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Cumulative effect or independent effect? 总被引:2,自引:0,他引:2
D W Bailey 《Transplantation》1971,11(4):419-422
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Layton F. Rikkers M.D. 《Journal of gastrointestinal surgery》2002,6(6):787-794
Conclusion Although surgery has a glorious past that includes numerous seminal contributions to the medical sciences, at times progress
has been and continues to be impeded by the bandwagon effect. Although many factors contribute to this phenomenon, the major
obstacle that is sometimes in the pathway to truth is ourselves. The rigor of our clinical investigation has been less than
it should be and our educational templates have overemphasized memorization of facts and creating clones of ourselves rather
than fostering independent critical thinking by our students.
Just as good basic science research is preceded by years of training in the laboratory, good clinical research will depend
on well-prepared, educated, and meticulous clinical scientists. Recent initiatives, such as the “Clinical Trials” course sponsored
by the American College of Surgeons and the Clinical Investigators Preparatory Program (CIPP) funded by the National Institutes
of Health, are promising aids for the development of effective clinical scientists.
Finally, we need to continually remind ourselves of the observation that “knowledge is always tentative and can only be made
incrementally more certain with increasing data or evidence.” direct our energies toward forming the basis of a more complete
knowledge. It is our challenge to make certain that the evidence generated in our clinical laboratories and published in our
journals is reliable and that we and surgeons of the future can temper it with critical judgment as it is applied in the optimal
care of our patients.
Presented at the Forty-Third Annual Meeting of The Society for Surgery of the Alimentary Tract, San Francisco, California,
May 19–22, 2002. 相似文献
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Arbabi S Wahl WL Hemmila MR Kohoyda-Inglis C Taheri PA Wang SC 《The Journal of trauma》2003,54(6):1090-1093
BACKGROUND: The pattern and severity of crash injury depends on a complex interaction of biomechanical factors such as deceleration velocity at impact (delta-V), seat-belt and airbag use, and type of impact. Human body characteristics such as height and weight may play an important role. We hypothesized that body mass index (BMI) will influence crash injury patterns. METHODS: The University of Michigan Program for Injury Research and Education database was queried. Three cohorts were analyzed, lean (BMI = 25 kg/m2), overweight (BMI 25-30 kg/m2), and obese (BMI > 30 kg/m2)RESULTS: There were 189 detailed crash cases, with 22 fatalities. There was an increased risk of fatal outcome associated with the obese cohort (adjusted odds ratio, 4.2 compared with lean; p = 0.04). Age, delta-V, seat-belt use, and type of impact were independent predictors of Injury Severity Score (ISS). After adjusting for other modifiers, being overweight was associated with decreased ISS (p = 0.03) and abdominal maximal Abbreviated Injury Scale (mAIS) score (p = 0.008) when compared with the lean cohort. However, the lower extremity mAIS score increased when overweight (p = 0.03) and obese cohorts (p = 0.001) were compared with the lean cohort. CONCLUSION: Although no difference in ISS was identified between the lean and obese cohorts, there was an increase in mortality with the obese cohort. The severity of lower extremity injuries increased with increasing BMI. The overweight cohort was associated with lower ISS and abdominal mAIS score compared with the lean cohort. This protection may be attributable to an increase in insulating tissue, or a "cushion effect," without a significant increase in mass and momentum. 相似文献
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M I Lytkin A T Grebennikova A L Kostiuchenko S B Singaevski? 《Vestnik khirurgii imeni I. I. Grekova》1987,139(12):21-24
The method of integral rheography was used for the examination of 126 patients with different forms of pericarditis. The authors have established different nature of the blood circulation insufficiency (heart compression and myocardiodystrophy), which should be taken into consideration in choosing the methods of treatment. 相似文献
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