Inverted papilloma of the prostatic urethra

The inverted papilloma is a rare urothelial tumor, and its localization at the prosthatic urethra is also exceptional. We present a case of inverted papilloma of the prostatic urethra in a 72 years-old male, with symptoms of urinary flow obstruction. The diagnose is obtained after urethrocistoscopy and transurethral resection at the same time. We discuss about the etiology, clinical presentation, diagnose and treatment of this rare tumor, making special attention to its malignancy ability.     

Inverted papilloma of the bladder with recurrence in prostatic urethra

Urothelial inverted papilloma is usually a solitary lesion with rare recurrences. Its behaviour is unclear, its potential for recurrence or progression is not well-known. We present a case of inverted papilloma of the bladder with recurrence in prostatic urethra after four years of follow-up. We review etiology, clinical presentation, diagnose, treatment and the present discussion about its malignancy ability.     

Inverted papilloma of the urinary bladder: report of two cases

Two cases of inverted papilloma of the urinary bladder are reported. The patients were a 39-year-old male with macrohematuria and a 36-year-old female with interrupted urination. In both of the patients, tumors were resected transurethrally, and histologic examination revealed them to be typical inverted papilloma.     

尿路内翻性乳头状瘤151例临床分析

目的探讨尿路内翻性乳头状瘤的临床表现、病理类型及临床诊治方法。方法回顾性分析1992年3月至2003年9月,我院收治尿路内翻性乳头状瘤151例,其中男134例、女17例,平均年龄54岁。临床表现主要为无痛性肉眼血尿。诊断依据泌尿系B超、尿路造影、膀胱镜检及病理检查。上尿路7例,除1例行肿瘤局部切除外余行患侧肾、输尿管全长切除术。下尿路144例,行经尿道膀胱肿瘤切除(TURBT)124例,其中11例合并良性前列腺增生者同时行经尿道前列腺切除术,前列腺部尿道肿瘤电切3例,膀胱部分切除术15例,膀胱全切术2例。结果118例随访1～12．5年,平均6．3年。5例膀胱内复发,其中2例分别于术后8,30个月发生恶变,行膀胱全切治疗。结论尿路内翻性乳头状瘤是良性肿瘤,多见于男性,好发于膀胱,TURBT是膀胱内翻性乳头状瘤的首选治疗方法。预后良好,但需定期随访。     

Inverted papillomas of the prostatic urethra

Inverted papillomas of the genitourinary tract are uncommon benign neoplasms usually occurring in the urinary bladder and less frequently in the upper urinary tract. To date, there are scant data and no comprehensive studies of inverted papilloma originating in the prostatic urethra. We identified 21 cases and evaluated their demographic, clinical, and histopathologic features. Patients had a mean age of 65.1 years (range: 30 to 89 y), with 10/21 (47.6%) presenting with gross hematuria (n = 8) or irritative symptoms (n = 2) related to the inverted papilloma and 11/21 (52.4%) detected incidentally during work-up/treatment of prostate cancer (n = 6) or benign prostatic hypertrophy (BPH) (n = 5). Fourteen cystoscopically evaluated lesions measured 0.1 to 2.0 cm, and were described as polypoid (n = 9), papillary (n = 4), or an enlarged median lobe (n = 1). Lesions were diagnosed on transurethral resection (n = 8), biopsy/polypectomy targeted to the lesion (n = 6), radical prostatectomy for prostate cancer (n = 4), or biopsy unrelated to the lesion (n = 3). Histologically, 14/21 cases (67%) displayed classic inverted papilloma architecture. The remaining cases showed foci of squamous metaplasia with moderate atypia (n = 4), rare true papillary fronds in a classic inverted papilloma background (n = 2), or both (n = 1). Eleven cases with prostatic tissue revealed adenocarcinoma of the prostate [n = 6; Gleason score 6 (n = 3) or 7 (n = 3)], high-grade prostatic intraepithelial neoplasia (n = 1), benign prostatic hypertrophy (n = 3), or adenosis (n = 1). No patients had a prior history of either inverted papilloma or urothelial carcinoma, whereas 2 patients were diagnosed with high-grade urothelial carcinoma of the bladder synchronous with their inverted papilloma diagnosis. Only 1 of the 18 patients with available follow-up had a recurrence of inverted papilloma in the prostatic urethra. None of the other patients had local recurrences or recurrences at other locations in the urinary tract (mean follow-up 39.9 mo; range: 3 to 120 mo). Inverted papillomas of the prostatic urethra are benign lesions that are commonly detected incidentally and are not associated with a history of urothelial malignancy. Although urothelial carcinoma elsewhere in the genitourinary tract may occur simultaneously, malignant transformation or recurrence as a malignant lesion has not been identified in inverted papilloma of the prostatic urethra.     

Inverted papilloma of the ureter: two cases of conservative therapy

We report 2 cases of inverted urothelial papilloma of the ureter. The second case demonstrates inverted papilloma and papillary transitional cell carcinoma in a single polypoid lesion. Conservative therapy was performed and a follow-up 12 months later shows no evidence of recurrences.     

膀胱内翻性乳头状瘤37例临床分析

目的 探讨膀胱内翻性乳头状瘤(IPB)的临床表现、临床诊治方案,提高对IPB的诊疗水平.方法 回顾总结本院2011年1月～ 2013年12月收治的具有完整临床及随访结果的37例IPB的资料.结果 37例术后病理均明确为内翻性乳头状瘤,其中2例并发低级别尿路上皮癌,3例伴有炎症改变.术后随访时间为10 ～34个月(平均28个月),随访期内其中36例未见复发,1例于术后第15个月复发,再行TUR-BT术,病理提示低级别尿路上皮癌.结论 IPB是一种少见的良性肿瘤,外科手术(TUR-BT)是主要治疗方法.因IPB有复发性、且与尿路上皮癌(TCC)伴生或进展为TCC,故术后定期膀胱灌注、膀胱镜检查是极其重要的.     

膀胱内翻性乳头状瘤36例报告

目的 提高对膀胱内翻性乳头状瘤(inverted papilloma of the bladder,IPB)的诊治水平.方法 回顾分析我科1995年1月至2010年5月收治的具有完整临床和随访结果的36例IPB患者的资料.结果 36例患者均接受手术治疗,其中1例患者同时合并有膀胱尿路上皮细胞癌,1例在内翻性乳头状瘤中合并有尿路上皮细胞癌成分,术后27例行定期膀胱内灌注化疗,9例仅作定期随访,其中1例同时合并有膀胱尿路上皮细胞癌者术后3年复发.结论 IPB是一种预后良好的良性肿瘤,诊断有赖于病理检查,TURBT是治疗该病的标准方法,术后应行膀胱内灌注化疗及定期随访.     

Papillary adenoma of the prostatic urethra: Report of two cases

Papillary adenoma of the prostatic urethra is a rare cause of hematuria, hemospermia and lower urinary tract obstruction, especially in young adults. We report two cases of papillary adenoma and their endoscopic views. One of the patients had a lesion located on the verumontanum and presented with hematuria, hemospermia and symptoms of lower urinary tract obstruction. The other patient had papillary lesions located in the paramontanal gutter and presented with persistent painless hematuria. The origin of both lesions was proven to be prostatic epithelial differentiation using immunohistochemical identification of prostate-specific antigen. Papillary adenoma is believed to be benign, therefore, both lesions were carefully excised and fulgurated transurethrally.     

Congenital polyp of the prostatic urethra: report on 2 cases

Congenital polyps of the prostatic urethra are an uncommon cause of obstructive uropathy, infection and/or hematuria in male children. A filling defect localized in the posterior urethra on the voiding cystourethrogram represents the peculiar diagnostic finding. Transurethral resection is the treatment of choice, according to the size of the polyp. Two cases of congenital posterior urethral polyps are reported and the main clinical and radiological features are discussed. This lesion has to be considered in the differential diagnosis of the voiding dysfunction in young boys.     

尿路内翻性乳头状瘤的诊治(附113例报告)

目的 探讨尿路内翻性乳头状瘤的生物学行为，临床特点及诊治方式。方法 尿路内翻性乳头状瘤患者113例。男102例，女11例。平均年龄55岁。发生于下尿路108例，其中行TuRBT87例，TuRBT加TuRP6例，膀胱部分切除术10例，膀胱部分切除术加前列腺摘除术4例，膀胱全切术1例。发生于上尿路5例，均行患侧肾、输尿管全长切除。结果 86例随访0．5～10年。5例膀胱内复发，其中2例恶变，1例行膀胱全切。结论 尿路内翻性乳头状瘤为良性肿瘤，多见于男性，好发于膀胱。膀胱镜检是主要的诊断方法，大部分可行TuRBT治愈。预后良好。     

A case of inverted papilloma of the prostatic urethra

A 59-year-old male with a complaint of gross hematuria was found to have a pedunculated and non-papillary tumor on the prostatic urethra. The tumor was resected transurethrally. The pathological finding was inverted papilloma. Although the majority of the cases of inverted papilloma have been found in the bladder, we reported the 32nd case located on the prostatic urethra in Japan.     

Inverted papilloma of the renal pelvis: report of a case

Inverted papilloma of the upper urinary tract is a rare lesion. To our knowledge, we report here the 32nd case of inverted papilloma of the renal pelvis. A 50-year-old man presented with asymptomatic gross hematria. Excretory urography showed a filling defect in the left upper calyx. Computerized tomography showed a poorly enhanced low-density area within the renal pelvis. Since radiographic findings suggested a renal pelvic tumor, the patient underwent total nephroureterectomy. Unexpectedly, a 3 x 2.5 cm polypoid tumor of the renal pelvis was consistent with inverted papilloma. Since this benign lesion is extremely rare within the upper tract and its radiographic characteristics closely resemble those of urothelial carcinoma, the preoperative diagnosis of inverted papilloma of the upper tract cannot be conclusively established even by modern imaging techniques. Therefore treatment consistent with that for urothelial carcinoma should be applied in this disease entity.