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1.
目的:观察奥美拉唑联合莫沙必利治疗反流性食管炎的疗效。方法:将132例经内镜检查确诊的反流性食管炎患者随机分为治疗组(66例)和对照组(66例)。治疗组:奥美拉唑20 mg,晨服1次,莫沙必利每次5 mg,每日3次于餐前半小时口服;对照组:西咪替丁800mg,每晚睡前1次。疗程均为8周。结果:治疗组临床有效率98.5%,内镜下有效率95.5%;对照组临床有效率74.2%,内镜下有效率71.2%,两组比较差异有显著性(P<0.01)。结论:奥美拉唑联合莫沙必利治疗反流性食管炎的疗效优于西咪替丁联合莫沙比利。 相似文献
2.
目的 :观察奥美拉唑联合莫沙必利治疗反流性食管炎的疗效。方法 :将 6 5例患者随机分为观察组 (34例 )和对照组(31例 ) ,观察组 :奥美拉唑 2 0mg ,晨服 1次 ,莫沙必利每次 5mg ,每日 3次于餐前半小时口服 ;对照组 :单用奥美拉唑 2 0mg ,晨服 1次。两组治疗 4周后均行内镜复查。结果 :观察组临床有效率 94 .1 2 % ,内镜下有效率 88.2 4 % ;对照组临床有效率70 97% ,内镜下有效率 6 1 .2 9% ,两组比较差异有显著性 (P <0 .0 5 )。结论 :奥美拉唑联合莫沙必利治疗反流性食管炎比单独服用奥美拉唑具有更好的疗效。 相似文献
3.
奥美拉唑联合莫沙必利治疗反流性食管炎的近期疗效 总被引:3,自引:0,他引:3
目的 观察奥美拉唑联合莫沙必利缓解胃食管反流症状和治疗反流性食管炎的疗效.方法 106例反流性食管炎病人,其中治疗组36例用奥美拉唑和莫沙必利,对照l组35例用奥美拉唑;对照2组35例用莫沙必利,观察治疗前及治疗后2、4、8周的临床症状改善和治疗8周的内镜变化.结果 用药2周、4周时,治疗组症状好转与对照组相比,差异有统计学意义(P<0.05),用药8周结束时,治疗组症状改善明显优于对照组1和2组(P<0.05),内镜8周复查治疗组、对照组1和2组食管粘膜病损愈合率分别为86.1%、62.9%和57.1%,差异有统计学意义(P<0.05).结论 奥美拉唑和莫沙必利联合用药较单一用药治疗反流性食管类疗效更好. 相似文献
4.
目的:观察莫沙必利联合奥美拉唑治疗反流性食管炎的临床疗效.方法:48例经内镜检查确诊的反流性食管炎患者随机分为治疗组和对照组,每组24例患者.治疗组患者餐前30min口服莫沙必利5mg,3次/d,另早晨空腹及晚上睡前各服用奥美拉唑20mg,2次/d;对照组单纯服用奥美拉唑,服用方法同治疗组.两组患者疗程均为8周,观察两组患者的治疗总有效率和胃镜下粘膜的愈合情况.结果:治疗后,治疗组的总有效率为95.84%,明显高于对照组(P<0.05);治疗组胃镜下粘膜的愈合情况明显优于对照组(P<0.05).结论:莫沙必利联合奥美拉唑治疗反流性食管炎优于单独使用奥美拉唑. 相似文献
5.
奥美拉唑联合莫沙必利治疗反流性食管炎65例疗效观察 总被引:1,自引:0,他引:1
目的:观察奥美拉唑联合莫沙必利治疗反流性食管炎临床疗效。方法:选取收治的反流性食管炎患者130例,随机分为观察组和对照组各65例,观察组给予奥美拉唑20 mg,早晚餐前30 min服药,莫沙必利5 mg,3次/d。疗程4周;对照组用单用奥美拉唑。结果:经过4周治疗,观察组疗效明显优于对照组,差异有统计学意义(P<0.05)。结论:奥美拉唑联合莫沙必利治疗反流性食管炎疗效明显,值得临床推广。 相似文献
6.
达克普隆和莫沙必利治疗反流性食管炎的对比观察 总被引:1,自引:0,他引:1
目的评价达克普隆和莫沙必利治疗反流性食管炎的疗效及应用范围.方法对84例反流性食管炎患者进行随机对照治疗观察,达克普隆组42例,30mg,每日1次,莫沙必利组42例,5mg,每日3次,疗程均为4周,观察指标包括烧心、胸痛、反酸、打嗝等临床症状,内镜及24小时食管PH监测数据.结果达克普隆组和莫沙必利组2周末症状控制有效率分别为71.4%和52.4%(P<0.05),4周末分别为83.3%和76.2%(P>0.05),内镜有效率分别为90.5%和85.7%(P>0.05),食管PH监测数据改善,两药相似,但在Ⅱ~Ⅳ级食管炎,内镜有效率及食管PH监测改善方面,达克普隆优于莫沙必利.结论达克普隆,莫沙必利对反流性食管炎疗效良好,但治疗Ⅱ级以上食管炎前者疗效优于后者,说明对反流性食管炎进行分级治疗是十分合理而有实际意义的. 相似文献
7.
目的 探讨雷贝拉唑联合莫沙必利治疗反流性食管炎(Refiux esophagitis,RE)的近期疗效和安全性.方法 将经胃镜证实的反流性食管炎患者110例随机分成治疗组和对照组各55例.治疗组:口服雷贝拉唑10mg,早晚各1次餐前服用,莫沙必利每次5mg,3次/日,餐前半小时服用;对照组:奥美拉唑20mg/日,餐前服用,莫沙必利服用方法同上.2组病人均完成6周治疗,对其临床疗效和安全性进行临床观察.结果 2组临床症状缓解总有效率(临床症状改善和胃镜下病变粘膜缓解情况)分别为治疗组94.54%(52/55),对照组76.36%(42/55),治疗组总有效率优于对照组(p<0.05),且不良反应少.结论 雷贝拉唑联合莫沙必利治疗反流性食管炎临床症状改善迅速,临床疗效优于奥美拉唑联合莫沙必利治疗反流性食管炎,且安全可靠. 相似文献
8.
目的:观察奥美拉唑联合莫沙必利治疗反流性食管炎临床疗效。方法:选取收治的反流性食管炎患者92例,随机分为观察组和对照组各46例,观察组给予奥美拉唑20 mg,早晚餐前30分钟口服,莫沙必利5 mg,3次/d口服。对照组单用奥美拉唑20 mg,2次/d,早、晚餐前30分钟口服。结果:经过4周治疗,观察组疗效明显优于对照组,差异有统计学意义(P<0.05)。2组都无严重不良反应。结论:奥美拉唑联合莫沙必利治疗反流性食管炎临床疗效明显,值得基层医院临床应用。 相似文献
9.
目的:观察雷贝拉唑联合莫沙必利治疗反流性食管炎的疗效。方法:将124例经内镜检查确诊的反流性食管炎患者随机分为治疗组(62例)和对照组(62例)。治疗组:雷贝拉唑10 mg,每天1次,莫沙必利每次5 mg,每天3次,于餐前半小时口服;对照组:雷尼替丁150mg,每天2次,莫沙必利每次5 mg,每天3次,于餐前半小时口服。疗程均为8周。结果:治疗组临床有效率98.4%,内镜下有效率95.2%;对照组临床有效率75.9%,内镜下有效率67.7%,2组比较差异有显著性(P<0.05)。结论:雷贝拉唑联合莫沙必利治疗反流性食管炎的疗效优于雷尼替丁联合莫沙比利。 相似文献
10.
奥美拉唑联合莫沙必利治疗反流性食管炎疗效观察 总被引:1,自引:0,他引:1
目的探讨奥美拉唑联合莫沙必利治疗反流性食管炎的疗效。方法 78例患者随机分为治疗组和对照组,每组39例。治疗组服用奥美拉唑肠溶胶囊,20~60mg/次,1~2次/d。晨起空腹吞服或早晚各1次,莫沙必利5mg,3次/d,餐前口服,疗程8周。对照组:雷尼替丁150mg,2次/d,餐前口服,莫沙必利5mg,3次/d,餐前口服,疗程8周。观察两组患者的治疗效果。结果治疗组治疗8周后疗效与对照组比较差异有统计学意义(u=2.9545,P〈0.01)。结论奥美拉唑联合莫沙必利治疗反流性食管炎疗效确切。 相似文献
11.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD. 相似文献
12.
Jiageng Zhu Jun Li Ruipeng Ji Jianghao Su Mingshun Shen Zhigang Cao 《南京医科大学学报(自然科学版)》2007,21(2):125-128
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment. 相似文献
13.
Tao Ye * Zhi-quan Liu Jian-jun Mu Xi-han Fu Jun Yang Bao-lin Gao and Xiao-hong Zhang Department of Cardiology First Hospital of Xi'an Jiaotong University Xi'an Hanzhong Cardiovascular Institute Hanzhong 《中国医学科学杂志(英文版)》2004,19(4):248-251
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure. 相似文献
14.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险. 相似文献
15.
Jingming Zhu Ningning Hui Xiuhong Jiang Huaxing Zhang Chengzhang Fu 《南京医科大学学报(自然科学版)》2007,21(6):386-389
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients. 相似文献
16.
Objective:To investigate the gene expression of osteoprotegerin(OPG) and osteoclast differentiation factor(ODF) in the bone tissue of patients with hip fracture due to osteoporosis. Methods:OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers(over 50 years old) with hip fracture(Observer Group) and 30 cases of hip facture sufferers with no osteoporosis(Control group) were analyzed with the Semi-Quantitative RT-PCR method. Results:The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion:Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption. 相似文献
17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P. 相似文献
18.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine. 相似文献
19.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center. 相似文献
20.
Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine
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A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes. 相似文献