Peripapillary changes after vitrectomy and silicone oil tamponade for rhegmatogenous retinal detachment

Purpose:To evaluate the peripapillary changes after vitrectomy and silicone oil (SO) tamponade in eyes with rhegmatogenous retinal detachment (RRD).Methods:In this study, 25-gauge vitrectomy with SO tamponade was performed in 22 eyes with RRD. The radial peripapillary capillary (RPC) vessel density (VD) and retinal nerve fiber layer thickness (RNFLT) were assessed by optical coherence tomography angiography at 2, 4, 8, and 12 weeks postoperatively. The values of healthy fellow eyes were used as controls.Results:The global RPC VDs were significantly lower in the eyes with RRD than in fellow healthy eyes at 2 weeks (P < 0.001), and increased at 4 weeks, then decreased over time after surgery (F = 1.046, P = 0.377). The RPC VDs in the superior-hemifield were lower than those in the inferior-hemifield at 12 weeks postoperatively (t = −2.844, P = 0.010). The global RNFLTs decreased gradually after vitrectomy in the eyes with RRD (F = 1.312, P = 0.276). The RNFLTs in the superior-hemifield were thinner than those in the inferior-hemifield at 12 weeks postoperatively (t = −2.222, P = 0.037). The global, superior, and inferior RNFLTs were correlated with corresponding RPC VDs in the eyes with RRD at all time-points postoperatively (P < 0.05).Conclusion:RRD resulted in the decrease of RPC VDs. The RPC VDs recovered in the early postoperative period but were still lower than the normal level. Long-term application of SO tamponade resulted in the reduction of peripapillary VDs secondary to loss of RNFLTs.     

视网膜脱离硅油充填术继发性青光眼临床观察

目的 探讨视网膜脱离硅油充填术继发性青光眼的相关因素及硅油取出对继发性青光眼的影响。方法 统计玻璃体切除硅油充填术视网膜复位后行硅油取出的病例，并对继发性青光眼的发生及其转归进行了随访观察。结果 120例121眼中25眼发生继发性青光眼(20．66％)，硅油取出后经1-3月随访23眼眼压降至正常，2眼药物控制。结论 随着硅油在眼内停留时间的延长继发性青光眼的发生率明显增加，玻璃体切除硅油充填术后以在视网膜复位后3-6月取出为宜。一旦发生继发性青光眼即是硅油取出的指征。     

Retinal displacement following pars plana vitrectomy with silicone oil tamponade for rhegmatogenous retinal detachment

International Ophthalmology - To evaluate the frequency of retinal displacement after pars plana vitrectomy (PPV) using silicone oil tamponade in patients with rhegmatogenous retinal detachment...     

Conventional buckling surgery or primary vitrectomy with silicone oil tamponade in rhegmatogenous retinal detachment with multiple breaks

Background There is controversy about the most appropriate operating methods for complicated rhegmatogenous retinal detachment (RD) including multiple tears, and surgical techniques may be changed according to the preference of the surgeon. In this retrospective study, we compared the surgical results of conventional buckling surgery and vitrectomy with silicone oil tamponade for rhegmatogenous (RD) with multiple breaks.Methods Thirty patients who underwent scleral buckling surgery (group 1) and 22 patients who underwent pars plana vitrectomy with silicone oil tamponade (group 2) as the primary surgery for rhegmatogenous RD with multiple breaks were included in this study. The follow-up period was longer than 6 months after surgery. The anatomical success rates and complications were evaluated for both groups.Results Retinal reattachment was achieved in 24 of 30 eyes (80%) in group 1 and in 20 of 22 eyes (90.9%) in group 2 after the initial surgery. In group 1, subretinal hemorrhage developed due to the drainage of subretinal fluid in 2 eyes (6.6%) intraoperatively. Elevated intraocular pressure (3.3%), ocular motility disturbances (13.2%), and proliferative vitreoretinopathy (3.3%) were seen in the postoperative period. In group 2, iatrogenic breaks (7.3%) and lens damage (9.09%) occurred during the operation. Macular pucker (4.5%), postoperative cataract progression (22.7%), ocular hypertension (9.09%) and PVR (9.09%) were noted postoperatively.Conclusions Both surgical procedures can achieve favorable and comparable anatomic outcomes in the majority of patients in the treatment of RD with multiple breaks. Intra-and postoperative complications are different in the two procedures.     

Outcome of temporary silicone oil tamponade in complex rhegmatogenous retinal detachment

PURPOSE: To evaluate the anatomic and visual outcomes and complications of temporary silicone oil (SO) retinal tamponade in patients with complex rhegmatogenous retinal detachments (RD). METHODS: The retrospective study included 100 eyes of 93 consecutive patients. Indications for the use of SO were proliferative vitreoretinopathy (PVR) (30 eyes), difficult RD (30 eyes), giant retinal tears (17 eyes), RD after penetrating trauma (14 eyes), and macular holes in highly myopic eyes (9 eyes). Vitrectomy surgery was performed with 5000-centistoke SO as the retinal tamponade. All eyes underwent prophylactic 360 degree retinopexy at the time of the retinal reattachment operation. The mean duration of SO tamponade was 26.4 weeks, with a mean follow-up of 67.5 weeks after removal of SO. RESULTS:. In 6 of 100 eyes (6%), the retina redetached after removal of SO. Including the successfully reoperated eyes, the final anatomic success rate was 96%. Other complications were cataract (61%), increased intraocular pressure (13%), hypotony (4%), keratopathy (4%), intravitreal hemorrhage (1%), and suprachoroidal hemorrhage (1%). Correspondence analysis demonstrated that redetachment and hypotony were associated with PVR and trauma. Overall, good visual outcome (20/200 or better) was achieved in 51% of the whole study group, and in 70.6% of eyes with giant tears, 62.1% of eyes with difficult RD, 44.8% of eyes with PVR, 33.3% of eyes with macular holes, and 28.6% of eyes with trauma (p=0.0382). Logistic regression analysis identified initial visual acuity of 20/200 or better as a factor associated with good visual outcome and occurrence of retinal redetachment/hypotony and old age ( > or = 50 years) as factors negatively associated with good visual outcome. CONCLUSIONS: The low redetachment rate might be due to prophylactic 360 degree retinopexy. Giant tears had the best visual outcome. Redetachment/hypotony had a negative impact on achievement of good visual outcome and were associated with PVR and trauma.     

玻璃体切割联合空气或硅油填充术对黄斑脱离型孔源性视网膜脱离患者黄斑区微血管结构的影响

目的 探讨黄斑脱离型孔源性视网膜脱离(RRD)患者经玻璃体切割联合空气或硅油填充术后黄斑区结构和功能的改变以及扫频源光学相干断层扫描血管成像(SS-OCTA)测量参数与最佳矫正视力(BCVA)的相关性。方法 回顾性分析郑州大学第一附属医院眼二科于2021年1月至2022年3月收治的黄斑脱离型RRD患者77例(77眼),根据玻璃体切割术中眼内填充物的不同,分为空气组(37眼)和硅油组(40眼)。分别于术后1周、1个月、2个月通过SS-OCTA观察比较两组患者术眼BCVA和黄斑区微血管结构变化及其相关性。结果 空气组和硅油组患者的BCVA术后均较术前显著改善,差异均有统计学意义(均为P<0.01),两组间对比,术后1周、1个月、2个月空气组较硅油组患眼BCVA改善更明显,差异均有统计学意义(均为P<0.01)。术后2个月与术后1周比较,空气组患眼视网膜浅层血管复合体(SVC)和视网膜深层血管复合体(DVC)的整体血流密度(VD)、黄斑区中心凹血流密度(FVD)、黄斑区旁中心凹血流密度(PFVD)均增加,差异均有统计学意义(均为P<0.01);硅油组患眼SVC的整体VD、P...     

玻璃体切除联合重硅油填充治疗下方PVR视网膜脱离

目的探讨玻璃体切除联合重硅油眼内填充治疗下方严重PVR视网膜脱离的效果。方法对26例（26眼）诊断为合并下方PVR视网膜脱离者行玻璃体切除联合眼内重硅油填充,并同时随机抽取26眼患相似类型的视网膜脱离者,在玻璃体切除术后给予眼内硅油填充作为对照治疗。术后随访7～12月,观察其视网膜复位、视力、眼压及硅油乳化等情况。结果重硅油组视网膜一次性完全复位者24眼,占92．30％,硅油组一次性视网膜完全复位者18眼,占69．23％,（P〈0．05）。视网膜完全复位者绝大部分视力有不同程度提高。所有患者均未见明显炎症反应。结论玻璃体切除联合重硅油眼内填充是治疗下方PVR视网膜脱离的有效方法,可以降低术后视网膜脱离的复发率。     

玻璃体切除联合硅油填充术后高眼压的病因

继发性高眼压是硅油填充术后较常见的并发症,其主要原因有:(1)硅油填充过多;(2)硅油乳化;(3)硅油进入前房;(4)硅油的慢性毒性作用;(5)联合其他手术;(6)眼外伤;(7)患者术前眼基础状况;(8)术后用药及术后体位等.本综述对玻璃体切除联合硅油填充术后继发高眼压的病因、治疗、预后等进行回顾性分析.     

巩膜外黄斑外垫压术治疗硅油填充术后复发性超高度近视黄斑裂孔性视网膜脱离

目的　探讨巩膜外黄斑外垫压术治疗硅油填充术后复发性超高度近视黄斑裂孔性视网膜脱离（macular hole retinal detachment，MHRD） 的可行性及疗效。方法　回顾性分析 2016年6月至2018年1月玻璃体切割硅油填充术后的复发性超高度近视MHRD患者10例（10眼），所有患者均由同一术者行巩膜外黄斑外垫压术，将MEDPOR种植体+人造血管+环扎条带制成的“三明治加压块”固定垫压于黄斑区，术后行眼眶CT检查明确加压块位置。术后6~12个月取出硅油。术后随访18个月，观察并记录术后并发症、视网膜脱离复位、黄斑裂孔闭合情况、术后视力、眼轴长度等指标。结果　眼眶CT显示10眼加压块均位于黄斑区；末次随访 SD-OCT示10眼视网膜完全复位，7眼黄斑裂孔完全闭合，3眼黄斑裂孔部分闭合；9眼术后最佳矫正视力（best corrected visual acuity，BCVA）较术前提高，1眼提高不明显；术前患者 BCVA为（1.55±0.26）LogMAR，术后3个月BCVA为（0.99±0.05）LogMAR，与术前比较差异有统计学意义（P<0.001）；术前患者眼轴长度为（31.27±1.18）mm，术后3个月为（28.81±0.87）mm，与术前比较差异有统计学意义（P<0.001）。所有患眼均未发生眼底出血、眼内炎、涡静脉回流障碍、眼前部缺血综合征等并发症。结论　巩膜外黄斑外垫压术是治疗硅油填充术后复发性超高度近视MHRD安全有效的手术方法，能提高视网膜解剖复位率、黄斑裂孔闭合率和视力。     

视网膜脱离硅油注入术后白内障的手术治疗

目的探讨视网膜脱离硅油注入术后白内障的手术治疗方法及各项术前、术后注意点。方法回顾性分析了本科2003．1～2004．5视网膜脱离硅油注入术后并发白内障病例共35例35眼。硅油注入术后时间6～90月，平均19．7月。术后视力开始下降即白内障发生时间2～48月，平均10．1月。采用传统晶体囊外摘除术或超声乳化白内障摘除 人工晶体植入术。其中术前前房硅油合并继发性青光眼者未放置人工晶体行6：00虹膜周切。采用白内障摘除联合硅油取出术8眼，其中晶体囊外摘除 硅油取出术3眼，超声乳化白内障摘除 硅油取出术5眼。结果经过随访，视力提高33眼，占94．29％；视力达到视网膜脱离术后白内障发生前的最佳视力的有25眼，占71．43％。最高矫正视力达0．4；脱盲率为60％。结论白内障摘除手术对于提高视网膜脱离硅油注入术后并发白内障患者的视力，改善其生活质量有很大的帮助，并有利于对眼底视网膜情况的随访。     

Follow-up of functionally lost eyes after vitrectomy and silicone oil tamponade for tractional retinal detachment

· Background: Is there any association between, on the one hand, retention or removal of silicone oil or any specific ocular finding in patients with functionally lost eyes after vitrectomy and silicone oil tamponade for tractional retinal detachment and, on the other, a greater chance of preservation of the eye? This information is important in deciding whether to remove silicone oil, as well as in counseling patients about their individual chances of preserving their eye. · Methods: Seventy-three consecutive patients with a functionally lost eye with a minimum follow-up of 3 years were retrospectively studied. The relation between the variables at study entry or the removal of silicone oil during the follow-up period and a subsequent intervention (enucleation, evisceration or conjunctival cover with a scleral shell) were tested for statistical significance with Cox proportional hazards analyzis. · Results: The absence or removal of silicone oil was not associated with a greater chance of finally preserving the eye. Nor could we identify other factors which predicted better chances of preservation. · Conclusion: The notion that functionally lost eyes after treatment with vitrectomy and silicone oil tamponade for complicated tractional retinal detachment have better chances of preservation of the eye without silicone oil is not supported by our study.     

玻璃体切割注硅油术治疗复杂性视网膜脱离的远期疗效和并发症

目的探讨玻璃体切割注硅油术治疗复杂性视网膜脱离的远期疗效和并发症,并对如何改进硅油应用方法进行讨论。方法回顾性分析了５０例硅油注入病例。结果手术后视网膜复位率为９４％,随访１２～４１个月,复位率降为７０％,并发症总发生率９０％,其中白内障发生率为７８％（有晶体眼白内障为９７．５％）,硅油进入前房、继发性青光眼、角膜病变各为２４％,１０例行硅油取出,其中５例视网膜再脱离,另有２例先发生前房出血后视网膜脱离。结论硅油长期在眼内导致严重并发症,硅油取出后又有视网膜再脱离及其它新并发症的危险,临床上应用硅油要严格掌握适应症和方法。     

内外路手术治疗孔源性视网膜脱离后黄斑前膜生成的比较与分析

目的 观察巩膜扣带术和玻璃体切除术治疗孔源性视网膜脱离后黄斑前膜的发生情况.方法 回顾性分析研究.筛选我院2013年8月至2014年12月入院诊断为“孔源性视网膜脱离”的患者70例(70只眼),均为有经验的同一组术者行巩膜扣带术或玻璃体切除术,根据其所接受的不同术式划分为A组(行巩膜扣带术)及B组(行玻璃体切除术),术后所有患者均在同一时间点接受相干光断层扫描(OCT)检查,并进行统计分析.结果 OCT检查两组视网膜黄斑区纤维增生膜的发生率,差异有显著性.结论 对于孔源性视网膜脱离,内路玻璃体切除术较之外路巩膜扣带术,有更高的术后黄斑前膜发生率.     

Primary rhegmatogenous retinal detachment: evaluation of a minimally restricted face-down positioning after pars plana vitrectomy and gas tamponade

AIM: To systematically understand the genetic association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and primary open angle glaucoma (POAG). METHODS: A comprehensive literature search in Google Scholar, PubMed, SCI, foreign medical literature retrieval service, CNKI and Wanfang databases was performed to collect all eligible studies up to August 2019. Study selection, data abstraction and study quality evaluation were performed by two independent investigators. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Publication bias was tested by funnel plot and Begg’s test. RESULTS: Totally 18 case-control studies involving 2156 cases and 2201 controls were retrieved. There was no evidence of significant association in the Caucasian population (for allelic model: OR=1.11, 95%CI=0.88-1.39; for additive model: OR=1.01, 95%CI=0.76-1.36; for dominant model: OR=1.15, 95%CI=0.84-1.58 and for recessive model: OR=1.02, 95%CI=0.78-1.33). However, significant associations were revealed in the Asian population (for allelic model, OR=1.34, 95%CI=1.12-1.59; for dominant model: OR=1.41, 95%CI=1.14-1.76). CONCLUSION: This Meta-analysis shows that there were significant associations between MTHFR C677T polymorphism and POAG in allelic model and dominant model for Asians subgroup indicating that the T allele or TT +TC genotype might increase the risk of POAG.     

玻璃体切除联合空气填充治疗高度近视合并非黄斑孔的孔源性视网膜脱离的疗效

目的 初步观察玻璃体切除手术(PPV)联合空气填充治疗高度近视眼合并非黄斑孔的孔源性视网膜脱离(RRD)的可行性及疗效.设计回顾性病例系列.研究对象2017年5月至2021年2月期间在南京爱尔眼科医院接受23G PPV术治疗的高度近视合并非黄斑孔的增生性玻璃体视网膜病变(PVR)C3以下的RRD患者56例(56眼).方...     

硅油填充在病理性高度近视眼黄斑裂孔性视网膜脱离术后的1年观察

目的通过对病理性高度近视眼黄斑裂孔性视网膜脱离(MHRD)的患者进行玻璃体切除术后填充硅油,主要观察和探讨此类疾病玻璃体手术填充硅油后视网膜的首次复位率和手术并发症,为此类手术后玻璃体腔填充材料提供临床指导依据。方法观察玻璃体切割联合眼内填充硅油的病理性高度近视MHRD患者,对手术后1周及1、3、6、12个月,视网膜复位率和眼压进行研究,观察患者视网膜复位及眼压的情况,得出个体化的填充方式。结果初次手术后,视网膜复位率为88.0%,半年后硅油取出,视网膜总复位率为75.0%;高眼压的发生在1周内最多,多数药物控制良好。结论病理性高度近视MHRD患者玻璃体手术联合硅油填充视网膜复位率较高,高眼压的发生较常见,但药物控制良好,无其它严重并发症发生。