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1.
Kenji Ibukuro Takaya Takeguchi Hozumi Fukuda Shoko Abe Kimiko Tobe 《Surgical and radiologic anatomy : SRA》2016,38(9):1061-1067
Purpose
To analyze the vascular structure of the liver in patients with a right-sided round ligament.Methods
We reviewed 16 patients with a right-sided round ligament and 3 polysplenia and situs inversus patients with a left-sided round ligament who underwent multidetector row CT with contrast media. The patient population consisted of 13 men and 6 women (mean 62 years). We analyzed the axial and volume-rendered images for the location of the round ligament, gallbladder, portal veins, hepatic veins, and hepatic artery. The following imaging findings for the patients with polysplenia and situs inversus were horizontally reversed.Results
The prevalence of a right-sided round ligament with and without polysplenia was 75 and 0.11 %, respectively. The gallbladder was located to the right, below, and left of the round ligament in 27.7, 38.8 and 33.3 %, respectively. Independent branching of the right posterior portal vein was noted in 57.8 %. PV4 was difficult to identify in 36.8 %. The middle hepatic vein was located to the left of the round ligament. Two branching patterns for the lateral and medial branches of the right anterior hepatic artery were noted: the common (44.4 %) and separated types (55.5 %). Both of the right anterior hepatic artery and portal vein ramified into two segments; the lateral segment with many branches and the medial segment with a few branches.Conclusions
The right-sided round ligament divided the right anterior section into the lateral and medial segments based on the portal vein and hepatic artery anatomy.2.
Camilla Melholt Katrine Joensson Helle Spindler John Hansen Jan Jesper Andreasen Gitte Nielsen Astrid Noergaard Anita Tracey Charlotte Thorup Rikke Kringelholt Birthe Irene Dinesen 《Patient education and counseling》2018,101(5):854-861
Objective
The aims of this study are two-fold: 1) To explore how cardiac patients experience their use of a telerehabilitation tool for recuperation from surgery, and 2) To study how the patients’ use of the interactive ‘Active Heart’ web portal affected their eHealth literacy skills.Methods
The ‘Active Heart’ telerehabilitation web portal offers patients and their relatives information and exercises for recovery from cardiac surgery. 109 cardiac patients were using the Active Heart web portal for a duration of three months.Results
49 patients completed questionnaires that were administered both before and after their use of the portal, resulting in a 45% response rate. Respondents had a mean age of 60.64?±?10.75 years, and 82% of the respondents were males. The respondents had a positive impression of Active Heart, reporting that it was easy to access, user-friendly, and written in an understandable language. The patients’ eHealth literacy skills increased during the trial period.Conclusion
Use of a cardiac telerehabilitation web portal can be beneficial for patient education and can increase cardiac patients’ eHealth literacy skills.Practice implications
Online telerehabilitation portals may be used as a tool in patient education and cardiac rehabilitation. 相似文献3.
Introduction
Stress affects the central nervous system leading indirectly to modulation of the activity of steroid, catecholamine and opioid systems. It also affects behaviour, immune system, cardiovascular responses and gastrointestinal tract. In response to stress, a cascade of neurohumoral events chiefly at the level of hypothalamic-pituitary-adrenocortical (HPA) axis, is triggered, the result of which is the termination of stress reaction leading to normalization.During Induction of stress hormone epinephrine concentration increases many times in the body.Methods
In the present study short term (5 days) and long term (21 days) foot shock stress was given to Albino mice of old age of BALB C strain (481 days old) to see any the histological changes in liver, spleen and kidney.Results
Mice subjected to long term stress showed in liver vacuolization, elongation of nucleus of hepatic cells and infiltration. While in kidney dilated Bowman’s capsule, frequent vacuolization in renal cortex, degeneration of cells of proximal convoluted tubule, whereas in spleen there was increase in size of the follicles and red pulp morphology of parenchyma (increase in red pulp).Discussion
Thus it is concluded from the entire study that long term stress causes degeneration in hepatic cells, infiltration in liver, degeneration of glomerulus, bowman’s capsule, convoluted tubules in kidney which finally leading to both hepato-toxicity and nephro-toxicity. In spleen long term stress alters the immune response in Old age Albino Mice by inducing morphology changes, explaining in part the indicating impaired immunity that develops in organisms that are exposed to chronic stress. 相似文献4.
Li Xue Xiaolan Lu Juntao He Ting Zhang Xiaokang Wu Yanping Zhang Ningning Wang Zhe An Jiru Xu Yan Geng 《Pathology, research and practice》2018,214(11):1778-1786
Background
CK 18-M30 was increased in patients with NAFLD. However, little is known about the relationship between CK 18-M30 and NAFLD progression. We aimed to analyze the variety of CK 18-M30 and other metabolism indices during NAFLD progression. Meanwhile, we aimed to investigate the correlation between CK 18-M30 and liver pathology during NAFLD progression.Materials and methods
Rats were fed with high sucrose and high fat diet for building NAFLD models. We detected liver pathology by hematoxylin–eosin (HE) staining. We also detected serum CK 18-M30 and metabolism indices including liver enzymes, serum lipids and glycometabolism indices.Results
The aggravating degree of liver pathology appeared with prolonged feeding period. The relevance of CK 18-M30 to the severity of liver pathology were higher relative to other indices.Conclusion
Our results suggested the significance of CK 18-M30 in the progression of NAFLD and provided new evidence for the early diagnosis and prognostic estimation of NAFLD. 相似文献5.
Yang Yang Zhiliang Chen Lvyu Deng Juan Yu Kai Wang Xing Zhang Guang Ji Fenghua Li 《Acta histochemica》2018,120(6):578-585
Objective
To explore whether Pien Tze Huang (PTH) exerts a hepatoprotective effect via inhibiting the PERK/eIF2ɑ signaling pathway using an experimental animal model of alcoholic and high-fat diet rats.Methods
A liver injury rat model was established and treated with PTH. Pathological changes in the liver were evaluated by hematoxylin and eosin staining. Hepatic biochemical indexes were detected using an automatic biochemical analyzer. The level of Hcy in serum samples was analyzed using an ELISA. Levels of mRNAs related to ER stress signaling were measured by real-time quantitative-PCR, and protein expression levels were measured by Western blot analysis.Results
PTH ameliorated the defects in hepatic function, hepatic pathology and the impairment in lipid metabolism observed in the alcoholic and high-fat diet rats. Moreover, PTH reduced the serum Hcy level and inhibited the PERK/eIF2ɑ pathway in response to ER stress.Conclusions
These results suggest that the administration of PTH ameliorated the severity of alcoholic and high-fat diet rats possibly by inhibiting the Hcy-induced PERK/eIF2α pathway. 相似文献6.
Evaluation of NCAM and c-Kit as hepatic progenitor cell markers for intrahepatic cholangiocarcinomas
Jing Xu Yanhong Tan Xiaoxia Shao Cuiming Zhang Yanling He Jie Wang Yanfeng Xi 《Pathology, research and practice》2018,214(12):2011-2017
Background
Intrahepatic cholangiocarcinomas (ICCs) are primary liver malignancies and are the second most common type of malignancy after hepatocellular carcinoma. ICCs are heterogeneous in clinical features, genotype, and biological behavior, suggesting that ICCs can initiate in different cell lineages.Aim
We investigated intrahepatic cholangiocarcinoma RBE cell lines for the markers neural cell adhesion molecule (NCAM) and c-Kit, which possess hepatic progenitor cells properties.Methods
NCAM?+?c-Kit?+?cells were tested for hepatic progenitor cell properties including proliferation ability, colony formation, spheroid formation, and invasiveness in NOD/SCID mice. The Agilent Whole Human Genome Microarray Kit was used to evaluate differences in gene expression related to stem cell signaling pathways between NCAM?+?c-Kit?+?and NCAM-c-Kit- subset cells. Microarray results were further confirmed by real-time RT-PCR.Results
NCAM?+?c-Kit?+?cells showed hepatic progenitor cell-like traits including the abilities to self-renew and differentiate and tumorigenicity in NOD/SCID mice. Differences were observed in the expression of 421 genes related to stem cell signaling pathways (fc ≥ 2 or fc ≤ 0.5), among which 231 genes were upregulated and 190 genes were downregulated.Conclusion
NCAM?+?c-Kit?+?subset cells in RBE may have properties of hepatic progenitor cells. NCAM combined with c-Kit may be a valuable marker for isolating and purifying ICC stem/progenitor cells. 相似文献7.
Joanna Maria Lotowska Maria Elzbieta Sobaniec-Lotowska Dariusz Marek Lebensztejn 《Advances in medical sciences》2018,63(1):127-133
Purpose
Activation of hepatic stellate cells (HSCs), mainly responsible for extracellular matrix synthesis, is assumed to be central event in the process of liver fibrogenesis. The major objective of the research was to analyze the ultrastructural profile of activated HSCs in children with chronic hepatitis B (chB), with respect to fibrosis intensity.Materials/methods
Ultrastructural investigations of HSCs were conducted on liver bioptates from 70 children with clinicopathologically diagnosed chB before antiviral treatment. Biopsy material, fixed in paraformaldehyde and glutaraldehyde solution, was routinely processed for electron-microscopic analysis.Results
In children with intensive liver fibrosis (S-2 and S-3), the ultrastructural picture showed almost total replacement of quiescent HSCs (Q-HSCs) by activated, i.e. transitional HSCs (T-HSCs). Among T-HSCs, two types of cells were distinguished: cells exhibiting initiation of HSC activation (Ti-HSCs), never before described in chB, that were frequently accompanied by activated Kupffer cells, and cells with features of perpetuation of activation (Tp-HSCs). Tp-HSCs were elongated and characterized by substantial loss of cytoplasmic lipid material; they contained an increased number of cytoskeletal components, extremely dilated channels of granular endoplasmic reticulum and activated Golgi apparatus, which indicated their marked involvement in intensive synthesis of extracellular matrix proteins. Many collagen fibers were found to adhere directly to Tp-HSCs.Conclusions
The current study showed T-HSCs to be an important link between Q-HSCs and myofibroblastic HSCs (Mf-HSCs). Transformation of HSCs into new morphological variations (Ti-HSCs; Tp-HSCs and Mf-HSCs), observed along with growing fibrosis, indicates their high plasticity and a key role in fibrogenesis in pediatric chB. 相似文献8.
Kimaporn Khamanarong Worawut Woraputtaporn Pattama Amarttayakong Anucha Ahooja Narong Khuntikeo 《Surgical and radiologic anatomy : SRA》2016,38(6):735-739
Purpose
To compare portal vein tributaries in Thai with Thompson classification.Methods
In 211 Thai cadavers, abdominal regions were dissected to identify the portal veins and their tributaries. The subjects were classified into types based on modes of drainage of the left gastric and inferior mesenteric veins. Percentages of all types of venous drainage were counted.Results
There are four types of portal tributaries as defined by Thompson, type I_47.87 %, type II_13.27 %, type III_7.58 %, and type IV_29.86 %. There were 1.42 % of whose inferior mesenteric veins entered the joining angle of the superior mesenteric and splenic veins, and were classified as type V. The left gastric vein mostly drained into the portal vein in 79.15 %, while the inferior mesenteric vein emptied into the splenic vein mainly in 55.45 %.Conclusions
A new variance of portal tributaries in Thai cadavers is reported. The variations of portal vein formations are critical for liver surgery and interventional radiological procedures.9.
Hongcui Cao Jinfeng Yang Jiong Yu Qiaoling Pan Jianzhou Li Pengcheng Zhou Yanyuan Li Xiaoping Pan Jun Li Yingjie Wang Lanjuan Li 《BMC medicine》2012,10(1):1-20
Background
Stem cell-based therapy to treat liver diseases is a focus of current research worldwide. So far, most such studies depend on rodent hepatic failure models. The purpose of this study was to isolate mesenchymal stem cells from human placenta (hPMSCs) and determine their therapeutic potential for treating Chinese experimental miniature pigs with acute liver failure (ALF).Methods
hPMSCs were isolated and analyzed for their purity and differentiation potential before being employed as the donor cells for transplantation. ALF models of Chinese experimental miniature pigs were established and divided into four groups: no cell transplantation; hPMSCs transplantation via the jugular vein; X-ray-treated hPMSCs transplantation via the portal vein; and hPMSCs transplantation via the portal vein. The restoration of biological functions of the livers receiving transplantation was assessed via a variety of approaches such as mortality rate determination, serum biochemical analysis, and histological, immunohistochemical, and genetic analysis.Results
hPMSCs expressed high levels of CD29, CD73, CD13, and CD90, had adipogenic, osteogenic, and hepatic differentiation potential. They improved liver functions in vivo after transplantation into the D-galactosamine-injured pig livers as evidenced by the fact that ALT, AST, ALP, CHE, TBIL, and TBA concentrations returned to normal levels in recipient ALF pigs. Meanwhile, histological data revealed that transplantation of hPMSCs via the portal vein reduced liver inflammation, decreased hepatic denaturation and necrosis, and promoted liver regeneration. These ameliorations were not found in the other three groups. The result of 7-day survival rates suggested that hPMSCs transplantation via the portal vein was able to significantly prolong the survival of ALF pigs compared with the other three groups. Histochemistry and RT-PCR results confirmed the presence of transplanted human cells in recipient pig livers (Groups III, IV).Conclusions
Our data revealed that hPMSCs could not only differentiate into hepatocyte-like cells in vitro and in vivo, but could also prolong the survival time of ALF pigs. Regarding the transplantation pathways, the left branch of the portal vein inside the liver was superior to the jugular vein pathway. Thus, hPMSCs transplantation through the portal vein by B-ultrasonography may represent a superior approach for treating liver diseases. 相似文献10.
11.
Sara L. Jackson Catherine M. DesRoches Dominick L. Frosch Sue Peacock Natalia V. Oster Joann G. Elmore 《Patient education and counseling》2018,101(5):956-959
Objective
Chronic disease management can require daily attention, and increased levels of patient activation and engagement. We examined whether patients with diabetes perceive a greater benefit to having electronic access to their doctors’ clinic notes compared to patients without diabetes. We hypothesized that easy electronic access to these notes may help patients with self-care by improving education and communication.Methods
Survey of patients with and without diabetes in Massachusetts and Pennsylvania about perceptions of potential benefits and risks of reading their visit notes via an electronic patient information portal. Administrative data were used to identify patients with diabetes; we compared their perceptions to those of patients without diabetes.Results
The majority of patients (both with and without diabetes) perceived a positive impact of using the portal. Patients with diabetes were significantly more likely to believe that having access to and reading their notes would help them take their medication better and take better care of themselves.Conclusions
Patients with chronic diseases such as diabetes might receive an even greater benefit from access to their doctors’ notes than the general patient population.Practice implications
Doctors should encourage their patients with diabetes (or other chronic diseases) to use patient portals. 相似文献12.
Pei-ning Yan Wei-feng Tan Xin-wei Yang Chuan-sen Zhang Xiao-qing Jiang 《Surgical and radiologic anatomy : SRA》2014,36(10):1071-1077
Purpose
The objective of this study was to provide the morphological details on small branches of the portal vein in transverse groove of hepatic hilum.Methods
According to the surgery significance, the small branches of portal vein in transverse groove of hepatic hilum were named as “Short hepatic portal veins (SHPVs)”. SHPVs were minutely dissected in 30 adult cadaveric livers. The number, diameter, length, origin points, and entering liver sites of SHPVs were explored and measured.Results
There were 181 SHPVs in 30 liver specimens, including 46 % (83/181) from the left portal vein, 31 % (56/181) from the bifurcation, and 23 % (42/181) from the right portal vein. At the entering liver sites of SHPVs, 22 % (40/181) supplied for segment IV, 9 % (17/181) for segment V, 4 % (7/181) for segment VI, 23 % (41/181) for segment VII, and 42 % (76/181) for segment I (caudate lobe). There were 6.0 ± 2.4 branches per liver specimen with range 3–12. The mean diameter of SHPVs was 2.25 ± 0.89 mm. The average length of SHPVs was 4.86 ± 2.12 mm.Conclusions
SHPVs widely existed in each liver specimen. The detailed anatomical study of SHPVs could be useful to avoid damaging the short portal branches during hepatic operations, such as isolated or combined caudate lobectomy. 相似文献13.
14.
Introduction
External carotid artery has eight named branches distributing to head and neck. The rich vascularity of most parts of head and neck (except brain and eye) is mainly maintained by external carotid artery through its branches. The detailed knowledge of external carotid artery and its branches is important for procedures like catheterization, radical neck dissection, reconstruction of aneurysms and carotid endarterectomy to prevent vascular accidents.Material and methods
Twenty formalin fixed adult human cadavers, obtained from the Department of Anatomy were dissected.Results
Mean distances of origin of eight branches of external carotid artery from carotid bifurcation were measured. The most common variation found was linguo-facial trunk in fourteen specimens (35%). The other variations found were common trunk for ascending pharyngeal artery and occipital artery in five specimens (12.82%) and thyrolingual trunk in one specimen (2.56%).There was appearance of two roots of ascending pharyngeal artery in one case.Discussion
Knowledge about the variations of origin of branches of external carotid artery is important for surgeons performing head and neck surgeries. It is also helpful for radiologists for diagnostic imaging of vascular lesions and for interventional procedures. 相似文献15.
Mobin Mohammadi Mehdi Mohammadi Mohammad Ali Rezaee Tayyeb Ghadimi Massume Abolhasani Mohammad Reza Rahmani 《Advances in medical sciences》2018,63(1):119-126
Purpose
Migration ability of mesenchymal stem cells (MSCs) towards chemotactic mediators is a determinant factor in cell therapy. MSCs derived from different sources show different properties. Here we compared the migration ability of the term and the pre-term human umbilical cord vein MSCs (hUCV-MSCs).Materials/Methods
MSCs were isolated from term and pre-term umbilical cord vein, and cultured to passage 3–4. Migration rate of both groups was assessed in the presence of 10% FBS using chemotaxis assay. Surface expression of CXCR4 was measured by flow cytometery. The relative gene expression of CXCR4, IGF1-R, PDGFRα, MMP-2, MMP-9, MT1-MMP and TIMP-2 were evaluated using real time PCR.Results
The isolation rate of the pre-term hUCV-MSCs was higher than the term hUCV-MSCs. Phenotype characteristics and differentiation ability of the term and pre-term hUCV-MSCs were not different. The migration rate of the pre-term hUCV-MSCs was more than the term hUCV-MSCs. Gene and surface expressions of the CXCR4 were both significantly higher in the pre-term hUCV-MSCs (P ≤ 0.05). The mRNA levels of PDGFRα, MMP-2, MMP-9, MT1-MMP and TIMP-2 showed no significant difference between the two groups.Conclusion
Our results showed that the gestational age can affect the migration ability of the hUCV-MSCs. 相似文献16.
Una Stenberg Andre Vågan Maria Flink Vibeke Lynggaard Kari Fredriksen Karl Fredrik Westermann Frode Gallefoss 《Patient education and counseling》2018,101(6):1006-1035
Objectives
To provide a comprehensive overview of health economic evaluations of patient education interventions for people living with chronic illness.Methods
Relevant literature published between 2000 and 2016 has been comprehensively reviewed, with attention paid to variations in study, intervention, and patient characteristics.Results
Of the 4693 titles identified, 56 articles met the inclusion criteria and were included in this scoping review. Of the studies reviewed, 46 concluded that patient education interventions were beneficial in terms of decreased hospitalization, visits to Emergency Departments or General Practitioners, provide benefits in terms of quality-adjusted life years, and reduce loss of production. Eight studies found no health economic impact of the interventions.Conclusions
The results of this review strongly suggest that patient education interventions, regardless of study design and time horizon, are an effective tool to cut costs. This is a relatively new area of research, and there is a great need of more research within this field.Practice implications
In bringing this evidence together, our hope is that healthcare providers and managers can use this information within a broad decision-making process, as guidance in discussions of care quality and of how to provide appropriate, cost-effective patient education interventions. 相似文献17.
Donato P Coelho P Rodrigues H Vigia E Fernandes J Caseiro-Alves F Bernardes A 《Surgical and radiologic anatomy : SRA》2007,29(7):575-582
Due to constant innovations in radiological and surgical techniques, more accurate results are expected in the diagnostic and therapeutic procedures related to hepatic pathology. The aim of this work was to demonstrate the normal hepatic vascular and biliary anatomy using cadaveric livers and CT scans of the affected livers. Furthermore, using the CT scans, the authors intended to illustrate the most common morphological variations of the vascular and biliary anatomy. Four human cadaveric livers were injected with colored silicone mixed with radiological contrast solution in the common bile duct, in the proper hepatic artery, in the portal vein and in the inferior vena cava near the ostia of the hepatic veins (only one of these structures was injected in each liver). After obtaining the CT scans, 3D rendered models were created, which demonstrated the normal hepatic anatomy of the vascular and biliary structures. The International Anatomical Nomenclature was used for their classification (based on Couinaud's work). The 3D rendered CT models were also modified to illustrate the most common normal variations of the hepatic anatomy (found in the literature). 相似文献
18.
Pernille Urup Ruban Christian Nielsen Wulff Cecilie Dyg Sperling Mette Sandager Anders Bonde Jensen 《Patient education and counseling》2018,101(1):99-104
Objective
The purpose of this study was to determine how age influences the degree to which patients with breast cancer feel comfortable with standard follow-up and to assess their satisfaction with the contact to health professionals.Methods
Data was from a Danish population-based questionnaire survey from 2012 including adult cancer patients. 1120 patients with breast cancer returned the questionnaire (response rate: 73%). Age groups were decided before conducting analyses.Results
Overall, patients with breast cancer evaluated the follow-up programme positively. However, in five of six items of interest, patients aged 40–49 and 50–59 years differed statistically significantly from patients ≥70 years, by being less comfortable with the follow-up, less satisfied with the health care professionals’ ability to listen, and less satisfied with the health care professionals’ answers. Satisfaction with the length of consultations, and the number of involved health care professionals were also lower in these age groups compared to patients ≥70 years.Conclusion
Overall, satisfaction with follow-up was high, but considerable age-related variations were found.Practice implications
The findings suggest a potential for improving the services provided for patients aged 40–59 years with breast cancer. 相似文献19.
Dan Wang Xiaojing Zhang Yapeng Lu Xueting Wang Li Zhu 《Pathology, research and practice》2018,214(12):1987-1992
Background
Hypoxia inducible factor 1α (HIF-1α) is a protein related with carcinogenesis and metastasis in many tumors. However, little is known about the prognostic value of HIF-1α in hepatocellular carcinoma (HCC) patients with cirrhosis.Methods
Clinical-pathological information and follow-up data were collected from HCC (n?=?419) and chronic hepatitis (n?=?49) patients. HIF-1α expression was scored based on the percentage of immunohistochemical staining. Correlations between HIF-1α expression and clinical features were evaluated by Chi-square test. And survival analysis was performed by multivariate Cox regression analysis.Results
In cirrhosis patients, the frequency of HIF-1α positive expression in HCC was higher than in chronic hepatitis (P?=?0.002). HIF-1α positive expression was significantly associated with vascular invasion (P?=?0.002), TNM stage (P?=?0.005), HBV infection (P?=?0.005), tumor size (P?=?0.025) and portal vein tumor thrombus (P?=?0.001) in HCC with liver cirrhosis. While, in cirrhosis-free patients, HIF-1α positive expression had a significant correlation with vascular invasion (P?=?0.039) and AFP value (P?=?0.001) in. HIF-1α “positive” had decreased overall survival compared to HIF-1α “negative” patients and this was an independent adverse prognostic factor (multivariable analysis P?=?0.001) for HCC patients with cirrhosis, but not for cirrhosis-free patients.Conclusions
Our results suggested that HIF-1α served as a poor prognostic factor for HCC patients with cirrhosis. 相似文献20.
Vincent Kalumire Cubaka Michael Schriver Peter Vedsted Gregory Makoul Per Kallestrup 《Patient education and counseling》2018,101(9):1601-1610