口腔黏膜病

口腔癌前病变细胞凋亡状况及Bcl-2、Bmx表达的研究，SjOEgren综合征临床症状出现频率及诊断价值的研究，氦-氖激光和深海鱼油联合治疗复发性口腔溃疡的疗效评价，多抗甲素联合肿痛安治疗复发性口疮的疗效观察，iNOS在口腔扁平苔藓癌变过程中的表达研究     

复发性阿弗他溃疡患者25羟维生素D水平的研究

目的 比较轻型复发性阿弗他溃疡患者与健康人血清25羟维生素D的水平,分析25羟维生素D与复发性阿弗他溃疡发病机制间可能存在的关系.方法 选取48名确诊为轻型复发性阿弗他溃疡的患者和50名健康人为研究对象.分别在患者发病期(A1组)和无症状期(A2组)抽取5ml空腹静脉血,以健康人空腹静脉血为对照组.采用酶联免疫法检测血清25羟维生素D水平.结果 A1组25羟维生素D水平最低(14.73±5.18)ng/ml,显著低于A2组(17.36±5.96)ng/ml差异有统计学意义(P<0.05).对照组25羟维生素D水平最高(19.87±5.94)ng/ml,与A1、A2组差异均有统计学意义(P<0.05).结论 维生素D可能在复发性阿弗他溃疡的发病机制中具有一定的作用.     

Er:YAG激光联合引导骨组织再生术治疗种植体周围炎骨缺损的临床效果

目的 评估Er:YAG激光(erbium-doped:yttrium aluminium garnet)联合引导骨组织再生术(guided bone regeneration,GBR)治疗种植体周围炎骨缺损的临床效果.方法 选择形成环形牙槽骨吸收的种植体周围牙周炎患者15例,共26颗患牙,按照随机照原则分为2组,试验组(14颗)采用Er:YAG激光联合GBR的方式治疗种植体周围骨缺损;对照组(12颗)采用机械刮治联合GBR治疗牙槽骨的缺损.在基线和6个月时进行临床牙周指标的检查测定,包括菌斑指数(plaque index,PI)、龈沟出血指数(sulcus bleeding index,SBI)、牙周探诊深度(probing depth,PD)及临床附着丧失(clinical attachment lost,CAL),并进行比较.结果 2组术后PI、SBI、PD及CAL均较术前有明显改善(P<0.05).术后2组PI均值都维持在一个较低的水平,差异无统计学意义(P>0.05);试验组与对照组的SBI分别为(0.8±0.2)、(1.1±0.2);PD分别为(5.8±0.8)mm、(6.2±0.6)mm;CAL分别为(2.3±0.7)mm、(3.6±0.6)mm.组间比较差异均有统计学意义(P<0.05).结论 Er:YAG激光联合GBR在治疗种植体周炎骨缺损具有较好的临床效果.     

康复新液联合比拜克治疗复发性口腔溃疡疗效观察

目的探讨康复新液联合比拜克治疗复发性口腔溃疡的临床疗效。方法将100例轻型复发性口腔溃疡患者随机分为试验组和对照组,试验组给予康复新液10 mL,含漱5 min,3次/d,联合使用比拜克0.72 g,口服,3次/d;对照组给予复方氯己定15 mL含漱5 min,2次/d,联合使用复合维生素B,口服,3次/d。两组使用1周后复诊,观察两组溃疡愈合的时间,连续使用3周后,分别3、6、9、12个月电话随访,比较两组的显效率和总有效率。结果试验组显效率为82%,明显高于对照组(46%);试验组总有效率为96%,明显高于对照组(56%)。差异均有统计学意义(P<0.05)。结论康复新液联合比拜克治疗复发性口腔溃疡疗效显著,值得临床推广应用。     

关节液中MMP-2和MMP-3含量对颞下颌关节紊乱病诊断的意义

目的:探讨关节液中基质金属蛋白酶-2(matrixmetalloproteinase-2,MMP-2)和基质金属蛋白酶-3(matrixmetalloproteinase-3,MMP-3)的表达与关节病变程度的关系。方法:留取颞下颌关节紊乱病(temporomandibularjointdisorder,TMD)患者126侧关节和健康志愿者32侧关节的关节液标本,依据临床检查和TMJ影象学检查将标本分为(1)关节炎症性疾病(capsulitis/synovitis,C/S)组(n=24);(2)结构紊乱(internalderangement,ID)组(n=58);(3)骨关节病(osteoarthritis,OA)组(n=44);(4)健康志愿者对照组(n=32)。用双抗体夹心酶联免疫法检测关节液标本中MMP-2和MMP-3的含量。结果:关节液中MMP-2含量:OA组(42.656±14.515)ng/mL,ID组(34.772±12.647)ng/mL,C/S组(29.500±8.177)ng/mL,对照组(20.927±4.830)ng/mL。关节液中MMP-3含量:OA组(74.677±46.910)ng/mL;ID组(49.086±22.298)ng/mL;C/S组(32.609±9.470)ng/mL;对照组(23.663±8.767)ng/mL。统计学检验:MMP-2和MMP-3在OA组与其余3组间比较均有显著性差异(P<0.05);ID组、C/S组与对照组间比较均有显著性差异(P<0.05);但ID组与C/S组间比较无显著差异(P>0.05)。结论:TMD患者关节液中MMP-2和MMP-3的表达水平随着关节病变程度的增加而显著升高,表明它们不仅参与了关节组织的病理破坏,而且与关节破坏程度密切相关,它们在关节液中的表达水平反映了TMD病变的严重程度。关节液中的MMP-2和MMP-3可以作为代表TMD关节损害和代谢的客观生化分子标志。     

Er∶YAG激光辅助在年轻恒牙间接盖髓的应用效果

目的:探讨Er∶YAG激光联合三氧化物凝聚体治疗年轻恒牙间接盖髓的应用效果。方法:采用随机数表法将因年轻恒牙牙髓病患者160例分为2组,各80例。对照组采用三氧化物凝聚体盖髓,观察组采用Er∶YAG照射联合三氧化物凝聚体盖髓。比较两组盖髓成功率、龈沟液炎症因子水平、VAS疼痛评分、牙齿活动度以及生活质量变化。结果:观察组盖髓成功率(98.75%)明显高于对照组(91.25%)(P<0.05)。治疗6月后,2组龈沟液中白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、VAS评分、牙齿活动度均降低(P<0.05),且观察组以上指标水平低于对照组(P<0.05)。2组生活质量各项评分低于治疗前(P<0.05),且观察组低于对照组(P<0.05)。结论:Er∶YAG激光照射联合三氧化物凝聚体盖髓治疗年轻恒牙牙髓病疗效优于单用三氧化物凝聚体。     

低能量激光疗法联合Dycal用于大鼠磨牙直接盖髓术的体内研究

目的:观察低能量激光疗法(LLLT)联合Dycal用于大鼠磨牙直接盖髓对牙髓炎、修复性牙本质形成及IL-1β、TRPA1表达的影响。方法:64只大鼠随机均分成对照组(NC)、低能量激光组(LLLT)、Dycal组(Dy)、联合组(LLLT+Dy)(n=16)。直接盖髓术后3、7、14、28 d取标本,行HE及免疫组化(IHC)染色观察。结果:LLLT组与LLLT+Dy组炎症反应在术后14、28 d都存在显著性差异(P<0.016 7);修复性牙本质桥形成在术后14 d, LLLT+Dy组与LLLT组、Dy组存在显著性差异(P<0.016 7);术后28 d, LLLT+Dy组与LLLT组存在显著性差异(P<0.016 7)。IL-1β、TRPA1阳性MOD值在术后7 d存在显著性差异,Dy组>LLLT组>LLLT+Dy组>NC组(P<0.05),术后14 d存在显著性差异,LLLT组、Dy组均>LLLT+Dy组(P<0.05)。结论:低能量激光联合Dycal可能通过减少IL-1β、TRPA1的表达来减轻牙髓炎症、促进修复性牙本质的形...     

中药和左旋咪唑联合治疗复发性口腔溃疡的疗效观察

目的:应用中药经验方(甘露饮)和左旋咪唑联合治疗复发性口腔溃疡,观察其临床效果.方法:选择临床轻型复发性口腔溃疡病例76例,随机分为治疗组和对照组,治疗组38例给予中药经验方和左旋咪唑,对照组38例仅给予左旋咪唑,观察2组的临床疗效,采用SAS 9.0软件包对数据进行Wilcoxon检验.结果:联合治疗组总有效率达92.10%,对照组总有效率为78.95%,2组比较有显著性差异.结论:中药经验方和左旋咪唑联合治疗复发性口腔溃疡的临床效果明显优于单独左旋咪唑治疗组.     

肿痛安联合地塞米松治疗复发性阿弗他溃疡的疗效评价

100例复发性口腔溃疡患者,随机分为实验组(55例)和对照组(45例),实验组用肿痛安胶囊联合地塞米松片治疗,对照组单纯用地塞米松片治疗,疗程9d,随访6个月,观察其临床疗效。结果,实验组总有效率为94.45%,对照组为77.78%,2组有显著性差异,P<0.05。认为肿痛安胶囊联合地塞米松对复发性阿弗他溃疡有良好的疗效。     

氨来呫诺糊剂治疗复发性阿弗他溃疡的临床研究

目的研究50g/L的氨来呫诺糊剂治疗复发性阿弗他溃疡的有效性和安全性.方法应用随机、双盲、平行对照的临床试验方法,试验组和对照组各纳入120例轻型复发性阿弗他受试者,分别应用50g/L氨来呫诺糊剂和空白基质糊剂,4次/d;应用5 d.于初诊后第4天和第6天进行随访,采用视觉类比量表获取的疼痛指数评估其镇痛效果,并比较2组受试者的溃疡愈合时间,用药前、后进行血常规、血生化和心电图检查.结果试验组和对照组完成病例分别为115例和113例(P＞0.05).初诊时2组的总体疼痛指数分别为18.12±7.18和18.09±7.15(P＞0.05);第4天分别为7.56±6.87和10.00±7.07(P＜0.01);第6天分别为2.14±4.70和3.84±5.75(P＜0.01).50%受试者溃疡愈合在试验组为5 d,空白基质组为6 d.与研究药物有关的不良事件在氨来呫诺组有10例(8.40%),在空白基质组中有9例(7.5%)(P＞0.05).全部不良事件均为轻度,未经处理即好转.2组受试者在治疗结束时血常规、血生化和心电图检查结果均为正常或异常但无临床意义.结论50g/L氨来呫诺糊剂治疗复发性阿弗他溃疡是安全有效的.     

Evidence of the validity of a model of determinants of quality of restorative dental care

A model describing the relationship between self-reported quality of restorative dentistry and dentist characteristics for 119 Montana general dentists is presented. The best predictors formed a significant model explaining 22% of the variance of the quality measure. Results are contrasted with a previous estimation of the model for 102 Washington general practitioners. Evidence for the external validity of the model is presented.     

Experimental evidence of formation of imines in the course of reduction of hydrazones

The reduction of hydrazones is generally suggested to proceed through a reductive cleavage of the nitrogen–nitrogen bond followed by a reduction of the carbon–nitrogen bond. This sequence of reduction processes is here supported for fluorenone (V) and benzophenone (VI) hydrazones as well as by a comparison of the reduction of fluorenone and benzophenone hydrazonium ions (I,III) with corresponding imines (II,IV). Another proof of the presence of imines as intermediates is the splitting of four-electron waves of hydrazones V and VI and hydrazonium ions I and VIII into two waves at pH < 2. This has been interpreted as due to differences in slopes dE_1/2/dpH and pK_a-values of protonated hydrazine derivatives on one side and corresponding imines on the other. In this pH-range imines formed in reductions of VI and VIII are reduced in a single two-electron wave, those of I and V in two one-electron steps. Fluorenone imine (II) is sufficiently stable to allow recording of time-independent current–voltage curves between pH 6 and 11. In this pH-range the imine (II) is reduced in two one-electron steps. Benzophenone imine (IV) has been found stable between pH 4.6 and 12. At pH 4.6–8 the reduction of the imine IV takes place in a single two-electron step, at pH 8–12 in two one-electron steps. Final proof of the initial cleavage of the N–N bond is presented by comparison with the reduction of nitrones.     

不同剂型玻璃离子水门汀溶解性比较研究

目的:研究、比较不同剂型玻璃离子水门汀的溶解性和表面微观形态改变,为临床使用提供依据.方法:将3M树脂加强型玻璃离子水门汀(水粉剂型)、GC玻璃离子水门汀(水粉剂型)及GC玻璃离子水门汀(双糊剂型)分别在人工唾液中浸泡30 d,冷热循环15000次,烘干测重,比较前后质量变化,计算溶解率,并用扫描电镜观察表面微观改变.结果:不同剂型的玻璃离子水门汀溶解率由高到低分别为3M树脂加强型玻璃离子水门汀(水粉剂型)、GC玻璃离子水门汀(水粉剂型)、GC玻璃离子水门汀(双糊剂型).3种玻璃离子水门汀经浸泡溶解后,SEM扫描表面微观形态可观察到GE玻璃离子水门汀(双糊剂型)表面形态改变较少,其他2组玻璃离子水门汀表面微观改变较多.结论:双糊剂型玻璃离子水门汀理化性能及溶解率均低于传统水粉剂型,是未来临床修复治疗的的良好选择.     

Evaluation of efficacy of chemiluminescence for diagnosis of leukoplakia

ObjectiveLeukoplakia is the most common potentially malignant disorder preceding oral cancer. Chemiluminescence has been developed as an adjunct to conventional examination for the diagnosis of these potentially malignant disorders. This study was conducted to assess the efficacy of chemiluminescence in the diagnosis of leukoplakia and to compare the results with histopathological examination.Study designA total of 50 patients with leukoplakia were included from the outpatients attending the Department of Oral Medicine and Radiology, Dental Hospital, Bengaluru, Karnataka, India. These patients were subjected to conventional oral examination followed by chemiluminescent examination with Vizilite (Zila, Fort Collins, CO, USA) and biopsy for histopathological confirmation.ResultsThe sensitivity, specificity, positive predictive value, and negative predictive value of chemiluminescence were 93.75%, 55.56%, 78.95%, and 83.3%, respectively. The overall accuracy of chemiluminescence was 80%. A statistically significant association was observed between histopathology results and chemiluminescence results.ConclusionAlthough it is an easy, safe, minimal time consuming, and noninvasive technique, it has only adjunctive utility and it does not replace biopsy for the diagnosis of leukoplakia.     

颌骨动静脉畸形的栓塞治疗

目的：总结直接穿刺结合经血管内介入栓塞治疗颌骨动静脉静脉畸形的经验。方法：收治凳骨动静脉畸形患者6例,均进行了介入栓塞治疗。采用的栓塞材料为附凝血棉纤毛的螺圈,聚乙烯醇泡沫微粒和二氰基丙烯酸对丁酯。数字减影颈动脉造影在PHILIPSV300下完成。结果6例颌骨动静脉畸形患者中4,例急性出血得到了快速、有效控制,1例慢性渗血的右下 骨动静脉畸形患者,介入栓塞治疗,拔除松动的右下凳第一磨牙,有效地控制了出血,另1例伴局部软组织搏动性膨隆的上凳骨动静脉畸形患者,介入治疗后膨隆的搏动性得到明显改善,栓塞治疗后分别随访3－24个月,均未发现有口腔内渗血或出血。随访的X线片上,病灶区可见新骨形成。结论：局部穿刺结合经血管内介入栓塞治疗颌骨动静畸形是一种安全、有效的治疗方法。     

Design of clinical trials of traditional therapies of periodontitis

The present paper on the design of clinical trials of periodontal therapy first addresses the issue of the etiology of periodontal disease. It is suggested that most if not all forms of destructive periodontal disease are caused by microorganisms and that there are different forms of disease with different microbial etiologies. The progressive nature of destructive periodontal disease is subsequently discussed and it is emphasized that, in a given patient, periodontal sites which show signs of inflammation and attachment loss may not over a period of several months and years show further sign of attachment loss. The present methods of assessing periodontal disease do not allow us to discriminate between potentially active and inactive sites in untreated patients. The significance and variability of indicators of periodontal disease such as bleeding on probing, probing pocket depth and probing attachment level measurements are discussed. The errors inherent in the various measurements are analyzed and suggestions are presented describing how alterations in any of the above parameters could be identified and presented in a clinical trial. Of concern for the statistical analysis of clinical data of periodontal disease is the definition of the "experimental unit". For a number of years, the "experimental unit" in periodontal trials was the patient. It is clear, however, that different sites within the same individual show different patterns of disease progression and lesion morphology and often respond differently to periodontal therapy. Statistical analyses must consequently be designed which recognize differences in site-to-site infection and lesion morphology within a common host. Until such analyses are available, the investigator should be wary of pooling data within the same individual, since such pooling may obscure meaningful alternatives which may take place in individual periodontal sites. Some goals of periodontal therapy are subsequently identified. 4 goals are discussed more in detail, namely: to establish conditions which will allow the patient to maintain a dentition without further breakdown of the periodontium; to reduce pocket depth to establish an anatomy in the dentogingival region which with proper maintainance care will prevent the re-establishment of the subgingival infection; to gain attachment as a result of treatment; to assess the effect of a certain chemotherapeutic agent on periodontal disease.     

正畸患者切牙影像失真发生情况分析

目的研究正畸患者曲面体层片上的切牙影像失真发生情况，并分析其原因。 方法从中山大学附属口腔医院放射科影像数据库中选取500例正畸患者的曲面体层片和头影测量侧位片，所有曲面体层片均采用咬合杆投照，分别从切牙牙体影像放大、缩小、牙根变短、根尖模糊等评价指标分析上下颌切牙影像失真的发生情况，在头影测量侧位片上测量中切牙根尖-对颌切牙切缘的距离，探讨切牙影像失真发生的原因。采用SPSS 19.0统计软件对所得数据进行统计学检验。 结果500例患者中，切牙牙体影像正常者共417例，切牙牙体影像失真者共83例，影像失真发生率16.6%，其中切牙牙体影像放大17例、牙体影像缩小0例、牙根变短30例，牙根影像变短伴模糊36例。影像失真患者的根尖-切缘距离大于影像正常的患者，差异有统计学意义（F = 5 187.18，P = 0）；影像失真患者的覆盖值大于影像正常的患者，差异有统计学意义（F>477，P = 0）。 结论严重牙颌面畸形如反 、深覆盖是导致曲面体层片的切牙影像失真的主要原因之一。     

正常青年Monson球面半径的测量研究

目的测量正常青年Monson球面半径。方法选择60名(男30名,女30名)正常青年制取全口印模,应用立体摄影成像的原理与方法对Monson球面半径进行测量和统计学处理。结果Monson球面的半径平均为10.173 cm,大于理论值10.160 cm,差异有显著性(P<0.01);男、女性球面半径差异无显著性。结论本实验所得到的数据可作为全口义齿修复中记录颌位关系的一个参量。     

鼻测量法的进展

唇裂术后继发畸形是指唇裂修复术后,仍遗留或继发于手术操作和生长发育变化而表现出来的一类畸形[1]。包括唇畸形、鼻畸形和颌骨畸形。其修复较原发性唇裂修复更复杂,更灵活多变。而导致其修复复杂性的一个重要原因即是局部组织结构复杂变异和缺乏可靠的三维测量手段[2],鼻畸形     

口底癌34例临床分析

目的探讨口底癌的临床特性、治疗方法及预后。方法对我院自1992—2002年住院治疗的34例口底癌患者进行回顾性分析。结果34例口底癌患者中,男28例(82.4%),女6例(17.6%),男女比为4.7∶1,平均发病年龄58岁。发病部位:前口底22例(64.7%),后口底12例(35.3%)。淋巴结转移率41.2%。单纯手术组、化疗加手术组、放疗加手术组、化疗加手术加放疗组的5年生存率分别为45.5%、60.0%、50.0%、62.5%。结论口底癌以中老年患者好发,男性居多。易发生淋巴结转移,综合疗法疗效较好。