儿童外伤性白内障后囊连续环形撕囊人工晶状体植入术临床观察

目的 :研究儿童外伤性白内障后囊连续环形撕囊人工晶状体植入术对提高视力 ,预防弱视及后发性白内障发生的意义。方法 :观察 4 2例 (42眼 )儿童外伤性白内障施行现代囊外摘除、后囊连续环形撕囊及人工晶状体植入术的疗效和并发症 ,随访 1～ 2 4月 ,平均 12月。结果 :术后葡萄膜炎反应较成人严重 ,矫正视力较满意 ,>0 .3共 2 7眼。术后后发性白内障发生率明显下降。结论 :儿童外伤性白内障后囊连续环形撕囊人工晶状体植入术是目前恢复视力、预防弱视及后发性白内障发生的有效方法。     

超声乳化吸出及人工晶状体植入术治疗葡萄膜炎并发白内障的临床观察

目的 观察超声乳化吸出及人工晶状体植入术治疗葡萄膜炎并发白内障的疗效.方法 对52例(65眼)葡萄膜炎并发白内障患者行晶状体超声乳化吸出及人工晶状体植入术.结果 术后65眼视力均较术前提高.术后3月视力(或矫正视力)≥0.4者51眼(78.5％),0.1 ～0.3者8眼(12.3％),0.05者2眼(3.0％),数指/30 cm者4眼(6.2％).结论 对超声乳化吸出术及人工晶状体植入术治疗葡萄膜炎并发白内障者,只要掌握好手术时机,操作得当,可以有很好的疗效.     

眼球内异物合并外伤性白内障手术治疗16例临床分析

目的：探讨眼球内异物合并外伤性白内障的手术方法。方法：对我院收治的16例眼球内异物合并外伤性白内障患者施行异物取出与白内障摘除加人工晶状体植入术。结果：术后视力：4眼达1.0,5眼0.6~0.8,3眼0.3~0.5,4眼0.2~0.3。结论：眼球内异物合并外伤性白内障及时取出异物,根据晶状体受伤程度决定人工晶状体植入,可提高手术成功率。     

表面麻醉小切口非超声乳化白内障摘除术400例临床分析

目的观察表面麻醉小切口非超声乳化白内障摘除术的临床效果。方法对400例符合手术要求的白内障患者行表面麻醉小切口非超声乳化白内障摘除联合人工晶状体植入,观察其术后视力恢复及并发症情况。结果术后1天,裸眼视力〈0.05者30眼,占7.5%;0.05～0.3者124眼,占31%;≥0.3者246眼,占61.5%;术后1周复查视力,〈0.05者16眼,占4%;0.05～0.3者60眼,占15%;≥0.3者324眼,占81%;术中及术后各种并发症的发生率均很低。结论表面麻醉下行小切口非超声乳化白内障摘除联合人工晶状体植入术麻醉效果良好,能最大限度减少并发症,视力恢复快,患者易接受;适宜于我国大规模复明行动及基层医院开展的以白内障为主的防盲治盲工作。     

外伤性白内障摘除及人工晶状体植入术的最佳手术时机探讨

目的探讨外伤性白内障摘除及人工晶体植入术的最佳手术时机。方法回顾性分析本院眼科近年来收治的96例(96眼)外伤性白内障资料,根据患者的病情,选择不同的手术时机,施行白内障摘除及人工晶状体植入手术。结果手术均无严重并发症。矫正视力0.05～0.3者66例,占68.75%;矫正视力>0.3者30例,占31.25%;无论是人工晶体一期植入还是二期植入,对术后矫正视力并无显著影响(P>0.05),而术后矫正视力较术前视力均得到显著提高。结论外伤性白内障人工晶体植入术选择最佳的手术时机,对于获取好的疗效至关重要。     

晶状体异物合并外伤性白内障治疗15例临床分析

目的评估晶状体异物合并外伤性白内障治疗的临床效果.方法对15例晶状体异物合并外伤性白内障病例进行回顾性分析.晶状体异物取出、白内障超声乳化或前段玻璃体切割以及人工晶状体的植入同期完成,13眼植入后房型人工晶状体,2眼植入前房型人工晶状体.结果晶状体异物全部顺利取出,超声乳化或前段玻璃体切割及人工晶状体的植入同期完成.术后半年到一年,视力0.05～0.3者9例,0.4～0.8者5例,1.0者1例.2眼发生虹膜后粘连.结论大多数晶状体异物合并外伤性白内障的病例可通过手术及人工晶状体的同期植入得到安全有效的治疗.     

超声乳化联合零度或负度数人工晶状体植入术治疗白内障合并超高度近视的临床分析

目的:分析白内障超声乳化联合零度或负度数人工晶状体植入术治疗白内障合并超高度近视的临床疗效及手术技巧。方法:对30例(36只眼)白内障合并超高度近视患者行超声乳化白内障吸除零度或负度数人工晶状体植入术,观察术中和术后并发症,术后视力和屈光度数。随访时间4～36个月。结果:术中无并发症发生,术后3个月最佳矫正视力<0.1者5只眼。0.1～0.4者18只眼,0.3～0.9者12只眼,1.0～1.5者1只眼;3只眼(8.33%)晶状体后囊膜混浊,无发生视网膜脱离者。结论:在熟练掌握手术技巧的情况下,超声乳化白内障吸除零度或负度数人工晶状体植入术是治疗白内障合并超高度近视患者安全、有效的手术方法。     

儿童白内障摘除联合前节玻璃体切割及人工晶状体植入术临床观察

目的评价儿童白内障摘除联合前节玻璃体切割及人工晶状体植入术的应用价值。方法对14例17眼儿童白内障患者行白内障摘除联合前节玻璃体切割及人工晶状体植入术，术后随访6个月～3年。结果术后末次随访视力〉0．5者9眼（52．9％），0．1-0．5者5眼（29．4％）。无明显并发症。结论儿童白内障摘除联合前节玻璃体切割及人工晶状体植入术是一种安全、有效的方法。     

外伤性白内障手术治疗体会

目的探讨外伤性白内障手术治疗时机,术式选择及其效果。方法总结我院2003年7月～2005年7月收治的61例外伤性白内障,分别采用白内障一期和二期摘除、人工晶体一期或二期植入术共56眼,经随访3～12个月,对其效果进行分析。结果一期白内障摘除联合后房型人工晶体植入37眼,术后矫正视力在0.06￣0.8之间,其中0.1以上31眼,0.3￣0.8者22眼,二期白内障摘除联合人工晶体植入和单纯二期人工晶体植入术19眼,术后视力在0.12～1.0之间,其中0.3～1.0者17眼。二期人工晶体植入组的并发症较一期手术组少而轻。结论二期人工晶体植入组效果较好,对于后囊裂开,眼后段情况不明者,不要一期植入人工晶体。     

外伤性白内障手术时机及术式探讨

目的探讨复杂外伤性白内障采用小切口白内障摘除联合折叠式人工晶状体植入术的时机、术式选择及疗效。方法回顾性分析67例（67眼）合并跟前后节组织紊乱的外伤性白内障患者不同的手术时机、术式及疗效。所有患者均采用白内障超声乳化或小切口囊外摘除联合折叠式人工晶状体植入术，其中37例（37眼）为Ⅰ期白内障摘除人工晶状体植入联合眼前节损伤修复或玻璃体视网膜手术。结果术后矫正视力0．6—1．2者12眼（17．91％），0．3—0．5者31眼（46．27％），0．05—0．2者20眼（29．85％），〈0．05者4眼（5．97％）。结论选择适当手术时机和手术方式，采用小切口植入折叠式人工晶状体，可使复杂外伤性白内障获得较好治疗效果。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.