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1.
Jian De Z. Chen Ph.D. Robert D. Richards M.D. Richard W. McCallum M.D. F.A.C.P. F.A.C.G. 《The American journal of gastroenterology》1994,89(1):79-85
Objective : The objective of this study was to investigate whether gastric contractions in the fasting and fed state can be identifled from the cutaneous electrogastro-gram. Methods : Simultaneous measurements of gastric myoelectrical and manometric activities were made in 10 healthy female volunteers from 1:00 AM to 9:45 AM. For manometric recording, a catheter incorporating solid state transducers was used. Cutaneous electro-gastrography (EGG) was used for myoelectrical recording. All EGG data from 1:00 AM to 7:30 AM that occurred during motor quiescence, all EGG data that occurred during antral contractions, and 2-h EGG data after breakfast given at 7:30 AM were quantitatively analyzed and compared with each other. The EGG in three specific periods (fasting without antral contractions, fasting with contractions, and postprandial) was characterized by four parameters that include frequency, power, and stabilities of the frequency and power. Results: 1 ) the peak power of the postprandial EGG was, respectively, 12.5 dB (about 2-fold increase n i amplitude) and 6.8 dB (ahout 1-fold increase in amplitude) higher than that during motor quiescence (p < 0.05) and motor activity in the fasting state; 2) the dominant frequency of the postprandial EGG was, respectively, 6% and 13% higher than that during motor quiescence and motor activity (p < 0.05) in the fasting state; 3) the peak power of the fasting EGG was 48% more unstable during motor activity than motor quiescence (p < 0.05); 4) the stability of the EGG frequency was not significantly different during the three different periods. Conclusion : The EGG provides important and useful information for the assessment of gastric motility. An unstable EGG peak power is indicative of gastric contractions in the fasting state. An increase in EGG peak power and/or dominant frequency after a solid test meal suggests a normal postprandial gastric motility. 相似文献
2.
Inhibitory effects of cholecystokinin on postprandial gastric myoelectrical activity 总被引:2,自引:0,他引:2
J. D. Z. Chen PhD Z. Y. Lin S. Parolisi R. W. McCallum MD 《Digestive diseases and sciences》1995,40(12):2614-2622
While a number of studies have investigated the effects of cholecystokinin (CCK) on gastrointestinal motility, little is known on the effects of CCK on gastric myoelectrical activity, which regulates gastric motility. The aim of this study was to investigate the effects of intravenous infusion of CCK-8 on gastric myoelectrical activity in normal humans. Gastric myoelectrical activity was measured in 10 healthy subjects with a noninvasive electrogastrographic technique by placing abdominal electrodes on the epigastric area. Two study sessions were performed in each subject on two separate days with double-blinded infusion of either saline or CCK (24 pmol/kg/hr). The procedure for each session was as follows: (A) 30-min baseline fasting electrogastrogram (EGG); (B) start infusion, another 30-min EGG; (C) give meal, 60-min EGG; and (D) stop infusion, another 60-min EGG. The dominant frequency and peak power (amplitude) of the EGG, and the percentage of normal 2–4 cycles/min slow waves during each recording session were computed and compared between placebo and CCK. It was found that normal 3 cpm slow waves were recorded in all EGGs. Infusion of CCK had no effect on the frequency of the gastric slow wave and did not induce gastric dysrhythmias. It was also found that intravenous infusion of CCK significantly decreased the EGG peak power (amplitude) during the first hour after the meal (the infusion was given during this period) in comparison with placebo (P<0.05). This inhibitory effect on EGG peak power was sustained but not significant during the second postprandial hour (the infusion was not given during this period). It was concluded that intravenous infusion of CCK at a physiological concentration significantly decreased the postprandial EGG amplitude in normal humans, suggesting an inhibitory effect on postprandial gastric motility, but did not change the frequency and regularity of the gastric slow wave. 相似文献
3.
BACKGROUND: Cholinergic regulation of chronotropic (frequency) and inotropic (force) aspects of antral contractility and how these impact on gastric emptying are not well delineated. AIMS: To determine the effects of cholinergic stimulation and inhibition on myoelectric, contractile, and emptying parameters of gastric motility. METHODS: Ten normal subjects underwent three studies each, using simultaneous electrogastrography (EGG), antroduodenal manometry, and gastric emptying with dynamic antral scintigraphy (DAS). After 30 minutes of baseline fasting manometry and EGG, subjects received saline intravenously, atropine (0.6 mg then 0.25 mg/hour intravenously), or bethanechol (5 mg subcutaneously). This was followed by another 30 minutes' recording and by three hours of postprandial recording after ingestion of a technetium-99m labelled solid meal. RESULTS: During fasting, atropine decreased, whereas bethanechol increased, the antral manometric motility index and EGG power. Postprandially, atropine decreased the amplitude of antral contractions by DAS, decreased the postprandial antral manometric motility index, and slowed gastric emptying. Atropine caused a slight increase in postprandial frequency of antral contractions by DAS and gastric myoelectrical activity by EGG. Bethanechol slightly increased the amplitude, but slightly decreased the frequency of antral contractions by DAS and decreased the frequency of gastric myoelectrical activity by EGG, with no significant increase in the motility index or gastric emptying. CONCLUSIONS: Cholinergic antagonism with atropine reduces antral contractility and slows gastric emptying. Cholinergic stimulation with bethanechol increases antral contractility, but decreases the frequency of antral contractions, without altering the antral motility index or gastric emptying. 相似文献
4.
Enhanced postprandial gastric myoelectrical activity after moderate-intensity exercise 总被引:2,自引:0,他引:2
OBJECTIVE: The aim of this study was to investigate the change of postprandial gastric myoelectrical activity and its relation with vagal activity after exercise. METHODS: Nine subjects were studied in two sessions. In the control session, gastric myoelectrical activity was recorded using electrogastrography (EGG) for 30 min in the fasting state and 60 min after a test meal. In the exercise session, after the baseline recording of both the EGG and electrocardiogram (ECG), the subject was put on a cycle ergometer for exercise until reaching 50% of the maximum age-predicted heart rate for 10 min. The test meal was then given and the recording was resumed for 60 more minutes. Spectral analyses were performed on both the EGG and the heart rate variability derived from the ECG. RESULTS: The postprandial increment of the dominant power (p<0.05) and the percentage of the 2-4 cpm slow waves (p = 0.01) were significantly higher with exercise. The standard deviation of the postprandial dominant frequency was significantly decreased (more stable slow waves) with exercise (p<0.04). While cardiac vagal activity was significantly decreased after the meal, exercise did not significantly affect the postprandial change. CONCLUSIONS: Gastric slow waves become more regular, more stable, and of higher amplitude after exercise, and this enhancement is probably not mediated via the vagal pathway. 相似文献
5.
Simonian HP Panganamamula K Chen JZ Fisher RS Parkman HP 《The American journal of gastroenterology》2004,99(3):478-485
OBJECTIVES: To determine the value of multichannel versus conventional single-channel electrogastrography (EGG) and of an additional postprandial hour recording in symptomatic patients. METHODS: Eighteen normal subjects and 47 patients with upper GI symptoms underwent multichannel EGG with four cutaneous recording electrodes placed on the antral axis. Fasting EGG was recorded for 1 h, followed by meal ingestion, followed by two 1-h postprandial EGG recordings. Variables assessed: (1) dominant frequency (DF) and its power; (2) percent time in normal (2-4) cpm frequency; (3) average percent of slow wave coupling (% SWC). RESULTS: Normal values for single-channel EGG were: (1) DF from 2.5-3.3, 2.7-3.5, and 2.6-3.5 cpm in the fasting, first, and second postprandial hours; (2) percentage of time in 2-4 cpm: >50%, >65%, and >65% in the fasting, first, and second postprandial hours. Normal values for percent SWC using multichannel EGG were >50%, >55%, >55% in the fasting, first, and second postprandial hours. In the symptomatic patients, an abnormal 2-h single-channel EGG was obtained in 16 of 47 (34%) patients. Adding an additional 1 h of postprandial recording identified another 4 abnormal patients (20/47 = 43%). With multichannel EGG, abnormal results were obtained in 24 of 47 patients (51%) with the 2-h study. An additional 1 h of postprandial recording identified another 4 patients as abnormal (28/47 = 60%). CONCLUSIONS: Multichannel EGG recording improved the detection of abnormal gastric myoelectric activity in symptomatic patients. This study also demonstrates prolonging the postprandial recording to 2 h increases the diagnostic yield for both single-channel and multichannel EGG. 相似文献
6.
Edrophonium Provocative Testing During Electrogastrography (EGG) (Effects on Dyspeptic Symptoms and the EGG) 总被引:2,自引:0,他引:2
Eugene S. Bonapace Henry P. Parkman Robert S. Fisher 《Digestive diseases and sciences》1998,43(7):1494-1500
The aim of this study was to determine whetheredrophonium induces dyspeptic symptoms and/or gastricmyoelectric changes in normal subjects and patients withfunctional dyspepsia. Eighteen normal controls and 28 patients with functional dyspepsiaunderwent electrogastrography (EGG) with edrophoniumadministration. After EGG recording with 1-hr fastingand 2-hr postprandial periods, subjects received anintravenous infusion of saline (placebo) followed byedrophonium 10 mg. After each injection, the EGG wasrecorded for 15 min and symptoms scored. Patients withfunctional dyspepsia had significantly more frequent gastrointestinal symptoms in response toedrophonium than normal controls. Edrophonium had noeffect on EGG dominant frequency, but increased thepower of the dominant frequency in both controls anddyspeptic patients. In the dyspeptic patients,reproduction of the patient's symptoms was associatedwith an increase in the power of the dominant frequency,whereas when no symptoms were produced, there was nochange in power. Overall, 21 of 28 dyspeptic patients(75%) had either an abnormal baseline EGG (N = 10) or anormal EGG and positive edrophonium test (N = 11). Inconclusion, edrophonium administration can reproduce symptoms in some dyspeptic patients.Symptoms after edrophonium administration may be relatedto either more vigorous gastric contractions and/orincreased visceral perception of normal gastric contractions. 相似文献
7.
FULL-YOUNG CHANG CHING-LIANG LU SHOU-DONG LEE GEI-LIAN YU 《Journal of gastroenterology and hepatology》1998,13(10):1027-1032
This study assessed the reliability of an improved electrogastrographic (EGG) system in recording stomach myoelectrical parameters and tried to establish the normal ranges of myoelectricity using this system. The analytical software of the current system mainly included an autoregressive modelling program to compute myoelectrical frequency and power. Forty healthy subjects were enrolled to receive myoelectrical measurement in two consecutively fasting and one postprandial 30 min sessions. The myoelectrical frequencies in both fasting and postprandial sessions were almost three cycles per min (c.p.m.) and showed little variation. The percentage of dominant frequencies (2.5–3.5 c.p.m.) in three sessions was approximately 80% while the computed myoelectrical powers in the first and second fasting sessions exhibited a significant correlation ( r = 0.84, P < 0.001). Meal ingestion increased the myoelectrical powers by 6.8 dB compared with the second fasting recording ( P < 0.001). The mean variation in myoelectrical amplitude for the ratio of second: first fasting session was 110.3 ± 88.8% (16–478%, median 88%). This new EGG system is, indeed, reliable for measuring myoelectrical frequency and power, whereas the interassay of recorded amplitudes appears markedly variable. 相似文献
8.
Gastric myoelectrical activity and gastric emptying in patients with functional dyspepsia 总被引:24,自引:0,他引:24
Zhiyue Lin M.S. Ervin Y. Eaker M.D. Irene Sarosiek M.D. Richard W. McCallum M.D. 《The American journal of gastroenterology》1999,94(9):2384-2389
OBJECTIVES: The aims of this study were to investigate gastric myoelectrical activity and gastric emptying (GE) and their relationship in patients with functional dyspepsia. METHODS: The study was conducted in 15 healthy volunteers (six women, nine men, mean age: 42 yr) and 15 patients (13 women, two men, mean age: 43 yr) with functional dyspepsia. Gastric myoelectrical activity was recorded using cutaneous electrogastrography (EGG) for 30 min in the fasting state and for 120 min simultaneously with GE monitoring after an isotope-labeled solid meal. The anterior/posterior images of the stomach were taken using a technetium scanner immediately after eating, and then at 1, 2, and 4 h to determine the percentage of gastric retention. The dominant frequency of the EGG, the change of the postprandial EGG peak power (deltaP), and the percentage of normal 2-4 cycles/min (cpm) slow waves during each recording session were calculated and compared between the patients and healthy subjects. RESULTS: The patients had a significantly lower mean percentage of 2-4 cpm slow waves, both in the fed state and in the fasting state, than did healthy subjects. Compared to the EGG in the fasting state, a significant increase of the EGG dominant frequency in the fed state was observed in healthy subjects but not in the patients. The mean postprandial EGG power increase in the patients was substantially less than in the healthy subjects during the first postprandial hour but similar during the second postprandial hour. The mean percentage of gastric retention in patients is substantially higher than in the healthy subjects, both at 2 h after eating and at 4 h after eating. Of 15 patients, nine (60%) had delayed GE (gastric retention at 2 h >50%) and 10 (66%) had abnormal EGGs (percentage of 2-4 cpm <70% and/or deltaP < 0). Eight of these 10 patients (80%) with abnormal EGGs had delayed GE. CONCLUSIONS: A high proportion of adult patients (60%) with functional dyspepsia have abnormally slow GE and abnormalities in gastric myoelectrical activity. 相似文献
9.
Chang FY Lu CL Chen CY Lee SD Wu CW Young ST Wu HC Kuo TS 《Digestive diseases and sciences》2001,46(7):1458-1465
Using a homemade electrogastrography (EGG) system, we studied the characteristics of myoelectrical rhythm in gastric cancer (GC) patients. Based on a short-term Fourier transform, recorded slow waves could be automatically analyzed to obtain the following parameters: dominant frequency/power, percent of normal rhythm (2.4–3.7 cpm), power ratio, etc. Fifty histologically confirmed GC patients (34 men, 16 women) were enrolled before surgical intervention to measure their fasting and postprandial EGG parameters for 30 min. The cancerous parameters of GC patients were then obtained postoperatively. In addition, 46 healthy subjects were enrolled for comparison. When compared to controls, GC patients had the following characteristics: absence of postprandial increase in dominant frequency (GC: 3.04 ± 0.47 vs 3.07 ± 0.44 cpm, NS; controls: 3.02 ± 0.31 vs 3.21 ± 0.25 cpm, P < 0.001), marked power response after meal (P < 0.05), and obvious power ratio (4.58 ± 7.38 vs 2.27 ± 2.05, P < 0.05). Multivariate analysis indicated that advanced GC was the factor responsible for the obvious dominant power enhancement after meal (P < 0.05). Other demographic, clinical, and cancerous factors did not influence EGG parameters. We conclude that apparent arrhythmia is not encountered in GC patients, although they mainly exhibit obvious postprandial power response. Advanced GC is likely responsible for this power enhancement on EGG recording. 相似文献
10.
Dr. Kenneth L. Koch MD William R. Stewart MS Robert M. Stern PhD 《Digestive diseases and sciences》1987,32(11):1217-1222
The relationship between the cutaneously recorded electrogastrogram (EGG) and gastric contractions in man is unclear. We investigated: (1) the relationship between the electrogastrogram (EGG) signals and gastric contractions elicited by barium meals and (2) the effects of barium meals on frequency and amplitude of EGG signals. As documented by fluoroscopy in four healthy subjects, barium meals stimulated three per minute gastric peristalsis which corresponded with simultaneously recorded three cycle per minute (cpm) EGG waves. Eighteen other healthy volunteers ingested 45% (w/v) or 60% barium suspensions. As determined by Fourier analysis, the dominant EGG frequency before barium was 3 cpm in 16 subjects; two subjects had no distinct frequency peaks. After barium ingestion, the mean amplitude or power at 3 cpm and 1 cpm increased, but the increase was significant only after 45% barium. In conclusion: (1) individual EGG waves after barium reflect gastric peristaltic sequences, which are reflected in increases in amplitude or power of 3 cpm EGG activity; (2) density or viscosity of the barium meal affects the gastric myoelectric response; and (3) mechanical correlates of 1 cpm EEG activity are unknown. 相似文献
11.
Inhibitory effect of white wine on gastric myoelectrical activity and the role of vagal tone 总被引:3,自引:0,他引:3
Although extensively investigated throughout the gastrointestinal tract, the influence of alcohol on gastric motility is still unclear. Our aim was to investigate the effect of wine on gastric myoelectrical activity and vagal activity. Ten healthy subjects were studied in two sessions with the electrogastrogram (EGG) for 30 min at baseline, 30 min after ingesting the test liquid [white wine (12.5% alcohol) or matched juice], and 60 min after a standard test meal. Spectral analysis was performed to compute EGG parameters and their postprandial changes. The vagal activity was assessed based on spectral analysis of the heart rate variability (HRV) signal derived from the ECG recording. White wine preload significantly diminished the postprandial increase in EGG dominant power compared to juice preload (1.16 ± 1.57 vs 5.48 ± 1.01 dB, P < 0.001). A significant decrease in vagal activity was observed after wine (23.40 ± 4.30 vs 17.43 ± 3.40%, P < 0.005), which remained unchanged after the test meal (23.40 ± 4.30 vs 16.77 ± 4.40%, P < 0.05). This decrease was not noted in the juice session. A correlation was established between changes after wine consumption in EGG dominant power and in the percentage of the vagal activity (r = 0.89, P < 0.05). In conclusion, white wine preload inhibits the postprandial EGG dominant power, suggesting a possible inhibition of postprandial gastric contractions. This effect may be associated with diminished vagal activity. 相似文献
12.
Robert M. Stern PhD Howard E. Crawford BS William R. Stewart PhD Michael W. Vasey MS Kenneth L. Koch MD 《Digestive diseases and sciences》1989,34(4):521-527
The effects of sham feeding on gastric motility of human subjects have not previously been studied. The amplitude of 3-cpm electrogastrogram (EGG) waves increases after the ingestion of food. We hypothesized that sham feeding would stimulate a similar, but briefer gastric myoelectric response. Healthy human subjects chewed and expectorated a hot dog on a roll and later ate a second hot dog. EGGs were continuously recorded before, during, and after sham feeding and eating. The results of experiment I (N=27) showed that the hand-scored amplitude of the 3-cpm waves increased significantly (P<0.01) during sham feeding. Two minutes after sham feeding, the mean amplitude of 3-cpm EGG waves returned to baseline level. The increase in EGG amplitude during eating was also significant (P<0.01), and remained increased for approximately 30 min after ingestion. The procedure used in experiment II (N=20) was similar to experiment I, but EGGs were computer analyzed and power, ie, spectral intensities, at 3 cpm were obtained. The increase in power at 3 cpm during sham feeding and during eating was significant (P< 0.05 and P<0.02, respectively). Similar to experiment I, the duration of increase in power at 3 cpm was brief during sham feeding compared to the postprandial increase. Four vagotimized subjects failed to show an increase in power at 3 cpm in response to sham feeding. We conclude: (1) The cephalic—vagal stimulation of sham feeding increases briefly the amplitude and power of 3-cpm gastric myoelectric activity in healthy subjects but not vagotomized patients. (2) The increase in postprandial 3-cpm amplitude is prolonged, reflecting initial cephalic-vagal activity and subsequent gastric stimulation by luminal contents. 相似文献
13.
We designed a new three-channel electrogastrographic (EGG) system, which was easily operated on the Windows 95 platform and
could automatically provide slow wave parameters. The purpose of the present study was to test its reliability and accuracy
in clinical recording. The system included a signal acquisition device assembled on a printed circuit board. Recorded myoelectrical
signals were filtered, amplified, digitized, and transmitted via this device into a notebook personal computer (PC). Based
on the short-term Fourier transform the software could transfer the time domain of the signal into the frequency domain. Real-time
displayed slow wave parameters, including dominant frequency/power, percent of normal frequency (2–4 cpm), instability coefficient
in frequency/power, and power ratio, were automatically renewed every 64 s. Twenty healthy subjects (M/F, 12/8; age, 23–51
years) were enrolled to measure both fast and postprandial myoelectrical activities for each 30-min recording. Our results
indicated that meal ingestion significantly increased dominant frequency (3.15 ± 0.20 vs 3.23 ± 0.23 cpm; P < 0.05) and power (26.1 ± 3.8 vs 28.4 ± 3.9 dB; P < 0.05). The power ratio of the meal effect was 2.02 ± 2.07. Other parameters, including instability coefficient and percent
of normal frequency, remained similar despite food ingestion. This newly designed EGG system is acceptable for clinically
measuring gastric myoelectrical activity; the real-time display of many EGG parameters is an advantage with this new system.
Received: May 1, 2000 / Accepted: July 28, 2000 相似文献
14.
Stomach myoelectrical response of patients with gastroesophageal reflux disease receiving omeprazole treatment 总被引:1,自引:0,他引:1
Chang FY Lu CL Chen CY Luo JC Jiun KL Lee SD Wu HC 《Journal of gastroenterology and hepatology》2003,18(12):1399-1406
BACKGROUND AND AIM: Proton pump inhibitor treatment is effective for gastroesophageal reflux disease (GERD). It is unknown whether these agents effect any change in the stomach myoelectricity of GERD patients. Electrogastrographic (EGG) recording was used to study the probable effect of omeprazole on GERD patients. METHODS: Nineteen endoscopically confirmed GERD patients and 38 dyspepsia-free controls were invited to receive EGG recording. After daily omeprazole treatment for 4 weeks, the symptomatic response of GERD patients was scaled, healing of erosive esophagitis was endoscopically assessed, and EGG recording was repeated for comparison. RESULTS: Before treatment, GERD patients and controls displayed similar dominant frequency, whereas the former had higher dominant power compared with controls, either in fasting (29.2 +/- 6.0 dB compared with 25.3 +/- 3.8 dB, P < 0.01) or postprandial (31.9 +/- 5.6 dB compared with 27.7 +/- 3.8 dB, P < 0.001) recording. They also had diminished percentile normal rhythm (2-4 c.p.m.), irrespective of fasting (40.2 +/- 14.5% compared with 65.8% +/- 23.5%, P < 0.001) or postprandial (47.5 +/- 23.3% compared with 77.9 +/- 16.8%, P < 0.001) recording. After omeprazole treatment, healing was achieved in 12 patients (63.2%). Among the abnormal EGG parameters, only the postprandial percentile normal rhythm was restored (47.5 +/- 23.3% compared with 65.2 +/- 20.8%, P < 0.01). CONCLUSIONS: Gastroesophageal reflux disease patients may have obvious dysrhythmia and higher myoelectrical power. Effective omeprazole treatment only improves the postprandial myoelectrical regularity, whereas abnormal EGG parameters remain impaired. 相似文献
15.
Abnormal gastric myoelectrical activity and delayed gastric emptying in patients with symptoms suggestive of gastroparesis 总被引:28,自引:0,他引:28
J. D. Z. Chen PhD Zhiyue Lin MS Jie Pan MD Richard W. McCallum MD 《Digestive diseases and sciences》1996,41(8):1538-1545
Gastric myoelectrical activity modulates gastric motor activity. Abnormalities in gastric myoelectrical activity may be associated with gastric motility disorders. The aim of this study was to investigate the correlation of gastric myoelectrical activity with gastric emptying in symptomatic patients with and without gastroparesis. Ninety-seven patients with symptoms suggestive of gastroparesis participated in the study. Gastric myoelectrical activity was recorded using surface electrogastrography. The electrogastrogram (EGG) was recorded for 30 min in the fasting state and for 120 min after a solid test meal. Gastric emptying of the solid meal was simultaneously monitored for 120 min. Patients with delayed gastric emptying showed a significantly lower percentage of normal gastric slow waves (P<0.03) and a significantly reduced increase of the dominant power in the postprandial EGG (P<0.02). Postprandial EGG parameters were found to be able to predict delayed emptying of the stomach. Postprandial gastric dysrhythmia predicts delayed gastric emptying with an accuracy of 78%, while the abnormality in postprandial EGG power predicts delayed gastric emptying with an accuracy of 75%. All patients with abnormalities in both the rhythmicity and the power had delayed gastric emptying. Patients with delayed gastric emptying have a lower percentage of normal gastric slow waves in the EGG and a lower postprandial increase in the dominant power. Abnormalities in the postprandial EGG seem to be able to predict delayed emptying of the stomach. However, a normal EGG does not seem to guarantee normal emptying of the stomach. 相似文献
16.
Marie I Levesque H Ducrotté P Denis P Hellot MF Benichou J Cailleux N Courtois H 《The American journal of gastroenterology》2001,96(1):77-83
OBJECTIVES: This study aims to assess the prevalence of gastric electrical activity dysfunction with cutaneous electrogastrography (EGG), disturbances of gastric emptying function using radiopaque pellets, and gastric endoscopic abnormalities in patients with systemic sclerosis (SSc). We also investigate for an association between EGG and gastric-emptying data with clinical manifestations and esophageal motor disturbances. METHODS: Fasting and postprandial gastric electrical activity was studied in 22 consecutive patients with SSc (17 with and 5 without clinical gastric manifestations) and 22 age- and sex-matched healthy subjects. Gastric emptying of radiopaque pellets and gastroscopy were also performed in SSc patients. RESULTS: The prevalence of EGG disturbances was as high as 81.82% in SSc patients. SSc patients exhibited, compared with controls, higher median percentage of dominant frequency in bradygastria during the fasting period and lower median values for postprandial electrical power and postprandial to fasting ratio for electrical power. Gastric emptying of radiopaque pellets was delayed in 11 SSc patients, and gastroscopy demonstrated "watermelon stomach" in 3 SSc patients. No correlation was found between the severity of gastric impairment and clinical presentation, SSc duration and subsets, and esophageal manometric impairment. CONCLUSIONS: Our study underlines the high frequency of gastric dysfunction in SSc patients. It suggests the usefulness of EGG in SSc in noninvasively detecting disorders of gastric electrical activity at an early stage and symptomatic patients with gastroparesis (because there was a correlation between values of postprandial to fasting ratio for electrical power of < 1 on EGG and delayed gastric emptying). Gastric-emptying evaluation of radiopaque pellets may further be a helpful method to depict symptomatic SSc patients with gastroparesis. Finally, our series confirms that watermelon stomach diagnosis should be excluded in SSc patients presenting with gastrointestinal hemorrhage or with anemia related to iron deficiency. 相似文献
17.
Dr. Boris Pfaffenbach MD Romuald Joachim Adamek MD Klaus Kuhn Martin Wegener MD 《Digestive diseases and sciences》1995,40(7):1445-1450
Electrogastrography (EGG) permits measurements of the gastric electrical activity. However, normal values of electrical activity are poorly defined. In addition, limited data are available on the effect of age and gender. Therefore, in 40 healthy subjects (age range: 19–90 years) normal values for several EGG parameters were assessed after an overnight fast for 1 hr in the fasting and fed state after ingestion of a standardized solid-liquid meal. The electrical signals were capture by a pair of surface electrodes sonographically placed on the skin overlying the gastric antrum. The dominant electrical frequency was predominantly in the defined normal frequency range between 2 and 4 cycles per minute (cpm) (P<0.001) and was higher in the postprandial than in the preprandial period (3.1 cpm vs 2.8 cpm,P=0.02). The instability of the electrical rhythm calculated by a dominant frequency instability coefficient (DFIC) was postprandially lower than in the fasting state (P=0.04). The electrical power (amplitude) increased postprandially (postprandial to fasting power ratio =2.4). To evaluate the influence of age and gender on normal values the subjects were divided into four groups (median age: male, 28 and 69 years; female, 25 and 67 years). The most parameters did not differ significantly between the groups. However, DFIC was different between the groups (P<0.05), with elderly women revealing lowest DFIC. In conclusion, normal values for several EGG parameters evaluated in this study should be included in the analysis of gastric electrical activity. The magnitude of electrical frequency and power are not influenced by age and gender, whereas the instability of the electrical frequency is influenced by these factors. 相似文献
18.
Lu CL Chen CY Luo JC Chang FY Lee SD Wu HC Chen JD 《World journal of gastroenterology : WJG》2005,11(3):372-376
AIM: To investigate whether gastric myoelectrical activity was impaired in patients with chronic pancreatitis (CP) and to explore the role of pancreatic enzyme in regulating gastric myoelectrical activity. METHODS: Twenty CP patients and 20 controls participated in the study. Gastric myoelectrical activity was recorded by a homemade electrogastrography (EGG) device. Two experiments were carried out. In experiment one, EGG was recorded in both controls and CP patients. While in experiment two, either pancreatic enzymes or placebo was given together with test meals. Spectral analysis was used to generate various EGG parameters. RESULTS: The control subjects, but not the CP patients, showed typically increased postprandial dominant frequency. The postprandial dominant power (DP) increment (2.24±1.13 vs 5.35±0.96 dB, P= 0.04) and the percentage of normal 2-4 cpm slow waves (63.0±3.8% vs 77.4±3.1%, P<0.05) were lower in CP patients when compared with the control. In the 20 CP patients, the DP increment (4.76±1.02 vs 2.53±1.20 dB, P<0.05) and the postprandial percentage of normal 2-4 cpm (74.4±2.8% vs 64.8±5.7%, P<0.05) were significantly higher with pancreatic enzyme replacement than the placebo. CONCLUSION: CP patients have an abnormal postprandial stomach myoelectricity showing poor response in dominant frequency/power and regularity, whereas these abnormalities are corrected after pancreatic enzyme replacement. Maldigestion is likely to be the factor leading to abnormal postprandial gastric myoelectricity of CP patients. 相似文献
19.
Effects of epalrestat,an aldose reductase inhibitor,on diabetic neuropathy and gastroparesis 总被引:7,自引:0,他引:7
Okamoto H Nomura M Nakaya Y Uehara K Saito K Kimura M Chikamori K Ito S 《Internal medicine (Tokyo, Japan)》2003,42(8):655-664
OBJECTIVE: Diabetic patients with severe autonomic nervous disorder show delayed gastric emptying accompanied by diabetic gastroparesis, which decreases the electric activity of the stomach associated with gastric motility. It is reported that epalrestat, an aldose reductase inhibitor, is useful for treating diabetic neuropathy. Therefore, we evaluated whether this drug improves the decreased gastric motility in diabetic patients. METHODS: The present study evaluated the electrogastrograms (EGG) and autonomic nervous activity in 15 healthy volunteers (N group), and in 15 diabetic patients before and after the administration of epalrestat (DM group). Autonomic nervous activity was evaluated by spectral analysis of heart rate variability. The EGGs were recorded before and after oral administration of epalrestat (3 months or more) in the DM group. RESULTS: The dominant frequency of EGG was 3 cycles/min (cpm) in the N group. However, these 3 cpm waves disappeared with bradygastria, and postprandial increases in the peak powers of EGG were not observed in the DM group. Both the amplitude of 3 cpm waves and the postprandial peak powers were significantly increased after the administration of epalrestat. The parameters of autonomic nervous activities (LF power, HF power, and the LF/HF ratio) were significantly lower in the DM group before the administration of epalrestat than in the N group. However, these parameters were improved after the administration of epalrestat. CONCLUSION: Since gastroparesis is a form of diabetic dysautonomia, complication by gastroparesis may influence blood sugar control and the absorbance of oral antidiabetics. Epalrestat significantly increased the amplitude of 3 cpm waves on EGG and improved the spectral analytical parameters of heart rate variability. These findings suggest that epalrestat is useful for the treatment of diabetic gastroparesis. 相似文献
20.
Electrogastrographic power ratio in humans is not related to changes in antrum-skin distance but to antral motility 总被引:4,自引:0,他引:4
Yutaka Shimada Michio Watanabe Naotoshi Shibahara Toshiaki Kita Takashi Itoh Katsutoshi Terasawa 《Journal of gastroenterology》1998,33(3):310-317
It is not clear whether the power increase in electrogastrography (EGG) after meal or water ingestion reflects increases
in gastric motility or gastric distension bringing the stomach closer to the electrodes on the abdominal skin surface. We
recorded EGG and real-time ultrasonography simultaneously before and after 150-ml water ingestion in 17 healthy volunteers.
We calculated gastric power, by spectral analysis of EGG by the maximum entropy method, for 400 s before and after water ingestion,
and calculated their ratio (power ratio). We calculated, using sonography, the number of antral contractions before and after
water ingestion, the motility index after water ingestion, the distance between the antrum and the abdominal skin surface
before and after water ingestion, and the ratio of these distances (distance ratio). The number of contractions was positively
correlated with gastric power before water ingestion, and the antrum-skin distance was negatively correlated with gastric
power both before and after water ingestion. The motility index after water ingestion was positively correlated with both
gastric power after water ingestion (Spearman's rank correlation r = 0.492; P = 0.0498) and the power ratio (r = 0.615; P = 0.0141). There was no correlation between the distance ratio and the power ratio. These results suggest that the power
increase in EGG induced by water ingestion does not reflect the approach of the antrum to the abdominal surface, but rather,
reflects antral motility after water ingestion.
(Received June 16, 1997; accepted Nov. 28, 1997) 相似文献