CT引导肺穿刺组织学与印片细胞学的联合应用

目的评价CT引导下肺穿刺同时行组织学与印片细胞学检查的诊断价值和并发症。方法收集134例CT引导肺部穿刺活检病例作回顾性分析。统计印片细胞学、组织学以及2者结合的敏感性和并发症,并分析其影响因素。结果110例穿刺确诊为恶性肿瘤。穿刺未发现癌细胞者22例,后经手术和随访证实其中假阴性2例。组织学敏感性为82.1%(92/112),印片细胞学敏感性为87.5%(98/112),二者结合敏感性为98.2%(110/112),假阴性率为9.1%(2/22)。气胸发生率为7.5%(10/134),出血、喀血率为11.9%(13/134),仅有2例出血较多,需紧急处理。结论CT引导经皮肺穿刺是敏感性高和安全的定性诊断方法,如同时行组织学及印片细胞学检查,可提高诊断的敏感性,降低假阴性。     

CT引导下经皮肺及纵隔穿刺细胞学评价

目的评价针吸细胞学在CT引导下经皮肺及纵隔穿刺中的诊断价值,探讨提高细胞学诊断阳性率的方法.方法 CT引导下,对经皮肺及纵隔穿刺标本行细胞学检查,常规制片,HE染色,光镜下诊断,并与相应活检组织学对照分析.结果肺穿刺141例,细胞学诊断恶性病变83例,良性病变24例,细胞学确诊率75.89%(107/141).原发纵隔肿物穿刺10例,仅一例确诊.结论 CT引导下针吸细胞学诊断是临床诊断治疗的重要依据,可提高肺癌的早期诊断率,同时结合组织病理学检查可减少假阴性诊断.     

CT导引下经皮肺穿刺针吸活检

目的：对61例患CT导引下经皮肺穿刺术的应用进行评估。方法：CT导引定位下用7号腰穿针及TEMNO活检针进行穿刺活检。结果：61例均穿刺成功,获得细胞学和组织学材料。细胞学检查敏感性80.5%(33/41),组织学检查敏感性53.7%(22/41),两特异性均为100%。并发症6例（9.8%),其中气胸5例,痰血1例.结论:CT导引下经皮肺刺术为周围型肺内占位灶明确诊断提供了一种安全、有效的检查手段。减少了开胸探查手术。     

CT引导下经皮肺穿刺活检对肺肿瘤的诊断价值

  目的 探讨CT引导下经皮肺穿刺活检对肺部肿瘤的诊断价值及影响其准确性的因素。方法 对153例肺部病变患者经CT引导下经皮肺穿刺活检取材，所取组织经病理组织学和（或）细胞学检查，分析其准确性。结果 153例中经手术随访或临床检查证实恶性肿瘤128例，穿刺病理诊断118例，经皮肺穿刺恶性肿瘤确诊率92.2 ％（118／128），假阴性10例，假阴性率7.8 ％（10／128），无假阳性病例。诊断良性病例20例，良性病变确诊率为80.0 ％（20／25）术后发生气胸28例，发生率为18.3 ％（28／153），出血22例，发生率14.4 ％。结论 CT引导下经皮肺穿刺活检是一种安全、有效、准确性高、并发症少的诊断方法，对肺部肿瘤的诊断具有较高的价值。     

327例乳腺肿块针吸细胞学与组织学检查对比分析

目的:探讨乳腺针吸细胞学检查(FNAC)对乳腺癌诊断的准确性.方法:对1062例乳腺肿块行FNAC检查,其中327例获得病理组织学对照.结果:本组针吸细胞学检查敏感性为97.3%,特异性为95.0%,潜在假阴性率2.7%,符合率95.4%.结论:(1)针吸细胞学是检查乳腺肿块的一种重要的辅助诊断方法,但仍存在一定的局限性,对疑难病例需要通过病理组织学确诊.(2)肿块实质细胞较少或细胞异形性不明显是阴性诊断的主要原因.穿刺前详细询问病史,进行大体检查,精确选择穿刺部位,穿刺时仔细体会针感及重复针吸是减少假阴性的主要手段.     

63例肺内孤立性结节18F-FDG符合线路正电子显像临床分析

目的评估符合线路正电子显像在肺内孤立性结节中的诊断价值。方法对63例肺内结节行18F-FDG符合线路正电子显像检查,阳性显像者手术切除,阴性显像临床可疑者,行手术或肺内穿刺。结合术后或肺内穿刺病理,判定符合线路正电子显像检查的灵敏性,特异性和正确性。结果63例患者中阳性显像36例,其中病理证实阳性者31例,假阳性5例。阴性显像27例,其中病理证实真阴性24例,假阴性3例。灵敏性为91.2%(31/34),特异性为88.9%(24/27),正确性为87.3%(55/63),真阳性率为86.1%(31/36),假阳性率13.9%(5/36),真阴性率88.9%(24/27),假阴性率11.1%(3/27)。结论符合线路正电子显像作为一种安全、非创伤性的显像方法在鉴别肺内孤立性结节(SPN)性质时具有高敏感性,高特异性,极大地减少了不必要的诊断性开胸手术,因而有十分广阔的应用前景。     

现场细胞学在超声支气管镜引导下支气管针吸活检的应用价值

目的探讨现场细胞学在超声支气管镜引导下支气管针吸活检的应用价值。方法选取2013年1月至2013年12月间大连医科大学附属大连市中心医院收治的经胸部计算机断层扫描显示肺部病变伴(或不伴)纵隔与肺门淋巴结肿大、肺门和(或)纵隔淋巴结肿大以及纵隔病变患者。随机选取33例患者行现场细胞学联合超声支气管镜引导下经支气管针吸活检。比较分析现场细胞学与组织学的诊断率。结果 33例患者穿刺均成功,穿刺阳性率达到100.0%。其中25例取得阳性组织学病理诊断,8例为非特异性诊断,阳性诊断率为75.8%。现场细胞学涂片可见异型细胞26例,阳性率达到78.8%。现场细胞学疑诊恶性肿瘤阳性率78.8%,后经组织学诊断恶性肿瘤阳性率为66.7%,现场细胞学疑诊恶性肿瘤与组织学诊断恶性肿瘤阳性率的比较,差异无统计学意义(P>0.05)。现场细胞学诊断无假阴性,存在假阳性,假阳性率为15.4%。结论超声支气管镜引导下支气管针吸活检联合现场细胞学不仅可以减少不必要的穿刺,缩短操作时间,而且经济简便。     

针吸及印片细胞学在乳腺肿块诊断中的意义

目的　提高乳腺肿块细胞病理学检查的准确性。方法　对 3 3 1例乳腺肿块细针吸取细胞学检查 (FNAC)、术中印片与其术后病理组织学诊断对照分析。结果　 13 6例乳腺恶性肿瘤 ,FNAC确诊率 86% ( 117/ 13 6) ,假阴性率 3 7% ( 5 / 13 6) ,无假阳性诊断。 195例良性病变 ,FNAC确诊率 94 9% ( 185 / 195 )。诊断符合率 95 5 %。术中印片纠正 5例假阴性诊断 ,2 2例可疑病变得到确诊 ,印片对恶性肿瘤的确诊率为 98 5 % ,诊断符合率达 10 0 %。结论　FNAC、印片是乳腺肿块之便捷、有效的辅助诊断方法 ,能部份替代乳腺癌术前或术中活组织检查。重视体检 ,掌握临床资料 ,采取FNAC与术中印片相结合 ,可减少误漏诊。     

针吸及印片细胞学在乳腺肿块诊断中的意义

目的 提高乳腺肿块细胞病理学检查的准确性。方法 对33l例乳腺肿块细针吸取细胞学检查(FNAC)、术中印片与其术后病理组织学诊断对照分析。结果 136例乳腺恶性肿瘤，FNAC确诊率86％(117／136)，假阴性率3．7％(5／136)，无假阳性诊断。195例良性病变，FNAC确诊率94．9％(185／195)。诊断符合率95．5％。术中印片纠正5例假阴性诊断，22例可疑病变得到确诊，印片对恶性肿瘤的确诊率为98．50%，诊断符合率达100％。结论 FNAC、印片是乳腺肿块之便捷、有效的辅助诊断方法，能部份替代乳腺癌术前或术中活组织检查。重视体检，掌握临床资料，采取FNAC与术中印片相结合，可减少误漏诊。     

327例乳腺肿块针吸细胞学与组织学检查对比分析

目的：探讨乳腺针吸细胞学检查(FNAC)对乳腺癌诊断的准确性。方法：对1062例乳腺肿块行FNAC检查，其中327例获得病理组织学对照。结果：本组针吸细胞学检查敏感性为97．3％，特异性为95．0％，潜在假阴性率2．7％，符合率95．4％。结论：(1)针吸细胞学是检查乳腺肿块的一种重要的辅助诊断方法，但仍存在一定的局限性。对疑难病例需要通过病理组织学确诊。(2)肿块实质细胞较少或细胞异形性不明显是阴性诊断的主要原因。穿刺前详细询问病史，进行大体检查，精确选择穿刺部位，穿刺时仔细体会针感及重复针吸是减少假阴性的主要手段。     

CT引导下经皮肺穿刺活检对肺小结节的诊断价值

  目的 探讨CT引导下经皮肺穿刺活检对肺小结节的诊断价值。方法 自1996年10月到2005年11月，对384例肺小结节患者施行CT引导下经皮肺穿刺活检，对其结果进行回顾性分析。结果 CT引导下经皮肺穿刺活检诊断肺小结节的准确率为97.4 %（374／384），并发症发生率 16.1 %（62／384）；对恶性肿瘤诊断的敏感性为98.8 %（328／332），特异性为100 %。结论 CT引导下经皮肺穿刺活检是诊断肺小结节有效的、可靠的方法，值得推广。     

超声引导下甲状腺结节细针穿刺细胞学与粗针穿刺组织学检查的对比研究CSCD

目的比较超声引导下甲状腺结节细针穿刺细胞学与粗针穿刺组织学检查的诊断准确率、敏感度、特异性及并发症。方法收集95例超声检查疑似为恶性甲状腺结节患者的98个结节,行超声引导下细针穿刺细胞学与粗针穿刺组织学检查,并经术后常规病理检查证实。比较两种方法诊断甲状腺结节的准确率、敏感度、特异性及术后并发症。分析结节直径大小与取材满意率、诊断准确率的关系。结果 (1)细针穿刺取材满意率89.8%,粗针为96.9%。细针穿刺细胞学诊断甲状腺结节的准确率、敏感度、特异性分别为86.4%、90.5%、82.6%;粗针穿刺组织学诊断为90.5%、91.7%、88.6%;(2)粗针穿刺并发症发生率高于细针穿刺(14.3% vs.2.0%,P<0.05);(3)结节直径≥1.0 cm时,粗针穿刺诊断准确率高于细针穿刺(P<0.05)。结论细针穿刺细胞学与粗针穿刺组织学检查在甲状腺结节良恶性诊断中可互相补充。     

Touch imprint cytology of core needle biopsy specimens: a useful method for immediate reporting of symptomatic breast lesions.

AIMS: The aim of this study was to determine the diagnostic value and accuracy of touch imprint cytology (TIC) of core needle biopsy (CNB) specimens in predicting the final benign or malignant histology in patients presenting with symptomatic breast lesions. METHODS: One hundred and twenty-eight patients underwent CNB under ultrasonographic guidance with subsequent TIC preparation. TIC results were correlated with the histology of the core or the surgical resection specimen. RESULTS: The 128 lesions analysed included 106 malignancies and 22 benign lesions. TIC accurately predicted the final histology in 96.7% of cases, with a sensitivity of 96.2% and a specificity of 100%. CONCLUSIONS: The routine use of TIC to complement CNB can provide an immediate and reliable cytological diagnosis of symptomatic breast lesions. The potential use of this technique in a breast clinic setting may help allay patient anxiety and expedite the planning of further surgical management.     

Fine needle aspiration cytology of the pancreas

Fine needle aspiration cytology has been increasingly used in recent years to diagnose pancreatic lesions. During a 6 year period, we performed 33 aspiration cytologies of the pancreas. Twenty-one were performed during exploratory laparotomy, seven under the guidance of computed tomography and five guided by ultrasonography. In seven cases inflammatory lesions were found, while 26 cases were of malignant tumors. Out of these patients, 10 underwent additional tissue biopsy. The correlation between cytology and histology was 100%. We suggest that fine needle cytology of pancreatic and other intraabdominal lesions can be considered an accurate diagnostic procedure.     

Evaluation of various cytological examinations by bronchoscopy in the diagnosis of peripheral lung cancer

To improve the efficacy of fibreoptic bronchoscopy in the diagnosis of peripheral lung cancer, we evaluated the effectiveness of various techniques for obtaining samples for cytological examination. Between January 1984 and December 2000, flexible fibreoptic bronchoscopy under fluoroscopic guidance was performed in 1372 patients with lung cancer having no visible endoscopic findings. Histological examination of specimens obtained by forceps biopsy and cytological examinations on imprints of biopsy specimens, brushing, selective bronchial lavage, curettage, transbronchial needle aspiration, rinse fluids of the forceps, brush, curette, and aspiration needle, and all fluids aspirated during the bronchoscopic examinations were evaluated for diagnostic power. Using these techniques, the overall diagnostic rate with bronchoscopy was 93.4%. The sensitivity of the histological examination was 76.9%; additional imprint cytology increased the sensitivity to 84.8% (P<0.0001), while additional cytology on the rinse fluid of the forceps increased the sensitivity to 83.7% (P<0.0001). The addition of both imprint cytology and cytology on the rinse fluid of the forceps increased the diagnostic rate to 86.2% (P<0.0001). Our results indicate that cytological examinations of the imprints of biopsy samples and the rinse fluids of the forceps and the brush improve the efficacy of fibreoptic bronchoscopy in the diagnosis of peripheral lung cancer.     

穿刺细胞学与B超相结合在诊断乳腺癌中的意义

目的探讨细针穿刺细胞学与B超相结合对乳腺癌的诊断价值。方法采用B超引导下定位穿刺吸取细胞学及单纯应用针吸细胞学两种方法，与肿物切除后组织学检查相对比进行分析。结果肿物切除后组织学检查诊断乳腺癌98例，假阴性11例，其中36例应用B超引导下定位穿刺吸取细胞学检查，假阴性2例；62例单纯应用针吸细胞学检查，假阴性9例，细胞学诊断准确率分别为94．4％和85．5％，差异有显著性（P〈0．05）。结论细针穿刺细胞学检查具有安全、经济、方便、快速、痛苦小、准确率高的特点，结合B超引导下的定位穿刺更可获取足量的细胞成分，提高细胞学诊断正确率。对乳腺肿块尤其是对乳腺癌的筛选具有重要意义，可达到早期诊断和治疗目的。虽然乳腺的穿刺细胞学检查具有较高的可靠性，但仍存在一定的局限性和误诊率，需要组织学诊断解决。     

Cytologic results of fine-needle aspiration biopsies of the central nervous system

The cytologic results of 34 fine-needle aspiration (FNA) biopsies of the central nervous system (CNS) are reported. There were 31 intraoperative biopsies performed at the time of craniotomy. All the cases were diagnosed using direct smear preparations stained with Papanicolaou and Diff-Quik (Harleco, NJ) stains. The sensitivity of the procedure was 90.7%, specificity 100%, positive predictive value 100%, and efficiency of the test of 91%. There were no false-positive diagnoses and three false-negative diagnoses. This study attests to the diagnostic accuracy of FNA cytologic examination of the central nervous system. Statistical analysis of the few previous FNA biopsy series of the CNS are presented. Review of the indications, advantages and complications of CNS needle biopsy are discussed. This report supports the role of fine-needle aspiration cytology in the evaluation of CNS lesions. With recent developments in radiologic imaging, especially ultrasound and computed tomography (CT) using stereotactic guidance, specimens can be obtained for cytologic diagnosis using thinner needles. Excellent diagnostic accuracy can be obtained, as pathologists gain greater familiarity with interpreting FNA biopsy material. Other advantages of FNA biopsy of the central nervous system include the low morbidity and mortality of the procedure and the ability to perform the biopsy through a burr hole under local anesthesia and thereby decrease hospitalization time and cost.