差示双波长法测定复方酮康唑乳膏中酮康唑的含量

目的：建立新的复方酮康唑乳膏的含量测定方法。方法：改进撮针以波长紫外分光光度法和差示紫外分光光度法结合起来测定酮康唑含量。结果：得到标准曲线Ｃ（ｍｇ．Ｌ＾－１）＝４８．３０９△Ａ－０．２４６４,（ｒ＝０．９９９９）。平均回收率为９８．５１％,ＲＳＤ为１．２４％。结论：该方法重现性好,操作简便,可用于复方酮康唑乳膏的质量控制。     

高效毛细管电泳法测定何首乌中二苯乙烯甙的含量

目的：建立测定何首乌中二苯乙烯甙含量的高效毛细管电泳法。方法：电解液为２０ｍｍｏｌ·Ｌ＾－１硼砂,检测波长２１４ｎｍ,二苯乙烯甙为对照品,测定了何首乌及其制剂中二苯乙烯甙的含量。结果：进样量在１０．０￣１００．０μｇ·ｍｌ＾－１范围内线性关系良好（ｒ＝０．０９９９９）,加样回收率为９８．７１％,ＲＳＤ为１．５１％（ｎ＝３）,测得生何首乌,制何首乌及优生宝胶囊中二苯乙烯甙的含量分别为０．１２７％、０     

HPLC法测定复方苯甲酸醇液的含量

目的：建立反相高效液相色谱法测定复方苯甲酸醇溶液中两组份的含量,方法：ＯＤＳ柱上,以内标法（乙酰苯胺）测定,流动相为：甲醇－０．０１％水醋酸（内含０．００１ｍｏｌ．Ｌ＾－１醋酸钠）（４０：６０）,在２７４ｎｍ波长处检测。结果：样品平均回收率,苯甲酸９９．９０％,ＲＳＤ＝１．２６％,水杨酸１００．５４％,ＲＳＤ＝０．７６％,结论：含量测定方法简便快速,结果准确,可用于该制剂的质量控制．     

HPLC法测定丁香油—β—环糊精中丁香酚的含量

目的：测定丁香油－β－环糊精中丁香酚的含量。方法：固定相：Ｗａｔｅｒｓ Ｓｙｍｍｅｔｒｙ Ｃ１８柱（２５０ｍｍ×４．６ｍｍ,５μｍ）,流动相：甲醇－水（６５：３５）为,流速０．８ｍｌ／ｍｉｎ,检测波长２８０ｎｍ,选用丹皮酚作为人标物。结果：平均加样回收率为９７．５０％,ＲＳＤ＝０．４９％（ｎ＝６）;在０．０５￣１．６μｇ范围内线性关系良好（ｒ＝０．９９９２）。结论：本法快速、准确,样品处理简便易行     

高效液相色谱法测定痛风灵贴剂中盐酸小檗碱的含量

目的：采用反相高效液相色谱法，测定痛风灵贴剂中盐酸小檗碱的含量。方法：色谱条件为，流动相：甲醇－ ０．４ｍｏｌ·Ｌ－１ 硝酸铵（５２∶４８） ，检测波长３４８ｎｍ 。结果：样品萃取回收率９９．１４ ％ ，加样回收率９８．８３％ ，日内日间ＲＳＤ％ 分别为４．２ ％（ ｎ ＝１２） 和３ ．６ ％（ ｎ ＝９） 。测定３ 批痛风灵贴剂的含量，在０．８５１５～１ ．１０３５ｍｇ·ｇ－１ 范围。结论：本文方法可用于痛风灵贴剂的质量控制     

HPLC法测定酮康唑洗剂的含量

目的：用ＨＰＬＣ法测定酮康唑洗剂中酮康唑的含量。方法：固定相：ＲＰ－ Ｃ１８ 柱,流动相：８０％ 甲醇（ 含０ ．０５％ 三乙胺）,检测波长２４４ｎｍ 。结果：酮康唑浓度在４０～１２０μｇ·ｍｌ－ １范围内。线性关系良好,ｒ ＝ ０．９９９８。平均回收率９８．３ ％ , ＲＳＤ ＝０ ．７３％ 。日内、日间差均小于２％ 。结论：本法可用于酮康唑洗剂的质量控制。     

RP—HPLC法测定复方氧氟沙星栓剂中氧氟沙星和甲硝唑的含量

目的：建立反相高效液相色谱法,测定复方氧氟沙星栓剂中氧氟沙星和甲硝唑的含量。方法：采用ＯＤＳ－Ｃ１８（４．６×２５０ｍｍ）５μｍ不锈钢柱,以盐酸雷尼替丁为内标物,甲醇：水：磷酸：乙乙胺（３０：７０：０．３９：０．７０;ｐＨ＝３．１５）为流动相,检测波长２７５ｎｍ。结果：氧氟沙星在３．０￣２６．０μｇ·ｍｌ＾－１范围内线性关系良好,ｒ＝０．９９９９（ｎ＝５）,平均回收率为９８．８２％,ＲＳＤ＝０．７     

HPLC法测定盐酸普鲁卡因注射液中分解产物对氨基苯甲酸含量

目的：研究和测定盐酸普鲁卡因注射液中的降解产物对氨基甲酸,方法：采用离子对ＨＰＬＣ法,固定相Ｌｕｎａ５μＣ１８（２）柱,流动相为缓冲液（０．００５ｍｏｌ．Ｌ＾－１磷酸二氢钾,ｐＨ３．０,０．１％庚烷磺酸钠）－甲醇（７７：２３）;流速１．５ｍｌ／ｍｉｎ,柱温３５℃;检测波长２８７ｎｍ,结果：对氨基苯酸浓度在２．０～２０．０μｇ．ｍｌ＾－１范围,线性关系良好,回归方程为Ｃ＝５．８０４１×１０＾－５＋０．０７８２９,ｒ ＝０．９９９９。回收率为１００．２％,ＲＳＤ＝０．３２％,结论：本测定方法简便快速,结果准确,可用于该制剂有关物质检查。     

高效液相色谱法测定疏络止痛胶囊中粉防己碱的含量

目的：测定疏络止痛胶囊中粉防己碱的含量。方法：ＲＰ－ ＨＰＬＣ法选用Ｃ１８ 分析柱,流动相：甲醇－ 水－ 二乙胺（８２∶１８∶０．２） ,检测波长为２８３ｎｍ ,流速：１．０ｍｌ·ｍｉｎ－１ ,柱温：４０℃。结果：该法平均回收率为９８．１２ ％ , ＲＳＤ ＝ １．０６％ （ ｎ ＝ ５） 。结论：本法快速、准确,样品处理简便易行,重现性好。     

差示分光光度法测定扑麻滴鼻液中马来酸氯苯那敏的含量

目的：测定扑麻滴鼻液中马来酸氯苯那敏的含量,为该药提供质量控制方法。方法：应用差示分光光度法测定扑麻滴鼻液中马来酸氯苯那敏的含量。结果：马来酸氯苯建敏的线性范围１５￣７５μｇ·ｍｌ＾－１。回归方程Ｙ＝０．０１０１８＋０．００５９（ｒ＝０．９９９９）,平均回收率和ＲＳＤ分别为１００．１３％;０．７６％。结论：方法简便、快速、准确,可作为;可作为该制剂的质量控制方法。     

Knee injury and Osteoarthritis Outcome Score (KOOS) - validation of a Swedish version

The Knee injury and Osteoarthritis Outcome Score (KOOS) is a self-administered instrument measuring outcome after knee injury at impairment, disability, and handicap level in five subscales. Reliability, validity, and responsiveness of a Swedish version was assessed in 142 patients who underwent arthroscopy because of injury to the menisci, anterior cruciate ligament, or cartilage of the knee. The clinimetric properties were found to be good and comparable to the American version of the KOOS. Comparison to the Short Form-36 and the Lysholm knee scoring scale revealed expected correlations and construct validity. Item by item, symptoms and functional limitations were compared between diagnostic groups. High responsiveness was found three months after arthroscopic partial meniscectomy for all subscales but Activities of Daily Living.     

Endovascular management of carotid-cavernous fistulas

Objective To investigate endovascular treatment of traumatic direct carotid-cavernous fistulas （CCF） and their complications such as pseudoaneurysms. Methods： Over a five-year period, 22 patients with traumatic direct CCFs were treated endovascularly in our institution. Thirteen patients were treated once with the result of CCF occluded, 8 twice and 1 three times. Treatment modalities included balloon occlusion of the CCF, sacrifice of the ipsilateral internal carotid artery with detachable balloon, coll embolization of the cavernous sinus and secondary pseudoaneurysms, and covered-stem management of the pseudoaneurysms. Results All the direct CCFs were successfully managed endovascularly. Four patients developed a pseudoaneurysm after the occlusion of the CCF with an incidence of pseudoaneurysm formation of 18.2% （4/22）. A total number of 8 patients experienced permanent occlusion of the ICA with a rate of ICA occlusion reaching 36.4% （8/22）. Followed up through telephone consultation from 6 months to 5 years, all did well with no recurrence of CCF symptoms and signs. Conclusion Traumatic direct CCFs can be successfully managed with endovascular means. The pseudoaneurysms secondary to the occlusion of the CCFs can be occluded with stent-assisted coiling and implantation of covered stents.     

The acutely limping child

Acute limping may be the result of multiple pathologies in children. The differential diagnosis varies based on the age of the child. Irrespective of age, the initial imaging work-up includes AP and frog leg radiographs of the pelvis and ultrasound; MRI may sometimes be helpful. In children less than 3 years, infections and trauma are most frequent. MRI is the imaging modality of choice when osteomyelitis is clinically suspected. Between the ages of 3 and 10 years, transient synovitis of the hip and Legg-Calvé-Perthes disease are main considerations but infection, inflammation and focal bony lesions are also considered. In children over 10 years, slipped capital femoral epiphysis also is considered.     

Do Balance Board Training Programs Reduce the Risk of Ankle Sprains in Athletes?

Introduction Ankle sprains are the most common musculo-skeletal injury that occurs in athletes,particularly in sports that require jumping and landing on one foot such as soccer,and basketball(1-4).These injuries often result in significant time loss from participation,long-term disability,and have a major impact on health care costs and resources(5-8).     

High Intensity Interval Training:New Insights

KEY POINTS ·High-intensity interval training(HIT)is characterized by repeated sessions of relatively brief，intermittent exercise.often performed with an“a11 out”effort or at an intensity close to that which elicits peak oxygen uptake(i.e.，≥90%of VO2 peak).     

人体中的镭-226、镭-228、钋-210、铅-210

本文报道了广东阳江高本底地区6名、对照地区8名人尸体的骨²²⁶Ra、²²⁶Ra的浓度以及部分居民内脏器官中。²¹⁰Po、²¹⁰Pb的浓度。结果轰明阳江高本底地区和对照地区居民骨镭-226、镭-228的浓度分别为29.9pCi/kg, 26.9pCi/kgl 8.7pCi/kg, 8.2pCi/kg.由此估算出阳江高本底地区屠民骨中²²⁶Ra、²²⁸Ra的负薄璧及对骨衬、骨髓所产生的剂量当量分别为对照地区民民的3.4倍, 3.3倍。两地区居民内脏器官中^{210Po、210Pb的测定分析铡数较少但仍看出, 高本底地区均明显高于对照地区.}