Pathomorphology of experimental pseudotuberculous (Yersinia) arthritis

Experimental pseudotuberculosis arthritis was reproduced by means of antigenic irritation of the knee joint in the presence of specific sensibilization. Pathomorphology is characteristic of the acute exudative-proliferative synovitis and periarthritis. The results obtained allow one to draw the conclusion on the infectious-allergic genesis of the joint involvement in pseudotuberculosis. The stages in the allergic responses of the synovial membrane with subsequent development of early and late immune inflammation are revealed.     

Pathomorphology of chronization and outcomes of experimental mycoplasma-viral pneumonia]

Pathomorphology of pneumonia induced by successive contamination of the Syrian hamsters with a pathogenic strain of Mycoplasma pneumoniae and an influenza virus A/PR8/34 as well as after contamination with an influenza virus against the background of a previous administration of the mycoplasma membrane fractions was studied. Mixed Mycoplasma-viral infection results in a tumor-like bronchiolar epithelium proliferation having a morphological similarity with bronchiolo-alveolar or acinar carcinoma, influenza virus infection against the background of a previous administration of protein fractions of mycoplasma membranes resulted in a chronization of pneumonia with development of several types of morphological changes: reversible tumour-like proliferation of the bronchiolo-alveolar epithelium, "inflammatory" pseudotumours and sarcoid-like granulomas.     

Pathomorphology of experimental pneumocystosis and cytogenesis of the pathogen Pneumocystis carinii

A lung pneumocystosis model has been developed in white non-inbred rats (83 animals). The pathological process develops during 1 month versus 2-3 months in other models. Pathomorphology is in principle similar to human pneumocystosis. Bauer's method appeared to be the simplest and adequate for the detection of mature pneumocysts in the lung sections among many other methods used.     

Pathomorphology of mucopolysaccharidoses

Mucopolysaccharidoses are autosomal recessive or X-linked hereditary lysosomal storage diseases occurring to one in 10,000 to 16,000 births. The definitive diagnosis is based on the biochemical verification of the enzyme defect in cultured fibroblasts of amniotic fluid cells, in amniotic fluid, in chorionic biopsies and by determination of the urinary excretion of glycosaminoglycans. Morphological studies are of utmost importance both for genetic counselling and enlightenment of the pathogenesis. In recent years, numerous reports appeared dealing with morphological changes in different types of mucopolysaccharidoses. Based on own studies in pre- and postnatal cases, the present paper gives an update review on light and electron microscopic peculiarities of the different types and subtypes of mucopolysaccharidoses according to the classification of MCKUSICK and NEUFELD (1983). Lysosomal storage is found in practically all organs. However, there are quantitative and qualitative differences which are responsible for variations in clinical symptomatology. The purpose of this paper is to describe these differences with particular emphasis on changes in various tissues, on the pathogenetic mechanism of the storage as well as on pre- and postnatal morphological diagnostics.     

Pathomorphology of leprosy

Leprosy is a widely distributed infectious disease in countries with tropic or subtropic climate and the most frequent treatable polyneuropathy. Because the import into countries with temperature climate should be considered a review is given on different stages and forms of course. Special attention is paid to structural changes and to the significance of morphological studies in establishing the diagnosis.     

Pathomorphology of eclampsia

Pathomorphology of eclampsia is reviewed on the basis of literature data and it is noted that the problem has been studied insufficiently. Morphological features of eclampsia are subdivided into two groups; changes in the microcirculatory bed, that are generalized and undergo the following stages: spasm----wall swelling or necrosis----microthrombosis; and postischemic organ changes, such as dystrophy, necroses and hemorrhages. The role of disseminated intravascular coagulation syndrome is discussed in the development of some clinico-morphological features of eclampsia.     

Pathomorphology of congenital ventriculomegaly

The paper gives the results of a morphological investigation using ventricular system embedding, organometry, light and electron microscopies, histostereometry and immunohistohemistry of brains from 50 fetuses and neonatal infants of 22-27 weeks gestation. The comprehensive investigations revealed the morphological features of intrauterinally acquired ventriculomegaly, which reflect tissue immaturity of the parenchyma and the vascular component of the brain.     

Pathomorphology of lung changes caused by gramoxone poisoning. Human pathologic and animal experimental studies

An account is given in this paper of changes caused by Gramoxone, a week killer, to the human lung as well as to experimental material. The process of damage was found to depend on the amount of toxic substance involved and on the route of uptake. Fibrosis, eventually, is the greatest danger. Intraperitoneal application leads to squamous epithelium metaplasia in the lung.