冠状动脉造影对诊断急性冠状动脉综合征的意义

目的：探讨及时冠状动脉造影（CAG）检查对于临床诊断急性冠状动脉综合征（ACS）患者诊治的意义。方法：对临床诊断为ACS的183例患者进行CAG检查,并对不同治疗方式的患者进行6个月随访。结果：CAG证实无明显冠状动脉狭窄病变的为22．4％。初发劳累性心绞痛和急性心肌梗死患者以单支血管病变为主,恶化劳累性、自发性和混合性心绞痛以多支病变为主（P〈0．05）。142例有冠状动脉狭窄病变的ACS患者分为药物治疗组和干预组（介入治疗或冠脉搭桥）,随访6个月,药物治疗组死亡为11．5％,再次出现ACS为61．1％。干预组分别为6．4％、27．7％,两组比较差异有统计学意义（P〈0．01）。结论：对于临床诊断ACS患者及时进行CAG检查,明确冠状动脉病变的范围、程度,及时采取积极的干预治疗对预后有重要的意义。     

中国人与澳大利亚人冠状动脉病变规律的对比研究

目的：探讨中国人与澳大利亚人冠状动脉病变规律的差异。方法：选择中国南京冠心病患者3021例（男性占68．4％），澳大利亚悉尼同步入选3230例患者（男性占67．5％），分别进行冠状动脉造影（CAG），比较冠状动脉病变的支数及部位。结果：①中国人CAG阳性率为69．4％，右冠状动脉优势型为85．2％，澳大利亚人CAG阳性率为75．5％（P〈0．05），右冠状动脉优势型为82．9％：②两组冠状动脉病变主要累及的血管依次为左前降芰（LAD）、右冠状动脉（RCA）、左回旋支（LCX）、左主干（LM），中国人与澳大利亚人3支病变分别为26．0％和31．9％（P〈0．01）。③中国人男、女3支病变分别为29．8％和15．8％，澳大利亚人男、女3支病变分别为34．0％和26．2％，与中国人同性别比较，澳大利亚人男、女LM、RCA病变率均高（P〈0．01）。结论：中国人与澳大利亚人冠状动脉病变依次累及LAD、RCA、LCX、LM；与中国人比较，澳大利亚冠心病患者冠状动脉病变程度重，而且男、女患者均重：与女性比较，两组的男性患者冠状动脉病变均较重。     

180例冠心病危险因素与冠状动脉病变特点分析

目的：探讨福建地区冠心病（CHD）的危险因素与CHD患者冠状动脉病变特点。方法：根据冠状动脉造影结果将258例患者分为CHD组（n=180）和对照组（n=78），分析CHD患者的危险因素和冠状动脉病变特点。结果：冠状动脉病变者180例,CHD组各种危险因素在发生频率前3位是：高龄（73.33％）、低高密度脂蛋白胆固醇（HDL-C）（67.78％）、高血压（61．67％）；累积病变血管共375支，好发血管依次为左前降支、右冠状动脉、左回旋支、左主干；血管狭窄程度以75％-99％为主197支（52．53％）；患者多以三支病变为主71例（39．44％）：CHD组的性别、高龄、合并吸烟、高血压、高纤维蛋白原（FG）和高密度脂蛋白胆固醇／总胆固醇（HDL-C／TC）、LDL-C异常及FG、HDL-C/TC，LDL-C值与对照组存在显著差异（P〈0．05），2组间糖尿病发病率、HDL-C、TC、TG（甘油三酯）无显著差异（P＞0．05）。结论：高纤维蛋白原（FG）可能为CHD的危险因素，CHD患者中合并糖尿病的比例并不高，福建地区CHD的危险因素为：男性、高龄、吸烟、高血压、高FG、低HDL-C／TC、高LDL-C，冠脉的病变支数与严重程度随危险因素的个数增多而增加。     

冠心病合并2型糖尿病患者的冠状动脉造影分析

目的：探讨冠心病（CHD）合并2型糖尿病（TZDM）患者的冠状动脉造影特点。方法：从冠状动脉造影住院病例中选取585例（其中冠心病合并糖尿病283例,单纯冠心病302例）比较糖尿病与非糖尿病患者冠状动脉病变的特点,包括病变程度、累及的血管数目。结果：与非糖尿病组比较,糖尿病组左回旋支（LCX）、右冠状动脉（RCA）发生病变的比例高于非糖尿病组（均P〈0．05）,且血管狭窄的程度较重（狭窄程度≥75％的比例为61．1％比52．3％）,3支血管均发生病变的比例显著增高（49．1％比40．1％,P〈0．01）。而单支病变比例低（13．0％比21．5％,P〈0．01）。结论：合并2型糖尿病患者与非糖尿病患者的冠状动脉造影表现的差异有统计学意义,前者冠状动脉病变的程度较重、受累的血管数目较多。     

冠状动脉支架植入术临床应用初步报告（广州地区多中心经验）

目的：回顾性总结广州多中心冠状动脉支架植入术的初步结果。方法：340例（男282例，女58例，年龄33~83岁，平均58．3±20．9岁）冠心病640支病变血管中有387支共植入支架460个。病人有陈旧性心肌梗塞史者158例（46．4％），冠心病危险因索包括高血压243例（71．5％）、糖尿病107例（31．5％）、高脂血症219例（64．4％）及嗜烟217例（63．8％）。640支狭窄血管中三支病变者86例（25．3％），两支病变者128例（37．6％），单支病变者126例（37．1％）。按ACC／AHA分型则A型病变只占9．7％、B1型占35．2％、B2型占29．5％C型占25．6％．在植入支架的387支血管中，左前降支200支（51．7％），左回旋支47支（12．1％），右冠状动脉127支（32．8％）、左总干1支和其他12支，狭窄程度为91．7±9．1％。其中三支血管同时植入支架者3例，两支血管病变同时植入支架者47例。病例中有12．0％为PTCA过程中引起严重夹层撕裂及急性闭塞并发症而植入支架。结果：支架植入术的病倒成功率为97．6％，血管病变扩张成功率为98．3％，狭窄病变几乎100％消失。失败病例包括支架脱落4例，严重夹层撕裂3例，左前降支破裂1例，但无死亡及急性心肌梗塞并发症。结论：冠状动脉支架植入术是治疗冠心病的高效而安全的非外科手术疗法     

女性急性冠脉综合征特点分析

目的探讨女性急性冠脉综合征（ACS）患者的临床及冠脉病变特点。方法对因胸痛、胸闷而疑诊为ACS住院的750例患者,经冠脉造影（CAG）确诊为ACS的患者580例,进行回顾分析对比。结果①临床上：女性组发病年龄高于男性组（74．3±4．2 vs 62．1±3．5,P〈0．001）,女性ACS发病率和冠造阳性率低（18．9％vs 80．1％,P〈0．001;55．6％ vs 85．14％,P〈0．001）,女性组典型心绞痛发生率明显低于男组（34．5％ vs 76．8％,P〈0．001）,但男性组合并高尿酸血症明显高于女组（42．13％ vs 22．73％,P〈0．001）,女组体重指数明显高于男性性组（62．73％ vs 47．02％,P〈0．001）,女性组有吸烟史者显著低于男性组（12．73％ vs 68．9％,P〈0．001）。女性组合并高血压病、糖尿病者明显高于男性组（58．18％ vs 41．28％,P〈0．001;42．73％ vs 23．83％,P〈0．001）。②冠脉造影显示：女性组多支病变发生率明显高于男性组（47．27％vs 36．38％,P〈0．05）,侧支循环较男组多（50．90％vs35．16％,P〈0．005）,女性组血管狭窄程度以轻、中度为多（49．09％ vs 37．02％,P〈0．05）,重度狭窄差异无统计学意义33．64％ vs 29．36％,P〉0．05）。女组冠脉病变以A、C型病变为多（42．73％ vs 34．68％;38．18％ vs 31．49％）,但P值均〉0．05,无统计学意义。而两组病变血管分布情况无明显差异。结论女性发病率较男性低,发病年龄较男性大,女性临床症状不如男性典型,女性冠脉病变以多支病变为多,侧支循环形成较男性多,以B、C型为主,合并高血压、糖尿病、肥胖者较男性多。     

中国人和澳大利亚人冠状动脉病变对比研究

目的探讨中国人和澳大利亚人冠状动脉病变的差异。方法中国南京和澳大利亚悉尼3个中心同步注册入选临床可疑冠心病行冠状动脉造影病例6 251例(黄种人3 021例,白种人3 230例),其中黄种人确诊冠心病患者2 098例(占69．4％),白种人确诊冠心病患者2 439例(占75．5％)。冠脉病变程度由病变部位、支数及病变Gensini总积分表示．结果两组冠脉病变主要累及血管均依次为左前降支、右冠状动脉、左回旋支和左主干。黄种人和白种人男性三支病变分别为29．8％和34．0％,女性为15．8％和26。2％,男性左主干病变分别为9．6％和14．2％,女性为4．9％和11．6%,两组男性三支病变及左主干病变均高于女性,单支病变低于女性(P<0．01),双支病变不同性别间差异无统计学意义(P>0．05)。白种人三支病变及左主干病变为31．9%和13.5％,高于黄种人(分别为26．0％和8．3％,P<0．01),单支病变低于黄种人(38．0％比44．7％,P<0．01),双支病变两组间差异无统计学意义(30．1％比29．3％,P>0．05)。Gensini总积分随年龄增长而增加。40岁以上相同年龄段,白种人Gensini总积分均明显高于黄种人。结论冠脉病变随年龄增加而增加,男性冠脉病变严重程度较相同年龄段女性重。澳大利亚人冠心病患者冠脉病变严重程度均较同性别中国人重。同样程度冠脉粥样硬化,澳大利亚人比中国人早10余年。     

青年急性冠脉综合征冠脉造影特点及随访

目的 探讨青年急性冠状动脉综合征（ACS）冠状动脉（冠脉）造特点及其与远期心脏事件的关系。方法 比较青年ACS与老年ACS患冠脉病变程度、范围，并进行心脏事件随访。结果 78例青年ACS患有冠脉病变74例（94．9％），单支病变46例（58．9％）；171例老年ACS患有冠脉病变166例（97．1％），单支病变41例（23．9％）。平均随访9个月，青年ACS患发生心脏事件10例（12．8％），其中心绞痛再入院6例（7．7％）；老年ACS患发生心脏事件47例（27．5％），其中心绞痛再入院30例（17．5％），两组比较差异有显性（P＜0.05)。结论 ACS患冠状动脉粥样硬化青年时期之前已经发生，ACS预后与冠脉病变程度和年龄呈正相关。     

中国与澳大利亚心肌梗死患者冠状动脉病变特点的比较研究

目的：比较中国和澳大利亚部分心肌梗死（MI）患者心血管病危险因素和冠状动脉造影（CAG）结果的差异。方法：对中澳两国临床诊断MI的977例患者行选择性CAG检查，并对年龄、性别和CAG结果进行对比分析。结果：中国组CAG阳性（直径狭窄50％以上）550例，占95．16％，澳大利亚组CAG阳性376例，占94．24％，中国和澳大利亚MI患者比较，〈40岁患者2．08％vs6．02％（P〈0．05），男性患者85．6％vs79．7％（P=0．015），高血压、高脂血症患者分别为58．65％vs28．57％和11．59％vs68．42％（P〈0．01），糖尿病患者为17．30％傩16．29％（P〉0．05），3支病变及完全闭塞病变分别为32．87％vs24．31％和45．50％vs32．33％（P〈0．01），两组冠状动脉（CA）病变累及的血管，均依次为左前降支（LAD）、右冠状动脉（RCA）、左回旋支（LCX）和左冠状动脉主干（LM）。中国MI患者70—79岁年龄段发病率最高，为29．58％，澳大利亚人发病年龄段主要集中在50—59岁，为32．08％。结论：与澳大利亚人相比较，中国MI患者年轻人较少，高血压发生率高，高脂血症发生率低，CA病变中以多支病变及完全闭塞更为多见。     

早发冠心病患者的临床和冠状动脉病变特点的研究

目的：探讨早发冠心病患者的心血管病危险因素和冠状动脉病变特点。方法：采用Judins法对176例胸痛患者行冠状动脉造影。将108例确诊为早发冠心病患者与68例对照者比较，将早发冠心病组按年龄分为不同亚组，探讨早发冠心病组的心血管病危险因素和冠状动脉病变特点。结果：早发冠心病组血浆胆固醇、低密度脂蛋白胆固醇和脂蛋白(a）水平较对照组明显升高，而高密度脂蛋白胆固醇水平降低，高血压、吸烟史和心血管病家族史高于对照组，男性更容易患早发冠心病（P＜0．05）。两组空腹血糖和甘油三酯水平没有差异，早发冠心病组发病时越年轻，病变发生在左前隆支的比例越高，40岁以下组单支血管病变比例明显高于40－55岁组（P＜0．05）。随着年龄增加，回旋支和右冠状动脉发生病变的比例增加，两支以上血管病变比例明显增加（P＜0．05）。结论：早发冠心病患者的心血管病危险因素较多，发病时越年轻、单支血管病变（左前降支）比例越高，预防冠心病应从尽早积极控制心血管病危险因素开发。     

Gender based differences in patients with acute coronary syndrome: findings from Chinese Registry of Acute Coronary Events (CRACE)

Background Many studies have examined gender related differences in the presenting symptoms, management and prognosis of patients with acute coronary syndrome (ACS). Much data are available from industrialized countries, in which ACS is a major cause of morbidity and mortality, but relatively little information has been obtained from China, where an epidemic of cardiovascular disease is starting to emerge. The purpose of this study was to assess the differences in clinical practice in a national Chinese sample.Methods A total of 12 medical teaching hospitals participated in CRACE. Data collection began in 2001 and continued until 2004, 1301 patients with ACS were enrolled into the study. We compared the clinical demographics, different therapies and outcomes in hospitals between female and male patients with ACS.Results Patients had an average age of 63.13 years (ranging from 27 to 93 years) and 318 female and 983 male subjects were enrolled. Female subjects were older than male patients (67.23 years vs 61.80 years, P&lt;0.0001). The incidence of angina, heart failure, diabetes mellitus and hypertension in the female group was higher than in male group (73.6% vs 62.3%, P&lt;0.0001; 8.2% vs 5.7%, P=0.031; 30.8% vs 18.6%, P&lt;0.0001 and 66.4% vs 56.8%, P=0.001 respectively), but the incidence of smoking was less in the female group than in the male group (6.6% vs 66.2%, P&lt;0.0001). More male patients presented with ST-segment elevation myocardial infarction (STEMI) compared with female patients (48.5% vs 39%, P=0.002). With the exception of β-blocker administration, no differences were found among medications including aspirin, ACEI, lipid lowering agents and low-molecular-weight heparin (LMWH) between female and male patients presenting with ACS in hospitals. Compared with male patients with non-ST-segment elevation (NSTE) ACS, female subjects were more prone to receive β-blockers (75.1% vs 63.4%, P=0.001). Among STEMI and NSTE-ACS patients, fewer female subjects received reperfusion therapy compared with male subjects (37.1% vs 26.8%, P=0.013 for STEMI; 53.6% vs 37.2 %, P&lt;0.0001 for NSTE-ACS). Recurrent angina was more often seen in the female group of patients with the whole spectrum of ACS (25% vs 14.5%, P=0.005 for STEMI; 29.4% vs 20.2%, P=0.001 for NSTE-ACS) as was true for patients with congestive heart failure. There was no significant difference in in-hospital death rates between the two groups with ACS (5.6% vs 7.1%, P=0.2 for STEMI, and 2.1% vs 1.4%, P=0.738 for NSTE-ACS). Conclusions Female patients with ACS were older than male subjects and thus more often had concomitant diseases but less often had a history of smoking. They less often received reperfusion therapies and more often had higher in-hospital recurrent angina. However, there was no significant difference in in-hospital mortality between the female and male patients.     

Sex differences in cardiac catheterization: the role of physician gender.

CONTEXT: Many studies indicate that women are less likely than men to undergo cardiac procedures after an acute myocardial infarction (AMI), raising concerns of sexual bias in clinical care. However, no data exist regarding the relationship between patient sex, physician sex, and use of cardiac procedures. OBJECTIVE: To determine whether sex differences in cardiac catheterization after AMI were greater when patients were treated by male attending physicians compared with female attending physicians. DESIGN, SETTING, AND PATIENTS: Analysis of data from the Cooperative Cardiovascular Project, a retrospective medical record review. A total of 104 >231 Medicare fee-for-service beneficiaries who were hospitalized in US acute care hospitals for an AMI between January 1994 and February 1995. MAIN OUTCOME MEASURE: Use of cardiac catheterization within 60 days of admission, compared between the 4 groups of patient sex-physician sex combinations. RESULTS: Women underwent fewer cardiac catheterizations than men when treated by either male physicians (38.6% vs 50.8%; P =.001) or female physicians (34.8% vs 45.8%; P =.001). Sex differences in procedure use were not greater when a patient and physician were of different sexes (P for interaction =.85). After potential confounders in multivariable analysis were accounted for, women were less likely to undergo cardiac catheterization (risk ratio, 0.90 [95% confidence interval (CI), 0.88-0.92]), regardless of the treating physician's sex. Patients treated by male physicians were more likely to undergo cardiac catheterization (risk ratio, 1.06 [95%CI, 1.02-1.10]) than those treated by female physicians, regardless of patient sex. CONCLUSIONS: Women who have had an AMI undergo a cardiac catheterization less often than men, whether treated by a male or female physician. These results suggest that factors other than sexual bias by male physicians toward women account for sex differences in cardiac procedure use.     

不同性别老老年心肌梗死患者血脂水平及冠脉病变严重程度差异的分析

目的:探讨不同性别80岁及以上急性心肌梗死患者的血脂特点以及冠脉病变严重程度。方法:连续入选2012年1月-2017年12月于天津医科大学第二医院心脏科住院治疗的急性心肌梗死（包括STEMI和non-STEMI）患者（大于80岁）201人,其中男性组106例,平均年龄为（83.11±3.11）岁,女性组95例,平均年龄为（82.54±2.16）岁,依据冠状动脉造影进行Gensini评分,比较不同性别患者病史、血脂水平及病变严重程度。结果:老老年女性ACS患者的LDL（3.12±1.01 vs 2.71±1.03）、HDL（1.22±0.65 vs 1.00±0.30）、TC（4.75±1.37 vs 4.14±1.07）、TG（1.37±0.61 vs 1.00±0.42）均高于男性组,具有统计学意义（P＜0.05）。老老年男性ACS患者吸烟史（32.08% vs 17.89%）,饮酒史（22.64% vs 0.03%）比率高于女性患者,具有统计学意义（P＜0.05）,不同性别老老年心肌梗死患者的高血压及糖尿病患病率未见显著差异（P=0.178,P=0.499）,冠脉造影Gensini评分结果显示老老年ACS患者血管病变严重程度并无显著差异（P=0.412）。结论:老老年心肌梗死患者病变严重程度并无明显差异,而血脂紊乱存在性别差异,男性患者血脂更为理想,对老老年冠心病的降血脂治疗需要依据患者性别合理用药。     

A high maintenance dose of clopidogrel improves short-term clinical outcomes in patients with acute coronary syndrome undergoing drug-eluting stent implantation

Background Recurrent ischemic events occurred even during routine use of 75 mg clopidogrel in addition to aspirin, that indicated a potentially insufficient maintenance dosage of clopidogrel. The aim of the present study was to evaluate the short-term efficacy and safety of a 150 mg maintenance dose of clopidogrel following a 600 mg loading dose in patients with an acute coronary syndrome （ACS） undergoing drug eluting stent （DES） implantation.
Methods Between November 2005 and November 2006, a total of 813 consecutive ACS patients undergoing DES implantation were enrolled. A 600 mg loading dose was administered before percutaneous coronary intervention （PCI） and patients were randomized to receive clopidogrel 75 mg or 150 mg for 30 days in addition to 300 mg aspirin daily. Primary end points were the composite of cardiac death, non-fatal myocardial infarction （MI） and urgent target vessel revascularization （UTVR）. Secondary end points included stent thrombosis （ST）, major and minor bleeding events at 30 days. Results At a follow-up period of 30 days, 4 （1.0%） patients in the 150 mg group and 9 （2.2%） patients in the 75 mg group （P 〉0.05） reached the primary end points. There was no significant difference in the incidences of MI （0.5% vs 1.2%, P〉0.05）, UTVR （0.7% vs 2.0%, P 〉0.05）, and cardiac death （0.2% vs 0.2%, P 〉0.05） between the two groups. The incidence of ST （0 vs 1.5%, P 〈0.05） was significantly lower in the 150 mg group than that in the 75 mg group. There were no significant differences between both groups regarding the risk of major （0.2% vs 0, P 〉0.05） or minor （0.5% vs 0.2%, P 〉0.05） bleedings.
Conclusion A high clopidogrel maintenance dose of 150 mg daily following a 600 mg loading dose for the first month after PCI procedure reduces the risk of ST and appears to be safe in patients with ACS undergoing DES implantation.     

冠状动脉内支架置入术前后心电图的变化

目的 :探讨冠状动脉性心脏病 (简称冠心病 )时冠状动脉内支架置入术前后心电图的变化规律。　方法 :回顾性研究分析 1 36例冠心病冠状动脉内支架置入术前后的心电图资料及冠状动脉造影 (CAG)资料。　结果 :1 36例患者中 ,1 0 8例术后心电图发生改变 ,占 79.4 1 %。不同病变范围组的心电图改变差异无显著性意义 (P >0 .0 5 ) ,该研究分别从临床症状、诊断冠状动脉的优势类型、病变部位及手术前后累及导联数的改变等几个方面 ,具体探讨了不同病变范围组之间在介入手术前、后的心电图变化。结果提示 ,二支病变时急性冠状动脉综合征 (ACS)和非ACS患者支架置入前后的心电图改变有统计学意义 (P <0 .0 2 5 ) ,单支病变时 ,典型胸痛、不典型胸痛及无胸痛者置入支架后心电图改变差异有显著性意义 (P <0 .0 5 ) ,心电图有改变者术前、术后导联数对比分析结果 ,在单支、二支及多支病变组中差异均有显著性意义 (P <0 .0 0 1 )。　结论 :通过观察手术前后心电图的改变 ,可了解冠状动脉内支架置入术对心肌血供的影响     

早发冠心病不同性别患者临床危险因素和冠脉特点的对比研究

目的 探讨早发冠心病患者冠心病危险因素和冠脉病变特点的性别差异.方法 260例经冠状动脉造影确诊的早发冠心病患者,男性130例,女性130例,对其血脂异常、糖尿病、抽烟、冠心病家族史、高血压和既往缺血性脑卒中史等危险因素和冠状动脉造影病变特点进行分析.结果 在早发冠心病患者中,女性组高血压和糖尿病患病率明显高于男性组（P＜0.05）,而在男性组吸烟率明显增加（P＜0.05）.体重指数、高脂血症、既往脑卒中史和冠心病家族史在2组间未见显著差异（P＞0.05）.2组冠脉病变均以单支病变占优势（P＜0.05）,2组间冠脉病变特征无显著差异（P＞0.05）.结论 在早发冠心病患者中,吸烟是男性患者的主要危险因素,而高血压病和糖尿病是女性患者的主要危险因素.两者冠脉病变特点无显著差异.     

女性高危急性冠脉综合征早期PCI预后分析

目的:探讨女性高危急性冠脉综合征(ACS)患者早期经皮冠状动脉介入治疗(PCI)的预后是否与男性有差别。方法:分析24 h内接受PCI治疗的79例女性高危ACS患者冠脉病变及干预情况,记录手术成功率及随访期间终点事件发生率,并与同期133例男性患者作对照。结果:女性患者平均年龄较男性为高(P<0.01),较少吸烟(P<0．01),较多合并糖尿病(P<0．05)和高脂血症(P<0．05),三支病变较少(P<0．05),而手术成功率及(25．3±8．1)个月心血管事件发生率与男性组无统计学差异(P>0.05)。结论:早期PCI治疗高危ACS其院内疗效与长期预后无性别差异。     

Diver CE versus Guardwire Plus for thrombectomy in patients with inferior myocardial infarction: a trial of aspiration of thrombus during primary angioplasty for inferior myocardial infarction

Background Different feasible and safe thrombectomy and distal protection devices have been used in clinical practice. The efficiency and safety of adjunct thrombectomy using Diver CE device (Invatec, Italy) versus Guardwire Plus device (Medtronic, USA) before percutaneous coronary intervention (PCI) were compared in patients with acute inferior ST-segment-elevation myocardial infarction (STEMI) for less than 12 hours, thrombolysis in myocardial infarction (TIMI) flow grade 0 to 1, and total occlusion of the proximal right coronary artery (≥3 mm in diameter) in a prospective randomized single-center study.Methods The primary end point was the magnitude of ST-segment resolution (STR) (&gt;70% ) measured immediately, 90 minutes and 6 hours after PCI, myocardial blush grade and slow flow or no-reflow. Secondary end points were left ventricular end-diastolic volume (LVEDV), left ventricle ejection fraction (LVEF) and major adverse cardiac events (MACEs) including death, myocardial infarction, target vessel revascularization and stroke at 30 days.Results A total of 122 patients were equally divided into Diver CE group and Guardwire Plus group, which were comparable by age ((60±14) years vs (60±13) years), male (82% vs 84%), diabetes (31% vs 28%), previous coronary artery disease (25% vs 23%), onset-to-angiogram ((350±185) min vs (345±180) min), and use of glycoprotein IIb/IIIa inhibitor (11% vs 13%). The magnitude of ST-segment resolution was similar in the two groups as ST-segment resolution &gt;70% (57% vs 59%; P&gt;0.05). Similar slow flow/no-reflow rates were observed in the Diver CE group (8%) and the Guardwire Plus group (7%). TIMI flow grade 3 was obtained in 95% vs 97% patients, respectively (P&gt;0.05). Myocardial blush grade 3 was similar (70% vs 72%; P&gt;0.05). Thirty-day clinical outcome was comparable (LVEF, 0.54±0.12 vs 0.53±0.11; death, 3% vs 3%; myocardial infarction, 2% vs 0%; and target vessel revascularization, 2% vs 2%; P&gt;0.05, respectively). Conclusions Removal of thrombus burden with the Diver CE catheter before stenting leads to similar improvement of myocardial reperfusion in patients with inferior STEMI and total occlusion of the proximal right coronary artery (≥3 mm in diameter) compared with the Guardwire Plus device, as illustrated by a reduced risk of distal embolization and improved ST-segment resolution.     

Firebird药物洗脱支架联合国产替罗非班治疗急性冠脉综合征的安全性及疗效

目的 评估Firebird药物洗脱支架(DES)加替罗非班与Cypher支架加替罗非班治疗急性冠脉综合征(ACS)病人的安全性和有效性.方法 2005年7月至2007年7月323例ACS病人,其中接受Firebird支架(Firebird组)161例,接受Cypher支架(Cypher组)162例.两组同时加用替罗非班.首先给予负荷量10μg·kg-1,3 min内静注完毕,之后以0.15 μg·kg-1·min-1的速度微量泵持续静点36 h.比较两组支架植入后即刻到近期的有效性和安全性,并于30 d内进行随访,比较有效性和主要不良心脏事件的发生率.结果 Firebird组与Cypher组比较,术前左室射血分数、靶病变的部位、血小板计数、血红蛋白、红细胞压积差异均无统计学意义.两组手术成功率均为100%,术后出血并发症、血小板计数、血红蛋白、红细胞压积差异均无统计学意义,两组各有2例发生支架内急性血栓(1.2% vs 1.2%,P＞0.05).均无亚急性血栓发生、非致死性心肌梗死各2例(1.3% vs 1.3%)、靶血管再次重建分别为1例(0.6%),2例(1.3%)、再住院分别为2例(1.3%)1例(0.6%)差异均无统计学意义(均P＞0.05).30 d随访均未见支架内再狭窄.结论 Firebird药物洗脱支架加用冠替罗非班治疗ACS均有较好的安全性和有效性,具有与Cypher支架相似的临床疗效.