A mutated CRYGD associated with congenital coralliform cataracts in two Chinese pedigrees

AIM: To investigate the causal gene mutation and clinical characteristics for two Chinese families with autosomal dominant congenital coralliform cataract. METHODS: Two Chinese pedigrees with congenital cataract were investigated. Routine ophthalmic examinations were performed on all patients and non-affected family members. Peripheral blood samples were collected, and the genomic DNAs were extracted. The coding regions of proband’s DNAs were analyzed with cataract gene panel. The identified mutation was amplified by polymerase chain reaction, and automated sequencing was performed in other members of two families to verify whether the mutated gene was co-segregated with the disease. RESULTS: Congenital coralliform cataract was inherited in an autosomal dominant mode in both pedigrees. For each family, more than half of the family members were affected. All patients presented with severe visual impairment after birth as a result of bilateral symmetric coralliform lens opacification. An exact the same defect in the same gene, a heterozygous mutation of c.70C>A (p. P24T) in exon 2 of γD-crystallin gene, was detected in both probands from each family. Sanger sequencing analysis demonstrated that the mutated CRYGD was co-segregated in these two families. CONCLUSION: A c.70C>A (p. P24T) variant in CRYGD gene was reconfirmed to be the causal gene in two Chinese pedigrees. It is known that mutated CRYGD caused most of the congenital coralliform cataracts, suggesting that the CRYGD gene is associated with coralliform congenital cataract.     

Trends in research related to high myopia from 2010 to 2019: a bibliometric and knowledge mapping analysis

AIM:To evaluate the global trends in and explore hotspots of high myopia(HM)research.METHODS:This bibliometric analysis was used to reveal the publication trends in HM research field based on the Web of Science Core Collection(WoSCC).VOSviewer version 1.6.13 software was used to analyze the data and construct a knowledge map including the yearly publication number,journals,countries,international collaborations,authors,research hotspots,and intellectual base in HM.RESULTS:The search engine found 3544 peer-reviewed publications on HM between 2010 and 2019,and the yearly research output substantially elevated over the past decade.China is the top publishing country,and Sun Yatsen University was the most active academic institution.Jonas JB is the top publishing scientist,and Investigative Ophthalmology and Visual Science(IOVS)was the most productive journal.The highest cited references mainly focused on epidemiology and management.The keywords formed 6 clusters:1)refractive surgery;2)etiology and clinical characteristics;3)the mechanism of eye growth;4)management for myopic maculopathy;5)vitrectomy surgical treatment;6)myopia-associated glaucoma-like optic neuropathy.CONCLUSION:The evaluation of development trends based on the data extracted from WoSCC can provide valuable information and guidance for ophthalmologists and public health researchers to improve management procedures in HM field.     

Spectral domain anterior segment optical coherence tomography assessment of pterygium and pinguecula

Purpose: To study the morphological patterns of pterygia and pingueculae using high‐resolution anterior segment spectral domain optical coherence tomography (SD‐OCT). Methods: Prospective cross‐sectional study of 25 eyes presented with pterygia and pingueculae was conducted, and the eyes were examined by anterior segment SD‐OCT. Results: We examined 25 eyes, including 13 eyes with primary pterygia, six eyes with recurrent pterygia, one case with a pseudopterygium and five eyes with pingueculae. Primary pterygia revealed elevation of the corneal epithelium by a wedge‐shaped mass of tissue separating the corneal epithelium from the underlying Bowman’s membrane, which became wavy and interrupted. We found satellite masses of pterygium tissue advanced under the epithelium beyond the clinically seen pterygium margins. In recurrent pterygia, we detected that the central tip of the pterygium was more advanced and creeping beneath the basal corneal epithelium than the primary pterygium. In pseudopterygium, the SD‐OCT images showed that the overgrowing membrane was not really attached to the underlying cornea. In cases of pingueculae, SD‐OCT revealed a wedge‐shaped mass that was nearly similar in pattern to that of the pterygia but stopped at the limbal region. Immediately after removal of pterygia, we noticed many remnants of the pterygia masses over the corneal stroma in spite of the clinically clear appearance of cornea. Conclusions: SD‐OCT provided us with high‐resolution images of the pterygium and the pinguecula and showed clearly the anatomical relationship between the corneal tissues and these lesions. The use of this new modality of imaging may help to decrease the current recurrence rates after pterygium excision through using the anterior segment SD‐OCT in the evaluation of these lesions.     

Bibliometric study of diabetic retinopathy during 2000-2010 by ISI

AIM: To analyze the progress in diabetic retinopathy (DR) researches between 2000 and 2010 through bibliometric study. METHODS: Using ISI Web of Science database for statistical sources, we retrieved DR literatures during 2000-2010, analyzed "the number of published articles per year, authors, source publications, subject category, document type, document language, institution and country/region" by bibliometric statistical methods. RESULTS: The total number of published articles that were retrieved for the years during 2000-2010 was 8590. DR researches changed as a linear upward trend, the main researches focused on ophthalmology, endocrine and metabolic diseases. Article was the main document type. Harvard University was the major research institution. CONCLUSION: There has achieved a significant increase in the number of ISI publications and collaborations in DR literatures from 2000 to 2010. With the rising of the number of diabetes in the world, diabetic retinopathy has become a focus of scientific researches.     

Bibliometric analysis of hotspots and trends of global myopia research

AIM: To gain insights into the global research hotspots and trends of myopia. METHODS: Articles were downloaded from January 1, 2013 to December 31, 2022 from the Science Core Database website and were mainly statistically analyzed by bibliometrics software. RESULTS: A total of 444 institutions in 87 countries published 4124 articles. Between 2013 and 2022, China had the highest number of publications (n=1865) and the highest H-index (61). Sun Yat-sen University had the highest number of publications (n=229) and the highest H-index (33). Ophthalmology is the main category in related journals. Citations from 2020 to 2022 highlight keywords of options and reference, child health (pediatrics), myopic traction mechanism, public health, and machine learning, which represent research frontiers. CONCLUSION: Myopia has become a hot research field. China and Chinese institutions have the strongest academic influence in the field from 2013 to 2022. The main driver of myopic research is still medical or ophthalmologists. This study highlights the importance of public health in addressing the global rise in myopia, especially its impact on children’s health. At present, a unified theoretical system is still needed. Accurate surgical and therapeutic solutions must be proposed for people with different characteristics to manage and intervene refractive errors. In addition, the benefits of artificial intelligence (AI) models are also reflected in disease monitoring and prediction.     

Profile of complications in pterygium surgery - A retrospective analysis

Purpose:Analysis of complication profile after pterygium excision, in primary and recurrent pterygia.Methods:Retrospective analysis of all the patients who had undergone pterygium excision in a tertiary center in South India from 2010 to 2018 was analyzed. A total of 2356 eyes in 2028 patients were included in the study. Patients who had undergone conjunctival autografting for primary pterygium, conjunctival limbal autografting for recurrent pterygium, vertical split conjunctival autografting for double head pterygium were included in the study. In all the surgical procedures fibrin glue was used for fixation of the autograft. The follow-up period ranged from 6 months to 75 months, with an average of 17 months. Patients with less than 6 months of follow-up were excluded from the study.Results:The following postoperative complications were noted, Sub-conjunctival hemorrhage in 912 eyes (38.7%), edema of the graft in 522 cases (22.15%), graft loss in 22 cases (0.93%), graft retraction in 692 cases (29.37%) and sliding of the graft was seen in 9 cases (0.38%). Granuloma was seen in 4 cases (0.16%) at the host site and 5 cases (0.21%) at the donor site. Recurrence was seen in 34 patients (1.44%). Other severe complications like corneal melt were seen in only 1 case (0.04%) who was operated on for recurrent pterygium. In comparison between primary and recurrent pterygia; subconjunctival hemorrhage, edema of the graft, graft loss, and recurrence was significantly (P < 0.05%) higher in recurrent pterygia.Conclusion:Various complications can occur post pterygium surgery as listed above. Selecting a proper procedure for a particular type of pterygium with a proper graft fixation technique will improve the outcome with minimal complications.     

复发性翼状胬肉的治疗分析

目的:探讨复发性翼状胬肉的治疗方法。方法:对42例(45眼)复发性翼状胬肉先行激素点眼及用含950mL/L酒精的小棉片贴敷后手术切除。术中加用丝裂霉素C并行角膜缘干细胞移植,对有睑球粘连患者加用羊膜覆盖。结果:所有患者随访6～12mo,均恢复良好,无复发。结论:对复发性翼状胬肉应根据病情进行综合分析与治疗。     

人翼状胬肉中miR-486-3p的表达及其潜在靶基因的生物信息学分析

目的：通过检测人翼状胬肉组织及正常结膜组织中miR-486-3p的表达情况,探寻其在翼状胬肉发生发展中可能的作用机制。

方法：于2018-09/2019-12收集原发性翼状胬肉患者69例69眼,收集术中切除的翼状胬肉组织和术眼正常结膜组织,采用RT-PCR定量检测标本中miR-486-3p的相对表达量,并利用 Targetscan数据库、miWalk3.0数据库、miRDB数据库对miR-486-3p进行靶基因预测后将得到的潜在靶基因取交集; 采用DAVID数据库对miR-486-3p潜在靶基因进行功能和通路富集分析; 采用String网站对miR-486-3p潜在靶基因进行互作分析。

结果：miR-486-3p在翼状胬肉组织中的相对表达量\〖(6.183±1.366)×10^-6\〗与正常结膜组织的相对表达量\〖(7.930±1.394)×10^-5\〗有显著差异(P<0.0001)。通过对其靶基因预测及生物信息学分析发现miR-486-3p潜在靶基因436个,其生物学功能主要富集于对RNA聚合酶Ⅱ启动子转录的调控、囊泡介导的转运和转录调控、DNA依赖性RNA代谢过程的调控。KEGG通路主要富集于神经轴突导向(Axon guidance)通路及溶酶体通路上,其中Axon guidance通路可能对翼状胬肉的发生发展起着重要的调控作用。PPI网络分析进一步表明Axon guidance通路中的关键基因ABL1、PLXNA1对翼状胬肉具有重要作用。

结论：miR-486-3p可能通过SLIT(神经导向因子Slit)/Robo(回旋引导受体)和SEMA3A(神经导向因子Semaphorin 3A)/PLXNA1(丛蛋白受体 A1)等Axon guidance通路致翼状胬肉的新生血管异常,从而参与翼状胬肉的发生、发展。     

基于文献计量学的国内外儿童青少年近视研究现状与趋势

目的：探究国内外儿童青少年近视的研究现状、热点和未来的发展趋势,为该领域深入研究提供借鉴和参考。方法：以中国知网(CNKI)和Web of Science(WOS)为数据源,收集2003-01-01/2022-12-31儿童青少年近视研究领域的文献,使用VOSviewer进行发文量、作者、发文机构和期刊分析; 使用CiteSpace进行关键词共现、关键词聚类、关键词时间线图谱和关键词突现分析。结果：中文和英文文献量整体呈现增长趋势; 文献量最高的作者分别是何鲜桂和Saw Seang-Mei,期刊分别是《中国学校卫生》和Investigative Ophthalmology &#x0026; Visual Science,机构分别是上海市眼病防治中心和Sun Yat-sen University。国内外均以临床观察为主,研究热点显示,对于角膜塑形镜、户外活动、眼轴、患病率和影响因素等的研究备受关注。结论：目前国内外对于儿童青少年近视的研究主要围绕流行病学、干预措施和生物学参数展开,未来针对近视流行病学的研究将会成为热点。     

基于Web of Science ISI数据库白内障手术麻醉研究文献计量学分析

目的：从文献计量学的角度分析2001/2011年间白内障手术麻醉研究文献状况。

方法：利用Web of Science(科学网)为统计源,检索2001/2011年白内障手术麻醉研究文献,利用文献计量学方法,对“年出版文章数量、作者、来源出版物、学科类别、文献类型、文献语种、机构、国家/地区”方面进行统计分析。探讨研究趋势、文献分布等。

结果：统计Web of Science数据库中白内障手术麻醉文献量年度间变化呈波状趋势,发表以论著形式为主,约翰霍普金斯大学是主要研究机构,文献主要由眼科学人员报告,《白内障和屈光手术杂志》是主要文献来源。

结论：随着白内障手术的普及,手术麻醉的研究显得越来越重要,探索安全有效的麻醉方式具有重要的临床应用意义。     

PubMed数据库中1858/2010年有关青光眼的文献计量学分析

目的:对青光眼文献进行计量分析,以确定文献增长规律和发展趋势。方法:登录www.ncbi.nlm.nih.gov/PubMed后用"glaucoma(青光眼)"检索"从1858-01-01/2010-12-31"的文献量,同时检索数据库中文献的年文献量(每5a为一时间段)、中文收录情况、语言分布、文献类型分布、期刊分布、相关研究内容情况等,根据文献增长规律的理论,对检索出的数据进行分析。结果:1858/2010年PubMed数据库收录青光眼文献45514篇,逐年累积文献量均呈递增趋势,其方程近似直线(Y=579.34X-568.38,R2=0.882)。1858/2010年青光眼文献以英语为主导(71.50%),中文发表的文献量排在第12位(0.31%),PubMed收录中文青光眼文献从2006年开始,2009年后明显上升。根据PubMed数据库文献类型,包括Clinical Trial(2947篇)、Editorial(648篇)、Letter(1727篇)、Meta-Analysis(81篇)、Practice Guideline(15篇)、Randomized Controlled Trial(1787篇)、Review(3633篇)、Others(34678篇);收录青光眼文献根据JournalGroups分为Core Clinical Journals(625篇)、Dental Journals(5篇)、Nuring Journals(42篇)、Others(44844篇);与Humans相关文献37194篇,Animals相关文献4223篇,Others为4099篇。PubMed中19种青光眼核心期刊收录文献20526篇(45.10%)。结论:青光眼研究的文献量均呈上升趋势,表明青光眼的研究仍是一个热点,影响青光眼文献增长的主要因素是学科发展所处的环境条件。     

翼状胬肉术后巩膜并发症的临床分析及治疗观察

目的分析不同术式翼状胬肉切除术后巩膜并发症的临床表现、原因及治疗。方法回顾性研究翼状胬肉手术治疗且未再次复发的患者200例（200眼）,原发性翼状胬肉153眼,复发性者47眼。根据术式的不同分为3组,分析各组的临床表现,可能原因及治疗效果。结果术后出现巩膜局部轻度软化者24眼,14眼经停用皮质类固醇类及抗代谢类滴眼液后恢复;10眼经停用滴眼液及加用营养类药物后治愈。出现巩膜融解坏死者3眼,行羊膜覆盖治愈。结论因术式或术中术后用药等可导致胬肉切除术后出现巩膜并发症,早期诊断和有效治疗对改善其后果至关重要。     

2012-2016年中文青光眼相关文献的计量学分析

目的 探讨2012-2016年我国中文青光眼相关文章的整体情况。设计 文献计量学分析。研究对象  2012-2016年中文的青光眼相关文献。方法 利用中国学术期刊、万方电子期刊、中国生物医学文献数据库联合检索2012-2016年我国的中文青光眼相关文献,利用文献计量学的方法,对所发表的相关文献的论文数量及年代、发文机构、核心作者、期刊分布情况进行统计描述,对文献的关键词进行文本挖掘词云和聚类分析,以归纳青光眼领域的研究热点。主要指标 文献的年份分布、作者单位分布、作者分布、所属期刊分布、关键词聚类分析。结果 共检索到青光眼相关中文论文8332篇,自2014年起文献发表呈下降趋势（1707篇,1781篇,1698篇,1611篇,1535篇）。发表文章数量前三的单位是北京同仁医院（205篇）、中山眼科中心（109篇）、复旦大学附属眼耳鼻喉科医院（78篇）。发表文章前三的作者是王宁利（65篇）、李建军（37篇）、孙兴怀（30篇）。刊载文献数量最多的期刊是国际眼科杂志（622篇）。近五年青光眼研究的热点是晶状体与青光眼的关系及青白联合手术、原发性闭角型青光眼的治疗及白内障手术在抗青光眼中的应用、急性闭角型青光眼的降眼压治疗及临床护理、抗青光眼手术（包括小梁切除术、复合式小梁切除术、房角分离手术等）的临床效果及并发症、相干光断层扫描在青光眼中的应用。结论 文献计量学分析可有效归纳我国青光眼相关文章发表的大体状况,我国中文青光眼相关文章发表有下降趋势,原发性闭角型青光眼的研究仍是近五年我国眼科的研究热点。     

Efficacy of second donor conjunctival graft from the same site for pterygium - A retrospective analysis

Purpose:To know the efficacy of the second donor conjunctival graft from the same site as that of the previous donor area in pterygium treatment.Methods:Case record of patients were retrospectively analysed and those patients who had undergone pterygium excision previously, either for nasal or temporal pterygium excision and came with complaints of pterygium growth in opposite side of the bulbar conjunctiva in the same eye were included in the study. The patients with double head pterygium previously treated only over one side were also included. Total of 23 such patients were included in the study. The patients were followed up on post-operative day 1, 2 weeks, 6 weeks, 6 months and 1 year. The outcome measures like recurrence, graft edema, graft retraction, graft loss and other complications were noted in each follow up.Results:Among the 23 patients included in the study 9 were male and 14 were female patients with a mean age of 44±7.2 years (range 24-57 years). On an average follow up period of 15±8.5 months, only 1 patient among 23 patients had recurrence (4.43%). Other complications noted were graft retraction in 4 eyes (17.4%), sub conjunctival hemorrhage in 8 eyes (34.8%) and graft edema in 11 eyes (47.8%). Only one patient presented with granuloma (4.34%).Conclusion:The second conjunctival graft from the same site is safe and effective with encouraging results in indicated cases.     

不同类型翼状胬肉手术方式的临床对比研究及大样本回顾性统计分析

目的　探索一种复发率低、简易可行的翼状胬肉手术方式,规范翼状胬肉的治疗。方法　采用回顾性分析的方法统计中国期刊网近年翼状胬肉不同手术方式的研究结果,研究对象分为６组:单纯切除组、结膜移植组、羊膜移植组、羊膜移植＋丝裂霉素Ｃ（ｍｉｔｏｍｙｃｉｎＣ,ＭＭＣ）浸润组、角膜缘干细胞（ｌｉｍｂａｌｓｔｅｍｃｅｌｌ,ＬＳＣ）移植组、角膜缘干细胞移植（ＬＳＣ）＋ＭＭＣ浸润组,同时对临床常用的３种不同手术方式进行临床观察对比研究。所有数据采用ＳＰＳＳ１９．０统计软件分析。结果　翼状胬肉６种手术方式的复发率总体比较差异有显著统计学意义（χ２ ＝１３３．２６０,Ｐ＜０．００１）,其中单纯切除术（２０．００％）、结膜移植术（４６１５％）与其他术式间复发率差异均有统计学意义（均为Ｐ＜００５）;羊膜移植术、羊膜移植＋ＭＭＣ术、角膜缘ＬＳＣ移植术两两组间比较,差异均无统计学意义（均为Ｐ＞０．０５）;角膜缘ＬＳＣ移植＋ＭＭＣ术的术后复发率最低（０．３６％）。结论　角膜缘ＬＳＣ移植＋ＭＭＣ术是一种复发率低、可进行临床推广治疗翼状胬肉的有效术式。     

基于BiblioShiny的先天性白内障可视化文献计量分析（2011─2020年）

目的：基于BiblioShiny程序分析2011 ─2020 年全球先天性白内障的研究现状与发展趋势,为进一步 的研究提供参考信息。方法：文献计量分析方法。运用基于R语言的科学文献计量BiblioShiny程序, 对2011 ─2020 年Web of ScienceTM核心合集数据库（WoSCC）收录的关于先天性白内障的相关文献, 从期刊、国家与作者分布、共词分析、共被引分析、合作网络等深入分析全球先天性白内障的研究 知识基础和研究前沿热点。结果：①共纳入1 492篇研究文献,以中国和美国发文量最多。②《Molecular Vision》杂志的出版物发表量排名榜首,刊文74 篇,其次是《PLoS One》,刊文66 篇,二者均为美国 期刊。③发文量第1位的是来自加利福尼亚州帕罗奥多市斯坦福大学医学院眼科的Lambert SR博士。 ④先天性白内障领域的知识基础是先天性白内障和基因突变,目前的学术研究热点是基因表达主题。 ⑤研究方向可以分为3大集群：第1集群为先天性白内障的发病率、危险因素和手术治疗等;第2集群 的研究内容主要是分子遗传、基因突变和蛋白质功能改变等;第3集群的研究内容主要集中在晶状体 蛋白的结构、稳定性和功能等。结论：2011 ─2020 年先天性白内障研究领域中,中国和美国为发文 量最多的国家,但是美国在国家间、机构间的合作网络均远大于中国,提示中国可提高国家、机构 间的合作率。目前先天性白内障主流研究方向可分为临床治疗、基因层面和蛋白质层面。     

翼状胬肉患者屈光状态的检测

目的 :探讨翼状胬肉患者的特殊屈光状态。方法 :对 40例 6 2眼翼状胬肉患者进行视力检查、主客观屈光度检查、角膜曲率检查和翼状胬肉侵入角膜的长度测量。结果 :5 0眼裸眼视力在 0 .4以上 ;5 7眼均有不同程度的散光 ,其散光程度与胬肉长度有关 ,其中顺规性散光 33眼 (占 5 7.9% ) ,远视性散光 36眼 (占 6 3.2 % ) ;5 0眼 (80 .6 % )矫正视力在 0 .8以上。综合验光、检影验光得出的散光度与电脑验光得出的散光度差异有显著性。结论 :翼状胬肉患者的角膜散光以顺规性散光和远视性散光为主 ,翼状胬肉的长度与散光关系较为密切 ,其散光度的检查应该以检影验光和规范的主觉验光为准 ,配戴矫正的框架眼镜可提高翼状胬肉患者的视力 ,并可缓解其疲劳程度     

翼状胬肉组织微量元素的同步辐射微束X射线荧光分析法研究

目的 应用同步辐射微束X射线荧光分析法测定翼状胬肉组织、自体同侧正常结膜组织中钙、铁、铜、锌、铅等微量元素的分布及其差异.方法 8例(10眼)原发性翼状胬肉患者,行翼状胬肉切除+自体角膜缘干细胞移植术.应用同步辐射微束X射线荧光分析法测定翼状胬肉组织、自体同侧正常结膜组织中钙、铁、铜、锌、铅等微量元素的相对含量及差异.结果 翼状胬肉组织和自体同侧正常结膜组织中存在钙、铁、铜、锌、铅等微量元素,检出率均为100％.正常结膜组织中钙、铜、铅等微量元素的含量分别为8 545.50±903.65、1 605.25±524.30、5 171.02±712.04,均高于自体同侧翼状胬肉组织(4 226.50±647.19、1 004.10±135.55、3 971.23±183.88),差异均有统计学意义(t值分别为26.92、7.69、11.32,均为P＜0.05).正常结膜组织中铁、锌元素的含量(17 653.67±10 851.02、9 703.88±3 286.05)均低于自体同侧翼状胬肉组织(49 198.48±21 297.67、14 907.71±1 820.60),差异均有统计学意义(t值分别为8.56、9.60,均为P＜0.05).翼状胬肉组织微量元素分布在头部聚集较多,结膜组织微量元素分布呈分散性.结论 翼状胬肉组织中,微量元素钙、铜、铅元素较自体同侧正常结膜组织减少;锌、铁元素较自体同侧正常结膜组织增加.在翼状胬肉组织中微量元素分布呈一定规律性,正常结膜组织微量元素分布呈分散性.     

Comparison of conjunctival graft thickness after primary and recurrent pterygium surgery: Anterior segment optical coherence tomography study

Objective:

The objective of the following study is to compare the conjunctival graft thickness measured with anterior segment optical coherence tomography (OCT) after primary and recurrent pterygium excision.

Design:

Prospective, interventional and comparative study.

Participants:

A total of 20 eyes of 20 patients with primary pterygium (primary group) and 20 eyes of 20 patients with recurrent pterygium (recurrent group) were enrolled.

Materials and Methods:

All patients underwent pterygium excision with conjunctival autograft transplantation. Conjunctival graft thickness was measured at 1 week, 1 month and 3 months after surgery using the Visante-OCT (Carl-Zeiss Meditec, Dublin, CA, USA). Main outcome measure was the mean conjunctival thickness determined as the mean of three measurements at 1, 2 and 3 mm posterior to the scleral spur.

Results:

There were no statistically significant differences in age, sex, or laterality between the groups. Mean thickness of the graft in primary and recurrent groups, respectively, was 430 ± 127 μm and 461 ± 178 μm at 1 week after surgery (P = 0.587), 114 ± 19 μm and 162 ± 48 μm at 1 month after surgery (P = 0.001) and 109 ± 15 μm and 107 ± 18 μm at 3 months after surgery (P = 0.726).

Conclusion:

The findings revealed that conjunctival thickness after primary or recurrent pterygium excision was greatest at 1 week after surgery and continued to decrease for up to 3 months. Mean graft thickness differed significantly between the two groups only at 1 month after surgery.     

Bibliometric analysis of research relating to refractive cataract surgery over a 20-year period: from 2003 to 2022

AIM: To investigate the research trend on refractive cataract surgery, compare the contributions of different countries, institutions, journals, and authors in the past 20y, and explore its potential research hotspots.METHODS: All publications were extracted relating to refractive cataract surgery from 2003 to 2022 from Web of Science. Document types were limited to original articles and reviews, and the language was limited to English. Quantitatively and qualitatively of the publications were analyzed through Microsoft Excel and GraphPad Prism. VOSviewer and CiteSpace were used for bibliometric and visualized analysis.RESULTS: A total of 2090 publications were enrolled. The United States contributed the most publications (434, 20.8%), followed by China (345, 16.5%) and England (163, 7.80%). Publications from the United States were cited more frequently (9552 citations) with the highest H-index of 48. China ranked second in the total number of publications, the papers were not cited that frequently (3237 citations), and the H-index ranked sixth (H-index=29). Journal of Cataract and Refractive Surgery published the most papers (333, 15.9%), and the University of London had the highest number of publications (75, 3.59%). Dick HB from Germany published the most papers. Corneal astigmatism-related research, cataract surgery method-related research, postoperative visual-quality relate to research, and postoperative complications-relate research are the hotspots in this field. The most significant limitation was that the database was updated frequently and the latest publications were not included.CONCLUSION: The bibliometric analysis shows a brief summarization of the contribution of the authors, institutions, countries, and journals. Corneal astigmatism, cataract surgery method, postoperative visual-quality and postoperative complications related researches have become the emerging hotspots, which can give a direction in the future researches.