Traditional Chinese Medicine Combined with Hepatic Arterial Chemotherapy and Embolization in Tresting Primary Hepatocellular Carcinoma

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Embolization of Tumors and Vascular Lesions in the Oral and Maxillofacial Regions

The embolization was used for the treatment of 10 patients with tumors and vascular lesions in the oral and maxillofacial region. The patients were diagnosed as having vascular deformity, hemangioma, hemangiofibroma and chemodectoma. The selective and supersetective target artery embolization were conducted and the satisfactory results were achieved. The procedures, effects and precautions of the embolic therapy were also discussed.     

The Change of Copper Contents and Its Clinical Significance in Patients with Liver Cirrhosis and Hepatocarcinoma

Copper contents(CU) in bodies and serum cerulopasmin(Cp) were assayed in patients with liver cirrhosis(LC) and hepatocarcinoma(HCC) with atomic absorption and other methods.     

Variations and Clinical Significance of Coagulation and Fibrinolysis Parameters in Patients with Diabetes Mellitus

We observed the changes of parameters of coagulation and fibrinolytic system in order to understand the clinical implication of these variations in type diabetic patients. Subjects consisted of 22 patients with type Ⅱ diabetes mellitus and 25 healthy controls. Compared with the control, activated partial thromboplastin time, prothrombin time were shortened in the patients. The diabetic subjects also displayed higher levels of D-dimer, serum fibrin degradation products,median concentrations of fibrinogen (3.99 vs 2.96 g/L, P<0.01) and yon Willebrand factor (149% vs 87%, P<0.01). Levels of antithrombin Ⅲ activity or antigen were not different from control values. Simple linear regression analysis revealed a negative correlation between antithrombin Ⅲ activity and fast blood glucose. Diabetic patients with vascular complications had significantly higher levels of fibrinogen and D-dimer than those without diabetic angiopathy. Our data demonstrated that patients with type Ⅲ diabetes mellitus had a hyperco     

Comparative Study on the Long－term Effect of Permanent Embolization of Hepatic Artery with Bletilla Striata in Patients with

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The Effects of Human Fetal Liver Cells on Experimental Fulminant Hepatic Failure in Rats

The beneficial dffects of human fetal liver cells on the D-galactosamine-inducedfulminant hepatic failure were observed in rats and the mechanisms of the effects investi-gated.The survival rate of the rats intraperitoneally injected with liver cell suspensionand cytosol was 47.37% and 42.11% respectively which was significantly higher than5.26% of the controls(P<0.05).There was no statistical significance between the differ-ence of the survival rates due to two preparations.The administration of cytosol two hours before the intoduction of D-galactosamine re-sulted in a significant lowering of the plasma level of endotoxin and hepaticmalondialdehyde in rats and a marked increase of ~3H-thymindinc incorporation intohepatic DNA(DPM/OD_(260))as compared with the parameters of the controls.These re-sults suggest that there might be some biological active substance in human fetal liver cellswhich is responsible for thc effects to increase the survival rate.     

Use of ABC Method in the Study of Lectin Receptors in Liver Tumors

The high affinity interaction of avidin-biotin inimmunoenzymatic techniques has provided a simple and sen-sitive method to localize antigens in formalin-fixed and paraf-fin-embedded tissues. The distribution of lectin receptors inprimary hepatooellular carcinoma, intrahepaticcholangiocarcinoma and cavernous hemangioma was studied     

Expression and Clinical Significance of p27kipl Protein in Primary Liver Cancer

To investigate the expression and clinical significance of p27kip1 protein in primary liver cancer, the expression of p27kip1 protein and the relationship with clinicopathological factors were studied in primary liver cancer by using SABC immunohistochemical staining in specimens of 40 cases of primary liver cancer and 20 cases of liver cirrihosis. Our results showed that positive expression rate of p27kip1 protein in primary liver cancer was 37.5% (15/40), which was lower than that in benign lesion of liver 80.0% (16/20, P<0.01). The expression level of p27kip1 protein in primary liver cancer showed significant differences in tumor size, Edmonson histological grade, portal invasion, lymph node metastasis, TNM stage (P<0.05, for all), but not significantly correlated with patient's age and histological types. Log rank test showed that the p27kip1 expression was significantly related with prognosis of the patients (P<0.05), and the prognosis of the patients with p27kip1 positive expression was markedly better than that of those with p27kip1 negative expression. It is concluded that the expression of p27kip1 was significantly related clinicopathological factors of primary liver cancer. p27kip1 protein may be used as a novel tumor marker for primary liver cancer.     

Expression and Clinical Significance of p27kip1 Protein in Primary Liver Cancer

Theactivityofcellproliferationisakeyindicatorforevaluatingthetumorcellinvasiveability.Inacellcycle,thetransitionofG1toSisthemostimportantphaseofcellproliferation.p27proteincanextensivelyinhibittheactivityofCDKs,andtherebypreventstheentryofcellstoG1phase,a…     

急诊肝动脉栓塞治疗原发性肝癌破裂出血36例

目的探讨急诊肝动脉栓塞治疗原发性肝癌破裂出血的效果。方法收集2007年9月～2010年9月北京军区总医院实施急诊肝动脉栓塞治疗原发性肝癌破裂出血患者36例为观察组,另随机抽取北京军区总医院2007年9月前实施保守治疗的原发性肝癌破裂出血患者26例为对照组。比较两组即时止血率、输血量、肝功能恢复率及生存率。结果观察组即时止血率、输血量和肝功能恢复率均显著优于对照组,差异均有高度统计学意义（均P〈0.01）。观察组治疗后6、12个月时生存率均显著高于对照组,差异均有高度统计学意义（均P〈0.01）。结论与保守治疗相比,急诊肝动脉栓塞具有止血成功率高、输血量少、肝功能恢复快及病死率低的优点,值得临床推广应用。     

经肝动脉栓塞治疗肝海绵状血管瘤的临床分析

目的研究肝动脉栓塞治疗肝海绵状血管瘤的临床疗效。方法共15例经CT增强扫描及血管造影确诊的肝海绵状血管瘤,选择供血动脉插管成功后,注入平阳霉素与碘油制成的乳剂栓塞。结果介入治疗1-2次后所有患者肝内海绵状血管瘤均明显缩小,症状明显改善。结论经肝动脉栓塞治疗肝海绵状血管瘤是一种疗效可靠的治疗方法。     

阿霉素脂质体犬肝动脉栓塞后阿霉素体内特征

目的：研究阿霉素脂质体－碘油犬肝动脉栓塞后的体内靶向性特征和药代动力学，方法：用高效液色相色谱法（ＨＰＬＣ）测定犬血浆和肝组织中阿霉素的浓度。结果：阿霉素脂质体－碘油栓塞组犬血浆阿霉素浓度显著低于阿霉素溶液灌注组（Ｐ〈０．０１）和阿霉素－碘油栓塞组（Ｐ〈０．０５），而其血浆阿霉素消除半衰期和肝组织中阿霉素中浓度与后两组比则显著增加（Ｐ〈０．０１，Ｐ〈０．０５）。结论：阿霉素脂质体与碘油混合肝动脉栓     

盐酸去氢骆驼蓬碱肝动脉栓塞微球处方工艺研究

目的:从新疆民族药蒺藜科植物骆驼蓬种子中提取的抗肿瘤活性生物碱成分——盐酸去氢骆驼蓬碱(HM) ,制成可供肝动脉栓塞的微球新剂型 ,对其处方设计及制备工艺进行研究。方法:选择具有生物可降解性、无毒、价廉且与盐酸 HM无相互作用的明胶为载体 ,采用乳化分散法制备盐酸去氢骆驼蓬碱明胶微球 ,以外观、粒径、载药量、包封率等为考察指标 ,采用正交设计确定了盐酸去氢骆驼蓬碱微球的制备工艺。结果:含药微球为淡黄色粉末 ,光镜及电镜观察微球球形圆整 ,表面附有少量药物结晶。平均产率为 86 .6 3% ,表面药量平均值为 (2 6 .2 4±0 .30 ) % (g/ g) ;载药量为 (34.4 5± 0 .35 ) % (g/ g) ;包封率为 (8.19± 0 .5 1) % (g/ g)。平均算术径为 6 3.0μm ,平均体积径为 6 9.6μm,粒径分布基本属正态 ,跨度 Span为 0 .76 9。 结论:所研制微球符合肝动脉栓塞微球剂的要求     

经皮肝穿刺活检联合动脉造影及栓塞技术在肝肿瘤诊疗中的应用(附46例报道)

 目的 探讨超声导引或透视下经皮肝穿刺活检结合动脉造影技术在肝肿瘤诊疗中应用的安全性及可行性。方法 选取难以明确诊断或欲知病理类型的肝占位患者共46例,肝穿刺活检前先行股动脉插管动脉造影,暂时保留导管于肿瘤动脉,用B超或透视导引下行肝穿刺活检。活检后再行一次动脉造影,判断有无穿刺道出血。如存在出血征象,则行肿瘤供血经导管动脉栓塞术(transcatheter arterial embolization,TAE)治疗,在栓塞完成后,再行最后一次动脉造影,显示肿瘤血供是否阻断以及出血是否停止。患者每次重复穿刺肝内病灶前,均用无水酒精纱布擦拭穿刺活检针,以避免穿刺道肿瘤种植。结果 46例患者肝穿刺活检均顺利完成,其中37例用B超导引,9例患者在透视下肝穿刺活检成功。46例患者共取出114条0.8～1.5 cm细条组织,26例血管造影显示为富血供肿瘤,供血血管紊乱,不规则。4例肿瘤病灶较小,穿刺活检后造影显示造影剂弥散至瘤周并有小的门脉分支显影,考虑存在动静脉瘘或出血;3例显示造影剂外渗;此7例患者中有3例选用单纯超液化碘化油加明胶海绵颗粒行肿瘤血管栓塞,另4例选择了化疗栓塞。本组中共有36例患者术中明确诊断为恶性肿瘤,均对肿瘤进行了化疗栓塞,5例患者进行了单纯灌注化疗。大部分患者(80.4%)术后仅有轻度穿刺点疼痛,与穿刺时肝包膜刺激有关,均在术后第2～3天好转,无需使用镇痛剂;患者均未出现气胸、胸腔积液、腹膜炎;患者未出现穿刺道、肝包膜下出血及出血性休克等严重并发症表现。术后随访2个月未发现穿刺道肿瘤种植。穿刺活检阳性率为91.2%。结论 在肝肿瘤诊疗中,经皮肝穿刺活检结合动脉造影及栓塞,可及时发现和治疗肝穿刺出血等并发症,是一种安全、可行的技术组合方案。     

原发性肝癌介入治疗效果及严重并发症分析

目的　探讨肝动脉化疗栓塞 (TAE)对原发性肝癌的疗效 ,并对严重并发症原因予以分析。方法选择原发性肝癌 3 96例 ,60 5次介入 ,观察疗效 ,记录并发症。结果　总体 1、2、3、4、5a生存率分别是 4 5 4 %、4 2 1%、19 2 %、2 3 %、1 3 % ,最长 1例存活 8a 3个月 ;严重并发症发生 2 1例 ,发生率为 5 3 % ,死亡 17例 ,病死率 81% ( 17/ 2 1) ;3 2例经TAE后行了Ⅱ期切除术 ;4 0例右肝巨大肝癌有异常血供。结论　TAE是中晚期肝癌有效的治疗方法 ;使部分病人可行Ⅱ期切除 ;但在行介入时应严格掌握指征 ,减少严重并发症发生 ,一旦发生 ,其病死率高 ,应引起高度重视 ;发现肿瘤异常血供并予以栓塞是提高疗效的措施之一。     

Study on treatment of primary hepatic carcinoma by arterial perfusion embolization with zedoary turmeric oil

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经动脉途径区域性栓塞对原发性肝癌病灶坏死速度的影响

目的探讨经动脉途径区域性栓塞对肝癌病灶坏死速度的影响。方法肝癌患者64例,随机分为2组,经动脉途径区域性栓塞组(观察组)32例,介入栓塞化疗(TACE)加热疗组(对照组)32例。观察治疗前及治疗1个月后肿瘤直径的变化,1个月坏死率,并复查MR,观察病灶坏死情况。结果 2组治疗前后肿瘤直径均无显著变化(P>0.05)。观察组1个月病灶坏死率(93.8%)高于对照组(25.0%),差异有统计学意义(P<0.05)。观察组病灶全范围坏死,极个别边缘残存活性;对照组病灶坏死与实变混杂,部分边缘区域残存活性。结论经肝动脉区域性栓塞原发性肝癌的病灶坏死速度较快。     

弥漫型与局灶型子宫腺肌病动脉栓塞术后疗效观察

目的：探讨子宫动脉栓塞术（Uterine arterial embolism UAE）对弥漫型子宫腺肌病（adenomyosis AM）和局灶型子宫腺肌病是否具有相同的，性床疗效。方法：选择56例AM患者进行UAE治疗，其中局灶型16例、弥漫型40例，观察两组患者UAE前及UAE后3、6、12、24、48个月月经量、痛经程度评分、子宫体积、血清CA125的变化及两组的副作用情况。结果：56例患者全部栓塞成功，根据临床症状，两组有效率分别达83．3％（10／12）、81．3％（26／32）。其中两组患者月经量、痛经程度评分于UAE后3个月开始下降（P〈0．05），于UAE后6个月下降最显著（P〈0．01）。血清CA125下降和子宫体积缩小相一致，术后12个月达最低点（P〈0．01）；两组组间比较差异无显著性（P〉0．05）。所有病例随访48个月，无一例复发。结论：子宫动脉栓塞治疗弥漫型和局灶型子宫隙肌病的效果显著，疗效相似。     

子宫动脉栓塞术治疗子宫腺肌病的近期疗效分析

目的 探讨子宫动脉栓塞术(UAE)治疗子宫腺肌病(AM)的近期效果.方法 采用Seldinger置入导管至双侧子宫动脉,注入超液化碘油 平阳霉素乳剂 明胶海绵颗粒,UAE后1、3、6个月随访观察疗效.结果 39例AM患者中,痛经缓解率达97.6%(P<0.01),月经改善有效率达100%(P<0.01).26例贫血患者UAE后3～6月血红蛋白浓度均得到显著升高或恢复正常.UAE后6个月B超复查子宫体积平均缩小43.2%(P<0.01),病灶大小平均缩小59.0%(P<0.01),无严重并发症发生.结论 UAE治疗AM有较好的近期疗效,远期效果有待于进一步观察.