67例急性白血病患者血液中锌,铜,铁等14种元素含量的测定

对67例急性白血病(50例初发病例,17例化疗后完全缓解CR者)检测血液中钙、磷、镁、锌、铜、铁、锰、铬、铅、钒、铍、钛、钴以及镍等14种元素的含量,并与40例正常对照组进行比较,结果初发病例血钙、钢、铅、钒、镍以及铜/锌比值增高很显著;而锌、铁与铬则降低非常显著;其他元素无明显改变。与CR 1年以上者进行比较,发现后者锌、铁与铬增高非常明显;而镍显著降低;说明随CR时间的延长元素的含量有所恢复。同时发现铬/镍比值与铜/锌比值一样,有可能成为提示疗效与预后的指标;而伴血钙显著增高者预后较差。     

急性白血病与血液中微量元素相关性的研究

目的 观察急性白血病患者急性期及缓解期血液中微量元素的动态变化以及铁和锌与化疗合用的效果。方法 应用高频等离子体反射光谱仪,对110例急性白血病患者和100例健康儿童血液中14种微量元素进行分析,并比较化疗加锌和铁治疗组及单纯化疗组的疗效。结果 急性期白血病患者血、铁、钙和锰水平低于正常儿童,而铜和镍水平明显高,尤以铜／锌比值增大显著,在疾病缓解期则下降接近正常水平;化疗加锌和铁治疗组病情开始缓解及完全缓解所需时间较单纯化疗组明显缩短。结论 白血病急性期血液中微量元素有明显变化,且化疗时加用铁和锌有促进疗效的作用。     

肺癌与头发微量元素关系的探讨

目的探讨肺癌与头发微量元素之间的关系。方法对肺癌、健康人各50例，用原子吸收分光法，对六种微量元素（硒、铜、锌、锰、铁、镍进行测定，并将单元素比较及致癌／抗癌元素比值和致癌／未明确元素比值来分析与肺癌的关系。结果肺癌组镍、铜和锰的含量明显高于正常组（P＜0．001和P＜0．01），肺癌组镍／锌，铜／锌，镍／硒的比值明显大于正常组（P＜0．01和P＜0．001），肺癌组铜／铁，镍／锰的比值明显低于健康组（P＜0．001和P＜0．01）。结论测定头发六种微量元素的含量对肺癌可能有一定的辅助诊断价值。     

急性白血病患者血清中锰镍镉铜锌及全血中铜锌锰的研究

用原子吸收光谱法测定３４例急性白血病患者和４０例正常人血清中锰（Ｍｎ）、镍（Ｎｉ）、铜（ｃｕ）、锌（ｚｎ）、镉（Ｃｄ）及全血中Ｃｕ、Ｚｎ和Ｍｎ的含量，观察到急性白血病的ＡＬＬ组和ＡＮＬＬ组患者血清、全血Ｃｕ的含量、铜锌比值（Ｃｕ／Ｚｎ）显著高于正常人（Ｐ＜０．００１）；血清、全血Ｚｎ、血清Ｍｎ含量均显著低于对照组（Ｐ＜０．００１，Ｐ＜０．０５）；血清Ｎｉ含量升高仅见于ＡＬＬ组（Ｐ＜０．０１）．血清铜含量升高与合髓白血病细胞增殖有关。     

白血病及恶性淋巴瘤患者血清CER检测及临床意义

目的 探讨急、慢性白血病、恶性淋巴瘤患者血清铜蓝蛋白ＣＥＲ水平变化及临床意义。方法：用免疫化学全自动分析仪全自动散色比浊法测定白血病９０例恶性淋巴瘤３２例，良性血液病５１例及正常人４４例的血清铜蓝蛋白ＥＣＲ值。结果 急性白血病组及恶性淋巴瘤组患者血清ＣＥＲ测定值均较正常对照组及良性血液病组明显增高（Ｐ〈０．００１和Ｐ〉０．０１），血清ＣＥＲ在急淋组和急非淋组间无显著性差异（Ｐ〉０．０５），急性白血     

强化疗加G—CSF对急性髓细胞白血病治疗转归的影响

观察强化疗加重组集落刺激因子对急性髓细胞白血病治疗转归的影响。方法诱导化疗采用ＤＮＲ每日４５ｍｇ／ｍ＾２，静脉注射，第１天－第３天，Ａｒａ－Ｃ每日２００ｍｇ／ｍ＾２，静脉点滴第１天－第７天。结论ＡＭＬ强化疗中加用Ｇ－ＣＳＦ对ＣＲ率无影响，而且不增加近期复发率。     

强化疗加G-CSF对急性髓细胞白血病治疗转归的影响

目的观察强化疗加重组集落刺激因子对急性髓细胞白血病治疗转归的影响。方法诱导化疗采用ＤＮＲ每日４５ｍｇ／ｍ２,静脉注射,第１天～第３天,Ａｒａ－Ｃ每日２００ｍｇ／ｍ２,静脉点滴,第１天～第７天。化疗后白细胞计数（ＷＢＣ）＜１．０×１０９／Ｌ时起加用Ｇ－ＣＳＦ,剂量为每日２００μｇ／ｍ２,皮下注射,直至ＷＢＣ计数＞３．０×１０９／Ｌ或中性粒细胞绝对值（ＡＮＣ）＞１．５×１０９／Ｌ后停用。初治急性髓细胞白血病（ＡＭＬ）１５例。结果完全缓解（ＣＲ）１２例,ＣＲ率８０％,ＰＲ１例,总有效率８６．６％,无治疗相关性死亡。治疗中未发现Ｇ－ＣＳＦ的明显副作用。对ＣＲ１２例进行了连续１２个月的随访,失访２例,持续ＣＲ（ＣＣＲ）７例,复发３例。复发者中２例于ＣＲ后不久中断治疗３个月和４个月后复发,另１例治疗４疗程后于治疗中复发。结论ＡＭＬ强化疗中加用Ｇ－ＣＳＦ对ＣＲ率无影响,而且不增加近期复发率     

46例急性白血病患者血清及头发中13种微量元素测定

测定了46例急性白血病患者血清及头发中13种微量元素的含量,并与同一时间、相同部位采集的正常对照做了比较。结果表明急性白血病患者铜、锌、硒、铁、锰、钡等微量元素失调,其与急性白血病的关系有待于进一步研究。     

急性白血病与血清、尿、头发的铜、锌、锰、铬和镍关系的研究

本文对38例急性白血病患者在不同时期测定同一天血清,24小时尿及头发中的铜、锌、锰、铬和镍等含量。结果表明:血清中这5种微量元素的含量最能反映这些微量元素变化与病情变化的关系。急白发病初期有血清铜含量的升高,血清锌含量降低。急白发病初期及恶化期均有血清镍含量升高,缓解期则下降。急白在三个时期血清锰含量均降低。急白在三个时期均有铜/锌比值增大和锰/镍比值减少。结果亦表明:血清镍含量与病情变化有伴随性关系,提示测定血清镍含量可作为急白疗效观察的一个指标。微量元素镍与急性白血病的发病可能有着内在的联系。     

滋养细胞肿瘤患者血清微量元素的变化

采用原子吸收光谱法检测１６例滋养细胞肿瘤患者治疗前后血清微量元素铜、锌、锰和铬的含量，结果表明，滋养细胞肿瘤患者血清铜水平和铜／锌比值均显著高于正常未孕对照组（Ｐ〈０．０１）。经手术和ＡＣＭ三联序贯化疗后，随着病情的完全缓解，血清铜水平和铜／锌比值则明显下降（Ｐ〈０．０１），我们认为血清铜水平和铜／锌比值与滋养细胞肿瘤的病情和疗效有关。     

回族血清中微量元素含量与胃癌的相关性研究

目的探讨回族血清中微量元素含量与胃癌的关系。方法采用原子吸收分光光度法对回族胃癌患者和回族非胃癌对照人群血清中锌(Zn)、铜(Cu)、铁(Fe)、镁(Mg)、钙(Ca)、锰(Mn)、镍(Ni)元素含量进行检测,并用SPSS统计软件对实验结果进行配对t检验分析。结果回族胃癌病例组血清中Cu、Cu/Zn、Mn均比对照组高,而Zn、Fe、Ca、Mg、Ni的含量低于对照组。配对t检验结果显示,血清中Cu、Zn、Cu/Zn、Ca、Mg含量差异有统计学意义(P<0.05)。结论回族胃癌的发生、发展与血清内微量元素变化密切相关。高Cu、Cu/Zn比值高以及低Zn、低Ca、低Mg是回族胃癌发生的危险因素。     

消化道良,恶性疾病的12种微量元素的测定与临床意义

本文测定174例胃肠道疾病,40例原发性肝癌及85例正常人血清Cu、Zn、Ca、Mg、Fe、Sr、Mn、Mo、Cr、Ti、Ni、Se等12种微量元素。结果表明:血清铜升高、锌降低,Cu/Zn比值升高最明显为原发性肝癌,其次为胃肠癌,再次为胃肠息肉,最后为慢性腹泻。慢性腹泻与正常比仅锌下降,钙与锌在各组改变与锌相似。胃肠癌转移组与正常组比,术前组、术后组与正常组之间其Cu/Zn比值升高,且均有统计学意义(P<0.05)。胃肠癌组与息肉组比较,血清钙显著降低(P<0.001),铁无差异;而胃肠癌组与慢性腹泻组比,血清铁降低显著而钙无差异。胃肠癌中65例腺癌病理分化与微量元素无明显关系。由此表明微量元素改变对鉴别消化道良、恶性疾病和临床观察有一定帮助。     

骨陛关节炎滑膜组织中16种元素的分析

目的骨性关节炎（osteoarthritis,OA）是一种退行性骨关节病,该病病因和发病机制尚不明确。微量元素能通过参与人体内的新陈代谢、各种生物和化学反应等,维持机体正常生理活动,如果体内各种微量元素含量失调,就有可能引发多种疾病。本研究通过测定骨性关节炎滑膜组织中B、Mg、A1、K、Ca、n、Cr、Mn、Fe、Ni、Cu、Zn、Se、Sr、Ba、Pb等16种元素含量,探讨OA患者滑膜组织中这些元素的水平和疾病发生、发展的关系,为OA的机制研究和诊治提供相关的理论依据。方法选择骨性关节炎患者为实验组,单纯外伤引起的半月板损伤患者为对照组。术中采集患者滑膜组织样本,经微波消解处理,用电感耦合等离子体质谱（ICP—MS）测定组织中16种元素含量,数据经SAS9．0软件统计分析。结果实验组滑膜组织中硒（se）、铁（Fe）、锌（Zn）、铜（Cu）、硼（B）、钙（Ca）和钾（K）7种元素含量与对照组比较,差异均有统计学意义（P〈0．05）,其中实验组滑膜组织中Fe、B、Se元素含量低于对照组,而Ca、K、Cu、Zn元素的含量高于对照组;锰（Mn）、铬（Cr）、锶（Sr）、镍（Ni）、钡（Ba）、铝（A1）、铅（Pb）、锑（Sb）、镁（Mg）元素含量没有明显变化。结论骨性关节炎患者滑膜中硒、铁、锌、铜、硼、钙和钾7种元素含量变化明显,这些元素都是机体的必需元素,它们可能通过影响蛋白质、酶的代谢导致骨性关节病的发生。     

Trace elemental analysis of normal, benign hypertrophic and cancerous tissues of the prostate gland using the particle-induced X-ray emission technique.

Trace elemental analysis was carried out in the tissue samples of normal, benign hypertrophic and carcinoma prostate using the particle-induced X-ray emission technique. A proton beam of 3 MeV energy was used to excite the samples. The elements Cl, K, Ca, Ti, Cr, Mn, Fe, Ni, Cu, Zn, Se, and Br were identified and their concentrations were estimated. It is observed that in benign tissues the concentrations of Cl, K, Zn, and Se are lower (P<0.05) and those of Cr, Fe, Ni, and Cu are higher (P<0.05 ) than in normal tissues. The concentrations of K, Ca, Zn, Se, and Br are lower (P<0.01) and those of Ti, Cr, Mn, Fe, Ni, and Cu are significantly higher (P<0.0005) in cancerous tissues than in normal tissues. Free radicals generated by elevated levels of Cr, Fe, Ni, and Cu possibly initiate and promote prostate cancer by oxidative DNA damage. The excess Cu levels in cancerous tissues support the fact that Cu promotes cancer through angiogenesis. The higher levels of Fe observed in cancerous tissues might be a consequence of tumor growth through angiogenesis. Significantly higher levels of Ni and Cr observed in carcinoma tissues support the well-established role of Ni and Cr as carcinogens. It is likely that the observed low levels of Zn and Se in cancerous tissues lead to the development of prostate cancer owing to a decrease in antioxidative defense capacity and impaired immune function of cells and also suggest that the inability to retain high levels of Zn and Se may possibly be an important factor in the development and progression of malignant prostate cells. In order to substantiate the observed elevated or deficient levels of trace elements in initiating, promoting, and inhibiting prostate cancer, several cellular and molecular studies are required.     

急性白血病患者全血中微量元素研究

 目的 观察急性白血病患者血液中微量元素的动态变化。方法 用原子吸收光谱法测定50例急性白血病患者和40例正常人全血中铜（Cu）、锌（Zn）、锰（Mn）、铁（Fe）、钙（Ca）、镁（Mg）的含量,同时对20例患者缓解前后进行了动态观察。结果 急性白血病初发组及复发组全血Cu、Ca的含量、Cu／Zn比值显著高于正常组及缓解组,全血Zn,Fe,Mg的含量低于对照组及缓解组,全血Mn含量与正常组及缓解组无显著改变。结论 白血病急性期血液中微量元素有明显变化,全血Cu,Zn含量有更显著参考价值。     

Variation of urinary and serum trace elements (Ca, Zn, Cu, Se) in bladder carcinoma in China

Backgrounds: Deficiency or excess of trace elements can induce body metabolic disorders and cellulargrowth disturbance, even mutation and cancerization. Since there are few studies of the effect of trace elementsin bladder carcinoma in China, the aim of this study was thus to assess variation using a case control approach.Methods: To determine this, 81 patients with bladder carcinoma chosen as a study group and 130 healthypersons chosen as a control group were all assayed for urinary and serum trace elements (calcium [Ca], zinc[Zn], copper [Cu], selenium [Se]) using an atomic absorption spectrophotometer, and the results were analyzedby independent sample t tests. The correlative factors on questionnaires answered by all persons were analyzedby logistic regression. Results: The results showed urinary Ca, Zn and serum Cu levels of the study group tobe significantly higher (P<0.05) than those of he control group. Serum Ca and Se levels of study group weresignificantly lower (P<0.05) than those of control group. Conclusion: There were higher urinary Zn and serumCu concentrations in bladder carcinoma cases. Bladder carcinoma may be associated with Ca metabolic disorder,leading to higher urinary Ca and lower serum Ca. Low serum Se and smoking appear to be other risk factorsfor bladder carcinoma in China.     

Altered serum levels of elements in acute leukemia cases in Turkey

Objective: The purpose of the study was to compare serum concentrations of some elements [zinc (Zn), copper (Cu), manganese (Mn), magnesium (Mg), lead (Pb), iron (Fe), cadmium (Cd) and cobalt (Co)] in acute leukemia patients with those of healthy subjects. Methods: The study group consisted of newly diagnosed acute leukemia patients and the controls were matched for socioeconomic stauts and eating habits. The elements levels in the patient group were measured before treatment with an atomic absorption spectrophotometer. The selection criteria for the patients and controls were the lack of recent blood transfusion history and taking any medication with mineral supplement. Results: The acute leukemia group composed of 42 patients and there were 40 persons in the control group. There was no difference between the age of the two groups (p=0.239). Serum levels of Zn, Mg and Mn were significantly lower with acute leukemia than in controls (p<0.001, p=0.011, p<0.001, respectively), while Cu, Pb and Cd were significantly elevated (p=0.003, p<0.001, p<0.001, respectively). There were no significant differences regarding Co and Fe (p=0.323 and p=0.508, respectively) Conclusion: In this study, we found levels of Zn, Mg and Mn to be lowered and of Cu, Pb and Cd to be elevated in patients with leukemia. Further studies are needed to clarify the role of these elements in pathogenesis of acute leukemia.     

喉癌与微量元素

喉癌与微量元素关系的研究,文献报道不多。本文自1987年开始对血清Zn、Cu、Fe、Se,进行了检测,企图探索与喉癌的关未,从检测结果可以看出喉癌的发生与血清Zn、Cu、Fe、Se的含量有一定关系,可能直接参与了喉癌的发生和发展。