不同品种肉苁蓉药材一些药理作用的比较

肉苁蓉、管花肉苁蓉及水浸后肉苁蓉的水煎物醇溶部分能显著增加去势大鼠精囊前列腺的重量,肉苁蓉及管化肉苁蓉的水煎物,还可提高小鼠腹腔巨噬细胞的吞噬活力。     

肾亏康药效学的实验研究

肾亏康胶囊能明显增强和恢复实验动物的性功能，并促进雄性动物附性器官的发育，如提高精子数和交配能力及生殖能力，促进前列腺及储精囊、包皮腺、阴茎、会阴复合体的发育；具有睾酮样作用，降低Ｅ２／Ｔ比值；对于糖尿病模型小鼠具有较好的降糖作用。     

原蚕蛾的药理研究

原蚕蛾的毒性甚低。对未成年雄性小鼠体重增长有促进作用。能明显增加去势小鼠和去势大鼠的前列腺-贮精囊、包皮腺的重量,表明具有雄激素样作用。     

玛咖提取物的激素样活性实验研究

目的初步研究玛咖提取物的激素样活性作用。方法采用雄性去势小鼠，经灌胃玛咖不同提取物22d后，观察各组小鼠前列腺和精囊腺的重量并测定血清中睾丸酮的含量。用幼龄雌性小鼠，灌胃玛咖醇提物10d后，观察各组小鼠子宫、卵巢重量以及阴道上皮角化细胞。结果玛咖提取物可以显著提高雄性去势小鼠前列腺和精囊腺重量，但并不升高血清睾丸酮水平。玛咖醇提取物对雌性幼年小鼠子宫、卵巢重量以及阴道上皮角化细胞没有显著影响。结论玛咖具有弱的雄激素样作用，但对幼年雌性小鼠未显示雌激素样活性。     

中华宫宝性激素样作用的药理研究

药理研究表明，中华宫宝能使去势♂幼小鼠的前列腺－精囊腺、肾上腺增重；能预防实验性“阳虚”小鼠的体重减轻、Ｈｂ和ＲＢｃ的减少、包皮腺和肾上腺的萎缩；能使♀幼小鼠的子宫增重。     

鱼鳔补肾益精丸的药理作用实验研究

鱼鳔补肾益精丸可使大剂量皮质激素诱发的肾阳虚模型小鼠自主活动次数增加，游泳时间延长，体重、体温降低减少；使去势大鼠精囊、前列腺、包皮腺明显增重；缩短去势大鼠电刺激阴茎勃起的潜伏期；提高雄性大鼠的交配能力；并可改善神经性性功能障碍小鼠的性活动，表明本品具有明显的补肾壮阳作用。     

痤疮颗粒的药效学研究

目的：研究痤疮颗粒的作用机理。方法：用放射免疫法测定大鼠血清睾酮浓度，测算大鼠睾丸、附睾、精囊、前列腺系数，观察痤疮颗粒对性激素的影响；分别进行二甲苯致小鼠耳廓肿胀实验，醋酸所致小鼠毛细血管通透增加实验，观察该药的抗炎作用。结果：痤疮颗粒能够降低丙酸睾酮（TP）引起的未成熟大鼠血清睾酮的升高，降低其附睾、精囊、前列腺的重量；降低醋酸所致小鼠腹腔毛细血管的通透性；减轻二甲苯所致小鼠耳廓的肿胀。结论：痤疮颗粒能够调节体内激素分泌，缓解二甲苯致小鼠耳廓肿胀程度，减轻醋酸所致小鼠毛细血管通透性增加现象。     

桂枝不同提取物对小鼠良性前列腺增生的影响

目的:观察桂枝不同提取物对丙酸睾丸素致小鼠良性前列腺增生的影响。方法:皮下注射丙酸睾丸素造成小鼠良性前列腺增生动物模型。给药组分别灌胃给予桂枝不同成分提取物;前列康做对照。末次给药24小时后,处死动物,取前列腺称重,计算前列腺指数并进行病理学检查。结果:桂枝水煎剂可明显降低良性前列腺增生模型小鼠的前列腺湿重与前列腺指数(P<0·01),改善小鼠前列腺病理组织学变化。结论:桂枝水煎液有抑制小鼠良性前列腺增生作用。     

含鱼腥草的新的前列腺肥大抑制剂

一种新的前列腺肥大抑制剂含有鱼腥草Houttuynia cordata Thunb.。将7周龄摘去睾丸的ddY 小鼠分为:水组、睾酮组、鱼腥草合并睾酮组。给药2周后,解剖小鼠,测定其前列腺大小和精囊质量。结果表明:鱼腥草能显著抑制小鼠的前列腺肥大。     

茄根的镇痛、抗炎作用研究

目的：对茄根水煎剂及醇提物进行药理作用研究。方法：用小鼠耳肿胀、热板法等试验观察茄根的抗炎、镇痛作用及对微循环的影响；离体动物器官对茄根及相应工具药的反应，研究茄根对子宫及十二指肠平滑肌的作用。结果：茄根可提高小鼠热板痛阈值，抑制二甲苯致小鼠耳廓肿胀，增加小鼠耳廓毛细血管交叉数；抑制子宫和肠道平滑肌的收缩，其对子宫平滑肌的抑制作用与阻断胆碱受体和组胺受体有关。结论：茄根有镇痛、抗炎、改善微循环及抑制子宫和肠道平滑肌的作用。     

Reduction of inflammatory hyperplasia in the intestine in colon cancer-prone mice by water-extract of Cistanche deserticola

Cistanche deserticola has commonly been used in traditional Chinese medicine to treat many health problems including irritable bowel syndrome or constipation. This study was designed to test the efficacy of a water‐extract of C. deserticola in the prevention of colorectal cancer in a mouse model. Polysaccharide‐rich water‐extract of C. deserticola was prepared by boiling its stem powder in distilled water. Tgfb1Rag2 null mice were used as an experimental model. Here we showed that feeding of water‐extract of C. deserticola significantly reduced the number of mucosal hyperplasia and intestinal helicobacter infection in mice. This beneficial effect correlated with significant stimulation of the immune system, evidenced by the enlargement of the spleens with increased number of splenic macrophage and natural killer cells, and with more potent cytotoxicity of splenocytes. In vitro water‐extract of C. deserticola enhanced the cytotoxicity of naïve splenocytes against a human colon cancer cell line, and in macrophage cultures up‐regulated nitric oxide synthase II expression and stimulated phagocytosis. In conclusion, our data indicate that oral administration of C. deserticola extract reduces inflammatory hyperplastic polyps and helicobacter infection in mice by its immune‐stimulatory activity, suggesting that C. deserticola extract may have potential in preventing intestinal inflammation disorders including colorectal cancer. Copyright © 2011 John Wiley & Sons, Ltd.     

Antifatigue activity of phenylethanoid‐rich extract from Cistanche deserticola

A phenylethanoid‐rich extract (ECD) of Cistanche deserticola Y.C. Ma, a holoparasitic plant and a valuable traditional Chinese medicine, was evaluated for antifatigue activity in ICR mice. ECD (0.25, 0.50, 1.00 g/kg) was administered orally to mice for 3 weeks. The swimming time to exhaustion was longer in the treatment groups (0.50, 1.00 g/kg) than in the control group (p < 0.01). The serum creatine kinase, lactate dehydrogenase and lactic acid levels were decreased significantly in the treatment groups compared with the control group, while the contents of hemoglobin and glucose were increased significantly. In conclusion, ECD appeared to enhance the swimming capacity of mice by decreasing muscle damage, delaying the accumulation of lactic acid and by improving the energy storage. These results provide scientific evidence for the traditional Chinese medical practice of C. deserticola. Copyright © 2009 John Wiley & Sons, Ltd.     

肉苁蓉对小鼠血清肌酸激酶和骨骼肌超微结构的影响

肉苁蓉水煎液小白鼠灌胃,可使其游泳时间延长,负荷运动后血清肌酸激酶升高幅度降低。骨骼肌超微结构显示肌糖原含量丰富,运动后线粒体普遍增生、肥大,未见肿胀、空泡等。肌原纤维结构保持完整,无明显损伤。     

Studies on the sedative effect of Cistanche deserticola

In this study, we investigated the sedative effect of Cistanche deserticola Ma. (CD) on hexobarbital-induced sleeping time in mice and spontaneous motor activity by using automated activity meter in rats. It was found that crude extract of CD could prolong the hexobarbital-induced sleeping time and reduce spontaneous motor activity, including horizontal activity, ambulatory time and total distance. Then the water fraction of CD extract could prolong the hexobarbital-induced sleeping time and reduce the spontaneous motor activity more than that of the other fraction of CD extract in rats. These results suggest that CD ethanol extract and its water fraction possessed the sedative effect.     

海嘧啶毒性的实验研究

目的：研究海嘧啶的毒性作用。方法：通过海嘧啶对FC小鼠和S180，H22荷瘤小鼠胸腺和精囊重量及指数的研究，观察海嘧啶的毒性作用。结果：海嘧啶可使不同荷瘤小鼠胸腺及精囊萎缩，使不同荷瘤小鼠白细胞及血小板数量下降，但其萎缩及下降程度均小于5－Fu。结论：海嘧啶在毒性方面产生了拮抗作用，使5－Fu的毒性明显下降，即海嘧啶在增强5－Fu抗肿瘤作用的同时，显著降低了5－Fu的毒性。     

鹿茸精注射液性激素样作用的实验研究

鹿茸精注射液能明显促进去势大白鼠的前列腺、精囊和包皮腺的生长,并能明显促进幼鼠子宫的发育。     

附子的温中止痛药理研究

本文观察附子水煎剂能显著对抗小鼠水浸应激型和大鼠盐酸损伤性溃疡。附子煎剂能显著对抗蓖麻油和番泻叶引起的小鼠药物性腹泻。在热板法和乙酸扭歪试验中它有明显镇痛效应。认为这是附子温中止痛的药理学基础。     

七味温阳软胶囊补肾温阳作用的实验研究

目的: 研究观察七味温阳软胶囊对肾阳虚模型动物垂体-肾上腺皮质系统、垂体-性腺系统功能及应激反应的影 响。方法: 将60只Wistar种大鼠、78只昆明种小鼠,分别按性别体重均衡随机分为正常对照组,模型对照组,阳性药对照组,七味温阳软胶囊高、中、低剂量组。大鼠从给药第1天起,除正常对照组外,各组均ig氢化可的松5×10^-5g·kg^-1 每天1次,连续9 d,制造肾阳虚模型,继续给药至第12天,各组动物股动脉取血,离心,取血清,检测促肾上腺皮质激素(ACTH)、皮质醇(Cortisol)水平;小鼠连续给药14 d,于给药的第8至14天时,除正常对照组外,每只ig氢化可的松0.75 mg·kg^-1,每天1 次,连续7 d,末次给药后检测小鼠包皮腺、精液囊脏器指数及小鼠游泳和耐缺氧时间。结果: 七味温阳软胶囊0.96,0.48 g·kg^-1 2个剂量可明显升高肾阳虚模型大鼠血清ACTH,Cortisol水平(P<0.05);1.35, 0.68 g·kg^-12个剂量可明显增加肾阳虚小鼠包皮腺脏器指数(P<0.05);0.68,0.34 g·kg^-12个剂量可明显增加肾阳虚小鼠精液囊脏器指数(P<0.05,P<0.01);1.35,0.68,0.34 g·kg^-13个剂量均可明显延长小鼠游泳时间和常压耐缺氧时间(P<0.05)。结论: 七味温阳软胶囊对肾阳虚模型大鼠垂体-肾上腺系统功能和小鼠垂体-性腺系统功能具有一定的保护作用。