槟榔对功能性消化不良模型大鼠胃运动的影响

目的观察槟榔对功能性消化不良(FD)模型大鼠胃平滑肌运动的影响.方法夹尾刺激复制FD模型,采用应变片传感器整体记录方法,测定FD模型大鼠胃运动并与正常对照鼠比较,以鉴定模型的合理性;测定高浓度槟榔煎液(100%)和低浓度槟榔煎液(25%)对FD模型大鼠胃运动振幅和频率的影响.结果模型组大鼠空腹和灌注0.85%氯化钠溶液后与对照组比较,胃运动频率明显下降(P<0.01),振幅减弱(P<0.05).两种浓度槟榔煎液均可显著增强FD大鼠胃收缩振幅指数,而对FD大鼠胃运动频率无明显影响(P>0.05).结论造模符合FD病理生理特点;槟榔有显著的促FD大鼠胃平滑肌收缩的作用,主要增强收缩振幅.     

胆囊收缩素与功能性消化不良患者胃电活动及胃运动相关性的临床研究

胆囊收缩素 (ＣＣＫ)是一种具有广泛生物活性的脑肠肽 ,能引发胃电节律失常及胃运动功能障碍。我们旨在探讨功能性消化不良 (ＦＤ)患者血浆ＣＣＫ浓度与胃电活动及胃排空运动的相关性。一、资料与方法1.对象 :对照组 15例 ,男 12例 ,女 3例 ,年龄 2 3～ 5 8岁 ,平均 2 9岁 ,均无消化系统疾病及胃肠道症状 ,无腹部手术史。ＦＤ组 2 8例 ,男 2 3例 ,女 5例 ,年龄 2 5～ 5 4岁 ,平均 32岁。受试前 1周禁用影响消化道运动功能的药物。2 .方法 :①胃肌电活动测定 :用ＹＷＣ 4型胃肠电放大仪、30 6 6型多导生理记录仪进行空腹及试餐状态下 ,从肘静…     

功能性消化不良发病机理的研究进展

功能性消化不良是十分多见的症群，近年来颇引人注目，其发病是多因素参与的，并与个体素质，环境因素等有关。本文综述了胃酸、胃肠运动和胃排空变化，腹腔感觉变化，幽门螺杆菌定值和慢性胃炎等在ＦＤ发病机理中的作用。     

针刺对功能性消化不良患者近端胃动力的影响

目的：观察针刺对功能性消化不良患者机械性胃扩张近端胃动力的影响．方法：功能性消化不良患者60例分为针灸组和对照组,分别进行等容机械性胃扩张．观察近端胃动力参数：最小牵张压(MDP),初始容积和压力,最大耐受容积、压力和顺应性(容积和压力的比值)．结果：两组最小牵张压无显著性差异(5．28±2．62mmHg vs 4．98±1．87mmHg,P＞0．05),针灸组的初始压力和容积(8．06±2．95mmHg vs 5．40±2．41mmHg,560．9±119．5mL vs 352．0±139．3mL),最大耐受压力和容积(13．25±2．23mmHg vs 9．82±1．9mmHg,810．7±119．62mL vs 504．1±159．6mL),顺应性(61．2±18．6mL/mmHg vs 51．4±17．8mL/mmHg)均显著高于对照组(P＜0．05)．结论：针灸可以显著提高功能性消化不良患者的近端胃动力,降低内脏敏感性．     

调胃汤治疗功能性消化不良的临床及实验研究

[目的]通过实验和临床研究探讨中药复方调胃汤治疗功能性消化不良（FD）的作用机制。[方法]予大白鼠分别灌服调胃汤及其双倍剂量调胃汤、西沙必利溶液、蒸馏水，再灌服葡聚糖蓝2000，然后处死动物取胃肠，以分光光度计λ620nm测定胃内葡聚糖蓝2000残留量，并计算自幽门括约肌至色素最前端及至盲肠距离百分比为小肠推进比。FD患者95例，随机分成治疗组67例．予调胃汤加减治疗；对照组28例，子多潘立酮治疗，4周为1个疗程，观察治疗前后疗效。[结果]调胃汤组胃内色素残留率小于空白组和西沙比利组（P〈0．01，〈0．05），平均小肠推进率大于对照组（P〈0．01），与西沙比利组相似（P〉0．05）。治疗组改善主要症状作用优于对照组（P〈0．05），总疗效作用相似（P〉0．05），但显效率明显高于对照组。[结论]调胃汤有较好的促进胃肠运动的作用，是治疗FD的有效方剂，值得进一步研究。     

枳实总黄酮苷提取物对功能性消化不良大鼠近端胃适应性的影响

[目的]探讨枳实总黄酮苷提取物(aurantii fructus immaturus flavonoid,AFIF)对功能性消化不良(functional dyspepsia,FD)模型大鼠胃适应性的影响及其可能的作用途径。[方法]10日龄雄性SD大鼠86只,随机分为正常组22只及造模组64只,造模组采用碘乙酰胺(iodoacetamide,IA)灌胃法联合夹尾应激法诱导大鼠FD模型;至大鼠8周龄时将造模组大鼠随机分为枳实总黄酮苷提取物大、中、小剂量组及模型组,分别予大、中、小剂量的枳实总黄酮苷提取物或生理盐水干预14d,给药结束后,各组大鼠经食道置入胃内气囊,应用电子恒压器对胃内气囊分阶段加压,检测大鼠胃适应性,加压程序为:以1mmHg为起始压力,维持10min后,每分钟压力升高1mmHg直至10mmHg(斜坡期),在10mmHg压力下维持10min(平台期)。应用离体平滑肌张力测定技术检测不同浓度的枳实总黄酮苷提取物对大鼠近端胃体离体纵行平滑肌张力的影响。[结果]近端胃适应性检测结果显示:在斜坡期及平台期,模型组大鼠胃适应性较正常组显著降低(P<0.05);枳实总黄酮苷提取物大剂量组(大剂量组)大鼠胃适应性在斜坡期及平台期均较模型组显著升高(P<0.05);枳实总黄酮苷提取物中剂量组(中剂量组)大鼠胃适应性在平台期较模型组显著升高(P<0.05);枳实总黄酮苷提取物小剂量组(小剂量组)大鼠胃适应性较模型组差异无统计学意义。近端胃体离体平滑肌张力测定结果显示:近端胃体纵行平滑肌张力随枳实总黄酮苷提取物浓度升高而降低,当枳实总黄酮苷提取物浓度达到6 000μg/ml及10 000μg/ml时具有统计学意义(P<0.05)。[结论]枳实总黄酮苷提取物对功能性消化不良大鼠近端胃适应性具有一定的调节作用,其作用途径可能与降低近端胃体平滑肌张力有关。     

针刺功能性消化不良患者足三里穴对其胃运动功能的影响

目的针刺功能性消化不良（functional dyspepsia，FD）患者足三里穴（ST36），采用胃电测定和胃排空测定的方法，观察胃运动的变化，为临床治疗提供依据。方法根据罗马Ⅲ标准，确定FD患者。预先测定FD患者进餐前、后胃电活动的变化和B超测定胃排空，采用针刺FD患者双侧足三里穴（连续3d），再测定进餐前、后胃电活动的变化，以及B超测定胃排空，观察针刺FD患者足三里穴对其胃动力作用的影响。同时设立健康志愿对照组。结果FD患者在进餐前后，胃电活动呈现不规律的电活动改变。胃的排空呈现减慢趋势。与正常对照组相比，存在显著性差异。而给予针刺足三里后，患者胃电活动逐渐趋于规律，且胃排空较未针刺状况相比，明显加快，接近于正常对照组。结论针刺FD患者足三里穴，可以调节FD患者胃电节律紊乱，改善胃排空障碍。     

和胃胶囊对运动障碍样功能性消化不良患者胃排空的影响

目的：观察和胃胶囊对运动障碍样功能性消化不良（DFD）患者胃排空的影响。方法：随机选取DFD患者12例,设西药对照组和正常对照组,以核素法动态测定DFD患者和胃胶囊治疗前后近端胃、远端胃及全胃的排空情况,并计算近端胃、全胃的半排空时间（T1／2）。结果：DFD患者近端胃、远端胃及全胃的排空速度均较正常人明显减慢（P＜0．05－0．01）,近端胃、全胃T1／2比正常人延长（P＜0．05－0．01）;和胃胶囊治疗后,近端胃、全胃排空速度明显加快,全胃T1/2缩短,与治疗前比较差异有显著性意义（P＜0．05－0．01）,与正常人比较差异无显著性意义。结论：和胃胶囊能明显促进DFD患者的胃排空,是治疗DFD的有效药物。     

功能性消化不良的胃肠运动与胃排空

功能性消化不良的胃肠运动与胃排空第三军医大学西南医院消化科张树荣综述王振华审校功能性消化不良（ｆｕｎｃｔｉｏｎａｌｄｙｓｐｅｐｓｉｎ，ＦＤ）又称非溃疡性消化不良（ｎｏｎ－ｕｌｃｅｒｄｙｓｐｅｐｓｉａ，ＮＵＤ）。其病因尚未确定，可能与胃肠运动障碍有关。...     

生物阻抗技术评价多潘立酮对功能性消化不良胃动力的影响

目的 研究多潘立酮对功能性消化不良(functional dyspepsia,FD)患者胃动力的影响.方法 应用胃动力检测系统检测2007年6月至2008年2月重庆医科大学附属第一医院消化门诊30例FD患者餐后胃动力,同步提取胃阻抗信号和胃电信号,并对FD患者进行症状评分,多潘立酮10 mg每日3次治疗1周后,复查餐后胃动力并再次症状评分.结果 经多潘立酮治疗后FD患者腹胀、腹痛、早饱、嗳气症状积分明显下降(P＜0.05),餐后不适综合征(PDS)组症状改善较明显(P＜0.05).胃电主功率百分比治疗后[(58.03±8.05)%]较治疗前[(52.07±7.01)%]有显著提高(P＜0.05).治疗前,PDS组和上腹疼痛综合征(EPS)组主功率百分比差异无统计学意义(P＞0.05);治疗后,PDS组主功率百分比[(46.50±4.08)%]显著高于EPS组[(41.99±3.10)%](P＜0.01);PDS和EPS两组各频段功率百分比治疗前后差异均无统计学意义(P＞0.05).结论 多潘立酮可改善FD患者的临床症状,恢复异常的胃电活动,阻抗胃动力紊乱并未完全恢复正常;经多潘立酮治疗后PDS组较EPS组阻抗胃动力紊乱改善较明显.     

功能性消化不良食管运动功能研究

目的:探讨FD患者食管运动功能变化。方法:采用PC polygraf HR台式高分辨上消化道气液压毛细管连续灌注测压系统对36例FD患者进行食管测压。结果:FD组食管下段平均蠕动收缩波幅显著低于对照组。FD组食管下段蠕动压低于上段蠕动压的发生率显著高于对照组。FD组出现异常蠕动波55.5％例,表现为类型不同、次数不等的双峰波、三峰波、多发重复收缩波、逆行收缩波、非传导性同步收缩波及自发性收缩波等。以双峰波最多见。7例存在两种或以上异常波,8例同时伴有食管下段低幅蠕动。本组食管体运动异常检出共86%。结论:FD患者存在食管运动功能异常,主要表现为食管体运动不协凋,其次为食管下段运动减弱。     

Effect of Vincristine on Gastric Motility in Conscious Rats

We investigated the possible involvement of the upper alimentary tract in vincristine (VCR)- induced dysmotility. Gastric contractions were recorded by a strain-gauge force transducer in conscious rats. Rats were injected with various doses of VCR followed by continuous recording for 12 hr. Additionally, 3-hr recordings to study the later effects were performed one and three days after injection. Gastric motility was dose-dependently increased by VCR. Post- versus preinjection motility index (MI; area under contraction waves) ratios were 0.78 ± 0.12 for saline and 1.95 ± 0.21 for VCR at 0.75 mg/kg. This increase in MI was completely inhibited by atropine and hexamethonium. MI one day after injection of VCR (0.75 mg/kg) was significantly less than in control (0.32 ± 0.10 vs 0.92 ± 0.24, respectively). The decrease was reversed by acetylcholine. In conclusion, VCR first increased gastric motility, and this was followed by a gradual decrease in conscious rats. These alterations may involve a presynaptic cholinergic pathway.     

Inhibitory Effect of Dopamine on Gastric Motility in Rats

Background: There is disagreement with regard to the involvement of dopamine (DA) receptors in gastric motility. The mechanism of the inhibitory effect of DA on rat gastric motility was investigated in association with acetylcholine (Ach) release in the present study.

Methods: In vivo vagotomized, splanchnicectomized rats and control rats were used, and gastric movement was determined as the gastric motility index after DA administration. In vitro study of Ach release from the circular muscle strips of the gastric corpus was investigated after administration of domperidone, SCH23390, phentolamine, or propranolol.

Results: In the in vivo study DA inhibited gastric motility in a dose-dependent manner. Vagotomy and splanchnicectomy had no effect on the inhibitory effect of DA. In the in vitro study DA inhibited [³H]-Ach release in a dose-dependent manner. The inhibitory effect of DA was antagonized by domperidone but not by phentolamine, propranolol, or SCH23390.

Conclusions: Inhibition of gastric motility by dopamine is independent of extrinsic innervation and seems to be mediated by DA₂ receptors in the gastric wall.     

Pattern of Gastric Emptying in Functional Dyspepsia. An Ultrasonographic Study

We assessed the ultrasonographic pattern of gastric emptying in patients with functional dyspepsia, evaluating its relationship with symptoms. Twenty dyspeptic patients, with slight (group A) and severe (group B) symptoms, and 10 controls (group C) underwent ultrasonographic study of gastric emptying by measuring postprandial variations of the antral area at regular intervals. The time at which the antral area returned to the basal value was assumed to be the final emptying time. The final emptying time was significantly longer in both group A (294 +/- 42 min) and group B (340 +/- 36 min) compared to controls (244 +/- 21 min), but no significant difference was observed between them. A significantly (P < 0.05) greater dilation of the antral area was found at 50 min in group B compared to group A patients. A different pattern of antral motor function rather than a delay of gastric emptying correlates with the severity of symtoms in dyspeptic patients.     

功能性消化不良患者幽门与胃窦十二指肠运动的时空关系

本文通过连续5小时上消化道测压观察了11例健康人(HS)和14例功能性消化不良(FD)病人消化间期和消化期胃窦、幽门、十二指肠运动功能变化。结果显示,HS组胃窦部、幽门、十二指肠移行性复合运动(MMC)Ⅲ期出现率为7/11、8/11和10/11,FD组分别为3/14(P<0.05)、4/14(P<0.05)和6/14(P相似文献   

Suppression of Anger and Gastric Emptying in Patients with Functional Dyspepsia

Bennett EJ, Kellow JE, Cowan H, Scott AM, Shuter B, Langeluddecke PM, Hoschl R, Jones MP, Tennant CC. Suppression of anger and gastric emptying in patients with functional dyspepsia. Scand J Gastroenterol 1992;27:869-874.

Psychologic distress and gastric motor dysfunction have both been implicated in the pathogenesis of functional (non-ulcer) dyspepsia (FD). This study assesses the association between psychologic factors and gastric emptying in 28 FD patients. Subjects completed an extensive range of psychologic questionnaires and underwent dual-isotope scintigraphic assessment of solid and liquid gastric emptying. Attempts to resist, control, suppress, and hold in anger, to adopt a fighting spirit whilst dealing with chronic stressors, and manifest unhappiness were predictors of prolonged gastric emptying. These findings suggest that psychologic factors may be important in the aetiology of gastric stasis and subsequent upper gastrointestinal symptoms in patients with functional dyspepsia.     

Evaluation of Individual Symptoms Cannot Predict Presence of Gastric Hypersensitivity in Functional Dyspepsia

Recently, the concept of gastric hypersensitivity was introduced as an important factor in the pathophysiology of functional dyspepsia (FD), but it is unclear which symptoms can predict the presence of gastric hypersensitivity. Therefore, we evaluated the relationship between common symptoms of FD and various parameters measured by gastric barostat in FD patients. Gastric barostat tests were performed in 64 FD patients and 20 healthy control subjects without gastrointestinal symptoms. Individual symptoms such as early satiety, postprandial fullness, sense of delayed emptying, nausea, vomiting, and epigastric soreness were collected and graded as mild to severe. Basal tone, gastric compliance, and postprandial receptive relaxation were similar in controls and patients, the threshold of abdominal discomfort was lower in FD patients than in controls (8.9 ± 3.6 mm Hg and 14.5 ± 3.7 mm Hg, respectively, P < 0.05). However, there were no significant differences in the threshold of abdominal discomfort according to the severity of individual symptoms. In conclusion, a simple evaluation of individual symptoms could not predict the presence of gastric hypersensitivity.     

升降汤治疗功能性消化不良的临床与实验研究

采用中药升降汤治疗功能性消化不良（FD）50例，并与吗丁啉进行对照，结果中药组总有效率90．00％，对照组总有效率80．95％，两组疗效比较有显著性差异（P＜0．05）。实验证明升降汤能明显增强小鼠胃肠蠕动，具有胃肠动力作用，其作用强于吗丁啉；升降汤又能抑制新斯的明引起的胃肠强烈运动，而吗丁啉则无此作用。提示升降汤对胃肠运动具有双向调节作用，这也是其治疗FD的机制之一。     

Relationships Between Intragastric Food Maldistribution, Disturbances of Antral Contractility, and Symptoms in Functional Dyspepsia

We investigated the relationships between intragastric food maldistribution and antral dysmotility in functional dyspepsia, and whether these abnormalities relate to meal-induced symptoms. Intragastric distribution of food throughout gastric emptying was determined in patients (n = 24) and controls (n = 38) after a liquid nutrient meal labeled with ^99mtechnetium phytate. Antral contractility was also periodically assessed by dynamic scintigraphy and postprandial symptoms were monitored with visual analog scales. Residence of food in the proximal stomach was decreased in 8 (33%) and antral contractility was increased in 9 (37.5%) and decreased in 2 (8%) patients. Proximal and distal stomach motor abnormalities were neither significantly correlated nor associated. Increased antral contractility was significantly correlated (Rs = 0.54; P < .01) with postprandial nausea. We conclude that diminished residence of food in the proximal stomach and disturbed antral contractility occur independently in different subsets of functional dyspepsia patients. Increased antral contractility seems to play a role in postprandial nausea in functional dyspepsia.