TIME伤口床准备联合封闭式负压引流用于慢性伤口护理

目的探讨基于TIME原则的伤口床准备联合封闭式负压引流治疗慢性伤口的效果。方法将80例患者随机分为观察组和对照组各40例。观察组采用TIME原则进行伤口床准备,并应用封闭式负压引流,对照组在TIME原则指导下采用传统清创联合无菌敷料换药方法进行伤口护理。比较两组干预前和干预后7d、14d、21d的伤口面积缩小率、深度缩小率、局部症状体征以及观察期内伤口愈合率及所有愈合伤口的愈合时间、伤口换药时数、伤口换药费用。结果观察组伤口面积、深度缩小率和局部症状体征改善显著优于对照组(均P0.01);观察组90d内伤口愈合率显著高于对照组,伤口愈合时间、护理时数和换药费用显著低于对照组(均P0.01)。结论基于TIME原则的伤口床准备联合封闭式负压引流能够显著促进慢性伤口愈合,减少护理工作量及患者经济负担。     

改良式负压封闭引流技术联合局部氧疗在犬咬伤Ⅲ级暴露创面的应用

目的探讨改良式负压封闭引流技术联合局部氧疗治疗犬咬伤Ⅲ级暴露创面的效果。方法将45例犬咬伤Ⅲ级暴露创面患者按入院先后顺序分为观察组23例和对照组22例。观察组以优拓SSD为负压介质敷料行负压封闭引流联合局部氧疗进行创面治疗;对照组采用传统无菌纱布换药。结果观察组细菌清除率、换药疼痛程度、创面床准备时间及换药次数显著优于对照组(均P0.01)。结论采用改良式负压封闭引流联合局部氧疗治疗犬咬伤Ⅲ级暴露创面,可有效清除细菌,减轻换药疼痛,缩短创面床准备时间,有利于创面愈合。     

给氧负压伤口治疗在骨科慢性伤口中的可行性研究

目的评价负压伤口治疗联合局部给氧对骨科慢性伤口的可行性及效果。方法对60例骨科创伤性慢性伤口患者随机分为两组,每组30例,对照组给予负压伤口治疗,连续10d。观察组在负压伤口治疗基础上联合局部给氧2L/min,干预时间同对照组,观察指标:2组治疗0d和10d监测伤口渗液pH、温度、PUSH愈合计分、肉芽组织覆盖率、伤口达到植皮条件所需时间、植皮成活率、愈合时间、治愈率。结果治疗10d后,观察组伤口渗液pH(7.22±0.16),低于对照组(7.50±0.26)(P0.01)。达到植皮条件所需时间(12.65±7.16)d,低于对照组(18.28±8.85)d,伤口床的温度(34.02±0.41)℃,高于对照组(33.25±0.35)℃(P0.01)。观察组肉芽组织覆盖率(34.30±2.83)%高于对照组(27.27±3.54)%(P=0.00)。植皮成活率(93.22±1.91)%,高于对照组(83.21±1.86)%(P=0.00)。压疮愈合计分量表(pressure ulcer scale for healing,PUSH)计分结果差异无统计学意义(P0.05)。所有患者随访3个月,观察组治愈率为86.67%(26/30),平均愈合时间为(35±15.5)d,对照组治愈率为53.33%(16/30),平均愈合时间为(49±23.4)d,差异有统计学意义(P0.05)。结论将负压伤口治疗与局部给氧联合应用于骨科慢性伤口能促进伤口愈合及肉芽组织生长,方法可行,效果优于单纯负压治疗。     

复方黄柏液负压滴灌联合局部氧疗在3、4期压力性损伤患者中的应用

目的 探讨复方黄柏液负压滴灌联合局部氧疗在3、4期压力性损伤创面中的治疗效果。方法 将98例3、4期压力性损伤患者随机分为两组,每组49例。对照组给予生理盐水负压滴灌治疗,观察组给予复方黄柏液负压滴灌联合局部氧疗。治疗前,治疗2周、4周时评估两组压力性损伤愈合量表得分、治疗效果、住院时间及血清炎性因子水平。结果 治疗2周、4周,观察组压力性损伤愈合计分、C-反应蛋白、白细胞介素-6及住院时间显著低于对照组(均P<0.05),治疗4周观察组治疗效果显著优于对照组(P<0.05)。结论 复方黄柏液负压滴灌联合局部氧疗,可有效降低炎性因子水平,提高3、4期压力性损伤创面的治愈率,缩短住院时间。     

芒硝溶液持续滴注结合负压封闭引流技术（VSD）治疗腹部感染性伤口的应用研究

目的为促进腹部感染性伤口的恢复,降低伤口耐药的发生率,在负压封闭引流技术(VSD)的基础上持续滴注芒硝溶液,与传统生理盐水滴注对比并评估其疗效,为治疗腹部手术部位感染提供更加有效经济的新方法。方法收集2018年1月至2018年12月南昌大学第二附属医院胃肠外科和中山大学附属第六医院胃肠、疝和腹壁外科收治的腹会阴部手术后出现伤口感染且较难愈合,伤口清创后予以负压封闭引流术的80例患者。随机将其分为两组,试验组40例,持续滴注芒硝溶液结合负压封闭引流技术,对照组40例,持续滴注生理盐水结合负压封闭引流技术,观察比较两组患者清创后创面新鲜肉芽覆盖情况、术后疼痛缓解情况、伤口达二期缝合时间、伤口缝合后愈合时间、换药总费用等。结果在相同时间内试验组患者的创面肉芽组织生长情况评分为(3.97±0.42),明显好于对照组(2.25±0.44),伤口达二期愈合时间为(11.75±1.69 d),明显短于对照组(16.4±2.74 d);试验组患者手术后疼痛评分为(2.87±0.36),明显低于对照组(4.05±0.85);试验组患者伤口缝合后愈合时间为(7.15±1.63)天较对照组(10.27±2.89)天明显缩短;试验组患者换药次数及费用明显低于对照组,以上差异均有统计学意义(P0.05)。结论持续滴注芒硝溶液结合负压封闭引流技术可以显著促进腹部感染性伤口的快速恢复,减轻患者负担,节约医疗资源,为临床治疗腹部感染性伤口提供更加经济有效的方案。     

负压引流治疗腹部手术切口渗液18例

目的 探讨皮下持续负压引流术对腹部切口脂肪液化或感染的治疗作用.方法 选取2001年7月至2011年9月行腹部手术的病人36例,随机分为传统方法组与负压引流组各18例,传统组按传统方法对液化或感染伤口进行部分拆线撑开,挤压切口下渗血、渗液填塞纱条引流换药,创面肉芽理想后二期缝合.负压引流组切口敞开清创放置负压引流管后缝合切口,连续3d无引流液且体温正常后拔管,术后常规时间拆线,均达到甲级愈合.结果 对照组切口完全愈合时间8～35 d,平均21 d;负压引流组切口愈合时间7～10d,平均8.2d;两组对比差异有统计学意义(P＜0.01).结论 在腹部术后切口液化或感染采用敞开切口清创缝合并放置持续负压引流能早期达到切口愈合,简单、有效,值得基层医院推广使用.     

负压封闭引流治疗高位肛周脓肿的临床研究

探讨负压封闭引流治疗高位肛周脓肿的疗效。94例高位肛周脓肿患者按数字随机表法分为两组,每组47例。治疗组给予负压封闭引流治疗,对照组给予低位切开引流治疗,比较两组手术时间、住院时间、创面愈合时间、住院费用;比较两组术后第2日疼痛视觉模拟评分(VAS)和Wexner肛门失禁评分;比较两组术前及术后7 d血清肿瘤坏死因子-α(TNF-α)和表皮生长因子(EGF)水平;术后4周比较两组治愈率。治疗组术后住院时间、创面愈合时间及住院费用均少于对照组(P<0.01);术后第2日治疗组VAS评分、Wexner评分均低于对照组(P<0.01);术后7 d治疗组血清TNF-α水平低于对照组(P<0.01),EGF水平高于对照组(P<0.01),术后4周治疗组治愈率高于对照组(P<0.05),差异均有统计学意义。负压封闭引流术治疗高位肛周脓肿可有效保护肛门功能,缓解术后疼痛,减少创面愈合时间和住院时间,提高治愈率。     

红光和红外线辅助治疗创伤性伤口减痛促愈效果观察

目的 观察评价红光与红外线辅助治疗创伤性伤口的减痛促愈效果.方法 将107例创伤性伤口患者随机分为三组,分别为红光治疗20 min组(A组)36例和10 min组(C组)35例及红外线治疗10 min组(B组)36例,三组伤口处理均采用标准的湿性疗法,仅物理干预方法和时间不同,每种物理干预疗程均设为2个疗程28 d,治疗第1天、第7天和第14天测量每组伤口照射前后温度、疼痛评分;治疗后第7、14、21和28天测量伤口面积并计算伤口缩小率,记录伤口愈合时间.结果 干预治疗28 d,三组治愈率和愈合时间比较,差异无统计学意义(均P＞0.05).不同时间三组伤口缩小率、伤口温度和伤口疼痛评分比较,时间主效应均P<0.01.结论 红光10～20 min和红外线10 min均能提升伤口温度、减轻疼痛、促进伤口愈合和缩短愈合时间,连续干预28 d是安全有效的,以红光20 min法效果更优.     

银纤维敷料联合负压伤口疗法治疗深Ⅱ度烧伤创面

目的:探讨银纤维敷料联合负压伤口疗法治疗深Ⅱ度烧伤创面的临床疗效。方法:选择笔者医院2016年6月-2018年7月住院治疗的68例深Ⅱ度烧伤创面患者作为研究对象,采用随机数字表法分为观察组和对照组,各34例。观察组应用银纤维敷料联合负压伤口疗法治疗,对照组应用磺胺嘧啶锌软膏外涂。记录各时点创面疼痛程度评分、创面渗液量、创面愈合率、创面完全愈合时间和细菌阳性率,观察不良反应发生情况,比较两组治疗21d的总显效率。结果:两组在治疗前及治疗后15min的创面疼痛程度评分上差异均无统计学意义(P0.05);观察组治疗后即刻的创面疼痛程度评分明显低于对照组,差异有统计学意义(P0.05)。观察组治疗7d、14d、21d后的创面渗液量均明显少于对照组,创面愈合率均明显高于对照组,创面完全愈合时间明显短于对照组,差异均有统计学意义(P0.05)。治疗前两组创面分泌物细菌培养阳性率比较差异无统计学意义(P0.05);治疗7d、14d后观察组创面分泌物细菌培养阳性率均明显低于对照组,差异均有统计学意义(P0.05)。两组均顺利完成治疗,显著控制创面分泌物及肿胀,其中观察组治疗21d的临床总显效率为97.06%,明显高于对照组的82.35%,差异有统计学意义(P0.05);两组治疗期间的血常规和心、肝、肾功能均无明显异常,未见过敏反应及与治疗相关的严重不良反应。结论:银纤维敷料联合负压伤口疗法治疗深Ⅱ度烧伤创面的临床疗效显著,在减轻换药疼痛程度、清除细菌、减少渗液和促进愈合上具有优势,且安全可靠,值得临床推广应用。     

肝移植术后脂肪液化伤口采用水胶体拉合免缝法联合负压治疗效果观察

目的 探讨水胶体拉合免缝法联合负压治疗肝移植术后脂肪液化伤口的效果.方法 47例肝移植术后脂肪液化患者按照入院时间分组,2017年2月至2018年7月的患者分为对照组(26例),2018年8月至2019年12月的患者分为观察组(21例).两组均行伤口评估及常规伤口床准备,对照组采用常规方法行伤口换药,观察组采用水胶体拉合免缝法联合负压治疗.结果 两组伤口总愈合时间、总愈合速度、总换药时间、换药总次数、换药费用、单位时间伤口缩小面积、单位时间伤口深度改变、单位时间伤口愈合速度等指标比较,差异有统计学意义(均P＜0.01).结论 水胶体拉合免缝法联合负压治疗能促进肝移植术后脂肪液化伤口愈合,且不增加经济负担,同时减轻护理工作量.     

早期负压封闭引流治疗深Ⅱ度烧伤创面的临床疗效评价

Objective To evaluate the clinical curative effect of applying vaccum sealing drainage (VSD) therapy in treating deep partial-thickness burn wound at the initial stage prospectively, and to provide the basis for its clinical application. Methods Twenty-two patients with about 10% TBSA burn of the lower limbs, and in which partial-thickness wound exceeded 1% TBSA in each limb, were admitted to our hospital within 3 hours after burn from May 2009 to March 2010. Wounds in each patient were divided into VSD treatment group (treated with VSD therapy) and control group (treated with 10 g/L silver sulfadia-zine cream) based on the principles of symmetry of location, identical deepness, and similarity in size etc. The amount of water evaporation, the swelling intensity, the status of bacterial colonization, the degree of pain, the healing time, and the quality of healing of wounds in 2 groups were observed and compared. Data were processed with t test and rank-sum test. Results The observation was completed in 21 patients. All of the wounds were treated within 4 hours post burn (PBH). The amount of water evaporation of the normal skin and burn wounds before dressing coverage in VSD treatment group was respectively close to that in control group (with t value respectively 1.310, - 0. 911, P values all above 0.05) ; the amount of water evaporation on the surface of dressing in VSD treatment group [(44. 3 ±3.9) mL·h-1·m-2] was less than that in control group [(66.1 ±6.4) mL · h-1· m-2, t = -11.39, P <0.01]. In VSD treatment group, the circumference of proximal thigh increased (3.48 ±0.35) and (2.51 ±0.21) cm on post burn day (PBD) 3 , 7 as compared with that on PBH 5 , which was respectively smaller than that [(8.02 ± 0.41) , (3. 99 ± 0. 32) cm] in control group (with t value respectively 4. 110, 3. 569, P values all below 0. 01). Positive bacteria' culture rate on PBD 10 of each group was respectively lower than that at admission (with Z value respectively -3.220, -3.870, P values all below 0. 01) , and there was no significant statistical difference between 2 groups at admission or on PBD 10 (with Z value respectively - 0. 894, 0.000, P values all above 0.05). The wound surface in VSD treatment group was weak acidic (pH value 7. 12 ±0.06) on PBD 10,and it was neutral (pH value 7.41 ±0. 13) in control group. The wound pain degree in control group on PBD 1,3,7 was respectively higher than that in VSD treatment group (with t value respectively - 16. 132, -21.230, -16.453, P values all below 0.01). There was no significant statistical difference between 2 groups in healing time of wounds (t =1. 186, P >0.05). The healing quality of wounds in VSD treatment group (100. 00% , 100. 00%) 2 or 3 months after burn was better than that in control group (19. 05% , 85. 71%) (with Z value respectively -11.638, -3. 870, P values all below 0.01). Conclusions Early application of VSD therapy cannot expedite the healing process of deep partial-thickness burn wounds, but it can improve the healing quality. It is one of the effective methods to deal with deep partial-thickness burn wounds, which is worthy of clinical attention and further research.     

早期负压封闭引流治疗深Ⅱ度烧伤创面的临床疗效评价

Objective To evaluate the clinical curative effect of applying vaccum sealing drainage (VSD) therapy in treating deep partial-thickness burn wound at the initial stage prospectively, and to provide the basis for its clinical application. Methods Twenty-two patients with about 10% TBSA burn of the lower limbs, and in which partial-thickness wound exceeded 1% TBSA in each limb, were admitted to our hospital within 3 hours after burn from May 2009 to March 2010. Wounds in each patient were divided into VSD treatment group (treated with VSD therapy) and control group (treated with 10 g/L silver sulfadia-zine cream) based on the principles of symmetry of location, identical deepness, and similarity in size etc. The amount of water evaporation, the swelling intensity, the status of bacterial colonization, the degree of pain, the healing time, and the quality of healing of wounds in 2 groups were observed and compared. Data were processed with t test and rank-sum test. Results The observation was completed in 21 patients. All of the wounds were treated within 4 hours post burn (PBH). The amount of water evaporation of the normal skin and burn wounds before dressing coverage in VSD treatment group was respectively close to that in control group (with t value respectively 1.310, - 0. 911, P values all above 0.05) ; the amount of water evaporation on the surface of dressing in VSD treatment group [(44. 3 ±3.9) mL·h-1·m-2] was less than that in control group [(66.1 ±6.4) mL · h-1· m-2, t = -11.39, P <0.01]. In VSD treatment group, the circumference of proximal thigh increased (3.48 ±0.35) and (2.51 ±0.21) cm on post burn day (PBD) 3 , 7 as compared with that on PBH 5 , which was respectively smaller than that [(8.02 ± 0.41) , (3. 99 ± 0. 32) cm] in control group (with t value respectively 4. 110, 3. 569, P values all below 0. 01). Positive bacteria' culture rate on PBD 10 of each group was respectively lower than that at admission (with Z value respectively -3.220, -3.870, P values all below 0. 01) , and there was no significant statistical difference between 2 groups at admission or on PBD 10 (with Z value respectively - 0. 894, 0.000, P values all above 0.05). The wound surface in VSD treatment group was weak acidic (pH value 7. 12 ±0.06) on PBD 10,and it was neutral (pH value 7.41 ±0. 13) in control group. The wound pain degree in control group on PBD 1,3,7 was respectively higher than that in VSD treatment group (with t value respectively - 16. 132, -21.230, -16.453, P values all below 0.01). There was no significant statistical difference between 2 groups in healing time of wounds (t =1. 186, P >0.05). The healing quality of wounds in VSD treatment group (100. 00% , 100. 00%) 2 or 3 months after burn was better than that in control group (19. 05% , 85. 71%) (with Z value respectively -11.638, -3. 870, P values all below 0.01). Conclusions Early application of VSD therapy cannot expedite the healing process of deep partial-thickness burn wounds, but it can improve the healing quality. It is one of the effective methods to deal with deep partial-thickness burn wounds, which is worthy of clinical attention and further research.     

The effectiveness of negative pressure therapy on infected wounds: preliminary results

Vacuum‐assisted closure (VAC) therapy is a sophisticated system that maintains a closed, humid, sterile and isolated environment. Wound infection is considered a relative contraindication. The objective of this study is to extend the indications for VAC therapy to include infected wounds by demonstrating its ability to increase the antibiotic concentration in the damaged and infected tissues. Patients who presented with ulcers infected with daptomycin‐sensitive bacteria were eligible to be enrolled in this prospective study. They were given antibiotic therapy with daptomycin with a specific protocol. A biopsy of the lesion was carried out to detect tissue concentration of the drug at time 0. Afterwards, the patients were subjected to VAC therapy. At the end of VAC therapy, a second lesion biopsy was performed and analysed to detect tissue concentration of the drug at time 1. A control group was enrolled in which patients followed the same protocol, but they were treated with traditional dressings. Fisher's exact test was used to compare the two groups. The results highlighted a significant increase in the concentration of antibiotics in the study group tissue; the improvement was sensibly lower in the control group. Statistical differences were not found between the two groups. The preliminary analysis of the data showed an important increase of antibiotic concentration in the tissue after VAC therapy. Despite the encouraging data, it is necessary to broaden the sample of patients and perform the same study with other antibiotics.     

湿性愈合疗法在腹部二期愈合手术切口中的应用

目的比较湿性与干性愈合疗法对腹部二期愈合手术切口的疗效。方法腹部手术后切口二期愈合患者60例,随机分为治疗组(31例)和对照组(29例)。治疗组采用湿性愈合疗法处理伤口,对照组采用常规方法换药。结果治疗组治愈率为83.9%,总有效率为96.8%,对照组治愈率为51.7%,总有效率为69.0%,两组比较有统计学差异(P0.05)。治疗组换药(6.8±2.0)次,明显少于对照组的(26.6±6.8)次(P0.05);治疗组治疗时间为(16.2±4.0)d,明显短于对照组的(28.5±7.2)d(P0.05)。结论湿性愈合疗法治疗时间短,换药次数少,治愈率及总有效率高,优于传统的干性愈合疗法,值得临床推广。     

Transposition Flaps for Reconstruction of Perianal Skin Defects After Tumor Resection

ObjectiveTo investigate the application of transposition flaps in the reconstruction of perianal skin defects after tumor resection.MethodsFrom September 2018 to December 2019, 16 cases of perianal skin defects were repaired with unilateral or bilateral transposition flaps. The wound size before closure ranged from 4 cm × 8 cm to 7 cm × 10 cm. Fourteen patients achieved primary healing. Wound dehiscence occurred in one patient at the flap tip, whereas a slight infection occurred in another patient, which healed after a dressing change. During the follow-up period of 3–6 months, all patients were satisfied with the perianal area both aesthetically and functionally.ConclusionTransposition flaps are a promising option for the repair of perianal skin defects after tumor removal. Owing to the simplicity of the flap design, the wide popularity of this flap type among surgeons is anticipated.     

The impact of negative‐pressure wound therapy with instillation on wounds requiring operative debridement: Pilot randomised,controlled trial

Presence of bacteria in wounds can delay healing. Addition of a regularly instilled topical solution over the wound during negative‐pressure wound therapy (NPWT) may reduce bioburden levels compared with standard NPWT alone. We performed a prospective, randomised, multi‐centre, post‐market trial to compare effects of NPWT with instillation and dwell of polyhexamethylene biguanide solution vs NPWT without instillation therapy in wounds requiring operative debridement. Results showed a significantly greater mean decrease in total bacterial counts from time of initial surgical debridement to first dressing change in NPWT plus instillation (n = 69) subjects compared with standard NPWT (n = 63) subjects (?0.18 vs 0.6 log₁₀ CFU/g, respectively). There was no significant difference between the groups in the primary endpoint of required inpatient operating room debridements after initial debridement. Time to readiness for wound closure/coverage, proportion of wounds closed, and incidence of wound complications were similar. NPWT subjects had 3.1 times the risk of re‐hospitalisation compared with NPWT plus instillation subjects. This study provides a basis for exploring research options to understand the impact of NPWT with instillation on wound healing.     

The influence of a biofilm‐dispersing wound gel on the wound healing process

Topical antimicrobials that reduce the bacterial bioburden within a chronically‐infected wound may have helpful or harmful effects on the healing process. We used murine models of full‐thickness skin wounds to determine the effects of the novel biofilm‐dispersing wound gel (BDWG) and its gel base on the healing of uninfected wounds. The rate of wound closure over 19 days was comparable among the BDWG‐treated (BT) wounds and the controls. Compared with the controls, histology of the BT wounds showed formation of a stable blood clot at day 1, more neovascularisation and reepithelialisation at day 3, and more organised healing at day 7. Fluorescence‐activated cell sorting analysis showed a lower percentage of neutrophils in wounded tissues of the BT group at days 1 and 3, and significantly more M2 macrophages at day 3. Levels of proinflammatory cytokines and chemokines were increased over the uninjured baseline within the wounds of all treatment groups but the levels were significantly lower in the BT group at day 1, modulating the inflammatory response. Our results suggest that BDWG does not interfere with the wound healing process and may enhance it by lowering inflammation and allowing transition to the proliferative stage of wound healing by day 3.     

Wound dressings

The purpose of wound dressings is to support the local wound environment in order to facilitate wound healing. Dressings range from simple or passive dressings that essentially provide a contact layer to protect the wound bed from further damage and maintain a moist environment, to more advanced or interactive dressings that are capable of modifying the physiology of the wound milieu to optimize healing by, for example, promoting debridement, enhancing granulation tissue formation and re-epithelialization, managing exudate levels and bacterial load. There are also bioactive dressings which can change the cellular or biological aspects of the wound, an example of this would be a topical antimicrobial product. Hence a fundamental prerequisite to choosing the most appropriate dressing is having a clear objective in mind. Essential to this is an accurate assessment of the wound. This article will describe the features of the clinical assessment process as a basis for understanding the principles of wound management and provide details of various dressings and devices together with the indications and limitations of their use.     

Effects of negative pressure wound therapy on wound infection and healing in patients with open fracture wounds: A meta-analysis

A meta-analysis was conducted to comprehensively evaluate the impact of negative pressure wound therapy (NPWT) on wound infection and healing in patients with open fracture wounds. Computer searches were performed in EMBASE, Google Scholar, Cochrane Library, PubMed, Wanfang and China National Knowledge Infrastructure databases for randomized controlled trials (RCTs) on the application of NPWT in open fracture wounds, with the search period covering the databases inception to September 2023. Two researchers independently screened the literature, extracted data and conducted quality assessments. Stata 17.0 software was employed for data analysis. Overall, 17 RCTs involving 1814 patients with open fracture wounds were included. The analysis revealed that compared with other treatment methods, NPWT significantly shortened the wound healing time (standardized mean difference [SMD] = −2.86, 95% confidence intervals [CI]: −3.51 to −2.20, p < 0.001) and fracture healing time (SMD = −3.14, 95% CI: −4.49 to −1.79, p < 0.001) in patients with open fracture wounds. It also significantly reduced the incidence of wound infection (odds ratio [OR] = 0.36, 95% CI: 0.23–0.56, p < 0.001) and complications (OR = 0.29, 95% CI: 0.20–0.40, p < 0.001). This study indicates that in the treatment of open fracture wounds, NPWT, compared with conventional treatment methods, can accelerate the healing of wounds and fractures, effectively control infections and reduce the occurrence of complications, demonstrating high safety.