The curative effect of preoperative superselective arterial chemoembolization for sacrum tumor

目的:评估骶骨肿瘤术前超选择性动脉灌注化疗栓塞的疗效.方法:将22例行术前超选择性动脉灌注化疗栓塞(栓塞组)和16例未行化疗栓塞(对照组)骶骨肿瘤患者手术中失血量、输血量、术后引流量、手术时长、并发症发生率、住院天数及总费用、术后1年内复发率进行对比分析.结果:栓塞组平均术中出血量、输血量、术后引流量、手术时间均优于对照组(P＜0.05);栓塞组住院天数、住院费用与对照组差异无统计学意义(P＞0.05);术后骶神经损伤等并发症的发生率差异无统计学意义(P＞0.05);栓塞组的术后1年复发率明显低于对照组(P＜0.05);术后组织病理学证实:栓塞组肿瘤组织均有不同程度坏死、变性、液化、假包膜形成.结论:骶骨肿瘤术前超选择动脉灌注化疗栓塞在不增加医疗费用的情况下有利于手术切除、减少术中出血、缩短手术时间、延长存活时间.     

骶骨肿瘤术前超选择性动脉灌注化疗栓塞的疗效

目的:评估骶骨肿瘤术前超选择性动脉灌注化疗栓塞的疗效。方法:将22例行术前超选择性动脉灌注化疗栓塞(栓塞组)和16例未行化疗栓塞(对照组)骶骨肿瘤患者手术中失血量、输血量、术后引流量、手术时长、并发症发生率、住院天数及总费用、术后1年内复发率进行对比分析。结果:栓塞组平均术中出血量、输血量、术后引流量、手术时间均优于对照组(P<0.05);栓塞组住院天数、住院费用与对照组差异无统计学意义(P>0.05);术后骶神经损伤等并发症的发生率差异无统计学意义(P>0.05);栓塞组的术后1年复发率明显低于对照组(P<0.05);术后组织病理学证实:栓塞组肿瘤组织均有不同程度坏死、变性、液化、假包膜形成。结论:骶骨肿瘤术前超选择动脉灌注化疗栓塞在不增加医疗费用的情况下有利于手术切除、减少术中出血、缩短手术时间、延长存活时间。     

选择性靶动脉栓塞在骶骨肿瘤切除术中的价值

目的 探讨和评估选择性靶动脉栓塞骶骨肿瘤后对外科切除肿瘤的价值和方法。方法 运用Seldinger技术，对9例骶骨肿瘤患者进行肿瘤供血动脉及肿瘤内血管全部彻底栓塞，栓塞材料应用明胶海绵，栓塞后1周内行手术切除术。结果 彻底的术前栓塞手术中失血量明显减少，9例骶骨肿瘤均得到彻底切除，平均失血量为1090ml。术后平均随访15个月，未见肿瘤局部复发。结论 骶骨肿瘤切除术前选择性靶动脉栓塞可有效减少术中出血，有利于肿瘤的彻底切除，为顺利切除骶骨肿瘤提供了有价值的方法。     

骶骨肿瘤术前超选择性动脉栓塞的意义

目的：研究和评估骶骨肿瘤术前经导管超选择性动脉栓塞的价值和作用。方法：对１６例骶骨肿瘤用明胶海绵或白芨粉行超选择性动脉栓塞,栓塞后平均３．５天行手术切除。疾病包括：骨巨细胞瘤３例、脊索瘤８例、动脉瘤样骨囊肿２例、转移瘤３例。结果：本组１６例栓塞后造影的显示肿瘤染色均较术前减少８５％以上。术中失血５００～１５００ｍｌ之间,平均为７８０ｍｌ。所有肿瘤均被顺利切除。结论：超选择性动脉栓塞手术治疗骶骨肿瘤     

术前肿瘤动脉栓塞联合术中腹主动脉球囊阻断在骶骨肿瘤切除术中的应用

目的 探讨术前肿瘤动脉栓塞联合术中腹主动脉球囊阻断在骶骨肿瘤切除术中的应用价值.方法 本研究纳入56例患者.对照组(24例)行常规外科切除骶骨肿瘤;试验组(32例)行术前骶骨肿瘤动脉栓塞联合术中腹主动脉球囊阻断.计算两组的手术时间、术中出血量、术后1年肿瘤复发率,并进行统计学分析.结果 试验组患者造影显示骶骨肿瘤由多支血管供血,分别给予栓塞后在球囊阻断腹主动脉的辅助下成功切除肿瘤.试验组术中手术视野清晰,骶骨肿瘤切除时出血明显减少,术后未出现异位栓塞、肾缺血和肢体缺血等并发症.两组手术时间、术中出血量、术后1年肿瘤复发率差异均有统计学意义(P ＜ 0.05).结论 术前肿瘤动脉栓塞联合腹主动脉球囊阻断能有效缩短手术时间、减少术中出血,使肿瘤切除术中的手术视野更加清晰,明显提高了手术的安全性.     

双侧髂内动脉栓塞在骨盆肿瘤化疗栓塞中的临床应用

目的 :探讨双侧髂内动脉栓塞在骨盆肿瘤化疗栓塞中的临床应用价值。方法 :对 2 3例骨盆肿瘤患者采用Co bra或Yashiro导管进行超选择插管 ,找出肿瘤的所有供血动脉 ,然后根据血供进行超选择性灌注化疗 ,并用明胶海绵随机对其中 11例患者进行所有肿瘤供血动脉的选择性栓塞 (单纯栓塞组 ) ;对其中 12例患者除进行所有肿瘤供血动脉的选择性栓塞外 ,还对双侧髂内动脉主干进行栓塞 (双侧髂内动脉栓塞组 ) ,栓塞后 2 4～ 4 8h由同一组医生进行手术 ,计算术中出血量与手术时间。结果 :双侧髂内动脉栓塞组手术中暴露肿瘤的出血量为 80± 2 6 6 3ml,术中总出血量为 775± 2 35 97ml,手术时间为 16 4 17± 2 6 4 4min ;单纯栓塞组上述指标分别为 2 0 0± 4 8 5 8ml、176 3 6 4± 390 5 7ml、2 2 8 18± 37 37min。双侧髂内动脉栓塞组明显少于单纯栓塞组 (P <0 0 0 1)。手术中术野更清楚 ,易剥离 ,出血少 ,缩短手术时间。术后随访 6～ 18个月未见肿瘤复发和转移。结论 :双侧髂内动脉栓塞法能有效减少骨盆肿瘤的术中出血 ,利于肿瘤彻底切除 ,结合化疗能减少肿瘤复发或转移 ,是一种有价值的术前辅助性治疗方法     

骶髂骨肿瘤切除术前介入栓塞价值

目的 评估骶、髂骨肿瘤术前经导管超选择性动脉栓塞的价值和作用.方法对15 例骶、髂骨肿瘤用明胶海绵颗粒行超选择性动脉栓塞,栓塞后1～3 d行手术切除.疾病包括:骨巨细胞瘤5 例、动脉瘤样骨囊肿2例、转移瘤2 例、软骨肉瘤4例、脊索瘤3例.结果本组15 例栓塞后造影均显示肿瘤染色范围均较术前减少80 %以上.术中失血500～2600 ml 之间,平均为1100 ml .所有肿瘤均被顺利切除.结论 骶、髂骨肿瘤手术治疗前超选择性动脉栓塞能安全有效地减少术中出血, 提高肿瘤手术治疗效果并降低手术的风险.     

骨盆肿瘤术前经导管动脉栓塞治疗的价值

目的　评价骨盆肿瘤术前局部动脉内灌注化疗和栓塞治疗的价值。资料与方法　术前栓塞治疗 4 8例骨盆肿瘤患者 (栓塞组 ) ,观察其临床改善情况 ,计算术中失血量和手术时间 ,并与 16例术前未栓塞骨盆肿瘤患者(对照组 )进行对照。结果　血管造影可清楚显示肿瘤的大小及血供特点 ,栓塞组术中失血量 2 177.1± 96 9.8ml,手术时间 198.9± 97.4min ;对照组术中失血量 4 4 6 2 .5± 1876 .8ml,手术时间 2 86 .4± 14 4 .5min。栓塞组均明显低于对照组 (P <0 .0 1)。手术时机的选择影响栓塞治疗的效果。组织学证实 :肿瘤均有不同程度的坏死、液化和囊性变 ,部分肿瘤有假包膜形成。结论　术前栓塞是骨盆肿瘤手术前最有效的辅助治疗手段 ,并且使手术易于操作。手术时机应选择在栓塞后 6天以内     

术前选择性髂内动脉栓塞治疗骨盆肿瘤

目的：探讨术前选择性髂内动脉栓塞在骨盆肿瘤手术治疗中的价值。资料与方法：对12例骨盆肿瘤患者，采用明胶海绵作选择性髂内动脉栓塞，栓塞后平均2．7天手术。结果：本组病例中7例骶尾部肿瘤施行了双侧选择性髂内动脉栓塞，5例髂骨部肿瘤施行了单侧选择性髂内动脉栓塞。12例中11例获得了术中明显减少出血的效果，肿瘤得以彻底切除，术中失血量平均为751ml。结论：术前选择性髂内动脉栓塞对骨盆部肿瘤能明显的减少术中出血，提高手术切除率，是一种安全有效的辅助治疗手段。     

骶骨肿瘤术前栓塞的临床应用研究

目的：探讨经导管行肿瘤供血动脉术前栓塞在手术切除骶骨肿瘤中的价值和作用。方法：11例骶骨肿瘤患者进行数字减影血管造影明确靶血管情况后,采用明胶海绵结合弹簧圈栓塞靶血管,并于栓塞后1-3天行骶骨肿瘤切除。结果：11例肿瘤靶血管栓塞后,肿瘤染色基本消失,手术切除顺利,术中出血明显减少,平均出血量为750ml。11例平均随访12个月,未见局部复发。结论：骶骨肿瘤的术前动脉栓塞能有效降低术中出血,减少并发症的发生。增加了肿瘤切除率和彻底切除的可能性,是十分安全有效的治疗方法。     

Knee injury and Osteoarthritis Outcome Score (KOOS) - validation of a Swedish version

The Knee injury and Osteoarthritis Outcome Score (KOOS) is a self-administered instrument measuring outcome after knee injury at impairment, disability, and handicap level in five subscales. Reliability, validity, and responsiveness of a Swedish version was assessed in 142 patients who underwent arthroscopy because of injury to the menisci, anterior cruciate ligament, or cartilage of the knee. The clinimetric properties were found to be good and comparable to the American version of the KOOS. Comparison to the Short Form-36 and the Lysholm knee scoring scale revealed expected correlations and construct validity. Item by item, symptoms and functional limitations were compared between diagnostic groups. High responsiveness was found three months after arthroscopic partial meniscectomy for all subscales but Activities of Daily Living.     

The acutely limping child

Acute limping may be the result of multiple pathologies in children. The differential diagnosis varies based on the age of the child. Irrespective of age, the initial imaging work-up includes AP and frog leg radiographs of the pelvis and ultrasound; MRI may sometimes be helpful. In children less than 3 years, infections and trauma are most frequent. MRI is the imaging modality of choice when osteomyelitis is clinically suspected. Between the ages of 3 and 10 years, transient synovitis of the hip and Legg-Calvé-Perthes disease are main considerations but infection, inflammation and focal bony lesions are also considered. In children over 10 years, slipped capital femoral epiphysis also is considered.     

Do Balance Board Training Programs Reduce the Risk of Ankle Sprains in Athletes?

Introduction Ankle sprains are the most common musculo-skeletal injury that occurs in athletes,particularly in sports that require jumping and landing on one foot such as soccer,and basketball(1-4).These injuries often result in significant time loss from participation,long-term disability,and have a major impact on health care costs and resources(5-8).     

High Intensity Interval Training:New Insights

KEY POINTS ·High-intensity interval training(HIT)is characterized by repeated sessions of relatively brief，intermittent exercise.often performed with an“a11 out”effort or at an intensity close to that which elicits peak oxygen uptake(i.e.，≥90%of VO2 peak).     

Endovascular management of carotid-cavernous fistulas

Objective To investigate endovascular treatment of traumatic direct carotid-cavernous fistulas （CCF） and their complications such as pseudoaneurysms. Methods： Over a five-year period, 22 patients with traumatic direct CCFs were treated endovascularly in our institution. Thirteen patients were treated once with the result of CCF occluded, 8 twice and 1 three times. Treatment modalities included balloon occlusion of the CCF, sacrifice of the ipsilateral internal carotid artery with detachable balloon, coll embolization of the cavernous sinus and secondary pseudoaneurysms, and covered-stem management of the pseudoaneurysms. Results All the direct CCFs were successfully managed endovascularly. Four patients developed a pseudoaneurysm after the occlusion of the CCF with an incidence of pseudoaneurysm formation of 18.2% （4/22）. A total number of 8 patients experienced permanent occlusion of the ICA with a rate of ICA occlusion reaching 36.4% （8/22）. Followed up through telephone consultation from 6 months to 5 years, all did well with no recurrence of CCF symptoms and signs. Conclusion Traumatic direct CCFs can be successfully managed with endovascular means. The pseudoaneurysms secondary to the occlusion of the CCFs can be occluded with stent-assisted coiling and implantation of covered stents.     

Developmental validation of the PowerPlex(®) ESI 16 and PowerPlex(®) ESI 17 Systems: STR multiplexes for the new European standard

In response to the ENFSI and EDNAP groups’ call for new STR multiplexes for Europe, Promega^® developed a suite of four new DNA profiling kits. This paper describes the developmental validation study performed on the PowerPlex^® ESI 16 (European Standard Investigator 16) and the PowerPlex^® ESI 17 Systems. The PowerPlex^® ESI 16 System combines the 11 loci compatible with the UK National DNA Database^®, contained within the AmpFlSTR^® SGM Plus^® PCR Amplification Kit, with five additional loci: D2S441, D10S1248, D22S1045, D1S1656 and D12S391. The multiplex was designed to reduce the amplicon size of the loci found in the AmpFlSTR^® SGM Plus^® kit. This design facilitates increased robustness and amplification success for the loci used in the national DNA databases created in many countries, when analyzing degraded DNA samples. The PowerPlex^® ESI 17 System amplifies the same loci as the PowerPlex^® ESI 16 System, but with the addition of a primer pair for the SE33 locus. Tests were designed to address the developmental validation guidelines issued by the Scientific Working Group on DNA Analysis Methods (SWGDAM), and those of the DNA Advisory Board (DAB). Samples processed include DNA mixtures, PCR reactions spiked with inhibitors, a sensitivity series, and 306 United Kingdom donor samples to determine concordance with data generated with the AmpFlSTR^® SGM Plus^® kit. Allele frequencies from 242 white Caucasian samples collected in the United Kingdom are also presented. The PowerPlex^® ESI 16 and ESI 17 Systems are robust and sensitive tools, suitable for the analysis of forensic DNA samples. Full profiles were routinely observed with 62.5 pg of a fully heterozygous single source DNA template. This high level of sensitivity was found to impact on mixture analyses, where 54–86% of unique minor contributor alleles were routinely observed in a 1:19 mixture ratio. Improved sensitivity combined with the robustness afforded by smaller amplicons has substantially improved the quantity of data obtained from degraded samples, and the improved chemistry confers exceptional tolerance to high levels of laboratory prepared inhibitors.     

Bronchial stump fistula :treatment with covered retrievable hinged metallic stents-preliminary clinical experience

Objective To evaluate the preliminaily clinical efficacy and retrievability of a retrievable hinged covered metallic stent in the treatment of the bronchial stump fistula （BSF）. Methods Between April 2003 and March 2005, 8 patients with bronchial stump fistula after pneumonectomy or lobectomy were treated with two types （A and B） of retrievable hinged covered metallic stents. Type A stent was placed in 6 patients and type B in 2 under fluoroscopic guidance. The stent was removed with a retrieval set when BSF was healed or complications occurred. Results Stent placement in the bronchial tree was technically successful in all patients, without procedure-related complications. Immediate closure of the BSF was achieved in all patients after the procedure. Stents were removed from all patients but one. Removal of the stents was difficult in two patients due to tissue hyperplasia. Patients were followed up for 6 - 21 months. Placement of the stents remained stable in all patients except one due to severe cough. Permanent closure of BSF was achieved in 7 （87.5%） of 8 patients. Conclusion Use of a retrievable hinged covered expandable metallic stent is a simple, safe, and effective procedure for closure of the BSF. Retrieval of the stent seems to be feasible. （J Intervent Radiol, 2007, 16： 253-257）     

Prevalence and severity of hip and groin pain in sub‐elite male football: a cross‐sectional cohort study of 695 players

The purpose of this study was twofold: (a) to investigate the prevalence of hip and groin pain in sub‐elite male adult football in Denmark and (b) to explore the association between prevalence and duration of hip and groin pain in the previous season with the Copenhagen Hip and Groin Outcome Score (HAGOS) in the beginning of the new season. In total 695 respondents from 40 teams (Division 1–4) were included. Players completed in the beginning of the new season (July–Sept 2011) a self‐reported paper questionnaire on hip and/or groin pain during the previous season and HAGOS. In total 49% (95% CI: 45–52%) reported hip and/or groin pain during the previous season. Of these, 31% (95% CI: 26–36%) reported pain for >6 weeks. Players with the longest duration of pain during the previous season had the lowest HAGOS scores, when assessed at the beginning of the new season, P < 0.001. This study documents that half of sub‐elite male adult football players report pain in the hip and/or groin during a football season. The football players with the longest duration of pain in previous season displayed the lowest HAGOS scores in the beginning of the new season.