酸氢化可的松乳膏联合除湿止痒软膏,两种药物按1∶1混匀后外涂,2次/天;对照组单用丁酸氢化可的松乳膏外涂,2次/天。两组疗程均为1周。观察两组治疗1周后的疗效和不良反应。结果:两组总的有效率为72.5%,其中治疗组的有效率为85.0%,明显高于对照组的有效率60.0%,治疗组和对照组有效率之间的差别具有统计学意义(P<0.05);治疗组的复发率为17.5%明显低于对照组的复发率37.5%,两组复发率之间的差别具有统计学意义(χ2=4.013,P<0.05)。结论:丁酸氢化可的松乳膏联合除湿止痒软膏比单用丁酸氢化可的松乳膏治疗新生儿湿疹疗效显著,且安全性好,复发率低。     

乙氧苯柳胺软膏与0.05%维A酸乳膏联合应用治疗寻常性痤疮的临床观察

目的探讨乙氧苯柳胺软膏和0.05%维A酸乳膏联合应用治疗寻常性痤疮的临床疗效。方法采用开放对照临床实验,分别用乙氧苯柳胺软膏与0.05%维A酸乳膏联合治疗寻常性痤疮52例,0.05%维A酸乳膏单独应用治疗寻常性痤疮49例,首次及治疗后2、4、6周各随访1次,观察及记录炎性皮损和非炎性皮损的改善情况及用药后的不良反应。结果乙氧苯柳胺软膏和0.05%维A酸乳膏联合应用组疗效为71.1%,单用0.05%维A酸乳膏组疗效为48.9%,两者治疗寻常性痤疮的疗效差异有统计学意义(P0.01);乙氧苯柳胺软膏和0.05%维A酸乳膏联合应用组不良反应发生率为21.1%,单用0.05%维A酸乳膏组不良反应发生率18.3%,二者差异无统计学意义(P0.05),乙氧苯柳胺软膏与0.05%维A酸乳膏合用治疗寻常性痤疮不会增加不良反应率。结论乙氧苯柳胺软膏和0.05%维A酸乳膏联合应用治疗寻常性痤疮疗效优于单用0.05%维A酸乳膏,且不会增加不良反应。     

丁酸氢化可的松软膏及氟芬那酸丁酯软膏联合治疗儿童湿疹疗效观察

目的:观察丁酸氢化可的松软膏及氟芬那酸丁酯软膏联合治疗儿童湿疹的效果。方法:将符合诊断和入选标准的患儿随机分为实验组和对照组。实验组联合使用丁酸氢化可的松软膏及氟芬那酸丁酯软膏;对照组单纯应用丁酸氢化可的松软膏。两组涂药后均轻轻按摩3 min,连续应用2周为满足疗程。结果:实验组和对照组总有效率分别为95.0%和79.1%,两组比较有显著差异(χ2=4.57,P<0.05)。结论:联合应用丁酸氢化可的松软膏及氟芬那酸丁酯软膏治疗儿童湿疹疗效优于单纯外用丁酸氢化可的松软膏。     

新生儿湿疹联合应用丁酸氢化可的松乳膏与除湿止痒软膏的疗效观察

目的观察丁酸氢化可的松乳膏与除湿止痒软膏联用治疗新生儿湿疹的临床疗效。方法运用随机数字表法将96例患有湿疹的新生儿分为联合组和对照组各48例,对照组患儿单用丁酸氢化可的松乳膏,联合组在对照组基础上加用除湿止痒软膏,对比两组患儿的湿疹消退时间、治疗效果、药物不良反应等情况。结果联合组患儿的痊愈率为60.42%,总有效率为89.58%,均显著高于对照组的37.50%和60.42%,差异有统计学意义(P0.05)。联合组患儿的平均湿疹消退时间为(4.08±1.11)d,对照组为(6.55±2.06)d,组间比较差异有统计学意义(P0.05)。两组治疗后的EASI评分均显著降低,且联合组治疗后的EASI评分显著低于对照组,差异有统计学意义(P0.05)。联合组患儿的不良反应总发生率为6.25%,对照组为4.17%,差异无统计学意义(P0.05)。结论在新生儿湿疹的临床治疗中联合应用丁酸氢化可的松和除湿止痒软膏,能有效加快湿疹消退,提高治疗效果,预防复发。     

丁酸氢化可的松联合多磺酸黏多糖乳膏治疗颜面再发性皮炎疗效观察

目的 观察丁酸氢化可的松联合多磺酸黏多糖乳膏外用治疗颜面再发性皮炎的疗效和安全性.方法 将150例颜面再发性皮炎患者按照随机数字表法分为治疗组和对照组,失访6例,完成观察144例,其中治疗组74例,在口服抗组胺药物的同时将丁酸氢化可的松乳膏与多磺酸黏多糖乳膏均匀混合后外涂于面部患处,对照组70例,仅口服抗组胺药物.在治疗第8天评价疗效及不良反应.结果 治疗组总有效率为93.2％(69/74),对照组总有效率为41.4％(29/70),两组比较差异有统计学意义(P＜0.01).两组患者不良反应均轻微.结论 丁酸氢化可的松联合多磺酸黏多糖乳膏外用治疗颜面再发性皮炎,疗效肯定,不良反应少,值得临床推广使用.     

祛湿止痒霜治疗慢性湿疹114例

目的探讨祛湿止痒霜对慢性湿疹的治疗效果。方法 114例患者随机分为2组,治疗组采用祛湿止痒霜外涂,对照组采用丁酸氢化可的松乳膏外涂。结果经过4周治疗后,治疗组总有效率明显高于对照组(p<0.05),且未发现明显不良反应。结论祛湿止痒霜外涂治疗慢性湿疹疗效优于丁酸氢化可的松,且安全性好。     

溶菌酶肠溶片联合维A酸乳膏治疗扁平疣疗效观察

目的 对溶菌酶肠溶片和0.1% 维A 酸乳膏联合应用与0.1% 维A 酸乳膏单独应用治疗扁平疣的疗效进行观察,从而评价溶菌酶肠溶片联合0.1% 维A 酸乳膏治疗扁平疣的疗效.方法 采用开放对照临床实验,分别用口服溶菌酶肠溶片联合0.1% 维A 酸乳膏治疗扁平疣44例（治疗组）,单用0.1%维A酸乳膏治疗扁平疣41例（ 对照组）,疗程9周.结果 溶菌酶肠溶片联合0.1% 维A 酸乳膏治疗扁平疣总有效率72.7%,单用0.1% 维A 酸乳膏治疗扁平疣总有效率51.2%,比较差异有统计学意义（P〈0.05）.结论 溶菌酶肠溶片联合0.1% 维A 酸乳膏治疗扁平疣疗效优于单用0.1%维A 酸乳膏.     

氟芬那酸丁酯软膏治疗皮炎148例临床疗效观察

目的 探讨氟芬那酸丁酯软膏治疗皮炎的临床疗效.方法 选择我院治疗的面部激素依赖性皮炎患者296例,随机分为观察组和对照组,对照组给予丁酸氢化可的松乳膏治疗,观察组采用氟芬那酸丁酯软膏治疗,观察两组临床治疗效果.结果 观察组治疗效果优于对照组,经统计学分析,差异有统计学意义(P＜0.05).两组不良反应发生率比较,经统计学分析差异无统计学意义(P＞0.05).结论 采用氟芬那酸丁酯软膏治疗面部激素依赖性皮炎疗效显著,不良反应轻微,值得在临床上大力推广使用.     

中西医结合治疗湿疹疗效观察

目的观察盐酸西替利嗉片口服及丁酸氢化可的松乳膏外用联合养血祛风止痒汤口服治疗湿疹的疗效。方法选取2017年8月-2018年5月期间小东庄社区卫生服务中心中医科门诊收治的湿疹患者80例,随机分为对照组与观察组,每组各40例。对照组口服盐酸西替利嗪片及外用丁酸氢化可的松乳膏,观察组在口服盐酸西替利嗪片及外用丁酸氢化可的松乳膏的基础上联合应用养血祛风止痒汤口服。观察并比较两组患者治疗1周后总有效率及停止治疗半年后的复发率。结果治疗1周后,观察组总有效率为95.0%,对照组总有效率为87.5%。半年后观察组复发率为1 2.5%,对照组复发率为27.5%,差异有统计学意义(P0.05)。结论盐酸西替利嗪片口服及丁酸氢化可的松乳膏外用,联合养血祛风止痒汤口服治疗湿疹的疗效确切且复发率低。     

丁酸氢化可的松乳膏加红霉素软膏治疗哺乳期乳房湿疹的临床观察

正乳房湿疹是发生在乳头及乳晕处皮肤的一种非特异性变态反应性炎症,男女均可发病,但以哺乳期妇女多见,大多数为双侧病变,部分患者为单侧。皮疹为多形性,常有皲裂、瘙痒,易复发。有时可与身体其他部位皮肤损害同时伴发。哺乳期乳房湿疹给妇女带来了不同程度的困扰,严重的甚至中断哺乳,不利于婴儿的生长发育。现报道采用丁酸氢化可的松乳膏加红霉素软膏与单用丁酸氢化可的松乳膏或红霉素软膏治疗哺乳期乳房湿疹的疗效比较。     

三氧化二砷、维甲酸联合化疗序贯治疗对急性早幼粒细胞白血病的长期疗效

目的总结三氧化二砷（As2O3）、全反式维甲酸（ATRA）及化疗的序贯巩固方案对急性早幼粒细胞白血病（APL）的远期疗效。方法对我院1996～2006年间诊断为APL的40例患者,缓解后用序贯方案进行巩固治疗的24例,回顾性地与单用维甲酸进行巩固治疗的16例作比较,随访时间至少超过5年,评价两组间的复发率及5年无病生存率的差异。结果接受序贯巩固治疗患者的复发率仅4%,单用维甲酸组复发率为26.6%,5年生存率两组分别为96%及81%。结论接受序贯巩固方案有利于减低APL的复发率,提高患者的5年无病生存率。     

Hydrocortisone modulates RA-induced growth inhibition of normal and transformed human embryonic lung fibroblasts

All-trans retinoic acid (10(-5) M) added at seeding reduces the growth rate and saturation density of normal human embryonic lung fibroblasts of two lines (WI-38 and IMR-90) and similarly inhibits growth of SV40-transformed WI-38 cells (VA13A). The growth inhibitory effects of retinoic acid do not show serum dependency, and the viability of treated cells is 95-99% of controls. Old populations of WI-38 cells (cells at high population doubling levels) are more sensitive to the effects of retinoic acid than are young populations (cells at low population doubling levels), and population life span is reduced by continuous exposure to retinoic acid. When retinoic acid is combined with the glucocorticoid hydrocortisone, inhibition of VA13A cell growth is increased, whereas the retinoic acid-induced inhibition of normal cells is decreased. VA13A cells treated with retinoic acid alone, or in combination with hydrocortisone, exhibit a reversion to a more elongated, fibroblast-like appearance. This paper discusses the clinical implications of the relationship between retinoic acid and hydrocortisone.     

The short chain fatty acid butyrate induces promoter demethylation and reactivation of RARbeta2 in colon cancer cells

It has been proposed that cancer prevention results from multiple dietary agents acting together as "action packages." Here we obtain evidence that butyrate, which is generated from dietary fiber, enhances the responsiveness of colon cancer cells to all-trans retinoic acid (ATRA). Evidence was obtained that this interaction depends on histone deactylase one (HDAC1) inhibition by butyrate and retinoic acid receptor alpha (RARalpha) activation by ATRA. The enhancement of RAR beta 2 (RARbeta2) activation was accompanied by a rapid demethylation of the RARbeta2 promoter. This demethylation could be achieved by butyrate alone, and it differed from that triggered by the DNA methyltransferase inhibitor 5-Aza-2' deoxycytidine in that it was 1) sporadic on the RARbeta2 promoter, 2) not genome wide, and 3) independent of extensive DNA replication. An analysis of inter-methylated sites assay indicated that only a few percent of loci analyzed showed reduced methylation. In colon cancer cells that were particularly resistant to RARbeta2 reactivation, the actions of butyrate could be further enhanced by the soy isoflavone genistein, which has also been reported to work through an epigenetic mechanism. These data suggest that dietary compounds that modulate epigenetic programming are likely to function best in the presence of retinoids and other cancer-preventing compounds that are sensitive to a cell's epigenetic state.     

The Short Chain Fatty Acid Butyrate Induces Promoter Demethylation and Reactivation of RARβ2 in Colon Cancer Cells

It has been proposed that cancer prevention results from multiple dietary agents acting together as “action packages.” Here we obtain evidence that butyrate, which is generated from dietary fiber, enhances the responsiveness of colon cancer cells to all-trans retinoic acid (ATRA). Evidence was obtained that this interaction depends on histone deactylase one (HDAC1) inhibition by butyrate and retinoic acid receptor alpha (RARα) activation by ATRA. The enhancement of RAR beta 2 (RARβ2) activation was accompanied by a rapid demethylation of the RARβ2 promoter. This demethylation could be achieved by butyrate alone, and it differed from that triggered by the DNA methyltransferase inhibitor 5-Aza-2′ deoxycytidine in that it was 1) sporadic on the RARβ2 promoter, 2) not genome wide, and 3) independent of extensive DNA replication. An analysis of inter-methylated sites assay indicated that only a few percent of loci analyzed showed reduced methylation. In colon cancer cells that were particularly resistant to RARβ2 reactivation, the actions of butyrate could be further enhanced by the soy isoflavone genistein, which has also been reported to work through an epigenetic mechanism. These data suggest that dietary compounds that modulate epigenetic programming are likely to function best in the presence of retinoids and other cancer-preventing compounds that are sensitive to a cell's epigenetic state.     

Comparative study of the efficacy and tolerance of 12% glycolic acid cream and 0.05% retinoic acid cream for polymorphic acne]

Topical retinoic acid has demonstrated its efficacy in acne. Glycolic acid has also keratolytic action and could be interesting to treat acne. OBJECTIVE: To evaluate the efficacy and safety of topical glycolic acid (Glyco A 12%) and retinoin acid (Kefrane 0.05%) on facial acne lesions. METHOD: It was a randomised double blind study of 40 patients, divided in 2 groups, 20 receiving GlycoA cream (Group A) and 20 receiving Kefrane cream (group B). Medical exam was realised by the same physician at day 0, 21 and 45. The improvement of acne as well as side effects were assessed by both the physician and the patients themselves. RESULTS: 2 patients developed severe eczema of the face and were excluded (one from group A and one from group B). 22 patients followed totally the study. 90% of group A and 83.3% of group B patients improved significantly their lesions. A comparative tolerability was observed for both groups. CONCLUSION: Glyco A cream could be a good treatment for acne even in dark skin patients.     

维甲酸加化疗和小剂量肝素治疗急性早幼粒细胞白血病15例临床观察

目的总结维甲酸、化疗、小剂量肝素合用治疗急性早幼粒细胞白血病（APL）并预防弥漫性血管内凝血（DIC）的疗效。方法15例APL患者,采用全反式维甲酸（ATRA）、适量化疗诱导分化至完全缓解（CR）,同时予以小剂量肝素。结果APL的完全缓解率达86．7％,平均缓解时间达37．4d,无一例DIC发生。结论维甲酸、化疗、小剂量肝素合用治疗急性早幼粒细胞白血病并预防DIC效果满意。     

Constituents within pulp mill effluent deplete retinoid stores in white sucker and bind to rainbow trout retinoic acid receptors and retinoid X receptors

Wild female and male white sucker (Catostomus commersoni) inhabiting an area receiving pulp mill effluent had reduced hepatic levels of retinol, didehydroretinol, retinyl esters, and didehydroretinyl esters, while vitamin E levels were unaffected. This disruption of the retinoid system led us to test methanol and dichloromethane extracts from the effluent of 11 pulp mills from across Canada for their ability to bind to rainbow trout (Oncorhynchus mykiss) retinoic acid receptors (RARs) from the gill and retinoid X receptors (RXRs) from the liver. Concentrated extracts of the final effluent from 6 of the 11 pulp mills were able to displace greater than 25% of the receptor-bound [3H]all-trans retinoic acid (RA) or [3H]9-cis RA from trout RARs and RXRs, respectively. The ability of the extracts to displace retinoic acid did not appear to be linked to the pulping or treatment processes. Moreover, extracts with the greatest activity came from thermomechanical mills, suggesting the compounds may originate from the wood furnish. In addition, extracts prepared from wood furnish (wood chips: white spruce [50%], lodgepole pine [47%], and balsam fir [3%]) from one mill were able to displace [3H]RA from the RARs and RXRs. The 4-hydroxy RA, a metabolite of RA that has been shown to be generated in greater quantities in fish exposed to P450-inducing xenobiotics, was able to displace [3H]all-trans RA from trout RARs as effectively as unlabeled all-trans RA. These results suggest that pulp mill effluent may impact the retinoid system of fish at multiple sites, either by decreasing hepatic retinoid stores or through contributing additional ligands (from the wood furnish) that can bind to RA receptors.