共查询到15条相似文献,搜索用时 125 毫秒
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目的:探索台阶变温变湿加速试验法用于研究温度与湿度对药物稳定性影响的可行性。方法以维生素C为模型药物,通过恒温台阶变湿加速试验和恒湿台阶变温加速试验获得相关的降解动力学参数。结果台阶变温变湿法测得的降解动力学参数:m =4.5,Ea =111.5 kJ· mol-1,A =1.2×1013· h-1;经典恒温恒湿法测得:m =4.8,Ea =112.3 kJ· mol-1,A =8.9×1012 h-1;两者结果基本一致。结论该方法可用于维生素C稳定性的研究,且省时经济,容易操作。 相似文献
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目的建立台阶型变湿变温法对固体药物的稳定性研究方法。方法以哌拉西林钠为模型,采用台阶型变湿变温法研究哌拉西林钠的降解动力学过程。结果得到了哌拉西林钠降解过程的动力学参数A、m及Ea,与经典恒温恒湿法比较,结果一致。结论台阶法可用于哌拉西林钠的降解动力学研究,是否能用于其它固体药物还需进一步研究。 相似文献
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目的 建立一种研究湿度与温度同时影响药物稳定性的新方法.方法 以阿司匹林为模型药物,利用均匀优化设计分散原理组合所选的温度与湿度水平,以单测点法在组合点下进行稳定性加速试验,从而获得药物与湿度、温度有关的全部动力学参数.结果 所建立的方法与恒温恒湿法和程序变温变湿法得到的降解动力学参数基本一致.与程序变温变湿法相比,其准确度及精密度均高,且只需使用普通的恒温恒湿控制装置;与经典恒温恒湿法比较,能节约时间和样品.结论 平面单点测定法可应用于湿度和温度对药物稳定性的研究. 相似文献
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用线性变温法研究扑热息痛溶液和三磷酸腺苷注射液的稳定性 总被引:1,自引:0,他引:1
为了提高药品质量,保证药物疗效,研究制剂的稳定性及预测贮存期,对制剂生产是非常必要的。预测药物的稳定性通常在高于室温的条件下进行加速试验。加热加速的方法有两种,一种是恒温法,一种是变温法。近年来国内外对线性变温法研究较多,此法的优点在于只用一套升温装置,通过一次连续 相似文献
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The influence of both moisture and heat on the stability of aspirin was investigated by a single pair of experiments, one
with programmed humidity control and the other non-isothermal, rather than many standard isothermal studies, each at constant
relative humidity. In experiments, we adopted the acid-base back titration method to measure the content of aspirin in the
presence of its degradation products. It was found that the degradation of aspirin could be expressed as ln[(c
0−c)/c]=kt+D, where D was a lag time item not related to humidity and temperature. The relationship between the degradation rate constant k and humidity H
r
and temperature T could be described as Arrhenius equation multiplied by an exponential item of relative humidity: k = A · exp(mH
r
) · exp(−(E
a
/RT)), where A, E
a
and m were the pre-exponential factor, observed activation energy, and a parameter related to humidity, respectively. The results
obtained from the programmed humidifying and non-isothermal experiments, A=(1.09±2.04)×1012 h−1, E
a
=(93.5±2.2) kJ · mol−1 and m=1.18±0.19, were comparable to those from isothermal studies at constant humidity, A=(1.71±0.35)×1012 h−1, E
a
=(94.9±0.7) kJ · mol−1 and m=1.20±0.02. Since the programmed humidifying and non-isothermal experiments save time, labor and materials, it is suggested
that the new experimental method can be used to investigate the stability of drugs unstable to both moisture and heat, instead
of many classical isothermal experiments at constant humidity. 相似文献
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Programmed humidifying in drug stability experiments 总被引:2,自引:0,他引:2
The stability of penicillin potassium, as a solid state model, was investigated by a programmed humidity and temperature controlled method. An optimization calculational approach to data handling is suggested. The stability of drugs which are unstable to both heat and moisture could be studied by a single pair of experiments, one with programmed humidity control and one non-isothermal, rather than many standard isothermal studies, each at constant relative humidity. The controlling system, based on a pocket computer, was found to be accurate and reliable. The results indicated that the kinetic parameters obtained were comparable to those from isothermal studies. 相似文献
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盐酸特比萘芬搽剂的稳定性研究 总被引:1,自引:0,他引:1
目的考察盐酸特比萘芬搽剂的稳定性。方法通过光照、加速试验、室温留样试验,以HPLC法测定盐酸特比萘芬含量,溶液的外观性状为指标,考察本制剂的稳定性。结果制剂中盐酸特比萘芬在光照实验、加速试验及室温留样试验中含量变化小,含量均在95%以上,外观性状无明显变化。结论HPLC法可快速准确的测定盐酸特比萘芬的含量;盐酸特比萘芬搽剂稳定性好。 相似文献
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《International journal of pharmaceutics》1991,71(3):229-236
Dosage forms prepared using a humidity technique, and consisting of a polymer matrix in which the drug is dispersed, must be dried. The process of drying is rather complex, in the sense that it is controlled not only by evaporation of the vapour out of the surface but also by diffusion of the liquid through the solid. Generally, the diffusivity of the liquid through the polymer as well as the rate of evaporation increases with temperature exponentially. High temperature is able to reduce the time of drying, but a drawback appears with distortion of the shape of dosage forms because of the plasticity of humid beads at high temperature. A programmed temperature process is thus necessary to achieve drying under the best conditions, the rate of heating being a parameter of interest. 相似文献
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Performance of heated humidifiers with a heated wire according to ventilatory settings. 总被引:7,自引:0,他引:7
Delivering warm, humidified gas to patients is important during mechanical ventilation. Heated humidifiers are effective and popular. The humidifying efficiency is influenced not only by performance and settings of the devices but the settings of ventilator. We compared the efficiency of humidifying devices with a heated wire and servo-controlled function under a variety of ventilator settings. A bench study was done with a TTL model lung. The study took place in the laboratory of the University Hospital, Osaka, Japan. Four devices (MR290 with MR730, MR310 with MR730; both Fisher & Paykel, ConchaTherm IV; Hudson RCI, and HummaxII; METRAN) were tested. Hummax II has been developed recently, and it consists of a heated wire and polyethylene microporous hollow fiber. Both wire and fiber were put inside of an inspiratory circuit, and water vapor is delivered throughout the circuit. The Servo 300 was connected to the TTL with a standard ventilator circuit. The ventilator settings were as follows; minute ventilation (V(E)) 5, 10, and 15 L/min, a respiratory rate of 10 breaths/min, I:E ratio 1:1, 1:2, and 1:4, and no applied PEEP. Humidifying devices were set to maintain the temperature of airway opening at 32 degrees C and 37 degrees C. The greater V(E) the lower the humidity with all devices except Hummax II. Hummax II delivered 100% relative humidity at all ventilator and humidifier settings. When airway temperature control of the devices was set at 32 degrees C, the ConchaTherm IV did not deliver 30 mg/L of vapor, which is the value recommended by American National Standards at all V(E) settings. At 10 and 15 L/min of V(E) settings MR310 with MR730 did not deliver recommended vapor, either. In conclusion, airway temperature setting of the humidifying devices influenced the humidity of inspiratory gas greatly. Ventilatory settings also influenced the humidity of inspiratory gas. The Hummax II delivered sufficient water vapor under a variety of minute ventilation. 相似文献