共查询到20条相似文献,搜索用时 15 毫秒
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Statin Use and 25‐Hydroxyvitamin D Blood Level Response to Vitamin D Treatment of Older Adults 下载免费PDF全文
Heike A. Bischoff‐Ferrari MD DrPH Karina Fischer PhD Endel J. Orav PhD Bess Dawson‐Hughes MD Ursina Meyer PhD Patricia O. Chocano‐Bedoya MD PhD Otto W. Meyer MD Rahel Ernst MD Simeon Schietzel MD Franz Eberli MD Hannes B. Staehelin MD Gregor Freystätter MD Susanne Roas MD Robert Theiler MD Andreas Egli MD Nicholas M. Wilson PhD 《Journal of the American Geriatrics Society》2017,65(6):1267-1273
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Mario García‐Carrasco Claudia Mendoza‐Pinto Miriam Cabrera‐Jimnez Pamela Munguía‐Realpozo Socorro Mndez‐Martínez Ivet Etchegaray‐Morales Roberto Berra‐Romani Irma Zamora‐Ginez Aurelio Lpez‐Colombo Marianne G. Monroy‐Azuara Alejandro Ruiz‐Arguelles 《International journal of rheumatic diseases》2019,22(11):2067-2072
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Valerie K. Wilson MD Denise K. Houston PhD Laurel Kilpatrick MD James Lovato MS Kristine Yaffe MD Jane A. Cauley DrPH Tamara B. Harris MD MS Eleanor M. Simonsick PhD Hilsa N. Ayonayon PhD Stephen B. Kritchevsky PhD Kaycee M. Sink MD MAS the Health Aging Body Composition Study 《Journal of the American Geriatrics Society》2014,62(4):636-641
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María L. Brance Julio N. Miljevic Raquel Tizziani María E. Taberna Georgina P. Grossi Pablo Toni Elina Valentini Andrea Trepat Julia Zaccardi Juan Moro Baltasar Finuci Curi Norberto Tamagnone Mariano Ramirez Javier Severini Pablo Chiarotti Francisco Consiglio Raúl Piñeski Albertina Ghelfi Jorge Kilstein Eduardo Street Dino Moretti Viviana Oliveto Marcelo Mariño Jorge Manera Lucas R. Brun 《The clinical respiratory journal》2018,12(7):2220-2227
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25‐Hydroxyvitamin D and Cardiovascular Disease in Patients With Systemic Lupus Erythematosus: Data From a Large International Inception Cohort 下载免费PDF全文
Apinya Lertratanakul Peggy Wu Alan Dyer Murray Urowitz Dafna Gladman Sang‐Cheol Bae Caroline Gordon Ann Clarke Sasha Bernatsky John G. Hanly David Isenberg Anisur Rahman Joan Merrill Daniel J. Wallace Ellen Ginzler Munther Khamashta Gunnar Sturfelt Kristjan Steinsson Susan Manzi Mary Anne Dooley Kenneth Kalunian Michelle Petri Cynthia Aranow Thomas Stoll Rosalind Ramsey‐Goldman 《Arthritis care & research》2014,66(8):1167-1176
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P. Karhapää J. Pihlajamäki I. Pörsti M. Kastarinen J. Mustonen O. Niemelä J. Kuusisto 《Journal of internal medicine》2010,268(6):604-610
Abstract. Karhapää P, Pihlajamäki J, Pörsti I, Kastarinen M, Mustonen J, Niemelä O, Kuusisto J (University of Eastern Finland, Kuopio; University of Tampere, Tampere; and Laboratory and Medical Research Unit, University of Tampere, Tampere; Finland). Diverse associations of 25‐hydroxyvitamin D and 1,25‐dihydroxyvitamin D with dyslipidaemias. J Intern Med 2010; 268 : 604–610. Background and Aim. Previous studies have suggested a link between circulating levels of 25‐hydroxyvitamin D (25‐D) and dyslipidaemias. However, it is not known whether 25‐D and the active hormone 1,25‐dihydroxyvitamin D (1,25‐D) have similar associations with dyslipidaemias. Therefore, we studied the associations between both 25‐D and 1,25‐D and total cholesterol (total‐C), low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C) and triglycerides in a population‐based study. Design. Cross‐sectional population‐based study. Setting. Kuopio, Eastern Finland. Subjects. A total of 909 men, aged from 45 to 70 years, who were not receiving antidiabetic medication were enrolled. Main Outcome Measures. Fasting serum samples were obtained for measurement of 25‐D, 1,25‐D and lipid levels. An oral glucose tolerance test was performed, and insulin sensitivity was evaluated using the Matsuda insulin sensitivity index (Matsuda ISI). Results. We found a significant inverse association between 25‐D and total‐C, LDL‐C and triglycerides (β = ?0.15, ?0.13 and ?0.17, respectively, P < 0.001), but no association between 25‐D and HDL‐C was observed. By contrast, 1,25‐D was associated with HDL‐C (β = 0.18, P < 0.001), whereas no relationship was found between 1,25‐D and LDL‐C or triglycerides. The associations remained significant after the exclusion of subjects receiving statin treatment and after adjustment for age, waist circumference, body mass index, alcohol consumption, smoking, renal function, glucose tolerance and Matsuda ISI. Conclusion. Low levels of active vitamin D (1,25‐D) are associated with low HDL‐C levels, whereas low levels of the storage form 25‐D are associated with high levels of total‐C, LDL‐C and triglycerides. Our findings may provide new insights into the understanding of the link between vitamin D deficiency and cardiovascular disease. 相似文献
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Derun Taner Ertugrul Bunyamin Yavuz Hicran Cil Naim Ata Kadir Okhan Akin Metin Kucukazman Ahmet Arif Yalcin Kursad Dal Burcu Balam Yavuz Emre Tutal 《Cardiovascular therapeutics》2011,29(2):146-152
Several studies have shown that low 25‐hydroxyvitamin D levels are associated with higher risk of cardiovascular disease and an increase in 25‐hydroxyvitamin D levels protects against cardiovascular disease. In this study, we aimed to compare the effects of rosuvastatin and fluvastatin on vitamin D metabolism. The study population consisted of 134 hyperlipidemic patients who had not previously been treated with lipid lowering medications. Patients were randomized in a 1:1 ratio to rosuvastatin 10 mg or fluvastatin 80 mg XL during the study. Lipid parameters, 25 hydroxyvitamin‐D, and bone alkaline phosphatase (BALP) were obtained at baseline and after 8 weeks of rosuvastatin and fluvastatin treatment. Sixty‐nine patients were administered rosuvastatin, and 65 patients fluvastatin. Total Cholesterol and LDL cholesterol decreased after 8 weeks of both rosuvastatin and fluvastatin treatments. Rosuvastatin was significantly more effective than fluvastatin on lowering total (P < 0.001) and LDL cholesterol (P < 0.001). There was a significant increase in 25‐hydroxyvitamin D with rosuvastatin treatment (P < 0.001), whereas no significant change in 25‐hydroxyvitamin D was observed with fluvastatin treatment. Mean BALP fell from 18.5 to 9.6 u/I (P < 0.001) with rosuvastatin and from 17.0 to 12.8 with fluvastatin (P= 0.004). There was no significant difference in BALP levels between rosuvastatin and fluvastatin treatment (P= 0.368). The present study demonstrated that 25‐hydroxyvitamin D levels increased with rosuvastatin treatment; whereas fluvastatin treatment had no effect on 25‐hydroxyvitamin D. This disparity could be related to the potency or the bioavailability of these two statins. Further studies are needed to clarify the relationship between statins and the vitamin D physiology. 相似文献
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Andrea Giusti MD Antonella Barone MD Giulio Pioli MD PhD Giuseppe Girasole MD PhD Monica Razzano MD Monica Pizzonia MD Mario Pedrazzoni MD PhD Ernesto Palummeri MD PhD Gerolamo Bianchi MD 《Journal of the American Geriatrics Society》2010,58(8):1489-1495
OBJECTIVES: To compare the effects on parathyroid hormone (PTH) and 25‐hydroxy‐vitamin D (25(OH)D) of two dosing regimens of cholecalciferol in women with secondary hyperparathyroidism (sHPTH) and hypovitaminosis D and to investigate variables affecting 25(OH)D response to cholecalciferol. DESIGN: Randomized‐controlled trial with 6‐month follow‐up. SETTING: Two osteoporosis centers in northern Italy. PARTICIPANTS: Sixty community‐dwelling women aged 65 and older with sHPTH and hypovitaminosis D, creatinine clearance greater than 65 mL/min and without diseases or drugs known to influence bone and vitamin D metabolism. INTERVENTION: Cholecalciferol 300,000 IU every 3 months, once at baseline and once at 3 months (intermittent D3 group) or cholecalciferol 1,000 IU/day (daily D3 group). MEASUREMENTS: Serum PTH, 25(OH)D, calcium, bone‐specific alkaline phosphatase, β‐C‐terminal telopeptide of type I collagen, phosphate, 24‐hour urinary calcium excretion. RESULTS: The two groups had similar baseline characteristics. All participants had vitamin D deficiency [25(OH)D<20 ng/mL)], and 36 subjects (60%) had severe deficiency (<10 ng/mL), with no difference between the groups (severe deficiency: intermittent D3 group, n=18; daily D3 group, n=18). After 3 and 6 months, both groups had a significant increase in 25(OH)D and a reduction in PTH. Mean absolute increase±standard deviation of 25(OH)D at 6 months was higher in the intermittent D3 group (22.7±11.8 ng/mL) than in the daily D3 group (13.7±6.7 ng/mL, P<.001), with a higher proportion of participants in the intermittent D3 group reaching desirable serum concentration of 25(OH)D ≥ 30 ng/mL (55% in the intermittent D3 group vs 20% in the daily D3 group, P<.001). Mean percentage decrease of PTH in the two groups was comparable, and at 6 months, a similar proportion of participants reached normal PTH values. 25(OH)D response to cholecalciferol showed a wide variability. In a logistic regression analysis, body mass index and type of treatment appeared to be significantly associated with normalization of 25(OH)D values. CONCLUSION: Cholecalciferol 300,000 IU every 3 months was more effective than 1,000 IU daily in correcting vitamin D deficiency, although the two groups achieved similar effects on PTH at 6 months. Only 55% of the higher‐dose intermittent group reached desirable concentrations of 25(OH)D, suggesting that yet‐higher doses will be required for adequate vitamin D repletion. 相似文献
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Association Between Serum β2‐Microglobulin Levels and Prevalent and Incident Physical Frailty in Community‐Dwelling Older Women 下载免费PDF全文
Miji Kim PhD Takao Suzuki MD PhD Narumi Kojima MSc Hideyo Yoshida MD PhD Yuko Yoshida PhD Hirohiko Hirano DDS PhD Chang Won Won MD PhD Hunkyung Kim PhD 《Journal of the American Geriatrics Society》2017,65(4):e83-e88
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Association between serum 25‐hydroxyvitamin D and serum sex steroid hormones among men in NHANES 下载免费PDF全文
Gabriella M. Anic Demetrius Albanes Sabine Rohrmann Norma Kanarek William G. Nelson Gary Bradwin Nader Rifai Katherine A. McGlynn Elizabeth A. Platz Alison M. Mondul 《Clinical endocrinology》2016,85(2):258-266
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Slinin Y Paudel M Taylor BC Ishani A Rossom R Yaffe K Blackwell T Lui LY Hochberg M Ensrud KE;for the Study of Osteoporotic Fractures Research Group 《The journals of gerontology. Series A, Biological sciences and medical sciences》2012,67(10):1092-1098
Background: Results of prospective studies examining the association between 25 hydroxyvitamin D (25[OH]D) levels and cognitive decline have been inconsistent. We tested the hypothesis that lower 25(OH)D levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline. Methods: The study is a cross-sectional and longitudinal analysis of a prospective cohort of 6,257 community-dwelling elderly women followed for 4 years. Global cognitive function was measured by the Modified Mini-Mental State Examination and executive function was measured by Trail Making Test Part B (Trails B). Cognitive impairment at baseline was defined as a score >1.5 SD below the sample mean; cognitive decline was defined as decline from baseline to follow-up >1 SD from mean change in score. Results: Women with very low vitamin D levels had an increased odds of global cognitive impairment at baseline: odds ratio (95% confidence interval), 1.60 (1.05-2.42) for women with 25(OH)D <10 ng/mL (25 nmol/L) compared with those with 25(OH)D levels ≥30 ng/mL (75 nmol/L). Compared with women with baseline 25(OH)D level ≥30 ng/mL (75 nmol/L), women with lower levels had an increased risk of global cognitive decline: odds ratio (95% confidence interval), 1.58(1.12-2.22) for women with levels <10 ng/mL (25 nmol/L), and 1.31 (1.04-1.64) for those with levels 10-19.9 ng/mL (25-49 nmol/L). Levels of 25(OH)D were not associated with executive cognitive function. Conclusions: Low 25(OH)D levels among older women were associated with a higher odds of global cognitive impairment and a higher risk of global cognitive decline. 相似文献