Carcinoma arising in fibroadenoma: case report and review of the world literature

To date 119 cases of "carcinoma arising in a fibroadenoma" have been reported in the world literature. A total of 120 cases, including the case described here, are analyzed. The mean age of the affected females was 43 years. A few patients complained of several disorders other than breast tumor before and during the development of the tumor. The tumor was most frequently located in the upper outer quadrant of the breast. Most carcinomas in fibroadenomas were lobular carcinoma in situ followed by duct carcinoma in situ. There was only one squamous cell carcinoma. The malignant process was confined to the fibroadenoma in over half of the cases. In some cases additional foci outside the fibroadenoma were reported. Radical mastectomy was the most frequent treatment. The prognosis was usually good.     

Male breast carcinoma: an updated experience at a Veterans Administration Hospital and review of the literature

Ten cases of male breast carcinoma are reviewed. Male patients with breast cancer on the average are 10 years older than females, and they delay twice as long as females after noting a breast mass before seeking medical attention. Because of this patient's delay, male breast cancer tends to be more advanced at the time of diagnosis and initial therapy than female breast cancer.     

Priapism secondary to penile metastasis: A report of two cases and a review of the literature

Malignancy metastasis to the penis is an uncommon clinicopathological entity. We present two cases of malignant priapism following penile metastasis, in which the diagnosis was established by core needle biopsy of the corpus cavernosum. Primary tumors were urothelial carcinoma of the urinary bladder in one case (the patient having concomitant high-grade prostatic adenocarcinoma) and prostatic adenocarcinoma in the other. The clinicopathological features of 51 previously reported cases of penile metastasis in the recent literature are reviewed. J. Surg. Oncol. 1998:68:51–59. © 1998 Wiley-Liss, Inc.     

Adenocarcinoma arising in association with gastric heterotopic pancreas: A case report and review of the literature

We report a case of adenocarcinoma arising in a focus of heterotopic pancreas, occurring in the stomach of a 52-year-old man. The patient presented with gastric outlet obstruction. Radiographic studies revealed thickening of the gastric wall, but endoscopy failed to reveal a mucosal abnormality. A 50% distal gastrectomy was performed, along with vagotomy. Microscopic examination revealed extensive involvement of the muscularis propria of the distal stomach by heterotopic pancreas. The ectopic pancreas had a microscopic appearance consistent with Heinrich's class III, in which the majority of the heterotopic pancreas was characterized by cystically dilated duct structures. Occasional islets were present. Intimately associated with the cystically dilated ducts was a prominent number of small infiltrating ducts lined by columnar or cuboidal cells with enlarged hyperchromatic nuclei containing prominent nucleoli. These were consistent with a well-differentiated invasive adenocarcinoma. Despite multiple sectioning, no connection between the adenocarcinoma and the overlying gastric mucosa was seen. Adenocarcinoma arising within ectopic pancreas is a rare occurrence with fewer than 30 well-documented cases reported in the world literature to our knowledge.     

空肠腺癌1例及文献复习

目的:探讨小肠腺癌的临床表现及病理特点.方法:对1例空肠腺癌进行组织学表现及免疫组化结果观察和文献复习.结果:组织学特点:癌组织腺管状排列,分化比较好,癌细胞胞浆丰富,核大深染,异型性明显,可见病理性核分裂像,部分区域可见黏液组织,肿瘤侵及管壁全层.免疫组化特点:癌细胞呈CEA阳性,CK阳性,CK18阳性及EMA阳性.结论:小肠腺癌是一种少见的恶性肿瘤,临床表现缺乏特异性,需通过钡餐造影和腹部CT等方法协助诊断,手术是其最主要的治疗手段.     

Rectal metastases from lobular carcinoma of the breast: Report of a case and literature review

Metastatic involvement of the gastrointestinal (GI) tract secondary to breast cancer is rare. Reported herein is the case of a 74-year-old woman with metastatic lobular breast carcinoma to the rectum presenting with obstruction. The breast tumour was diagnosed nine years prior to the presentation of rectal metastases. Endoscopy was repeated twice until a diagnosis was established. Examination of endoscopy material revealed infiltration of the rectum by malignant signet ring cells identical to those of the primary breast tumour. The patient did not respond to chemotherapy and underwent laparotomy with a defunctioning colostomy. Literature review revealed only a few more cases of metastatic breast carcinoma to the rectum.Awareness of this condition may lead to accurate diagnosis and early initiation of systemic treatment, thus avoiding surgical intervention.     

Adenoid cystic carcinoma of Bartholin's gland: review of the literature and report of two cases

Two patients with adenoid cystic carcinoma of Bartholin's gland and a review of the relevant literature are presented. With the inclusion of these two patients, there are now 24 cases reported. Both patients had large vulvar masses with a short clinical history, and several local tumor recurrences within the first 21/2 years after radical vulvectomy. The characteristic cribriform pattern and perineural involvement in addition to vascular invasion were present in the pathological material. No metastases were found in the inguino-femoral lymph nodes removed. Both patients are alive, without evidence of local recurrence but with lung metastases. A chemotherapeutic treatment scheme (adriamycin and cyclophosphamide) is underway but it is too early to evaluate its results.     

Cutaneous melanoma arising in a burn scar: two recent cases and a review of the literature

Melanoma arising in a burn scar is extremely uncommon. We report two recent cases, including one patient in whom six distinct primary melanomas arose in the setting of an extensive truncal burn scar. Only 27 patients have been reported previously, and only three previous cases of multiple primary melanomas arising in a burn scar have been described.     

63例肾盂输尿管癌患者的临床病理特点并文献复习(英文)

Objective:The aim of this study was to summarize the clinicopathological characteristics of patients with renal pelvis and ureteral carcinomas,and analyze the recurrence in the remaining urinary tract and metastasis outside the urinary tract after surgical treatment.Methods:The patients' characteristics,tumor stage and grade,recurrence and metastasis distribution were summarized by tables,respectively.Spearman rank test,Log-rank test,Kaplan-Meier survival curve,and Cox proportional hazards regression model ...     

Pre-operative management of Pleomorphic and florid lobular carcinoma in situ of the breast: Report of a large multi-institutional series and review of the literature

BackgroundPleomorphic and Florid Lobular carcinoma in situ (P/F LCIS) are rare variants of LCIS, the exact nature of which is still debated.AimTo collect a large series of P/F LCIS diagnosed on preoperative biopsies and evaluate their association with invasive carcinoma and high grade duct carcinoma in situ (DCIS). Data obtained were compared with those reported in the literature.MethodsA multi-institutional series of P/F LCIS was retrieved. All cases were diagnosed on pre-operative biopsies, which was followed by an open surgical excision. Data on post-operative histopathology were available. A literature review was performed.ResultsA total of 117 cases were collected; invasive carcinoma and/or DCIS was present in 78/117 cases (66.7%). Seventy cases of P/F LCIS were pure on biopsy and 31 of these showed pathological upgrade in post-surgical specimens. Pre-operative biopsy accuracy was 47/78 (60.3%); pre-operative biopsy underestimation of cancer was 31/78 (39,7.%). In the literature review papers, invasive carcinoma or DCIS was associated with 274 of 418 (65.5%) cases of P/F LCIS. Pre-operative biopsy accuracy was 66% (181/274) whereas pre-operative biopsy underestimation of cancer was 33.9% (93/274).ConclusionsThe data presented here indicate that P/F LCIS is frequently associated with invasive carcinoma or high grade DCIS and that pre-operative biopsy is associated with an underestimation of malignancy. Open surgery is indicated when P/F LCIS is diagnosed pre-operatively.     

Primary adenocarcinoma of the appendix: report of five cases and review of the literature

Five patients with primary adenocarcinoma of the appendix are reported. All patients presented with symptoms resembling those of acute appendicitis or periappendicular abscess. In none of them was malignancy suspected prior to operation. It is advisable that every patient above 50 years of age presenting with symptoms of appendicitis undergo laparotomy, thus enabling a better exploration of the cecal region. If an appendiceal mass is present and frozen section shows malignancy, a right hemicolectomy should be performed. The prognosis of adenocarcinoma of the appendix is dismal as most patients present with an advanced stage of the disease.     

A Comparison of the Biological and Clinical Features of Invasive Lobular and Ductal Carcinomas of the Breast

Altogether 295 consecutive pure lobular invasive breast cancers diagnosed between 1990 and 1999 in the area of Tampere University Hospital were compared to 295 ductal invasive breast cancers. Biological factors, DFS, OS, recurrence types, survival after recurrence and other primary cancers were analyzed. ILC tumors were more often hormone receptor-positive, slowly proliferative and Erbb-2-negative. During the mean follow-up time of 5.1 years 76 recurrences in both groups were discovered. During the whole follow-up time there was more metastation to gynecological organs and GI tract in the ILC group. Bilateral breast cancers did not differ between the groups. DFS and OS were the same between the groups despite the fact that ILC patients received statistically significantly less adjuvant treatment. In conclusion, since ILC cancers are more often hormone receptor-positive, there is a good option to adjuvant endocrine therapy with present and future preparations, this possibly leading to improvement in OS.     

膀胱肉瘤样癌的诊断与治疗(2例报告及文献复习)

目的:探讨膀胱肉瘤样癌的组织学特性,提高对膀胱肉瘤样癌的诊治水平。方法:报告2例膀胱肉瘤样癌患者的临床、病理资料,复习相关文献进行讨论。结果:术后病理检查见上皮和肉瘤样间质2种恶性成分,癌与肉瘤样区有移行,诊断为膀胱肉瘤样癌。其中1例10个月后死于全身衰竭、多处转移。结论:膀胱肉瘤样癌具有浸润性生长的生物学特性,恶性程度高,预后不良,确诊依赖病理学及免疫组织化学检查;化疗、放疗都不太敏感[1],手术仍是首选治疗方式。     

肾上皮样血管平滑肌脂肪瘤2例及文献复习

  目的  探讨肾上皮样血管平滑肌脂肪瘤(epithelial angiomyolipoma, EAML)的临床病理特征, 进一步认识本疾病。  方法  回顾性研究2002年7月至2012年8月2例肾EAML患者的临床及病理资料并进行随访, 结合复习文献, 对其临床病理特点、生物学行为及预后进行分析。  结果  2例患者都为女性, 平均年龄47.5岁, 均为左肾EAML。无明显阳性体征, 2例在B超和CT均发现肾占位, 其中1例CT强化不均匀, 1例增强检查呈渐进性强化, 延迟期强化程度略减低。分别行左肾部分切除术和根治性左肾切除术。组织形态学的主要特征均呈明显的上皮样分化。  结论  分析结果提示: EAML生物学行为与经典型肾AML不同特征在于浸润性生长方式、细胞学异型性, CT对其诊断有重要意义, 但病理结合免疫组化能够确诊, 手术是主要的治疗方法, 其预后大多数良好。      

Primary bone lymphoma: a report of two cases and review of the literature

Primary bone lymphoma (PBL) is an uncommon tumor accounting for approximately 4-5% of extra nodal lymphoma and less than 1% of all non-Hodgkin's lymphoma. Disease may be complicated at presentation by pathological fracture or spinal cord compression. Diffuse large-B-cell lymphoma (DLBCL) accounts for the majority of cases of PBL. Owing to its rarity, only a few retrospective studies have been published addressing the prognosis and treatment of primary bone lymphoma. In this paper, we report our experience with two cases of PBL treated with chemotherapy and radiotherapy and review literature to elucidate the optimal treatment of primary bone lymphoma.     

慢性中性粒细胞白血病2例并文献复习

目的:研究对慢性中性粒细胞白血病(CNL)的特点.方法:报告2例CNL并结合文献进行复习.结果:患者中性粒细胞明显增多,脾大,中性粒细胞碱性磷酸酶积分增高,无Ph染色体、bcr-abl融合基因,骨髓粒系增生,无病态造血和明显纤维化依据,排除了如类白血病反应、其他克隆性血液病引起的中性粒细胞增多,其中1例伴有单克隆免疫球蛋白血症,2.5年后转化为急性白血病.结论:CNL是一种少见的骨髓增殖性疾病,多发生于老年人,预后差,治疗无标准方案,年轻患者应进行异基因造血干细胞移植以达到治愈目的.     

Infiltrating angiolipoma: report of two cases and review of the literature

Infiltrating angiolipoma is an infrequent cutaneous tumor, with skeletal muscle infiltration that should be differentiated from the common encapsulated angiolipoma. We present two cases in young women, and review the literature. Infiltrating angiolipoma may be a locally aggressive neoplasm, which makes its clinicopathologic recognition and appropriate therapy important.     

Intracystic papillary carcinoma: a review of 917 cases

BACKGROUND: Intracystic papillary carcinoma (IPC) is an uncommon breast neoplasm. To the authors' knowledge there are limited data regarding its epidemiology and only small studies focusing on outcomes. By using a large, population-based database, this study aimed to identify specific characteristics of patients with IPC, investigate its natural history, and determine its long-term prognosis. METHODS: The California Cancer Registry (CCR), a population-based registry, was reviewed from the years 1988 through 2005. The data were analyzed with regard to patient sex, age at presentation, tumor stage, and overall survival. Cumulative relative actuarial survival was determined using a Berkson-Gage life table method. The CCR classifies IPC as either in situ (CIS) or invasive, as determined by the local pathologist. RESULTS: A total of 917 cases of IPC were identified. Approximately 47% of cases (n = 427) were CIS, whereas 53% of cases had invasion (n = 490). The majority of the invasive cases were localized at the time of diagnosis (89.6%; n = 439). At 10 years, patients with CIS and invasive disease had a similar relative cumulative survival (96.8% and 94.4%; P = .18). CONCLUSIONS: IPC is a rare disease. There is no apparently significant difference in the long-term survival of patients in the 2 histologically derived subgroups of IPC. There is an excellent prognosis for patients diagnosed with IPC regardless of whether the tumor is diagnosed as in situ or invasive. Clinicians should keep this in mind when planning surgical and adjuvant treatments. Sentinel lymph node biopsy may be a prudent way to evaluate axillary involvement in patients with IPC.     

Somatostatinoma: a case report and review of the literature

Somatostatinomas are rare endocrine tumors that were first described in 1977. In addition to the present case report, there have been 31 cases reported in the literature. We have reviewed the literature to integrate the symptoms, physical findings, diagnostic tests, treatment, and length of survival of these patients. Although the symptoms that occurred in the majority of cases were those that are seen in most patients with intra-abdominal neoplasms, symptoms relating to the presence of excess circulating somatostatin--diabetes, maldigestion, and cholelithiasis--were frequently seen. Physical findings and the results of diagnostic tests were usually nonspecific. The majority of the patients underwent radical surgical procedures (Whipple procedure or pancreatic resection). The pancreas was the most frequent site of involvement (21/31 cases), but primaries in the duodenum, ampulla of Vater, cystic duct, and jejunum have been described as well. Metastases were most frequently seen in the liver and lymph nodes. Chemotherapeutic agents were administered to 10 patients, usually as adjuvant therapy, and appear to be useful in treating recurrent and metastatic disease. The one-year survival of these patients is 48%, which is better than that for patients with carcinoma of the pancreas or biliary tree. Therefore, it is important that the diagnosis of somatostinoma be made so that the patient may be treated accordingly and followed by serial somatostatin levels for evidence of metastasis or recurrent disease.