阿托伐他汀联合曲美他嗪治疗冠心病临床疗效观察

目的观察分析阿托伐他汀联合曲美他嗪治疗冠心病临床疗效。方法将该院120例冠心病患者随机分为治疗组和对照组,治疗组进行阿托伐他汀联合曲美他嗪治疗,对照组仅用阿托伐他汀治疗,分别观察两组治疗前与治疗后的低密度脂蛋白胆固醇的变化、动态心电图的改变、治疗有效率、不良反应及临床症状改善情况。结果相较于对照组,治疗组的治疗效果更为显著,低密度脂蛋白胆固醇分别下降为〈2.6mmol/L、3.37～4.14mmol/L。两组的治疗有效率分别为93.3%和88.3%。结论阿托伐他汀联合曲美他嗪治疗冠心病安全有效,疗效显著,具有临床推广价值。     

阿托伐他汀联合曲美他嗪治疗不稳定型心绞痛效果分析

目的:探讨阿托伐他汀联合曲美他嗪治疗不稳定型心绞痛的临床效果。方法:选择90例不稳定型心绞痛患者,随机分为观察组和对照组,两组均给予常规抗心绞痛治疗,对照组同时给予阿托伐他汀治疗,观察组同时给予阿托伐他汀联合曲美他嗪治疗。观察两组心绞痛发作次数和持续时间改变情况,评定治疗效果。结果:观察组治疗后心绞痛发作次数和每次发作持续时间均低于对照组治疗后,差异有统计学意义(P<0.05)。观察组总有效率(93.3%)高于对照组总有效率(73.3%),差异有统计学意义(P<0.05)。结论:阿托伐他汀联合曲美他嗪能够显著改善不稳定型心绞痛患者心绞痛发作症状,提高治疗效果。     

阿托伐他汀联合曲美他嗪治疗稳定型心绞痛效果分析

目的对应用阿托伐他汀与曲美他嗪联合治疗稳定型心绞痛患者的临床效果进行研究分析。方法抽取118例冠心病,稳定型心绞痛患者,将其分为3组:治疗组39例、对照A组39例、对照B组40例。治疗组患者采用阿托伐他汀与曲美他嗪联合治疗;对照A组采用阿托伐他汀;对照B组采用曲美他嗪。结果治疗组患者心绞痛治疗的总有效率明显高于对照组;治疗组急性冠脉综合征发生率明显低于对照组;3组患者在用药期间均未出现明显药物不良反应。结论对冠心病患者应用阿托伐他汀、曲美他嗪治疗有较好临床效果,两药合用效果尤为明显。     

曲美他嗪联用阿托伐他汀治疗冠心病不稳定型心绞痛临床治疗效果分析

目的探讨曲美他嗪联合阿托伐他汀治疗冠心病不稳定型心绞痛的临床治疗效果及应用价值。方法选择我院治疗的冠心病不稳定型心绞痛患者126例,随机分为观察组和对照组,对照组采用西医常规治疗,观察组在对照组治疗的基础上联合应用曲美他嗪和阿托伐他汀,观察两组临床疗效。结果观察组总有效率优于对照组,经统计学分析比较,差异有统计学意义(P0.05)。结论在西医常规治疗的基础上联合使用曲美他嗪和阿托伐他汀治疗冠心病不稳定型心绞痛疗效可靠,应用安全,值得在临床上大力推广使用。     

曲美他嗪与阿托伐他汀联合治疗冠心病的临床效果分析

目的通过对本院收治的冠心病患者临床使用曲美他嗪联合阿托伐他汀进行治疗,研究联合使用该两种药物治疗冠心病的效果。方法随机选取本院收治的86例冠心病患者作为研究对象,随机分为两组(观察组和对照组)。对照组使用常规治疗再给予对照组阿托伐他汀治疗方式;观察组则使用曲美他嗪联合阿托伐他汀治疗。对两组患者的临床疗效进行记录观察,比较两组患者心绞痛发生次数和持续时间、血脂各指标变化及不良反应情况。结果观察组的治疗总有效率(95.35%)明显优于对照组(65.12%);观察组心绞痛每周发生次数、持续时间均少于对照组,血脂各指标的改善情况也优于对照组,两组以上指标差异均具有统计学意义(P0.05)。结论给予冠心病患者应用曲美他嗪与阿托伐他汀联合治疗的方式,能有效改善血脂指标,疗效显著。     

分析阿托伐他汀联合曲美他嗪治疗冠心病心绞痛的疗效

目的分析阿托伐他汀联合曲美他嗪治疗冠心病心绞痛的疗效与应用价值。方法选取我院2016年4月至2017年4月收治的360例冠心病心绞痛患者,分为观察组与对照组。对照组仅采用曲美他嗪治疗;观察组在对照组基础上加用阿托伐他汀联合治疗。分析并对比两组患者临床情况。结果经不同药物治疗后,观察组患者治疗总有效率明显优于对照组,组间差异有统计学意义(P0.05)。结论在针对冠心病心绞痛患者的临床治疗时,相较于单独使用曲美他嗪,联合使用阿托伐他汀与曲美他嗪对患者进行联合治疗能有效改善其心绞痛症状,提高治疗有效率。     

阿托伐他汀、曲美他嗪联用对冠心病心绞痛的临床治疗价值分析

目的:探讨曲美他嗪、阿托伐他汀联合应用于冠心病心绞痛治疗过程中的实际效果。方法:选取我院于2015年2月—2018年9月期间收治的90例冠心病心绞痛患者作为观察对象,按照随机数字表法将其分为研究组和对照组,每组45例。对照组予以临床常规治疗+阿托伐他汀,研究组予以常规治疗+曲美他嗪+阿托伐他汀,各组均用药4周。结果:两组用药前心绞痛发作及心功能指标对比差异无统计学意义(P均>0.05),治疗后研究组心绞痛发作频率、持续时间LVEF检测值较之前改善幅度均优于对照组(P均<0.05);研究组临床治疗总有效率显著高于对照组(P<0.05);两组用药期间各项药物相关不良反应发生率对比差异无统计学意义(P均>0.05)。结论:应用阿托伐他汀、曲美他嗪联合治疗冠心病心绞痛有效性、安全性均较高,有利于保障患者预后、生活质量。     

阿托伐他汀联合曲美他嗪治疗冠心病的临床效果

目的阿托伐他汀联合曲美他嗪对冠心病的治疗。方法我院随机挑选180例接受手术的病患,将其分为阿托伐他汀组、曲美他嗪组、综合治疗组,平均每组60例患者,分析3组的治疗效果。结果综合治疗组的总胆固醇和甘油三酯以及低密度脂蛋白胆固醇的数据显著低于阿托伐他汀组和曲美他嗪组,而高密度脂蛋白胆固醇的数据而高于阿托伐他汀组合曲美他嗪组。综合治疗组的全身乏力、胸部疼痛以及心悸的缓解情况均明显优于阿托伐他汀组和曲美他嗪组。综合治疗组的治疗有效率明显高于阿托伐他汀组和曲美他嗪组。结论阿托伐他汀联合曲美他嗪治疗冠心病达到了更好的治疗效果,安全性也有所增高。     

阿托伐他汀联合曲美他嗪治疗冠心病临床效果分析

目的 分析阿托伐他汀联合曲美他嗪治疗冠心病临床效果.方法 方便选取2015年4月—2016年6月在该院就诊的92例冠心病患者,按照数字随机数字表法将患者分为对照组和试验组,每组46例患者;两组患者均行扩血管药、钙拮抗剂、抗血小板聚集、吸氧、利尿剂等常规治疗;对照组在以上治疗基础上给予阿托伐他汀治疗,实验组采用阿托伐他汀联合曲美他嗪治疗;对比分析两组患者临床治疗效果、血脂水平以及心绞痛发作持续时间.结果 ①对照组中,有9例患者无效,总有效率为80.43%;而实验组中,有3例患者无效,总有效率为93.48%;差异有统计学意义(P<0.05).②在治疗后,两组患者TC、TG、HDL-C和LDL-C血脂水平均显著的低于治疗前(P<0.05);在治疗后实验组TC、TG和LDL-C水平分别为(2.20±0.83)、(1.31±0.13)、(1.48±0.04)mmol/L,下降程度教对照组更为显著(P<0.05).③两组患者在治疗后心绞痛发作持续时间均显著的低于治疗前(P<0.05);治疗后实验组心绞痛发作持续时间为(3.18±0.70)min,显著的低于对照组(4.89±0.89)min(P<0.05).结论 与单独的阿托伐他汀临床用药相比,阿托伐他汀联合曲美他嗪临床效果更好,降低TC、TG和LDL-C血脂水平更为明显,患者心绞痛发作持续时间更短,在临床中具有推广和应用的价值.     

曲美他嗪联合阿托伐他汀治疗冠心病心绞痛的临床价值研究

目的探讨曲美他嗪联合阿托伐他汀治疗冠心病心绞痛的临床价值。方法选取2016年8月至2018年8月期间我院收治的110例冠心病心绞痛患者,随机将患者分为对照组(n=55)和观察组(n=55),对照组患者采取曲美他嗪进行治疗,观察组患者采取曲美他嗪联合阿托伐他汀治疗进行治疗,观察两组患者临床疗效。结果观察组临床有效率为94.55%,对照组临床有效率为70.91%,观察组明显高于对照组,差异具有统计学意义(P0.05)。结论曲美他嗪联合阿托伐他汀治疗冠心病心绞痛临床效果理想,值得临床推广借鉴。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.