活血化瘀法治疗消化性溃疡的实验研究及临床观察

为寻求高效、速效治疗消化性溃疡的药物，依据中医久病必瘀的理论，研制以活血化瘀为主要治则，由五灵脂、白芨、香附等中药组成的协定处方－益疡灵。实验研究表明益疡灵对大鼠应激性溃疡及幽门结扎性溃疡有明显抑制作用，尤其能降低胃蛋白酶的活性，可作为治疗溃疡病的重要依据。经长期临床观察，证实其安全有效，治愈率高，且复发率较低。     

消疡灵治疗消化性溃疡的疗效观察

消疡灵治疗消化性溃疡的疗效观察林道纲，陈少兴，莫青，梁亚花我们数年来对消化性溃疡病采用中药“消疡灵”和“消疡灵”加庆大霉素治疗取得很好效果，现报告如下。１临床资料１．１病例选择消化性溃疡病患者１５０例，多为门诊病人。男９８例，女５２例，年龄１９～６５...     

愈疡散治疗消化性溃疡156例临床观察

本文用愈疡散对１５６例消化性溃疡进行临床观察，并对１４４例患者进行对照观察。结果表明，愈疡散组治疗前后症状改善。胃镜及大便潜血好转均明显高于对照组，两组有效率分别是９９．３％和８４．０％。经统计学处理两组各项指标均有非常显著性差异（Ｐ＜０．０１）。提示：愈病散治疗消化性溃疡疗效明显优于单纯西药组，表明愈疡是一种治疗消化性溃疡的安全有效且值得推广的药物。     

胃疡宁汤治疗消化性溃疡57例

消化性溃疡是临床常见病多发病之一，我们自拟胃疡宁汤治疗消化性溃疡57例，取得较好疗效，现总结报告如下。     

宁血愈疡合剂治疗消化性溃疡并出血32例临床观察

目的：观察宁血愈疡合剂治疗消化性溃疡并出血的临床疗效。方法：采用完全随机对照，设宁血愈疡合剂治疗组及洛塞克胶囊对照组各32例，观察两组止血时间，对临床症状的改善情况，溃疡愈合疗效，幽门螺杆菌（Hp)清除率及1年复发率，结果：治疗组止血时间长于对照组,便其1周止血疗效及4周Hp清除率，溃疡愈合疗效均与对照组相当，且改善临床症状优于对照组，Hp 1年复发率低于对照组，结论：宁血疡合剂是治疗消化性溃疡并出血的效佳，安全，价廉的药物。     

止血愈疡颗粒治疗消化性溃疡并出血的临床研究

运用止血愈疡颗粒治疗消化性溃疡１５０例，并以雷尼替丁合羟氨苄青霉素为对照组。结果表明，ＺＹ组组止疗效与ＨＰ阴转率明显优于ＲＩ组，而在愈合溃疡与缓解症状方面与ＲＩ组疗效相当，对脾虚胃热型消化性溃疡疗效最佳。     

中西医结合治疗阿米巴肝脓疡病18例临床分析

中西医结合治疗阿米巴肝脓疡病１８例临床分析枣庄市中区安城医院（２７７５００）耿艳香山东省寄生虫病防治研究所李怀菊目前国内对阿米巴肝脓疡的治疗多采用非手术疗法，主要应用灭滴灵等抗阿米巴药物。作者近几年来选择了１８例阿米巴肝脓疡病患者，应用中西医结合方法...     

自拟益脑灵汤治疗老年期痴呆32例临床观察

目的探讨自拟益脑灵汤治疗老年期痴呆症的临床疗效。方法将62例老年期痴呆症病人随机分为治疗组（32例）与对照组（30例），治疗组以自拟益脑灵汤，对照组用吡拉西坦（脑复康），采用随机双盲给药；按长谷川痴呆量表统计评分。结果治疗组总有效率为81．3％明显优于对照组的50．0％（P〈0．05）；治疗组在记忆能力的提高和认知功能的改善方面均明显优于对照组。结论自拟益脑灵汤治疗老年期痴呆优于脑复康。     

痈疡剂在脾胃病治疗中的应用

某些胃肠疾病 ,如消化性溃疡、痘疹样胃炎、溃疡性结肠炎等 ,在内镜下具有痈疡的特征 ,属于“脏腑痈疽”范畴。笔者应用痈疡剂治疗 ,取得了理想效果 ,总结如下。1　消化性溃疡　　消化性溃疡 ,临床以胃、十二指肠溃疡多见。在溃疡活动期 ,临床可见胃痛、泛酸、口苦、舌质红、苔     

红藤蒲贝煎治疗消化性溃疡疗效分析

红藤蒲贝煎由《景岳全书》中连翘金贝煎化裁组成，具有清热解毒、活血化瘀、理气止痛、制酸敛疡等作用。应用红藤蒲口煎治疗消化性溃疡54例，同时与用呋硫硝胺治疗消化性溃疡30例进行对照。结果，在改善临床症状，促使幽门螺杆菌根除以及降低溃疡复发率等方面。治疗组疗效均明显优于对照组。     

Assessment of Underlying Blood Vessels in Gastric Ulcers with Bleeding Episode by Endoscopic Color Doppler Ultrasonography

We used endoscopic color Doppler ultrasonography to detect hemorrhagic gastric ulcer, and to determine whether this modality could show blood vessels present deep to ulcers and whether these vessels influenced clinical course. Subjects were 20 patients with hemorrhagic gastric ulcers which had visible vessels on the ulcer base endoscopically. In 11 of 20 patients (group P) color signals indicating blood flow were observed, in which a weak pulsatile wave was detected in five cases. In two operated cases the signals were confirmed as blood vessels histologically. The diameters of these vessels were over 0.35 mm. It was thought that in cases undetectable on endoscopic color Doppler ultrasonography (group N) the diameter of vessels was too narrow or the velocity of blood too slow. There were no differences in the clinical background of group P and group N. However, ulcer bleeding was more severe in group P cases (P<0.05). Many patients in whom blood flow was detected experienced repeated ulcer bleeding as well as ulcer recurrences. Patients with hemorrhagic ulcers and in whom ultrasonic imaging demonstrates blood flow should be managed with great care. (Dig Endosc 1999; 11: 231–235)     

Changes in Gastric Mucosal Blood Flow during Healing of EMR-Induced Ulcer

Abstract: We used the laser Doppler method to study the difference in gastric mucosal blood flow changes between peptic ulcer (65 cases) and artificial ulcer caused by endoscopic mucosal resection (35 cases) during their respective healing processes. At each endoscopic ulcer stage, blood flow at the ulcer margin and that in the surrounding mucosa were measured. In the artificial ulcer, which heals easily, blood flow at the ulcer margin was still high at the scarring stage as compared with that in the corresponding area of a peptic ulcer, which is prone to relapse. Moreover, the blood flow ratio (blood flow at the ulcer margin/blood flow in the surrounding mucosa) at the S1 stage in artificial ulcers was significantly higher than that in peptic ulcers (p<0.05). These results suggest that blood flow in the SI stage is an important aspect of ulcer healing and relapse.     

利胃复胶囊治疗痰瘀胃痛的临床及实验研究

化瘀祛痰中药利胃复胶囊（简称利胃复）治疗痰瘀胃痛型胃炎．结果：治疗组100例．临床治愈81例，有效15例，临床治愈率81．0％，总有效率96．0％。对照组29例．临床治愈率12例．有效9例．临床治愈率41．4％．总有效率72．4％，两组比较有显著性差异（P＜0．05），实验表明利胃复胶囊能增加胃粘膜血流量，减少胃内胆酸和胃酸，抑制幽门螺杆菌，促进醋酸溃疡模型愈合．抵抗纯酒精对胃粘膜的损伤，对肠胃返流性胃炎胃粘膜有保护作用。     

高血压患者24小时动态血压分析

对１００例高血压患者进行２４ｈ动态血压监测，结果２４ｈ动态血压波动规律呈双峰双谷状，第一高峰在上午７～１１时左右，第二高峰在下午１６～２１时左右，且收缩压第二高峰值明显高于第一高峰值，２４ｈ动态血压均值昼夜为１３９／８３ｍｍＨｇ，日间为１４０／８６ｍｍＨｇ，夜间为１３６／８０ｍｍＨｇ。血压负荷收缩压为４８％，舒张压为３２％。     

Effect of ABO Blood Group and Secretor Status on the Frequency of Helicobacter pylori Antibodies

Duodenal ulcer is associated with such genetic characteristics as blood group O and secretor status. Since Helicobacter pylori has been proved to be an important factor in the pathogenesis of duodenal ulcer, we wanted to study whether the frequency of H. pylori antibodies would vary in individuals with different blood group antigens. Antibodies against H. pylori were determined in 271 blood donors. Acid glycine extract from an H. pylori strain was used as antigen in enzyme immunoassay. Our results suggested no significant association of increased levels of H. pylori antibodies with ABO blood group and secretor status, which implies that H. pylori infection is not associated with the ABO group and secretor status. Thus H. pylori and blood group antigens seem to be independently linked to duodenal ulcer.     

A New Factor in the Blood of Patients with Peptic Ulcer

Previous work on a factor in the blood of patients with peptic ulcer which contracts smooth muscle was confirmed and the work extended to investigation of the activity of blood fractions. Whole heparinized blood and its fractions were tested on a strip of guinea pig ileum and height of contraction and latent period were used as criteria of activity. Whole heparinized blood of ulcer patients had significantly higher activity than that of normal controls. Differences between the fractions of ulcer patients and controls were less significant. With the lysed buffy coat, however, while the differences between the height of contraction between the groups did not differ statistically, the speed of the reaction (shorter latent period) was significantly greater in the ulcer patients. The cellular alterations causing this response are unknown.     

Colonic Mucosal Blood Flow in Ischemic Colitis

Altered colonic mucosal blood flow (CMBF) is thought to be involved in the onset mechanism of ischemic colitis (IC). This study was designed to clarify the features of CMBF in six patients with IC (average age, 61 yr) and 10 control subjects (44.6yr). In the IC patients, CMBF was measured at both the affected site (ulcer margin and surrounding mucosa) and at a normal appearing site, during the active, healing, or recovery phase, by the laser doppler method. In the control group, CMBF was measured in various segments of the colon. The CMBF around the ulcer site during the active phase was significantly lower than that at the homologous segment in normal controls, while CMBF at normal sites in IC patients did not differ markedly from that of normal controls. CMBF in reddened portions of the ulcer margin in IC patients was significantly higher than that of the surrounding mucosa. A significant increase in CMBF was also observed during PGEi administration as compared to that before administration. This evidence clearly indicates that decreased CMBF is involved in the pathogenic mechanism of IC. The CMBF at sites of active mucosal restoration was somewhat increased. Continuous intravenous administration of PGEi was found to increase CMBF in IC patients.     

Basal Serum Gastrin Concentration Related to Complications,Blood Groups,and Season in Duodenal Ulcer

In 229 consecutive duodenal ulcer patients basal serum gastrin concentration was examined in relation to ulcer complications, ABO blood groups, and seasons and was found to be independent of these factors.     

老年胃溃疡患者粘膜血流量和粘膜电位的变化

胃粘膜血流量(GMBF)在消化性溃疡的发生、发展和愈合过程中起着重要作用,胃粘膜电位(GMPD)为检测胃粘膜结构完整性的指标。我们于1988年1～6月对40例各期老年胃溃疡患者的GMBF和GMPD进行了检测,现报告如下。病例选择与方法一、病例选择 (一)老年胃溃疡组共40例,其中男性30例,女性10例,年龄60～75岁,平均64.5     

消化性溃疡与ABO血型、Lewis表型分布及幽门螺杆菌感染的相关性研究

目的探讨消化性溃疡（PU）与ABO血型、Lewis表型的分布及幽门螺杆菌（H．pylori）感染的关系。方法70例消化性溃疡患者为研究组,96例健康志愿者为对照组,比较ABO血型、Lewis表型分布和H．pylori感染的差异。结果PU组O型血者占52．9％,明显高于O型血在正常人群中的分布（31．3％,P〈0．05）;在非O型血患者中Lewis表型为Le（a＋b＋）者占51．5％,明显高于Le（a＋b＋）表型在对照组非O型血中的频率（9．1％,P〈0．001）。PU组不同ABO血型者H．pylori感染率比较无统计学差异（P〉0．05）;PU组Le（a-b＋）表型者H．pylori感染率为67．6％,明显高于其他Lewis表型（P〈0．05）。结论ABO血型中O型血者易患消化性溃疡,且非O型血Lewis表型为Le（a＋b＋）者也是消化性溃疡的高危人群。ABO血型间H．pylofi感染比较无显著性差异,Le（a-b＋）表型可能是H．pylori感染的一个危险因素。