Prevention of episodic migraine with topiramate: a prospective 24-week,open-label,flexible-dose clinical trial with optional 24 weeks follow-up in a community setting

Abstract

Objective:

To explore efficacy and safety outcomes of topiramate for episodic migraine prevention in community practice.     

Safety,tolerability, pharmacokinetics and pharmacodynamics of albiglutide,a long-acting GLP-1-receptor agonist,in Japanese subjects with type 2 diabetes mellitus

Abstract

Objective:

To investigate safety, pharmacokinetics and pharmacodynamics of albiglutide in Japanese subjects with type 2 diabetes mellitus.     

Hypoglycemia in patients with type 2 diabetes from India and Malaysia treated with sitagliptin or a sulfonylurea during Ramadan: a randomized,pragmatic study

Abstract

Objective:

To compare the incidence of symptomatic hypoglycemia between sitagliptin and sulfonylurea in Muslim patients with type 2 diabetes who fasted during Ramadan.     

Comparison of gastrointestinal safety and tolerability of aceclofenac with diclofenac: a multicenter,randomized, double-blind study in patients with knee osteoarthritis

Abstract

Objective:

To compare the gastrointestinal (GI) tolerability and efficacy of aceclofenac with diclofenac in patients with knee osteoarthritis (OA).     

Effect of application site,clothing barrier,and application site washing on testosterone transfer with a 1.62% testosterone gel

Abstract

Objectives:

To evaluate the effect of application site location, clothing barrier, and application site washing on testosterone transfer from males dosed with 1.62% testosterone gel to female partners.     

Quality of life in raloxifene-treated Japanese women with postmenopausal osteoporosis: a prospective,postmarketing observational study

Abstract

Objective:

To assess changes in quality of life (QOL) and pain in raloxifene-treated Japanese women with postmenopausal osteoporosis.     

Factors associated with warfarin discontinuation,including bleeding patterns,in atrial fibrillation patients

Abstract

Objective:

To determine risk factors for both warfarin discontinuation and bleeding in patients with atrial fibrillation (AF).     

Comparison of quetiapine and risperidone in Chinese Han patients with schizophrenia: results of a single-blind,randomized study

Abstract

Objective:

To evaluate the efficacy and safety of 750?mg/day quetiapine fumarate (Seroquel) in the treatment of Chinese Han patients with schizophrenia.     

Efficacy,safety, and pharmacokinetics of ambrisentan in Japanese adults with pulmonary arterial hypertension

Abstract

Objective:

To investigate the efficacy, safety, and pharmacokinetics of ambrisentan in Japanese adults with pulmonary arterial hypertension (PAH).     

Efficacy and tolerability of sitagliptin monotherapy in elderly patients with type 2 diabetes: a randomized,double-blind,placebo-controlled trial

Abstract

Objective:

Type 2 diabetes in the elderly is an important and insufficiently studied public health problem. This study evaluated sitagliptin monotherapy in patients with type 2 diabetes aged ≥65 years.     

Average daily dose,medication adherence,and healthcare costs among commercially-insured patients with fibromyalgia treated with duloxetine

Abstract

Objective:

What is the relationship between average daily dose (ADD) of duloxetine, adherence to therapy, and healthcare costs among patients with fibromyalgia?     

Efficacy and safety of rupatadine for allergic rhino-conjunctivitis: a systematic review of randomized,double-blind,placebo-controlled studies with meta-analysis

Abstract

Background:

Allergic rhinitis is a complex inflammatory disease whose pathophysiology involves local and systemic mechanisms. Rupatadine, a molecule with intense antihistaminic activity and with antagonist PAF effects through its interaction with specific receptors, is indicated for the treatment of intermittent or persistent allergic rhinitis and urticaria.     

Effect of a plaster containing DHEP and heparin in acute ankle sprains with oedema: a randomized,double-blind,placebo-controlled,clinical study

Abstract

Objective:

Ankle sprains are the most frequent injuries in sport and daily life, and are usually treated with anti-inflammatory drugs or compounds that have an effect on microcirculation. The efficacy and tolerability of a novel plaster containing both diclofenac epolamine (DHEP) and heparin in the treatment of acute painful ankle sprains with oedema was investigated in a randomized, double-blind, placebo-controlled study.     

Long-term safety,tolerability, and efficacy of fesoterodine treatment in men and women with overactive bladder symptoms

Abstract

Objective:

To evaluate long-term safety, tolerability, and efficacy of fesoterodine for men and women with overactive bladder (OAB) symptoms.     

Assessment of safety,tolerability and effectiveness of adjunctive aripiprazole to lithium/valproate in bipolar mania: a 46-week,open-label extension following a 6-week double-blind study

Abstract

Objective:

This study evaluated the long-term tolerability and effectiveness of aripiprazole adjunctive to lithium or valproate in partial responders with bipolar mania.     

Relationship between background cancer pain,breakthrough pain,and analgesic treatment: a preliminary study for a better interpretation of epidemiological and clinical studies

Abstract

Background:

The different operational definitions of breakthrough cancer pain (BTcP) has generated unclear epidemiological data.     

Patient experience with a new teriparatide delivery device

Abstract

Objective:

To determine functionality and acceptability of a new teriparatide (Forteo, Eli Lilly and Company, Indianapolis, IN, USA) delivery device by patients with osteoporosis.     

Flexible dosing with paliperidone ER in the treatment of patients with acutely exacerbated schizophrenia: results from a single-arm,open-label study

Abstract

Objective:

To extend findings from fixed-dose, double-blind, placebo-controlled clinical trials in selected patient populations by using flexibly-dosed oral paliperidone extended-release (ER) in a more naturalistic setting.     

Progression to type 2 diabetes,healthcare utilization,and cost among pre-diabetic patients with or without comorbid hypertension

Abstract

Objective:

This study examined progression to type 2 diabetes and compared healthcare utilization and costs among patients with pre-diabetes, with or without comorbid hypertension.     

Retrospective study of total healthcare costs associated with chronic nonvalvular atrial fibrillation and the occurrence of a first transient ischemic attack,stroke or major bleed

Abstract

Objective:

To determine the direct healthcare costs associated with the onset of chronic nonvalvular atrial fibrillation (CNVAF), warfarin utilization and the occurrence of cerebrovascular events in a commercially-insured population.