瑞格列奈联合二甲双胍及阿卡波糖对2型糖尿病患者糖脂代谢的影响

选择2016年1月至2018年9月2型糖尿病患者100例,随机平分为对照组采用瑞格列奈治疗,观察组采用瑞格列奈联合二甲双胍及阿卡波糖治疗。结果观察组血糖及血脂水平相对对照组明显降低,(P 0.05);并发症发生率相对于对照组明显降低(P 0.05)。结论 2型糖尿病患者采用瑞格列奈联合二甲双胍及阿卡波糖可有效改善患者血糖、血脂水平,降低并发症发生率。     

二甲双胍联合阿卡波糖治疗2型糖尿病并高血脂症的临床疗效分析

目的分析二甲双胍联合阿卡波糖治疗2型糖尿病(T2DM)并高血脂症的疗效。方法收集该院内分泌科住院的T2DM伴高血脂症患者364例,其中采用二甲双胍单药治疗182例为对照组,采用二甲双胍联合阿卡波糖治疗的182例为联合组。比较治疗前后两组血糖、血脂指标变化及治疗3个月后两组疗效。结果治疗后,两组患者各项血糖及血脂指标均有明显下降(P0.05),且联合组均优于对照组(P0.05)。联合组总有效率为94.51%,显著高于对照组的73.63%(P0.05)。结论二甲双胍联合阿卡波糖治疗2型糖尿病伴高脂血症可显著改善患者血糖水平和血脂水平,临床疗效值得肯定。     

阿卡波糖联合二甲双胍治疗2型糖尿病临床探讨

目的探讨研究阿卡波糖联合二甲双胍治疗2型糖尿病的治疗效果。方法随机选取2013年3月—2014年3月门诊2型糖尿病患者40例作为治疗组,将2013年3月以前40例2型糖尿病治疗病历作为对照组,治疗组采取阿卡波糖联合二甲双胍治疗方案,对照组患者单纯使用二甲双胍治疗方案,对比研究阿卡波糖联合二甲双胍治疗2型糖尿病的治疗效果及不良反应和临床适用性。结果治疗3个月后,复查治疗组患者餐后2 h血糖及空腹血糖水平明显低于对照组,两组结果差异有统计学意义(P0.05),治疗组患者总有效率95%,对照组总有效率80%,治疗组效果明显优于对照组患者,差异有统计学意义(P0.05),且两组患者不良反应症状均不明显,安全性良好。结论阿卡波糖联合二甲双胍治疗2型糖尿病疗效确切,不良反应小,治疗总有效率优于单独用药方案,值得在临床上推广应用。     

阿卡波糖、格列美脲分别联合二甲双胍治疗2型糖尿病对比研究

目的探索阿卡波糖、格列美脲分别联合二甲双胍治疗2型糖尿病,对比其临床疗效。方法以2018年1月—12月期间,于该院接受治疗的2型糖尿病患者,从中选取45例,给予其阿卡波糖联合二甲双胍进行治疗,以此作为该次研究的参照组;另取同期45例患者,给予其格列美脲联合二甲双胍进行治疗。对比两组患者的临床疗效。结果治疗后,试验组患者的血糖指标及波动幅度明显低于参照组(P0.05);试验组患者胰岛素抵抗水平、胰岛β细胞功能指数及血脂水平均优于参照组(P0.05);试验组患者治疗总有效率86.67%,显著高于参照组患者62.22%(P0.05)。结论结合该次研究结果说明,格列美脲联合二甲双胍对于2型糖尿病患者,能够显著降低其血糖水平,改善胰岛功能,较阿卡波糖联合二甲双胍更具疗效。     

比较二甲双胍分别联合达格列净、阿卡波糖治疗2型糖尿病的有效性及安全性

目的 分析探讨二甲双胍分别联合达格列净、阿卡波糖在2型糖尿病中的治疗有效性及安全性。方法选取2018年1月—2020年12月福建省三明市清流县中医院收治的80例2型糖尿病患者为研究对象,随机分为两组,每组40例。对照组患者采用二甲双胍与阿卡波糖治疗,观察组患者采用二甲双胍与达格列净治疗。对两组患者治疗前后的血糖水平、血脂水平及不良反应发生情况与治疗效果进行比较。结果 治疗前,两组血糖水平、血脂水平对比,差异无统计学意义（P>0.05）。治疗后,观察组血糖水平、血脂水平优于对照组,差异有统计学意义（P<0.05）。观察组患者不良反应发生率低于对照组,治疗效果优于对照组,差异有统计学意义（P<0.05）。结论 二甲双胍分别联合达格列净、阿卡波糖在2型糖尿病中都具有一定的治疗效果,其中达格列净的效果很明显,有临床应用价值。     

观察阿卡波糖联合二甲双胍治疗2型糖尿病伴高血脂症的疗效

目的 2型糖尿病伴高脂血症阿卡波糖联合二甲双胍疗效观察。方法选取该院2015年6月—2017年9月收治2型糖尿病伴高脂血症患者138例,67例常规联合二甲双胍治疗(对照组),71例在对照组基础上联合阿卡波糖(观察组),观察治疗效果。结果治疗3个月后,观察组FPG、2 hPG及HbA1c水平均显著低于对照组,差异有统计学意义(P0.05)。且观察组TC、TG、LDL-C水平均较对照组低,HDL-C水平显著高于对照组,组间差异有统计学意义(P0.05)。结论阿卡波糖联合二甲双胍用于2型糖尿病伴高血脂症可有效改善血糖及血脂水平,提高疗效。     

阿卡波糖联合二甲双胍治疗2型糖尿病临床探讨

目的探讨研究阿卡波糖联合二甲双胍治疗2型糖尿病的治疗效果。方法随机选取2013年3月—2014年3月门诊2型糖尿病患者40例作为治疗组,将2013年3月以前40例2型糖尿病治疗病历作为对照组,治疗组采取阿卡波糖联合二甲双胍治疗方案,对照组患者单纯使用二甲双胍治疗方案,对比研究阿卡波糖联合二甲双胍治疗2型糖尿病的治疗效果及不良反应和临床适用性。结果治疗3个月后,复查治疗组患者餐后2 h血糖及空腹血糖水平明显低于对照组,两组结果差异有统计学意义（P〈0.05）,治疗组患者总有效率95%,对照组总有效率80%,治疗组效果明显优于对照组患者,差异有统计学意义（P〈0.05）,且两组患者不良反应症状均不明显,安全性良好。结论阿卡波糖联合二甲双胍治疗2型糖尿病疗效确切,不良反应小,治疗总有效率优于单独用药方案,值得在临床上推广应用。     

二甲双胍联合阿卡波糖治疗2型糖尿病的临床效果分析

目的分析研讨二甲双胍联合阿卡波糖治疗2型糖尿病的疗效。方法采用随机、双盲、对照试验,纳入该院附属医院2016年4月—2017年4月接诊的124例2型糖尿病患者,根据治疗方案的差异性分为观察组和对照组,观察组患者采用二甲双胍联合阿卡波糖治疗,对照组患者仅使用二甲双胍治疗,观察两组患者的血糖控制效果。结果与对照组血糖控制率比较,观察组血糖控制率明显更高,差异无统计学意义(P0.05);治疗后,两组FPG、2 hPG、HbA1c水平比较,差异无统计学意义(P0.05),而治疗后FINS水平比较,观察组下降较对照组明显,差异有统计学意义(P0.05)。结论二甲双胍联合阿卡波糖治疗2型糖尿病的效果确切,血糖控制效果理想,可在临床推广。     

恩格列净联合阿卡波糖治疗2型糖尿病临床疗效探讨

目的探讨恩格列净联合阿卡波糖治疗2型糖尿病的效果。方法选取院内2020年1—8月收治62例2型糖尿病患者分组研究,对照组采用二甲双胍联合阿卡波糖治疗,观察组采用恩格列净联合阿卡波糖治疗,对比两组患者的治疗效果。结果观察组疗效优于对照组,差异有统计学意义(P0.05),观察组各项血糖指标以及不良反应发生率均低于对照组,差异有统计学意义(P0.05)。结论在2型糖尿病治疗中,与二甲双胍联合阿卡波糖相比,恩格列净联合阿卡波糖的治疗效果显著,血糖等指标改善明显,且不良反应较低,具有临床应用价值。。     

阿卡波糖联合二甲双胍治疗2型糖尿病合并高脂血症疗效观察

选取2018年5月-2019年12月2型糖尿病合并高脂血症患者100例,随机平分为对照组给予二甲双胍,观察组阿卡波糖联合二甲双胍。结果治疗后,观察组甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、糖化血红蛋白(GHb)、空腹血糖(FBG)、餐后2h血糖(2hPG)数值与对照组低,观察组治疗总有效率、高密度脂蛋白(HDL-C)数值较对照组高,(P 0.05)。结论阿卡波糖联合二甲双胍治疗2型糖尿病合并高脂血症可有效降低血脂水平、血糖水平。     

人体测量指标与血脂、血糖及血压水平的典型相关

目的：探讨人体测量指标与心血管危险因素水平的相互关系，确定与心血管危险因素相关最密切的人体测量指标。方法：在江苏省金坛县农村抽取３５～５９岁自然人群（男４９２名；女６０６名），测量身高、体重、腰围、腹围、臀围和血胆固醇、高密度脂蛋白胆固醇、血糖、收缩压、舒张压，计算出体重指数（ＢＭＩ）、腰／臀比（ＷＨＲ）、腹／臀比（ＡＨＲ）和锥削度指数（ＣＩ）后，与血脂、血糖及血压水平作典型相关分析。结果：人体测量指标与心血管危险因素指标呈典型相关（典型相关系数为０．３１～０．５０）；人体测量指标中，体重指数的贡献最大，与心血管危险因素的相关最密切；血压是心血管危险因素中与人体测量相关最密切的指标。结论：体重指数是本组人群中最简单但最有价值的人体测量指标；而血压是受肥胖影响最大的心血管危险因素指标。     

Left Ventricular Mass Is Better Correlated With Arising Blood Pressure Than With Office or Occasional Blood Pressure

The peak incidence of cardiovascular complications in the morning points to a possible role of the abrupt increase in blood pressure on arising. However, there is as yet no firm evidence linking the extent of the elevation in blood pressure on arising and the risk of cardiovascular complications. We sought a correlation between blood pressure on arising and left ventricular mass in a population of 181 previously untreated hypertensive patients. Ambulatory blood pressure was measured over a 24-h period, and each patient was requested to trigger a blood pressure determination immediately after standing on arising in the morning. Left ventricular mass was measured with M-mode echocardiography and indexed for height, height^2.7, and body surface area. The systolic blood pressure on arising was significantly (P <.01) better correlated than office blood pressure with left ventricular mass index and wall thickness. On multivariate analysis, the values of systolic blood pressure on arising and mean 24-h systolic blood pressure contributed significantly and independently to the correlation with left ventricular mass and wall thickness. These observations point to the significance of the arising blood pressure. A marked abrupt daily elevation in blood pressure on arising, then maintained for a certain time, could contribute to the development of left ventricular hypertrophy and may constitute a trigger for cardiovascular complications.     

Prediction of Blood Pressure and Blood Pressure Change With a Genetic Risk Score

The authors investigated whether a genetic risk score (GRS) constructed of 32 single nucleotide polymorphisms would predict incident hypertension and blood pressure (BP) change over time in a population cohort during an 11‐year follow‐up (n=5402 at baseline, 3266 at follow‐up). In multivariable models, GRS was associated with higher systolic/diastolic BP values at baseline (β±standard error [SE], 1.04±0.14/1.11±0.13 mm Hg; P<.0001 for both) and at reinvestigation (β±SE, 0.84±0.18/0.79±0.16 mm Hg; P<.0001 for both). Among participants who were normotensive at baseline (n=2045), GRS was not independently associated with systolic/diastolic BP change over time (β±SE, 0.16±0.18/0.20±0.18 mm Hg; P≥.28 for both). In participants in the top tertile of the GRS, as compared with the bottom tertile, the predicted increase in systolic/diastolic BP was 1.18±0.78/0.70±0.49 mm Hg (P=.046/.15) greater and the odds ratio for incident hypertension was 33% higher (P=.03). These data show that GRS is strongly associated with BP but weakly associated with BP increase and incident hypertension in a late middle‐aged population.     

Exaggerated Blood Pressure Response to Exercise Is Not Associated With Masked Hypertension in Patients With High Normal Blood Pressure Levels

The association between exaggerated blood pressure (BP) response to exercise (ExBPR) and “masked hypertension” is unclear. Medical records of patients with high‐normal BP who were evaluated in the Chaim Sheba Screening Institute Ramat Gan, Israel, during the years 2002–2007 and referred for 24‐hour ambulatory BP monitoring (ABPM) and exercise test were reviewed. Data on exercise tests performed in the preceding 5 years were retrieved. Reproducible ExBPR was defined when it was recorded at least twice. BP levels on 24‐hour ABPM were compared between patients with a normal BP response and those with an ExBPR (systolic BP ≥200 mm Hg). Sixty‐nine normotensive patients with high normal BP levels were identified. ExBPR was recorded in 43 patients and was reproducible in 28. BP levels on 24‐hour ABPM were similar in patients with and without ExBPR. In patients with high‐normal BP levels, ExBPR is not associated with masked hypertension.     

Association of Calcium-Phosphorus Product With Blood Pressure in Dialysis

J Clin Hypertens (Greenwich). 2010;12:96–103. ^©2009 Wiley Periodicals, Inc. Hypertension is very common in dialysis patients. Disorders of mineral metabolism have been linked to vascular calcification and hypertension in dialysis. Fifty-four hemodialysis patients were included in a cross-sectional study in a dialysis unit during a 6-month period. Linear regression analysis was done between averages of calcium and phosphorus (ca × ph) product and blood pressures (BPs). Ca × ph was significantly associated with systolic BP predialysis (P=.03, R=0.28), diastolic BP predialysis (P=.001, R=0.44), predialysis mean arterial pressure (MAP) (P=.002, R=0.4), and diastolic BP postdialysis (P=.03, R=0.26). No relationship was found with pulse pressures. Multilinear regression analysis was then done between ca × ph product and BPs adjusting for age, sex, hemoglobin, diabetes, albumin, parathyroid hormone, ultrafiltration volume, and average BP medications per patient. There was a strong positive association with predialysis systolic BP (P=.003, R²=0.49), predialysis MAP (P=.001, R²=0.51), and postdialysis MAP (P=.02, R²=0.65). No associations with pulse pressures were detected. The study findings suggest that ca × ph product is significantly associated with dialysis MAP and not pulse pressure. This is likely secondary to the stronger relationship with diastolic BP than with systolic BP. Prospective studies looking into the associated hemodynamic parameters related to arterial stiffness and endothelial dysfunction along with measures for calcifications would be very beneficial.     

Blood Pressure is Associated With Cerebral Blood Flow Alterations in Patients With T2DM as Revealed by Perfusion Functional MRI

Type 2 diabetes mellitus (T2DM) and hypertension are both associated with cognitive impairment and brain function abnormalities. We investigated whether abnormal cerebral blood flow (CBF) patterns exists in T2DM patients and possible relationships between aberrant CBF and cognitive performance. Furthermore, we examined the influence of hypertension on CBF alterations in T2DM patients.T2DM patients (n = 38) and non-T2DM subjects (n = 40) were recruited from clinics, hospitals, and normal community health screenings. Cerebral blood flow images were collected and analyzed using arterial spin labeling perfusion functional magnetic resonance imaging (fMRI). Regions with major CBF differences between T2DM patients and non-T2DM controls were detected via 1-way ANOVA. The interaction effects between hypertension and T2DM for CBF alterations were also examined. Correlation analyses illustrated the association between CBF values and cognitive performance and between CBF and blood pressure.Compared with non-T2DM controls, T2DM patients exhibited decreased CBF, primarily in the visual area and the default mode network (DMN); decreased CBF in these regions was correlated with cognitive performance. There was a significant interaction effect between hypertension and diabetes for CBF in the precuneus and the middle occipital gyrus. Additionally, blood pressure correlated negatively with CBF in T2DM patients.T2DM patients exhibited reduced CBF in the visual area and DMN. Hypertension may facilitate a CBF decrease in the setting of diabetes. T2DM patients may benefit from blood pressure control to maintain their brain perfusion through CBF preservation.