Demonstration in situ of subsets of T-lymphocytes in sarcoidosis

Five biopsy specimens of skin, four of lung, and one of a lymph node were taken from nine patients with sarcoidosis. Monoclonal antibodies were applied to frozen sections of the specimens by an immunoperoxidase technique to test for the presence and distribution of subsets of T-lymphocytes. T-cells expressing the suppressor/cytotoxic phenotype were found predominantly in lymphocytic mantles surrounding sarcoidal granulomas, whereas cells displaying the helper/inducer phenotype were distributed diffusely throughout granulomas. The ratio of helper to suppressor phenotypes in cutaneous sarcoidosis was 5.1 +/- 1.8. The microanatomic location of subpopulations of T-lymphocytes may be important in the pathogenesis of the granulomatous response of sarcoidosis.     

寻常型银屑病几项实验室指标的检测及应用螺旋霉素治疗的观察

对６４例鳞屑性红斑的主要表现的进行期寻常型银屑病作了血液检测和螺旋霉素治疗研究，结果表明，患者血液中Ｎ，Ｌ，ＡＮＡ，ＡＳＯ，ＨＢｓＡｇ，Ｃ３和Ｃ４检测值均为对照组的显著增高，合用螺旋霉素治疗组疗产优于对照组，其治愈率，无效率和总有效率均有显著差别，患者合用螺旋霉素治疗前后，ＡＮＡ，ＡＳＯ，Ｃ３和Ｃ４测定值存在显著差异，提示银屑病患者体内存在着潜在细菌或病毒感染因素，这是该病发生，复发或加重的可能病     

急性肾损伤早期诊断生物标记物的研究进展

急性肾损伤（acute kidney injury，AKI）一直是临床上一个头痛的问题。ICU收治患者中30％-50％是急性肾损伤，其中5％有明确的危险因子。有报道术后发生AKI患者的死亡率在24％-100％之间，重症监护室需要透析患者的死亡率为50％-70％。近年的研究认为，传统的血（肌酐、尿素氮）和尿标志物（管型、滤过钠排泄分数）对AKI的诊断缺乏一定的敏感性和特异性，所以AKI的治疗迫切需要早期生物标记物。但是，