Prevention of episodic migraine with topiramate: a prospective 24-week,open-label,flexible-dose clinical trial with optional 24 weeks follow-up in a community setting

Abstract

Objective:

To explore efficacy and safety outcomes of topiramate for episodic migraine prevention in community practice.     

A 26-week,placebo- and pioglitazone-controlled,dose-ranging study of rivoglitazone,a novel thiazolidinedione for the treatment of type 2 diabetes

Abstract

Objective:

To examine the efficacy and general safety of rivoglitazone, a novel thiazolidinedione, as a treatment for type 2 diabetes in a dose-ranging study over a period of up to 6 months.     

Short-term (2-week) effects of discontinuing milnacipran in patients with fibromyalgia

Abstract

Objective:

To examine the effects of abruptly withdrawing milnacipran during the 2-week discontinuation phase of a study in which FM patients had received 12 weeks of stable-dose treatment with milnacipran at 100?mg/day.     

Changes in schizophrenia-related hospitalization and ER use among patients receiving paliperidone palmitate: results from a clinical trial with a 52-week open-label extension (OLE)

Abstract

Background:

Schizophrenia affects ～1.1% of the United States population, resulting in substantial direct, indirect and societal costs.     

Relationship between background cancer pain,breakthrough pain,and analgesic treatment: a preliminary study for a better interpretation of epidemiological and clinical studies

Abstract

Background:

The different operational definitions of breakthrough cancer pain (BTcP) has generated unclear epidemiological data.     

Safety,tolerability, pharmacokinetics and pharmacodynamics of albiglutide,a long-acting GLP-1-receptor agonist,in Japanese subjects with type 2 diabetes mellitus

Abstract

Objective:

To investigate safety, pharmacokinetics and pharmacodynamics of albiglutide in Japanese subjects with type 2 diabetes mellitus.     

Safety and efficacy of olanzapine monotherapy and olanzapine with a mood stabilizer in 18-week treatment of manic/mixed episodes for Japanese patients with bipolar I disorder

Abstract

Objective:

To assess the safety and efficacy of 18-week olanzapine monotherapy in Japanese patients with bipolar mania, following a 6-week, placebo- and haloperidol-controlled double-blind study (acute study). For those who discontinued the acute study due to lack of efficacy, safety and efficacy was assessed with a combination therapy of olanzapine and a mood stabilizer.     

Further assessment of the clinically effective dose range of etoricoxib: a randomized,double-blinded,placebo-controlled trial in rheumatoid arthritis

Abstract

Objective:

To further assess the clinically active dose range of etoricoxib, a COX-2 selective inhibitor, in rheumatoid arthritis (RA).     

Clinical development of onercept,a tumor necrosis factor binding protein,in psoriasis

Abstract

Background:

Tumor necrosis factor (TNF)-α plays a critical role in psoriasis pathogenesis, and several anti-TNF agents have been developed as therapeutic drugs in this indication.     

Semiological evaluation of pain according to its origin: a prospective,observational, and national study of current French medical practice

Abstract

Objective:

To determine how the origin of acute pain influences its semiological characteristics, and to evaluate the efficacy and safety of two Level 2 analgesic combinations in general practice.     

Comparison of gastrointestinal safety and tolerability of aceclofenac with diclofenac: a multicenter,randomized, double-blind study in patients with knee osteoarthritis

Abstract

Objective:

To compare the gastrointestinal (GI) tolerability and efficacy of aceclofenac with diclofenac in patients with knee osteoarthritis (OA).     

Efficacy and safety of alogliptin in Japanese patients with type 2 diabetes mellitus: a randomized,double-blind,dose-ranging comparison with placebo,followed by a long-term extension study

Abstract

Objective:

To compare the efficacy and safety of different dosages of alogliptin with that of placebo and voglibose in drug-naïve Japanese patients with type 2 diabetes inadequately controlled by diet and exercise.     

Effect of application site,clothing barrier,and application site washing on testosterone transfer with a 1.62% testosterone gel

Abstract

Objectives:

To evaluate the effect of application site location, clothing barrier, and application site washing on testosterone transfer from males dosed with 1.62% testosterone gel to female partners.     

Chronopharmacology of nebicapone,a new catechol-O-methyltransferase inhibitor

Abstract

Objective:

To investigate the chronopharmacology of nebicapone, a new catechol-O-methyltransferase (COMT) inhibitor currently being developed for use as an adjunct to levodopa/carbidopa or levodopa/benserazide in the treatment of Parkinson’s disease.     

Hypoglycemia in patients with type 2 diabetes from India and Malaysia treated with sitagliptin or a sulfonylurea during Ramadan: a randomized,pragmatic study

Abstract

Objective:

To compare the incidence of symptomatic hypoglycemia between sitagliptin and sulfonylurea in Muslim patients with type 2 diabetes who fasted during Ramadan.     

Thorough QT study of the effects of vildagliptin,a dipeptidyl peptidase IV inhibitor,on cardiac repolarization and conduction in healthy volunteers

Abstract

Objective:

This randomized, double-blind study evaluated the effects of vildagliptin, a dipeptidyl peptidase IV inhibitor for treating type 2 diabetes, on cardiac repolarization and conduction.     

Quality of life in raloxifene-treated Japanese women with postmenopausal osteoporosis: a prospective,postmarketing observational study

Abstract

Objective:

To assess changes in quality of life (QOL) and pain in raloxifene-treated Japanese women with postmenopausal osteoporosis.     

Comparison of quetiapine and risperidone in Chinese Han patients with schizophrenia: results of a single-blind,randomized study

Abstract

Objective:

To evaluate the efficacy and safety of 750?mg/day quetiapine fumarate (Seroquel) in the treatment of Chinese Han patients with schizophrenia.     

Assessment of the pharmacokinetics of co-administered metformin and lobeglitazone,a thiazolidinedione antihyperglycemic agent,in healthy subjects

Abstract

Objective:

Lobeglitazone as a thiazolidinedione antihyperglycemic agent activates peroxisome proliferator-activated receptor (PPAR) γ and may be suitable as monotherapy or in combination with other antihyperglycemic agents. The primary objective of this study was to investigate potential pharmacokinetic interactions between lobeglitazone and metformin in healthy Korean subjects.     

Efficacy and tolerability of sitagliptin monotherapy in elderly patients with type 2 diabetes: a randomized,double-blind,placebo-controlled trial

Abstract

Objective:

Type 2 diabetes in the elderly is an important and insufficiently studied public health problem. This study evaluated sitagliptin monotherapy in patients with type 2 diabetes aged ≥65 years.