心理护理干预对肝癌介入治疗患者的心理状态及生活质量的影响

目的探讨心理护理干预对肝癌介入治疗患者的心理状态及生活质量的影响。方法将60例肝癌介入治疗患者分为两组,每组各30例,对照组予常规对症护理,干预组在对照组的基础上实施心理护理干预。比较两组患者干预前后心理状态、生活质量各项评分。结果干预后,干预组患者的SAS及SDS评分显著低于干预前(P0.05),且干预组患者干预后的SAS及SDS评分显著低于对照组。干预前,干预组与对照组患者的躯体功能、社会功能及心理功能及物质生活评分分别比较,无显著性差异;干预后,干预组与对照组患者的躯体功能、社会功能及心理功能评分均显著高于干预前,且干预组患者的躯体功能、社会功能及心理功能评分均显著高于对照组,两组差异具有统计学意义(P0.05)。但干预前后两组患者的物质生活评分及干预组与对照组物质生活评分比较,差异均无统计学意义(P0.05)。结论对肝癌介入治疗患者实施心理护理干预有利于缓解患者的焦虑抑郁心理,提高生活质量。     

心理护理联合健康教育在 HPV 感染的宫颈癌合并糖尿病患者中的应用效果分析

目的旨在探讨心理护理联合健康教育在HPV感染的宫颈癌合并糖尿病患者中的应用效果。方法选取2016年1月～2017年1月收治的76例宫颈癌合并糖尿病患者,所有患者均合并HPV感染,根据护理方法不同随机分成观察组和对照组,每组38例。对照组采取常规护理,观察组在对照组的基础上采取心理护理联合健康教育,对两组患者干预前后的负性心理及生活质量进行评价。结果观察组与对照组患者干预前的SAS评分、SDS评分组间比较,差异无统计学意义。干预后,观察组患者的焦虑(SAS)、抑郁(SDS)心理评分分别低于干预前及对照组,两组比较差异具有统计学意义(P0.05)。观察组与对照组患者干预前的生活质量评各项评分比较,差异无统计学意义。观察组患者的生活质量各项评分分别低于干预前及对照组,两组比较差异具有统计学意义(P0.05)。结论在HPV感染的宫颈癌合并糖尿病患者治疗过程中实施心理护理联合健康教育,可以显著缓解患者的负性心理,改善患者的生活质量,从而促进疾病的尽快恢复。     

针对性心理护理对腹腔镜子宫内膜癌患者术后心理状态及生活质量的影响

目的探讨对腹腔镜子宫内膜癌患者行心理护理干预对患者术后心理状态及生活质量的影响。方法选取我院2013年1月~2016年1月收治的腹腔镜子宫内膜癌患者64例,采用随机数字表法分为心理干预组和对照组,每组各32例。对照组患者采用常规护理,心理护理干预组在对照组的基础上采用有针对性的心理护理干预措施,比较两组患者干预前后的SAS、SDS评分及生活质量功能领域、症状领域评分的变化。结果心理护理干预组干预前的SAS评分、SDS评分分别与对照组比较,差异无统计学意义,干预后,心理护理干预组和对照组的SAS评分、SDS评分分别比干预前比较明显降低,且心理护理干预组干预后的SAS评分、SDS评分分别显著低于对照组,差异有统计学意义(P0.05)。心理护理干预组干预前的生活质量功能领域评分、症状领域评分分别与对照组比较,差异无统计学意义,干预后,心理护理干预组和对照组的生活质量功能领域评分与干预前比较显著升高,症状领域评分与干预前比较显著降低,且心理护理干预组干预后生活质量各项评分较对照组改善更显著,差异有统计学意义(P0.05)。结论对腹腔镜子宫内膜癌患者行有针对性的心理护理干预,有利于缓解患者的术后焦虑、抑郁心理及提高患者的生活质量。     

人性化护理与常规护理对糖尿病肾病患者抑郁、焦虑状态及生活质量的影响

目的探讨人性化护理与常规护理对糖尿病肾病患者抑郁、焦虑状态及生活质量的影响。方法收集2016年1月～2018年1月在我院住院治疗的糖尿病肾病患者80例,按照随机数字表法随机分为干预组与对照组,各40例,对照组采取常规护理,干预组在对照组常规护理的基础上实施人性化护理,比较两组对糖尿病肾病患者抑郁、焦虑状态及生活质量的影响情况。结果干预组与对照组干预前的SDS评分、SAS评分比较,差异不显著(P0.05)。干预组干预后的SDS评分、SAS评分分别较干预前比较显著降低,其中干预组患者干预后的SDS评分为(33.1±12.9)分,SAS评分为(35.1±11.4)分,对照组患者干预后的SDS评分为(41.2±11.4)分,SAS评分为(41.6±12.7)分,两组组间比较,差异有统计学意义(P0.05)。干预组与对照组干预前的生活质量各项评分比较,差异不显著(P0.05)。干预组干预后的生活质量评分中的角色功能、躯体功能、认知功能、社会功能评分分别为(25.32±2.49)分、(25.36±5.61)分、(26.23±6.11)分、(25.27±6.27)分,分别显著高于对照组干预后的生活质量评分中的角色功能、躯体功能、认知功能、社会功能评分(20.65±6.11)分、(20.35±6.11)分、(21.78±7.23)分、(21.18±7.64)分,两组组间比较,差异有统计学意义(P0.05)。结论人性化护理有利于缓解糖尿病肾病患者抑郁、焦虑状态,提高患者的生活质量水平,从而有利于促进疾病的恢复。     

优质护理干预对功能性便秘患者不良心理的影响分析

目的：分析优质护理干预对功能性便秘患者不良心理的影响。方法选择60例功能性便秘患者（FC）患者作为研究对象。将60例患者分为观察组和对照组,每组30例。对照组给予常规护理干预。观察组在常规护理干预基础上实施优质护理干预。干预4周后,比较2组患者干预前后焦虑自评量表（SAS）及抑郁自评量表（SDS）评分变化。结果干预前2组患者SAS评分及SDS评分差异无统计学意义。干预后,2组患者的SAS评分及SDS评分相比干预前均有所下降,但观察组患者下降幅度比对照组明显,2组患者SAS评分及SDS评分差异具有统计学意义（P＜0.05）。观察组患者干预前后SAS评分及SDS评分差异有统计学意义（P＜0.05）。结论优质护理能显著改善FC患者抑郁、焦虑等不良心理情绪,有助于FC治疗。     

心理护理对腹腔镜胆囊切除术患者的心理状态和术后疼痛的影响

目的探讨心理护理对腹腔镜胆囊切除术患者的心理状态和术后疼痛的影响。方法选择2015年2月~2016年2月期间我院收治的腹腔镜胆囊切除术患者100例,根据护理方法不同随机分为心理干预组和对照组,每组各50例,对照组患者接受常规护理,心理干预组在对照组的基础上主要实施心理护理,比较两组患者干预前后SAS、SDS、VAS评分的变化情况。结果干预前两组患者的SAS、SDS、VAS评分组间比较差异不显著(P0.05),干预后,心理干预组和对照组患者的SAS、SDS、VAS评分较干预前显著降低,且心理干预组患者的SAS、SDS、VAS评分显著低于对照组,组间比较差异具有统计学意义(P0.05)。结论心理护理有利于缓解腹腔镜胆囊切除术患者的焦虑、抑郁等消极心理状态,减轻术后疼痛,从而提高患者的生活质量及促进疾病的快速康复。     

胰岛素泵治疗糖尿病过程中的心理护理探讨

目的探讨心理护理在胰岛素泵强化治疗糖尿病期间的意义。方法将应用胰岛素泵强化治疗的糖尿病患者80例随机分为两组,观察组采用个性化心理护理措施,对照组采用常规护理。通过焦虑自评量表（SAS）和抑郁自评量表（SDS）对护理干预前后的心理状况进行评分。结果经护理干预后,两组患者SAS评分及SDS评分均显著降低（P〈0.05）;观察组患者SAS评分及SDS评分均明显低于对照组（P〈0.05）。结论针对胰岛素泵治疗过程中患者心理变化的个性化心理护理,能更有效地改善患者的心理状态,有利于促进患者的康复。     

人性化护理干预对慢性心力衰竭患者心功能及生活质量改善作用的影响

目的观察人性化护理干预对慢性心力衰竭患者心功能及生活质量的改善作用。方法将2015年1月~2016年1月我院的慢性心力衰竭患者160例作为研究对象,根据护理方法不同所有患者随机分为干预组和对照组。每组各80例,对照组采取常规护理,干预组实施人性化护理,比较两组患者干预前后LVEF、6MWT、生活质量MLHFQ各项评分包括体力限制、社会限制、情绪、症状及SAS、SDS评分。结果干预前,两组患者的LVEF、6MWT组间比较,无显著差异(P0.05),干预后,干预组患者的LVEF、6MWT分别较对照组明显改善,差异有统计学意义(P0.05)。干预前,两组患者的生活质量MLHFQ各项评分包括体力限制、社会限制、情绪、症状组间比较,无显著差异(P0.05),干预后,干预组患者的生活质量MLHFQ各项评分包括体力限制、社会限制、情绪、症状分别较对照组明显改善,组间比较,差异有统计学意义(P0.05)。干预前,两组患者的SAS、SDS评分组间比较,无显著差异(P0.05),干预后,干预组患者的SAS、SDS评分较对照组降低更显著,组间比较,差异有统计学意义(P0.05)。结论人性化护理干预对慢性心力衰竭患者心功能及生活质量的改善具有重要作用,有助于改善心功能及提高生活质量,缓解患者的负性心理,从而促进疾病的及早康复。     

无缝隙护理干预对老年冠心病患者的应用效果观察

目的：探讨无缝隙护理干预对老年冠心病患者的应用效果。方法：选取2020年6-12月钟祥市人民医院收治的150例老年冠心病患者作为研究对象,以随机数字表法分为两组,各75例。对照组实施常规护理,观察组实施无缝隙护理干预。比较两组焦虑自评量表(SAS)、抑郁自评量表(SDS)、西雅图心绞痛量表(SAQ)及生活质量评分。结果：干预前,两组SAS、SDS评分比较,差异无统计学意义(P>0.05);干预后,观察组SAS、SDS评分均低于对照组,差异有统计学意义(P<0.05)。干预前,两组身体活动受限、疾病知识掌握度、心绞痛发作、心绞痛稳定状况各项SAQ评分比较,差异无统计学意义(P>0.05);干预后,观察组各项SAQ评分均高于对照组,差异有统计学意义(P<0.05)。干预前,两组心理功能、生理功能、社会功能、物质生活各项生活质量评分比较,差异无统计学意义(P>0.05);干预后,观察组各项生活质量评分均高于对照组,差异有统计学意义(P<0.05)。结论：对老年冠心病患者实施无缝隙护理干预,有利于控制心绞痛症状,降低不良心血管事件的发生风险,促进其生活质量及...     

综合护理干预对乳腺癌根治术患者心理状态及生活质量的影响

目的 分析综合护理干预对乳腺癌根治术患者心理状态及生活质量的影响。方法 选择2018 年1 月～2019 年1 月我院80 例乳腺癌根治术患者作为观察对象,采用随机数字表法随机分为干预组、对照组,每组各40 例,对照组采取对症护理,干预组采取综合护理,对比两组患者的SAS、SDS 评分,生活质量改善情况、护理满意度。结果 干预组患者的SAS、SDS 评分干预后分别较干预前明显降低,对照组患者的SAS、SDS 评分干预后也分别较干预前明显降低,干预组患者干预后的SAS、SDS 评分分别显著低于对照组（P＜0.05）。干预组患者的躯体功能、角色功能、社会功能、情绪功能、认知功能、总体健康评分干预后分别较干预前明显升高,对照组患者的躯体功能、角色功能、社会功能、情绪功能、认知功能、总体健康评分干预后也分别较干预前明显升高,两组患者干预后生活质量各项评分比较,差异有显著统计学意义（P＜0.05）。干预组患者的护理满意度明显高于对照组（P＜0.05）。结论 对乳腺癌根治术患者实施综合护理,有利于改善患者的心理状态,提高患者的生活质量,改善预后。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.