Primary signet-ring cell carcinoma of urinary bladder

A case of primary signet-ring cell carcinoma of the urinary bladder is described clinically and pathologically. In this rare neoplasm the characteristic cells contain large amounts of cytoplasmic mucin which compresses the nucleus to one side. This tumor demonstrates nicely the ability of bladder epithelium to undergo metaplasia. Most previously described cases have pursued a relentlessly progressive and fatal course despite varied forms of therapy.     

Primary signet-ring cell carcinoma of the urinary bladder inducing renal failure

A case of primary signet-ring cell carcinoma of the urinary bladder that was found to have induced renal failure is the second such case reported in the world. Primary signet-ring cell carcinoma of the urinary bladder is a rare histologic variant of adenocarcinoma. The patient died of distant metastasis 8 months after undergoing total cystectomy. The neoplasm had a high stage at diagnosis, so the prognosis was very poor. To improve the prognosis, earlier diagnosis and establishing a regimen of chemotherapy is necessary.     

Primary signet-ring cell carcinoma of the urinary bladder (linitis plastica)

In this paper we describe the 16th case in the English medical literature of signet-ring cell carcinoma of the bladder, which occurred in a 65-year-old man who developed widespread abdominal metastases. This case illustrates the characteristic diffuse infiltrative pattern of this neoplasm. In addition to light microscopy, ultrastructural studies were performed.     

Primary signet-ring cell carcinoma of the urinary bladder: a case report

We report a case of signet-ring cell carcinoma of the urinary bladder. A 48-year-old female was hospitalized because of general fatigue, pollakiuria and residual sensation. Renal ultrasonography disclosed bilateral hydronephrosis. The serum level of cretinine was 3.1 mg/dl, and we diagnosed the patient with post-renal failure. Cystoscopic examinations revealed non-papillary sessile tumors in the trigone. Histopathological findings of the biopsy specimen demonstrated signet-ring cell carcinoma. There was no evidence indicating bladder metastasis from the cancer in other organs. The patient died of cachexia 5 months after the diagnosis. She was autopsied, and the diagnosis of signet-ring cell carcinoma of the urinary bladder with metastases in various organs was confirmed. This disease is extremely rare and has a poor prognosis. We review the previous cases reported in the literature.     

A case of signet-ring cell carcinoma of the urinary bladder

Signet-ring cell carcinoma of the urinary bladder is a rare disease. A 78-year-old man was admitted to our hospital on March 18, 1988 with the complaints of microhematuria and pollakisuria. Cystoscopic examination revealed non-papillary tumor at the dome of the bladder. partial cystectomy was done under epidural anesthesia. Pathological findings revealed signet-ring cell carcinoma. The gastrointestinal, respiratory and genitourinary tracts were examined but no other tumor lesions could be found. The postoperative course was uneventful, and chemotherapy such as biological response modifier was administered. However, the patient died of heart failure on July 14, 1988. This is the sixtieth case reported in the literature.     

Transitional cell carcinoma of the urinary bladder accompanied by signet-ring cell carcinoma: a case report

A 58-year-old man visited our clinic with complaints of gross hematuria and pollakisuria. Cystoscopic examination revealed multiple non-papillary broad based tumors and reddish unstable mucosa in the bladder. The pathological specimen of the transurethral biopsy of the tumors showed signet-ring cell carcinoma predominantly and adenocarcinoma transforming into signet-ring cell carcinoma partially. A total cystectomy with ileal conduit urinary diversion was performed. The histopathological finding of the radical cystectomy specimen was grade 3 transitional cell carcinoma accompanied by adenocarcinoma. These findings suggest that the adenomatous metaplasia of transitional cell carcinoma in the bladder could differentiate into signet-ring cell carcinoma.     

Primary signet-ring cell carcinoma of the colorectum

Background Objective of the study was to investigate particular clinicopathological features of colorectal signet-ring cell carcinoma.Methods The data of 34 patients with primary colorectal signet-ring cell carcinoma were compared with those of 4,458 consecutive patients with primary non-signet-ring cell colorectal adenocarcinoma between 1978 and 1999. For outcome analysis patients, after curative resection of signet-ring cell cancer, were matched for age, gender, tumour site and stage with patients suffering from poorly differentiated non-signet-ring cell colorectal adenocarcinoma.Results Signet-ring cell carcinoma patients were significantly younger than patients with non-signet-ring cell colorectal adenocarcinoma (median age 60 years vs 64 years, P=0.033). The most common tumour sites were the rectum (47%) and the right hemicolon (29%). They presented with significantly more advanced tumour stages and a significantly higher frequency of distant metastases (44% vs 21%, P=0.002). The rate of curative resections was significantly lower (35% vs 79%, P<0.001). However, the prognosis after curative resection of signet-ring cell cancer was as poor as in poorly differentiated non-signet-ring cell colorectal adenocarcinoma of the same stage (5-year survival rate 46% vs 57%, p=0.935).Conclusions Colorectal signet-ring cell carcinoma is characterized by diagnosis in more advanced tumour stages resulting in lower rates of curative resection. Prognosis is as poor as in non-signet-ring cell colorectal cancer of low differentiation in the same stage.     

Primary colorectal signet-ring cell carcinoma in Singapore

Background: Primary colorectal signet‐ring cell carcinoma is a rare but distinctive tumour of the colon and rectum. The clinicopathological features are still controversial. The aim of this study is to review the clinicopathological features and management of this type of tumour in our hospital. Methods: The clinicopathological features and survival data of all cases of primary colorectal signet‐ring cell carcinoma were reviewed retrospectively. Results: There were nine cases of primary colorectal signet‐ring cell carcinoma in 3000 consecutive colorectal carcinoma patients seen from 1989 to 1999. There were seven male and two female patients with a mean age of 54.7 years. Three patients were younger than 40 years. The common presenting symptoms were rectal bleeding (33%) and small bowel obstruction (33%). Two (22%) patients required emergency surgery due to acute small bowel obstruction. The most common tumour location was the right colon (44%) followed by the rectum (33%). All nine patients presented at a very late stage of disease. A majority (77%) had Dukes’ C disease while two (22%) had Dukes’ D disease with distant dissemination. Peritoneal spread (33%) was the most frequent way of dissemination. There was no patient with liver metastases at the time of diagnosis and initial presentation. The mean survival time was 30 (range 5–108) months. The 5‐year survival rate was 12%. Conclusions: Primary colorectal signet‐ring cell carcinoma is frequently diagnosed late with a very poor prognosis. A high incidence of peritoneal seeding and low incidence of liver metastases appears to be a characteristic of signet‐ring cell carcinoma of the colon and rectum.     

Primary large cell neuroendocrine carcinoma of the urinary bladder

Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is rare. It is a type of neuroendocrine carcinoma morphologically distinct from small cell carcinoma. We report here a case of primary LCNEC of the urinary bladder. We observed a very large invasive tumor, which was not able to be detected three months previously by cystoscopy or computed tomography. The tumor cells morphologically and immunohistochemically resembled that of pulmonary LCNEC. With prompt cystoprostatectomy and chemotherapy, the patient is free of disease 16 months after diagnosis. Although LCNEC is usually very aggressive, it may be controlled by early diagnosis and treatment.     

Primary lymphoepithelioma-like carcinoma urinary bladder

ObjectiveTo present a new case of a primary lymphoepithelioma-like carcinoma of the urinary bladder.Material and methodsWe describe the clinical, diagnosis, treatment and development of this kind of tumor. Review of the literature.ConclusionsIt is an unusual type of bladder cancer that requires a carefully analyse from the pathologist and a confirmation by means of immunohistochemistry techniques. The focal form is associated with poor prognosis. Radical cystectomy is the gold standard. This kind of tumor has sensibility to chemo and radiotherapy, who can be used as adyuvant therapy.     

原发性膀胱印戒细胞癌的诊断和治疗：附2例报告

目的提高对原发性膀胱印戒细胞癌的认识和诊治水平。方法回顾分析我院收治的2例原发性膀胱印戒细胞癌,结合文献就其临床表现、诊断及治疗进行讨论。第1例患者,男,57岁,以全程肉眼血尿和继发的贫血就诊,CT检查示膀胱顶部占位性病变,界限清楚,有斑点状钙化。第2例患者,男,66岁,以黏液尿就诊,无其他临床表现,CT示膀胱右侧壁占位性病变。均于术前膀胱镜活检明确诊断。第1例因患者拒绝膀胱全切除术行膀胱部分切除术加脐尿管和相邻腹膜的切除术,第2例因陈旧性心肌梗塞行膀胱部分切除术。结果第1例患者术后血尿消失,贫血纠正。7个月后发现肺部转移,术后8个月死亡。第2例术后黏液尿和膀胱刺激症状消失。随访37个月,患者恢复良好,无复发和转移。结论原发性膀胱印戒细胞癌临床罕见,预后较差,诊断主要依赖病理学检查,全膀胱切除术是其首选治疗方法。     

Primary signet-ring cell carcinoma of the colon and rectum

Background: Primary signet-ring cell carcinoma of the colon and rectum is a rare form of adenocarcinoma of the large intestine. The purpose of this study was to help better define the natural history of this entity. Methods: The medical records of 3,690 patients with colorectal cancer seen at The Roswell Park Cancer Institute between September 1971 and December 1993 were reviewed. We report on 29 patients with pathologic confirmation of primary signet-ring cell carcinoma. Patient demographics, clinical, and histologic parameters were evaluated. Survival was calculated by the Kaplan-Meier method. Results: There was a nearly equal distribution of primary signet-ring cell carcinoma between the right colon and left colon/rectum. In most cases the tumors were >6 cm, ulcerated, and involved the full thickness of the bowel wall. Nodal or metastatic disease was present in 21 of 29 patients (72%) at the time of diagnosis. Four patients (14%) had synchronous colorectal adenocarcinomas. Twenty-two patients died of disease progression. At the time of death, two patients (9%) had failed in the liver, whereas all 22 patients had peritoneal carcinomatosis. Conclusions: Patients with primary signet-ring cell colorectal carcinoma frequently present with late-stage disease. In 23 of 29 patients, the disease rapidly recurred or progressed. Peritoneal carcinomatosis is the most common pattern of failure.Results of this study were presented at the 48th Annual Cancer Symposium of The Society of Surgical Oncology, Boston, Massachusetts, March 23–26, 1995.     

原发性肺印戒细胞癌1例

正患者男,50岁,因"咳嗽、咳痰伴痰中带血1月余"入院;既往吸烟24余年。查体未见明显异常。实验室检查:神经元特异性烯醇化酶(neuron-specific enolase, NSE)35.04 ng/ml,细胞角蛋白19片段(cytokeratin-19-fragment, CY211)9.45 ng/ml,胃泌素释放肽前体(progastrin-releasing peptide, proGRP) 19.50 pg/ml。CT:右肺中     

Primary linitis plastica carcinoma of urinary bladder

Primary linitis plastica type carcinoma of the urinary bladder in a sixty-one-year-old man is described. Only 2 other cases have been reported in the English medical literature.     

The impact of signet-ring cell carcinoma histology on bladder cancer outcome

Background

Signet-ring cell carcinoma (SRCC) of the urinary bladder is a rare entity. No previous studies have directly compared the cancer-specific survival of patients with SRCC to patients with urothelial carcinoma (UC) of the urinary bladder.

Materials and methods

Patients with diagnosis of urinary bladder SRCC and UC were identified in the Surveillance, epidemiology, and end results program (SEER) (2001?C2004). Demographic of patients and clinical characteristics at diagnosis were compared. Differences in cancer-specific survival were compared using univariate and multivariate analysis.

Results

A total of 103 patients with SRCC and 14,648 patients with UC were indentified. Patients with SRCC were younger (P?<?0.001), more commonly presented with higher-grade histology (P?<?0.001) and advanced stage disease (P?<?0.001), in comparison with patients with UC. The 3-year cancer-specific survival rate was 67.0% for patients with UC and 33.2% for SRCC. On multivariate analysis, there was an increased mortality risk in patients with SRCC versus UC (HR 1.49, 95% CI 1.11?C2.00, P?<?0.01).

Conclusions

Even after adjusting for demographic, surgical, and pathological factors, cancer-specific survival rate was significantly worse in patients with SRCC compared to UC. Further research into the biology of this rare tumor is required to explain these results.