共查询到20条相似文献,搜索用时 15 毫秒
1.
Kang-Ping Xu Hui Zou Qiang Tan Fu-Shuang Li Jian-Feng Liu Hong-Lin Xiang 《Journal of Asian natural products research》2013,15(2):93-96
Selaginellins I (1) and J (2), two new compounds, were isolated from Selaginella tamariscina (Beauv.) Spring and were characterized as (R,S)-4-((2′,4′-dihydroxy-4-(hydroxymethyl)-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene)cyclohexa-2,5-dienone (1) and (R,S)-4-((3-((3,4-dihydroxyphenyl)ethynyl)-4′-hydroxy-4-(hydroxymethyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene)cyclohexa-2,5-dienone (2) on the basis of UV, IR, 1D and 2D NMR, and HR-ESI-MS spectroscopic analysis. 相似文献
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Xu KP Zou H Li FS Xiang HL Zou ZX Long HP Li J Luo YJ Li YJ Tan GS 《Journal of Asian natural products research》2011,13(4):356-360
Two new selaginellin derivatives, selaginellins K (1) and L (2), were isolated from Selaginella tamariscina (Beauv.) Spring and characterized as 2-formyl-4,4'-dihydroxy-3-[(4-hydroxyphenyl)ethynyl]biphene and 4,4'-dihydroxy-2-methyl-3-[(4-hydroxyphenyl)ethynyl]biphene on the basis of their spectroscopic data including UV, IR, 1D, and 2D NMR as well as HR-ESI-MS spectroscopic analysis. 相似文献
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Kang-Ping Xu Hui Zou Fu-Shuang Li Hong-Lin Xiang Zhen-Xing Zou Hong-Pin Long 《Journal of Asian natural products research》2013,15(4):356-360
Two new selaginellin derivatives, selaginellins K (1) and L (2), were isolated from Selaginella tamariscina (Beauv.) Spring and characterized as 2-formyl-4,4′-dihydroxy-3-[(4-hydroxyphenyl)ethynyl]biphene and 4,4′-dihydroxy-2-methyl-3-[(4-hydroxyphenyl)ethynyl]biphene on the basis of their spectroscopic data including UV, IR, 1D, and 2D NMR as well as HR-ESI-MS spectroscopic analysis. 相似文献
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卷柏的化学成分 总被引:1,自引:0,他引:1
目的研究卷柏[Selaginella tamariscina(Beauv.)Spring]的化学成分。方法采用硅胶柱色谱、ODS柱色谱、制备型HPLC等手段进行分离纯化,并利用波谱学方法鉴定化合物的结构。结果从卷柏乙醇提取物中分离得到13个化合物,分别鉴定为3β-羟基-7α-甲氧基-24β-乙基-胆甾-5-烯(1)、胆甾醇(2)、β-谷甾醇(3)、海棠果酸(4)、白桦脂酸(5)、5,4′-二羟基-7-甲氧基黄酮(6)、3-methoxychrysazin(7)、穗花杉双黄酮(8)、异柳杉双黄酮(9)、香草酸(10)、对甲氧基苯甲醛(11)、对羟基苯甲酸(12)、胡萝卜苷(13)。结论化合物1-2、4-7、10、13为本属植物中首次分离得到的化合物。 相似文献
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卷柏化学成分的分离与鉴定 总被引:1,自引:0,他引:1
目的研究卷柏属植物卷柏(Selaginella tamariscina(Beauv.)Spring)的化学成分。方法利用各种色谱法对卷柏的化学成分进行分离和纯化,通过理化性质和波谱数据分析进行结构鉴定。结果从卷柏中分离并鉴定了8个化合物,分别为尿苷(uridine,1)、垫状卷柏双黄酮(pulvinatabifla-vone,2)、selaginellin(3)、selaginellin C(4)、熊果苷(arbutin,5)、腺苷(adenosine,6)、β-谷甾醇(β-si-tosterol,7)、胡萝卜苷(daucosterol,8)。结论化合物1为首次从卷柏属植物中分离得到,化合物2~4为首次从卷柏中分离得到。 相似文献
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目的:通过比较实验室和工业化生产车间制备的卷柏总黄酮提取物中总黄酮及穗花杉双黄酮含量,探讨实验室和工业生产制备的卷柏总黄酮的质量差异。方法:采用紫外分光光度法测定卷柏提取物中总黄酮的含量;采用HPLC法测定穗花杉双黄酮的含量,并分析卷柏总黄酮部位中的总黄酮的成分组成。结果:工业化生产车间制备的卷柏总黄酮提取物中各含量指标与实验室制备样品无显著差异。结论:工业化生产车间大生产条件下制备的卷柏总黄酮部位与实验室制备的卷柏总黄酮部位无显著差异,为进一步的新药研究和工业化生产提供了保障。 相似文献
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Wei-Sheng Feng Hui Chen Xiao-Ke Zheng Yan-Zhi Wang Li Gao Hong-Wei Li 《Journal of Asian natural products research》2013,15(7):658-662
Two new secolignans, 3,4-trans-3-hydroxymethyl-4-[bis(4-hydroxyphenyl)methyl]butyrolactone (1) and 2,3-trans-3,4-trans-2-methoxy-3-hydroxymethyl-4-[bis(4-hydroxyphenyl)methyl]tetrahydrofuran (2), together with six known compounds, were isolated from the whole grass of Selaginella sinensis (Desv.) Spring. Their structures were elucidated by NMR and MS experiments. 相似文献
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卷柏中双黄酮类化学成分及卷柏属该类化合物的核磁共振特征 总被引:2,自引:0,他引:2
目的对卷柏属双黄酮类化合物的核磁共振特征进行归纳。方法应用核磁共振波谱法对卷柏[Selaginellatamariscina(Beauv.)Spring.]50%乙醇提取物中分离得到的5个双黄酮类化合物进行结构鉴定,并结合相关文献对卷柏属双黄酮类化合物的核磁共振特征进行归纳总结。结果首次初步归纳出卷柏属双黄酮类化合物核磁共振碳谱和氢谱的特征。结论通过总结卷柏属双黄酮类化合物的核磁共振特征规律,为快速鉴定该类化合物的结构以及进行核磁数据的归属提供依据。 相似文献
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卷柏中一个新木脂素苷的分离与鉴定 总被引:7,自引:0,他引:7
目的研究卷柏的化学成分。方法利用大孔吸附树脂、Sephadex LH-20、硅胶柱色谱进行分离纯化,根据化合物的理化性质和光谱数据鉴定结构。结果从卷柏中分离得到4个化合物,分别鉴定为(7S,8r)-7,8-二氢-7-(4-羟基-3,5-二甲氧基苯基)-8-羟甲基-[1′-(7′-羟基)乙基-5′-甲氧基]苯骈呋喃-4-O-β-D-葡糖苷(命名为卷柏苷C,化合物I)、D-甘露醇(化合物II)、酪氨酸(化合物III)、莽草酸(化合物IV)。结论化合物I为新化合物,化合物II和III为首次从卷柏属植物中分离得到,IV为首次从卷柏中分离得到。 相似文献
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Selaginella tamariscina is a traditional medicinal plant for treatment of some advanced cancers in the Orient. However, the effect of S. tamariscina on metastasis of osteosarcoma and the underlying mechanism remain unclear. We tested the hypothesis that S. tamariscina suppresses cellular motility, invasion and migration and also investigated its signaling pathways. This study demonstrates that S. tamariscina, at a range of concentrations (from 0 to 50 μg/mL), concentration-dependently inhibited the migration/invasion capacities of three osteosarcoma cell lines without cytotoxic effects. Zymographic and western blot analyses revealed that S. tamariscina inhibited the matrix metalloproteinase (MMP)-2 and MMP-9 enzyme activity, as well as protein expression. Western blot analysis also showed that S. tamariscina inhibits phosphorylation of p38 and Akt. Furthermore, SB203580 (p38 inhibitor) and LY294002 (PI3K inhibitor) showed the similar effects as S. tamariscina in U2OS cells. In conclusion, S. tamariscina possesses an antimetastatic activity in osteosarcoma cells by down-regulating MMP-2 and MMP-9 secretions and increasing TIMP-1 and TIMP-2 expressions through p38 and Akt-dependent pathways. S. tamariscina may be a powerful candidate to develop a preventive agent for osteosarcoma metastasis. 相似文献
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翠云草中酚性成分的分离与鉴定 总被引:10,自引:0,他引:10
目的研究翠云草[Selaginella uncinata(Desv.) Spring]的化学成分。方法利用硅胶、Sephadex LH-20、ODS柱色谱及反相制备型HPLC等方法进行分离纯化,根据化合物的理化性质及波谱数据鉴定它们的结构。结果与结论从体积分数为60%的乙醇提取液中分离得到7个酚性成分。结构分别鉴定为:阿魏酸棕榈酸-16-醇酯(1)、对羟基桂皮酸(2)、对羟基苯乙酮(3)、香草醛(4)、香草酸(5)、丁香酸(6)、对羟基苯甲酸(7)。化合物1~3为首次从该属植物中分离得到,化合物1~7为首次从该种植物中分离得到。 相似文献
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Five selaginellin derivatives, including two new selaginellins termed selaginellins M (1) and N (2), and three previously identified compounds, selaginellin (3), selaginellin A (4), and selaginellin C (5), were isolated from the Selaginella tamariscina (Beauv.) Spring plant. In addition, four known biflavonoids, namely neocryptomerin ( 6), hinokiflavone (7), pulvinatabiflavone (8), and 7'- O-methylamentoflavone (9), were also isolated. The structures of new compounds 1 and 2 were elucidated by spectroscopic analysis. The cytotoxic activity of compounds 1- 9 was evaluated against a small panel of human cancer cell lines, including U251 (human glioma cells), HeLa (human cervical carcinoma cells), and MCF-7 (human breast cancer cells). The two new selaginellins, selaginellins M (1) and N (2), showed medium activity against the human cancer cell lines. 相似文献
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卷柏中化学成分的分离与结构鉴定 总被引:18,自引:0,他引:18
目的研究中药卷柏(Selaginella tamariscina (Beauv.) Spring)水提物中的化学成分。方法用Sephadex LH-20及硅胶等色谱技术进行分离纯化,根据理化性质、光谱数据进行结构鉴定。结果得到9个化合物,分别鉴定为(2r,3s)-二氢-2-(3′,5′-二甲氧基-4′-羟基苯基)-3-羟甲基-7-甲氧基-5-乙酰基苯骈呋喃(1),3-羟基-苯丙酸-(2′-甲氧基-4′-羧基苯酚)酯(卷柏酯A,2),丁香脂素(3),1-(4′-羟基-3′-甲氧基苯基)丙三醇(4),阿魏酸(5),咖啡酸(6),香荚兰酸(7),丁香酸(8),7-羟基香豆素(9)。结论化合物1,2为新化合物,其余化合物均为首次从卷柏属植物中分离得到。 相似文献
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Gui-Shan Tan Kang-Ping Xu Fu-Shuang Li Chen-Jing Wang Tuo-Ying Li Chang-Ping Hu 《Journal of Asian natural products research》2013,15(12):1001-1004
A novel compound, selaginellin C (1), was isolated from Selaginella pulvinata Maxim (Hook et Grev.) as (R,S)-4-((1,2-dihydroxyethyl)-2′,4′-dihydroxy-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)((4-hydroxyphenyl)methylene)cyclohexa-2,5-dienone, along with two known compounds, selaginellin (2) and selaginellin A (3). The structure of the new compound was elucidated on the basis of 1D and 2D NMR as well as HR-ESI-MS spectroscopic analysis. 相似文献
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卷柏化学成分研究卷柏化学成分研究 总被引:16,自引:0,他引:16
目的研究中药卷柏(Selaginella tamariscina (Beauv.) Spring)水提物中的化学成分。方法利用Sephadex LH-20及硅胶等色谱技术进行分离纯化,根据理化性质、光谱数据进行结构鉴定。结果得到4个化合物,分别鉴定为1-羟基-2-[2-羟基-3-甲氧基-5-(1-羟基乙基)-苯基]-3-(4-羟基-3,5-二甲氧基苯基)-丙烷-1-O-β-D-葡糖苷(卷柏苷B,I),腺苷(II),鸟苷(III),熊果苷(IV)。结论卷柏苷B为新化合物,腺苷、熊果苷、鸟苷为首次从卷柏属植物中分离得到。 相似文献
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Xu KP Zou H Liu GR Long HP Li J Li FS Zou ZX Kuang JW Xie X Tan GS 《Journal of Asian natural products research》2011,13(11):1051-1055
A new selaginellin derivative, selaginellin M (1), together with one known compound, selaginellin E (2), was isolated from Selaginella pulvinata. The structure of the new compound was elucidated and named as (R,S)-4-((4'-hydroxy-4-((2-hydroxyethoxy)methyl))-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene)cyclohexa-2,5-dienone on the basis of the spectroscopic data including UV, IR, 1D, and 2D NMR as well as HR-ESI-MS analysis. 相似文献
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Kang-Ping Xu Hui Zou Guo-Ru Liu Hong-Ping Long Jing Li Fu-Shuang Li 《Journal of Asian natural products research》2013,15(11):1051-1055
A new selaginellin derivative, selaginellin M (1), together with one known compound, selaginellin E (2), was isolated from Selaginella pulvinata. The structure of the new compound was elucidated and named as (R,S)-4-((4′-hydroxy-4-((2-hydroxyethoxy)methyl))-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene)cyclohexa-2,5-dienone on the basis of the spectroscopic data including UV, IR, 1D, and 2D NMR as well as HR-ESI-MS analysis. 相似文献