康复新液治疗宫颈炎HPV阳性预防宫颈癌的临床分析

目的观察康复新液对HPV阳性患者转阴的治疗作用。方法对经门诊诊断为宫颈炎的患者行HPV、tct联合筛查,筛查HPV阳性的324例患者,随机分为研究组和对照组,分别给予康复新液、干扰素阴道用药治疗6个月,停药3个月及半年后复查,比较宫颈炎治疗效果和HPV转阴情况。结果研究组宫颈炎治愈率为75.31%,HPV转阴率为90.47%。治疗效果明显好于对照组(P0.05)。结论对于HPV阳性慢性宫颈炎患者给予康复新液治疗能够收到显著的效果,对于疾病的转阴具有重要意义,且有预防宫颈癌变的价值,值得在临床中进行推广应用。     

康复新液联合保妇康栓治疗慢性宫颈炎伴HPV感染疗效观察

目的:观察康复新液联合保妇康栓治疗慢性宫颈炎伴人乳头状瘤病毒(human papilloma virus,HPV)感染的临床疗效。方法:将315例患者按随机数字表法分为对照组158例和研究组157例。对照组采用保妇康栓治疗,研究组在对照组治疗基础上加用康复新液湿敷外治。两组患者均以每月用药10次为1个疗程,共治疗3个疗程。比较两组慢性宫颈炎伴HPV感染的治疗效果和HPV转阴情况。结果:研究组临床有效率为89.17%高于对照组的66.46%,差异有统计学意义(P0.05);研究组HPV转阴率为81.53%高于对照组的60.13%,差异有统计学意义(P0.05)。结论:康复新液联合保妇康栓治疗慢性宫颈炎伴HPV感染疗效显著,且能促进HPV转阴,有阻断子宫颈上皮内瘤变及癌变的作用。     

止带方联合重组人干扰素治疗慢性宫颈炎合并高危型HPV感染的疗效观察

目的 观察止带方联合重组人干扰素治疗慢性宫颈炎合并高危型HPV感染的临床疗效。 方法 以338例慢性宫颈炎合并高危型HPV感染患者为研究对象，使用随机数字表将全部研究对象分为对照组(169例)和研究组(169例)，对照组患者给予重组人干扰素α2b栓治疗，研究组患者给予止带方联合重组人干扰素α2b栓治疗，观察治疗期间药物不良反应，记录症状改善及高危型HPV转阴情况，评价疗效水平，统计宫颈炎症复发情况。 结果 研究组药物不良反应发生率(5.32%)与对照组(3.55%)差异无统计学意义(P>0.05)；研究组患者治疗后血清TNF-α、IL-6和IL-8含量均显著低于对照组(P<0.05)；研究组患者治疗后白带量改善率、白带脓性改善率和高危型HPV转阴率(96.45%、97.04%和92.90%)均显著高于对照组(85.21%、86.39%和80.47%)，P<0.05；研究组患者宫颈炎总体治疗有效率(95.27%)显著高于对照组(82.25%)，P<0.05；研究组患者治疗后6个月和12个月宫颈炎症复发率(3.55%和8.88%)均显著低于对照组(10.06%和19.53%)，P<0.05。 结论 相较重组人干扰素单纯治疗，止带方联合重组人干扰素可显著改善慢性宫颈炎合并高危型HPV感染患者相关临床症状，提高疗效水平和高危型HPV转阴率，有效预防宫颈炎症复发，且安全性较高。      

康复新液联合黄腐酸治疗重度宫颈糜烂经上皮组织特殊染色法评估HPV阳性转阴的研究

目的研究宫颈外敷康复新液联合口服黄腐酸促使重度宫颈糜烂HPV阳性患者的转阴效果,并经上皮组织特殊染色法进行评估。方法将2018年7月—2020年2月期间在石家庄市第四医院和张家口市第一医院就诊的HPV阳性重度宫颈糜烂患者共106例纳为研究对象,按就诊序号随机分为治疗组和对照组各53例。治疗组将浸透康复新液的棉球塞入阴道外敷在宫颈上,每晚1次,保留30 min/次,同时口服含黄腐酸成分的乌金液20 ml,2次/d,连续治疗3个月。对照组仅给予含黄腐酸成分的乌金液抑菌凝胶通过阴道注入治疗,每晚1次,连续治疗3个月。通过上皮组织特殊染色法对治疗前后HPV阳性检测进行评分,并观察患者治疗前后的临床症状指标、HR-HPV含量及HR-HPV16或18阳性的变化情况,同时对免疫相关指标CD4+进行观察。结果治疗后经上皮组织特殊染色法评分比较,治疗组评分低于对照组,差异有统计学意义(P 0.05)。同时两组患者的临床症状指标、宫颈糜烂恢复程度、经阴道超声观察宫颈管内糜烂恢复情况、HR-HPV含量变化及HR-HPV16或18阳性的变化比较,治疗组均优于对照组,差异均有统计学意义(P 0.05)。且治疗组治疗后免疫相关指标CD4+表达阳性率明显降低,与对照组比较,差异有统计学意义(P 0.05)。结论康复新液联合黄腐酸抑制HPV感染有确切疗效,通过上皮组织特殊染色法评估康复新液联合黄腐酸抑制HPV作用的效果简单且实用。     

康复新液治疗慢性糜烂性胃炎的效果研究

目的探讨康复新液治疗慢性糜烂性胃炎的效果。方法选取2011年12月至2015年12月我院收治的80例慢性糜烂性胃炎患者作为研究对象,根据随机抽签法分为研究组(n=40)和对照组(n=40),对照组患者应用硫糖铝混悬液进行治疗,研究组患者应用康复新液进行治疗,比较两组患者的临床治疗效果。结果两组患者临床治疗效果比较,研究组总有效率为97.50%(39例),对照组总有效率为75.00%(30例),研究组总有效率明显高于对照组(P0.05);两组患者幽门螺杆菌转阴率比较,研究组转阴率为97.50%(39例),对照组转阴率为75.00%(30例),研究组转移率明显高于对照组(P0.05)。结论应用康复新液治疗慢性糜烂性胃炎,能够取得十分理想的治疗效果,不仅能够提高幽门螺杆菌转阴率,也没有其他严重不良反应,并且能够有效消除患者的炎症因子,促进患者的康复,提高患者生活质量,建议临床进一步推广。     

干扰素α-2a栓联合保妇康栓治疗宫颈上皮内瘤变Ⅰ、Ⅱ级病变的临床观察

目的:探讨重组人干扰素α-2a栓联合保妇康栓治疗宫颈上皮内瘤变Ⅰ、Ⅱ级的临床疗效。方法:选取固始县妇幼保健院2010年2月至2014年4月收治的80例存在宫颈糜烂,人乳头瘤病毒(HPV)阳性,宫颈上皮内瘤变Ⅰ、Ⅱ级患者,随机分为观察组(40例)和对照组(40例)。观察组患者采用保妇康栓联合干扰素α-2a栓治疗,对照组未治疗,随访观察两组患者宫颈糜烂及HPV感染的改善情况。结果:观察组中38例患者(95.0%)宫颈糜烂均愈合,表明光滑。对照组中31例患者(77.5%)宫颈糜烂无明显改善,部分甚至加重。观察组宫颈糜烂改善情况明显较对照组好,差异具有统计学意义(P<0.05)。观察组35例患者(87.5%)宫颈HPV转阴,对照组中有10例患者(25.0%)宫颈HPV转阴。观察组宫颈HPV转阴率明显高于对照组(P<0.05)。结论:应用重组人干扰素α-2a栓联合保妇康栓治疗宫颈上皮内瘤变Ⅰ、Ⅱ级病变临床效果显著,可明显改善宫颈糜烂情况,抑制HPV增殖,值得临床推广。     

聚焦超声联合干扰素治疗宫颈重度糜烂的临床研究

目的 探讨干扰素联合高强度聚焦超声在治疗宫颈重度糜烂中的应用.方法 对2007年3～2007年8月在中南大学湘雅三医院收治,经细胞学、阴道镜明确诊断为慢性宫颈炎的重度糜烂患者80例,进行前瞻性随机对照研究,并对80例患者行聚焦超声前免疫荧光进行HPV检测,其中40例患者术后加用干扰素治疗3疗程作为研究组,同时将单纯行聚焦超声的40例患者作为对照组.分别于治疗后1、3、6个月行妇科检查及阴道镜检查,对HPV阳性者3、6个月行HPV检测,以判断两组的疗效.结果 80例患者随诊:研究组术后1、3、6个月治愈率分别为65%、82.5%和96%;对照组治愈率分别为62.5%、75%和80%.治疗组中13例HPV阳挂治疗后3个月复查11例转阴,6个月复查全部转阴;对照组中14例HPV阳性治疗后3个月复查9例转阴,6个月复查13例转阴.术后3个月及6个月研究组与时照组治愈率比较.研究组优于对照组(P<0.05).结论 聚焦超声联合干扰素治疗宫颈重度糜烂,提高了宫颈重度糜烂患者的一次性治愈率.     

电话随访对托里消毒散联合干扰素治疗宫颈 HPV 感染的护理效果研究

目的观察电话随访护理干预对托里消毒散联合干扰素治疗宫颈HPV感染的效果。方法选择2014年1~12月住院行HPV检测阳性患者214例,按照随机数字表法随机分成研究组112例和对照组102例,研究组对患者进行电话跟踪随访,进行有针对性的治疗性健康教育,在饮食、休息、活动、精神等方面给出正向的引导,持续的心理干预、复诊提醒及不良反应的应对措施等护理干预。对照组按常规主管医生门诊定期随访复诊,未进行电话随访护理干预。结果研究组患者治疗后HPV转阴率3个月100例(89.3%),6个月106例(95.0%),12个月104例(92.8%),TCT未见NILM 3个月100例(89.3%),6个月100例(89.3%),12个月104例(92.8%),两组比较,差异有统计学意义(P0.01或P0.05);对照组与研究组在对HPV感染焦虑程度上有显著性差异(P0.05);对照组与研究组在性行为史相关知识的认识上差异无显著性(P0.05),在避孕史、年龄、卫生习惯、免疫功能营养状况、吸烟饮酒、HPV感染有传染性相关知识的认识上均有显著性差异(P0.05);研究组和对照组患者坚持规律用药、定期复査、改变不良生活习惯等依从性方面比较,差异有统计学意义(P0.05)。结论电话随访护理干预可提高托里消毒散联合干扰素治疗宫颈HPV感染者的依从性,患者能正确认识HPV感染的重要性以及正确掌握HPV易感因素知识,通过护理干预减轻了过度焦虑者的焦虑程度,增进护患关系。     

槲皮素在HPV阳性的ASCUS患者中的临床应用

目的探讨槲皮素在HPV阳性的宫颈鳞状上皮不典型增生（ASCUS）患者中的临床应用效果。方法以宫颈癌高发区湖北五峰为试验点。使用TCT和HC-2筛查高危型HPV感染阳性的ASCUS患者90名,随机选取45名为实验组,另外45名为对照组。用中药槲皮素宫颈局部上药,6个月后复查,采用TCT和HC-2检测用药前后宫颈细胞学的变化以及高危型HPV阳性患者例数的改变。结果槲皮素治疗后,经TCT筛查,实验组正常患者38例,总有效率为84．4％。对照组正常患者20例,总有效率为44．4％。比较两组间差异有统计学意义（P〈0．05）。HC-2检测高危型HPV感染阳性例数的改变,实验组转阴30例,转阴率为66．7％,对照组转阴16例,转阴率为35．6％。比较两组间差异有统计学意义（P〈0．05）。结论槲皮素对HPV阳性的ASCUS患者有较明显的疗效。     

保妇康栓联合波姆光治疗HPV阳性中重度宫颈糜烂的临床分析

目的:探讨宫颈波姆光联合中药保妇康栓治疗HPV阳性中重度宫颈糜烂患者的疗效.方法:对妇科门诊130例HPV阳性中重度宫颈糜烂患者宫颈波姆光联合中药保妇康栓治疗进行回顾性分析,宫颈波姆光治疗后14天使用保妇康栓1个疗程16天,观察治疗后创面愈合情况及HPV转阴率.结果:130例HPV阳性中重度宫颈糜烂患者HPV转阴率达88.46%.宫颈糜烂治愈率达89.23%.结论:宫颈波姆光联合中药保妇康栓治疗HPV阳性中重度宫颈糜烂操作简便、治愈率高、并发症少、HPV转阴快,是效果显著的理想方法.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.